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Review: Methadone and Diclofenac





Summary: drug interactions are reported among people who take Methadone and Diclofenac together.

This review analyzes the effectiveness and drug interactions between Methadone and Diclofenac. It is created by eHealthMe based on reports of 129 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methadone and Diclofenac >>>

What are the drugs

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

Diclofenac sodium has active ingredients of diclofenac sodium. It is often used in arthritis. (latest outcomes from Diclofenac sodium 14,955 users)

On Dec, 15, 2014: 129 people who take Methadone Hydrochloride, Diclofenac Sodium are studied

Methadone Hydrochloride, Diclofenac Sodium outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Diclofenac Sodium (diclofenac sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective0.00%
(0 of 1 people)
n/an/an/an/a0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
n/a
Diclofenac Sodium is effectiven/a0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/a0.00%
(0 of 1 people)
n/a100.00%
(1 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationGait DisturbanceDysurian/aFanconi Syndrome AcquiredHyperglycaemiaWeaknessPain
Decreased AppetiteVomitingRenal Tubular DisorderNodulesFatigue
Gait DisturbanceDehydrationRenal FailureDizziness PosturalElectrocardiogram Abnormal
DeliriumDecreased AppetiteAnxietyMemory ImpairmentMultiple Drug Overdose Intentional
VomitingHypokalaemiaDizzinessDizziness AggravatedPyrexia
Electrocardiogram Qt ProlongedPneumoniaStomach DiscomfortAbnormal DreamsOedema Peripheral
Back PainDeliriumImpaired MemoryAnxietyPneumonia
HypokalaemiaDizziness AggravatedNauseaDizzinessBack Pain
Abdominal PainRenal FailureStomach DiscomfortAnxiety
PneumoniaMemory ImpairmentImpaired MemoryHepatic Cirrhosis

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
Diclofenac Sodium is effective0.00%
(0 of 2 people)
33.33%
(1 of 3 people)

Most common drug interactions by gender * :

FemaleMale
PainElectrocardiogram Abnormal
FatigueMultiple Drug Overdose Intentional
PyrexiaGait Disturbance
Oedema PeripheralPneumonia
Joint SwellingPain
Back PainUrinary Retention
Hepatic CirrhosisDeath
Alanine Aminotransferase IncreasedDizziness
Heart Rate IncreasedBlood Amylase Increased
Aspartate Aminotransferase IncreasedFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
0.00%
(0 of 6 people)
50.00%
(1 of 2 people)
Diclofenac Sodium is effectiven/an/an/an/a0.00%
(0 of 1 people)
0.00%
(0 of 7 people)
0.00%
(0 of 6 people)
50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aIntestinal AtresiaElectrocardiogram AbnormalPainDrug IneffectiveHeart Rate Increased
Congenital AnomalyMultiple Drug Overdose IntentionalFatigueSwellingPain
Congenital Intestinal MalformationBlood Amylase IncreasedOedema PeripheralInjection Site InflammationFatigue
PyrexiaCyanosisFibromyalgiaErythemaSepsis Nos
Electrocardiogram Qt ProlongedDeathDiscomfortContusionPyrexia
MalaisePulmonary OedemaPain In JawDyskinesiaVentricular Flutter
NauseaPruritusPneumoniaTremorMuscle Spasticity
HyperhidrosisHaemorrhageGingivitisAnaemiaMuscular Weakness
Abdominal PainCondition AggravatedUrinary Tract InfectionHypotensionUrticaria
Back PainDepressionMusculoskeletal PainSomnolenceWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Diclofenac?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Diclofenac
- support group for people who take Diclofenac Sodium
- support group for people who take Methadone Hydrochloride

Can you answer these questions (Ask a question):

  • I'm on two meds, can librium and diclofenac sodium be taken at the same time
    Trying too find out if I can safely take these two drugs together at the same time , or just take them times apart in the same day. Or don't take them together at all?
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • Can methadone cause my aynurism to burst?
    A doctor is lowering my dose of Methadone I take for severe back pain due to my aneurysm because he said the Methadone could cause a stroke w/my aneurysm. Has anyone else heard of this? Thank you!!!
  • I am prescribed methadone and lamictal. at my peak, i nod a little. is this normal? (2 answers)
    I began taking Methadone during my pregnancy per Drs order. I was only on Vicodine, Ambien, Seraquil and Lexapro and stopped immediately after the positive pregnancy result. I have never experienced the nod before. I hate it. Am I the only 1? I'm only on 55mgs of Methadone and 25mgs of Lamictal.
  • Treatment for a dvt in person with lung cancer
    Have contracted a large painful DVT in groin thru calf. Hospicis doctor will only administer Aspirin 325 mg. what I have researched does this not address dissolving clot. Hospicis doctor told me the tumor lung cancer was more likely to bleed with treatment to dissolve clot. She was negative and said the lung cancer was going to cause death anyway so she wouldn't treat large painful DVT because it may cause bleeding, i.e. more harm.



    Can anyone tell me if use of warfarin or other blood thinners are less likely used in lung cancer patients? When admitted to Hospicis in Dec I was on Warfarin and continued use for several weeks until Hospicis stopped treatment.



    I'm considering leaving Hospicis and returning to my previous doctors. I am significantly improved now from Dec. My oxygen use was 5 lt when admitted to Hospicis and now almost never require oxygen use.

More questions for: Diclofenac Sodium, Methadone Hydrochloride

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • I need advise, badly ckd!! (1 response)
    The orthostatic BP started in mid April, I was only dizzy upon wakening then it would subside. I have never been a big breakfast eater so I started doing that. We were in Disney later in April and I was extremely fatigued, to the point of not wanting to walk, Disney would be the first time I passed out when getting dizzy. I of course said I had gotten too warm and was exhausted from work the previous week. The dizziness continued in the mornings & I passed out several more times. On May 1st, I passed out while putting my make-up on and hit my eye on the faucet and head on the tile floor, despite that I went to work thinking it would subside, it didn't. I went to the ER directly after work. They ran a B-met on me and my GFR was 11 and creatinine 3.95. They admitted me to a larger hospital for evaluation. While in there, they pumped me with fluids continuously, saying I had severe dehydration. My kidney function improved, my creatinine levels went back down to 1.34. After 5 days I was discharged and told to see a cardiologist and endo. The endo doc cancelled my appointment on the basis it was not his area. I had had a cortisol and ACTH testing which I guess was normal. I saw the cardiologist, who said it wasn't cardio. I had had an echocardiogram in the hospital and EKG monitoring. Cardio sent me to neurology, the PNRN did a basic neurological exam and drew blood for disease markers such as Lupus, sjorgens, hepatitis, ect. All disease markers came back negative, but my GFR was at 11 again and creatinine was 4.25, BUN 50 along with an elevated ACE level. They called me and said I sarcoidosis. I really don't have any of the primary S/S of this autoimmune disease. I don't know where to go from here, they are referring me to another neurologist at a bigger hospital. I can't live my normal life, can't walk on my feet due extreme pain and I pass out at least 2x a week, which is not good for my old body. My BP upon laying and sitting runs like 117/72, upon standing it drops to like 70/50-50/30. I am on 0.1 mg of florinef, I tried increasing it but then my legs swelled up for a gain of 23#. I talked to Mayo Clinic today and all there specialists are booked out thru December. I have to be able to work, I can't stay home any longer than September 8th! Please advise me!
  • Memory loss (blockade)
    I was on a very long and unpleasant car trip (driving 900km from A to B), that started with 6 hours long border crossing, that involved occasional pushing of a heavy car in order to spare fuel. After that, another 8 hours of driving. I developed a spasm in the area of my low back pain.

    When we arrived at the destination, I asked my wife (of 60+kg) to press my back in that area with her foot. I did not pay attention how exactly she was doing that and she did it by applying stronger pressure, and over the whole spinal area, provoking strong pain in one moment, instead of a relief.

    This happened 6 days ago (10 Aug 2014).

    I went to bed after applying quite a big amount of Diclofenac gel on my back, and I did not get up for the next 36 hours, and was mainly sleeping, however, the whole muscular area was in a spasm and on certain moves very painful after that 'rest'.

    The place where I am now is quite remote, and doctors are not available. As the condition was really bad / painful, I decided to take an advice from a cousin, and started to take the Diclofenac 50 mg orally; and the advice was that it is allowed to take one tablet every 6 hours = 200 mg/day. This has had a good effect and the pain disappeared, except in a mild intensity on certain moves, in that area where I felt the strong pain during my wife's manipulation of my back (basically what happened was that she used her full weight to step on my back, trying to lower the weight by supporting herself with her arms opposed to a piece of furniture which was laid parallel to my laying position, which I think caused the force on my spinal chord to be not vertical, but under an angle).

    Anyway, after 5 tablets of 50mg Diclofenac taken in 6 hours intervals, and as I was feeling better I decided to stop with using the Diclofenac. However, I continued to take Diclofenac 50 mg next day as the back pain returned with greater intensity.

    As this time I read on the Diclofenac package that the maximum dosage should be 150 mg/day, I used it for 2 days in 8 hours interval. This kept the level of pain bearable i.e. not intense and appearing only with that specific move / bending of my body. I was also swimmming in the sea, which in general did not make the situation with the pain worse.

    Why am I writing this report?

    I noticed yesterday, when I had taken Diclofenac 50mg already 6 times in the 8hrs interval, that I had a strange memory blockage: I was watching a movie with a famous actor, and I could not remember the name of the actor. Then I realised, I cannot remember the name of another famous actor, of whom I was reading in newspapers a lot these last few days, and we were talking about that few times.

    Then I thought of another famous actor, and I could not remember his name either! (although I could remember the faces, names of the relevant movies, sequences from those movies etc, for all the 3 actors).

    I have to emphasise that the first actor's name which I realised I cannot remember I did not see during the broadcasting of the film on the TV (but had seen the photo and read the name in the newspapers on that day or a day earlier). Then I thought I could "help" myself by concentrating on that actor's most famous movie, remembering of which I do not have a problem, but that did not help retrieving the name of the actor!

    In spite of expecting to remember the names, this is still not happening.

    If it won't be the case that actor's names were not refreshed so recently, I would consider this as the result of aging, stress, lack of refreshing my memory 'on that side' as I do not watch movies too often in the last years, etc, but still in spite of that I would expect to remember those names.

    I am not obsessed with this situation, and ended up writing this after I wanted to learn more about the types of memory loss, and possible experiences in relation to the use of Diclofenac, when I read that one of the side effects is also related to memory loss.

    I have stopped now with taking the Diclofenac, and will try not to expose myself to sources of information that could help remembering those particular names, to see if and when I will possibly remember these particular names "on my own".

    I did not obsessively try to see if I remember or not remember some other names, but have 'tested' my memory by trying to remember some names of actors I would expect to remember with less chances than those names that instigated this situation, and basically had no problem to remember those 'less expected to remember' names...

    Can this be a 'good' time to discuss seriously about testing myself for early signs of Alzheimer's disease or something similar?
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.

More reviews for: Diclofenac Sodium, Methadone Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Can I use diclofenac sodium alongside methadone

    Reply

  • From this study (3 years ago):

  • I just wanted to check to see if there is any known interaction with my medication....

    Reply

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Diclofenac Sodium (diclofenac sodium) is often used to treat arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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