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Review: taking Melatonin and Levothyroxine together

Summary: drug interactions are reported among people who take Melatonin and Levothyroxine together.

This review analyzes the effectiveness and drug interactions between Melatonin and Levothyroxine. It is created by eHealthMe based on reports of 472 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Melatonin and Levothyroxine >>>

On Apr, 13, 2015: 453 people who take Melatonin, Levothyroxine Sodium are studied

Melatonin, Levothyroxine Sodium outcomes

Drug combinations in study:
- Melatonin (melatonin)
- Levothyroxine Sodium (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Melatonin is effective0.00%
(0 of 4 people)
(3 of 11 people)
(0 of 3 people)
(3 of 9 people)
(7 of 13 people)
(2 of 6 people)
(1 of 3 people)
Levothyroxine Sodium is effectiven/a0.00%
(0 of 1 people)
(2 of 4 people)
(1 of 7 people)
(6 of 12 people)
(5 of 9 people)
(14 of 20 people)

Drug effectiveness by gender :

Melatonin is effective33.33%
(15 of 45 people)
(1 of 4 people)
Levothyroxine Sodium is effective56.25%
(27 of 48 people)
(1 of 5 people)

Drug effectiveness by age :

Melatonin is effectiven/an/a100.00%
(1 of 1 people)
(0 of 19 people)
(0 of 9 people)
(2 of 8 people)
(7 of 24 people)
(6 of 40 people)
Levothyroxine Sodium is effectiven/an/a0.00%
(0 of 1 people)
(3 of 19 people)
(2 of 9 people)
(5 of 10 people)
(7 of 24 people)
(11 of 42 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Antepartum HaemorrhageAntepartum HaemorrhageBrain NeoplasmHigh Blood PressureMovement - UncoordinatedArthritisInsomniaNausea
Rash Maculo-papularFeeling AbnormalInsomniaDark Circles Under EyesVision BlurredFibromyalgiaDepressionHeadache
PruritusAnxietyRashSupraventricular TachycardiaSupraventricular TachycardiaSpondylolisthesisRheumatoid ArthritisFatigue
NasopharyngitisAlopeciaDystoniaDiarrhoea AggravatedDark Circles Under EyesAnemiaBipolarDrug Ineffective
SepsisUpset StomachMouth UlcerationUrethral PainHeadache NosCircadian Rhythm Sleep DisorderDry MouthPain
Pain In ExtremityGastrooesophageal Reflux DiseaseMuscle TwitchingUrinary IncontinenceTeeth Grinding And ClenchingHeart Valve CalcificationHot FlashesFall
Throat TightnessMood SwingsHigh Blood PressureLewy Body DementiaDiarrhoeaHypersomnia - IdiopathicDry EyesInsomnia
DysphagiaVitamin D DeficiencyBipolarVision BlurredNightmares - RepeatedSkin Blushing/flushingAnxiety DisorderConvulsion
Fungal InfectionSubchorionic HaemorrhageDry EyesMovement - UncoordinatedInsomnia Related To Another Mental ConditionInsomniaPtsdMalaise
HypertensionDeja VuCavities - ToothInsomniaDeja VuMood SwingsDyshidrotic EczemaDizziness

Most common drug interactions by gender * :

NauseaMyelodysplastic Syndrome
HeadacheRespiratory Failure
FatigueCrohn's Disease
InsomniaMetastases To Bone
PainAnal Fistula
Drug IneffectiveFall
MalaiseDrug Ineffective
ConvulsionConfusional State
FallBlood Creatinine Increased

Most common drug interactions by age * :

Respiratory DistressDiarrhoeaAnal FistulaMuscle SpasmsHeadachePruritusDrug IneffectiveNausea
DehydrationCrohn's DiseaseHypotensionConvulsionFatigueInsomniaFatigue
Radiation InjuryHeadacheDiplopiaEpilepsyWeight IncreasedHeadacheFall
Skin HypertrophyConfusional StateHypothyroidismUrinary Tract InfectionAnxietyFatigueAnxiety
Cerebrovascular AccidentSpastic DiplegiaPyrexiaPainDiarrhoeaRashConfusional State
Pulmonary OedemaPneumonia AspirationPhotopsiaCholecystitis ChronicRash Maculo-papularGastrooesophageal Reflux DiseaseDiarrhoea
Arterial Occlusive DiseaseTransverse Sinus ThrombosisLymphopeniaAbdominal Pain UpperNasopharyngitisBlood Creatinine IncreasedDepression
Abdominal PainHaemorrhagic Cerebral InfarctionMouth UlcerationScarSuicidal IdeationCellulitisDizziness
Cerebral InfarctionPerirectal AbscessLactic AcidosisBalance DisorderVomitingNauseaInsomnia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Melatonin and Levothyroxine on

Do you take Melatonin and Levothyroxine?




You are not alone! Join a related support group:
- support group for people who take Levothyroxine Sodium
- support group for people who take Melatonin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Melatonin (melatonin) is often used to treat insomnia. Levothyroxine Sodium (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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