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Review: Macrobid and Methotrexate

This review analyzes the effectiveness and drug interactions between Macrobid and Methotrexate. It is created by eHealthMe based on 153 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 153 people who reported to have interactions when taking Macrobid, Methotrexate are studied

Trend of Macrobid, Methotrexate's drug interactions, side effects and effectiveness reports (5960028)

Drug combinations in study:
- Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline)
- Methotrexate (methotrexate sodium)

eHealthMe real world results:

Most common interactions experienced by people in the use of Macrobid, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Arthralgia (joint pain)96
Dyspnoea (difficult or laboured respiration)72
Pain69
Anxiety60
Pneumonia47
Urinary Tract Infection43
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))38
Oedema Peripheral (superficial swelling)36
General Physical Health Deterioration (weak health status)34
Impaired Healing34

Most common interactions experienced by people in long term use of Macrobid, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Arthralgia (joint pain)9
Pyrexia (fever)6
Meningitis Cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)6
Pneumonitis (inflammation of the walls of the alveoli in the lungs)5
Cardiac Arrest4
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)4
Sepsis (a severe blood infection that can lead to organ failure and death)4
Cough4
Gastroenteritis (inflammation of stomach and intestine)4
Pulmonary Fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)3

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Macrobid0.000.000.000.000.00
Methotrexate0.00%100.00%0.00%0.00%0.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis
  2. Premedication
  3. Breast cancer
  4. Osteoporosis
  5. Asthma

Top co-used drugs for these people * :

  1. Folic acid
  2. Remicade
  3. Prednisone
  4. Tocilizumab
  5. Humira

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Macrobid, Methotrexate

You can also:

Complete drug side effects:

On eHealthMe, Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) is often used to treat urinary tract infection. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Can you answer these questions (what is this?):

More questions for: Macrobid, Methotrexate

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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