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Review: Lyrica and Tylenol





Summary: drug interactions are reported among people who take Lyrica and Tylenol together.

This review analyzes the effectiveness and drug interactions between Lyrica and Tylenol. It is created by eHealthMe based on reports of 2,931 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Lyrica and Tylenol >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 55,615 users)

On Dec, 1, 2014: 2,931 people who take Lyrica, Tylenol are studied

Lyrica, Tylenol outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Tylenol (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective37.50%
(3 of 8 people)
37.50%
(3 of 8 people)
0.00%
(0 of 2 people)
11.11%
(1 of 9 people)
42.86%
(3 of 7 people)
0.00%
(0 of 2 people)
n/an/a
Tylenol is effectiven/a25.00%
(1 of 4 people)
0.00%
(0 of 5 people)
0.00%
(0 of 6 people)
0.00%
(0 of 6 people)
12.50%
(1 of 8 people)
20.00%
(1 of 5 people)
75.00%
(3 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessPainOedema PeripheralFallHeadacheIrritabilitySweating IncreasedPain
Confusional StateMalaiseAmnesiaHallucinationOedema PeripheralJoint DislocationChronic Fatigue SyndromeNausea
SomnolenceCondition AggravatedDrug IneffectiveSomnolenceChillsUpper Limb FractureConfusionDizziness
Drug IneffectiveFatigueHaemoptysisNightmarePainDrowsinessSuicidal IdeationFatigue
FatigueFallFeeling AbnormalSleep Apnoea SyndromeAgranulocytosisDepression SuicidalFallDyspnoea
PainDecreased AppetiteLoss Of ConsciousnessDizzinessAstheniaWeight IncreasedSleep ApneaOedema Peripheral
Oedema PeripheralOedema PeripheralDizzinessDrug IneffectiveDepressionSleep DisorderDry MouthFall
Weight IncreasedDizzinessJaundiceMyalgiaAgitationFallUrinary RetentionAsthenia
AstheniaNauseaFatigueMemory ImpairmentFibromyalgiaInfluenzaDry Eyes AggravatedSomnolence
HeadacheWeight IncreasedPainful RespirationHepatitis CholestaticSuicide AttemptMalaiseConstipation AggravatedAnxiety

Drug effectiveness by gender :

FemaleMale
Lyrica is effective23.33%
(7 of 30 people)
50.00%
(3 of 6 people)
Tylenol is effective10.71%
(3 of 28 people)
37.50%
(3 of 8 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
NauseaRenal Failure Acute
DizzinessAnaemia
FatigueAnxiety
Oedema PeripheralVomiting
DyspnoeaFall
HeadacheNausea
AstheniaAsthenia
FallNeuropathy Peripheral
SomnolenceAbdominal Pain

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/a0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 5 people)
12.50%
(4 of 32 people)
23.53%
(4 of 17 people)
14.29%
(1 of 7 people)
Tylenol is effectiven/an/a0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
16.67%
(1 of 6 people)
0.00%
(0 of 31 people)
18.75%
(3 of 16 people)
11.11%
(1 of 9 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Myopathyn/aPyrexiaCardiac Failure CongestivePainPainPainPain
Renal Failure AcuteBalance DisorderMulti-organ FailureDizzinessFatigueNauseaConfusional State
RhabdomyolysisMulti-organ FailureDyspnoeaNauseaHeadacheHeadacheFall
Metabolic DisorderBrain OedemaHypertensionDepressionBack PainOedema PeripheralNausea
Iron Deficiency AnaemiaArthralgiaCerebral IschaemiaDyspnoeaDizzinessAstheniaDyspnoea
DyspnoeaDisseminated Intravascular CoagulationBack PainHeadacheNauseaPyrexiaRenal Failure Acute
GoutDrug Rash With Eosinophilia And Systemic SymptomsNauseaParaesthesiaAnaemiaDepressionSomnolence
Blood Urine PresentVomitingBronchitisFatigueVomitingAnxietyDehydration
ParaesthesiaInfluenza Like IllnessArthralgiaVision BlurredWeight DecreasedAsthenia
Device Related InfectionPulmonary EmbolismSuicidal IdeationPyrexiaDizzinessOedema Peripheral

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Tylenol?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Tylenol
- support group for people who take Lyrica
- support group for people who take Tylenol

Recent conversations of related support groups:

  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

More questions for: Lyrica, Tylenol

You may be interested at these reviews (Write a review):

  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Nightmare on lyrica st.
    r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyrica 2 weeks ago now up to 120 mg.With perks 4 times a day. The title says it all when trying to sleep :( my dream hands down beat any horror movies and directors. 2 hours of sleep per night and overly beat down :(.the only 2 good things I have going,my since of silliness and the Lord :) I guess family also.so far not much help with meds but willingly and pos, that both will work, the Lord :) thanks and God bless
  • Lyrica varied widely
    I was prescribed Lyrica for treatment of chronic pain. It was ineffective, but it knocked out the symptoms of interstitial. However, it also caused rapid weight gain (I went from 110 to 130 lbs. in just a few weeks) and my ankles started to swell. The pain doctor advised me to discontinue the drug, but the urologist suggested lowering the dose. I did, and the swelling went down. I weighed myself daily and watched what I ate, and my weight returned to normal within a month. Subsequently, I continued taking the lower dose and had no further problems. Then I developed severe spinal stenosis, and my dosage of Lyrica was increased to six 75 capsules daily, in addition to 480 mg of morphine sulphate. I tolerated the Lyrica well. After surgery, however, my ankles began to swell again, and although I didn't have a problem with weight gain, I developed a bright red rash from ankles to knees. I dropped the dosage of Lyrica to 50 mg twice daily, and had no further side effects. The rash simply disappeared, with no damage to the skin. Following the surgery, I was able to titrate off morphine completely. I continue to take Lyrica twice daily. It doesn't seem to affect pain (I still ache a bit, as I have degenerative changes in all joints) but it does dampen peripheral neuropathy, which I experience both in my toes and balls of my feet. It also dampens the neuropathy in my forehead, where I had four surgeries to remove a malignant melanoma. I have had no side effects other than those mentioned, and find it interesting the I could tolerate a high dosage of Lyrica prior to surgery, but after surgery could not, and that adverse side effects varied not only with the dosage but with my own physical condition. I don't find it to be highly effective in treating neuropathy, but it does still the tingling enough to let me sleep and take my mind off the condition.

More reviews for: Lyrica, Tylenol

Comments from related studies:

  • From this study (7 months ago):

  • Following moderate whiplash injury in a road traffic accident three years ago, symptoms of pain, exhaustion, IBS, headache, nausea have continued and my quality of life consists of work and recovering.

    Reply

  • From this study (2 years ago):

  • Aphasia, stroke like, M.S. like
    MRI, negative

    Reply

  • From this study (2 years ago):

  • The problems with my lips began in Feb 2013. It is mostly my upper lip, with symptoms of tiny blisters & a red "line" along the edge of my upper lip, just the redness around my lower lip. There is also burning, swellin, and cracking of the upper lip. It will almost completely heal then will come back again. I thought it was an allrgic reaction to Cindy Crawford's Meaningful Beauty Anti-Aging Night Cream; I had been using it off & on and after a break of a few weeks I used it on my face and within 30 minutes my upper lip was swollen & burning. I have not used it in 2 weeks but the swelling, burning, and blisters started again. I was off of Cymbalta for part of those 2 weeks (thanks to a new insurance pharmacy plan), started back on it 5 days ago. I am wondering if it is the Cymbalta because of the side effect of "mouth sores".

    Reply

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Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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