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Review: Methadone and Gabapentin





Summary: drug interactions are reported among people who take Methadone and Gabapentin together.

This review analyzes the effectiveness and drug interactions between Methadone and Gabapentin. It is created by eHealthMe based on reports of 1,968 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methadone and Gabapentin >>>

What are the drugs

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

Gabapentin has active ingredients of gabapentin. It is often used in neuralgia. (latest outcomes from Gabapentin 39,518 users)

On Dec, 1, 2014: 1,968 people who take Methadone Hydrochloride, Gabapentin are studied

Methadone Hydrochloride, Gabapentin outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Gabapentin (gabapentin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective30.00%
(3 of 10 people)
60.00%
(6 of 10 people)
0.00%
(0 of 3 people)
71.43%
(5 of 7 people)
36.36%
(4 of 11 people)
63.64%
(7 of 11 people)
57.14%
(4 of 7 people)
0.00%
(0 of 1 people)
Gabapentin is effective22.22%
(2 of 9 people)
0.00%
(0 of 4 people)
0.00%
(0 of 6 people)
35.71%
(5 of 14 people)
23.08%
(3 of 13 people)
41.67%
(5 of 12 people)
75.00%
(3 of 4 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Withdrawal SyndromeLoss Of ConsciousnessDepressionDepressionDrug IneffectiveDiarrhoeaBone PainPain
OverdoseNeoplasm MalignantBlood Urea IncreasedDysarthriaDiarrhoeaHypotensionAnxiety DisorderAnxiety
DehydrationMusculoskeletal StiffnessGoutDrug DependenceOedema PeripheralDehydrationSleepiness - During The DayDyspnoea
FallDrug IneffectivePain In ExtremityDental CariesMigraineConfusional StateBipolar DisorderOsteonecrosis Of Jaw
DysarthriaCompleted SuicideBlood Creatinine IncreasedAbnormal BehaviourDental CariesNeutropeniaAnxietyBack Pain
Electrocardiogram Qt ProlongedHypertensionDrug IneffectiveTooth AbscessFistula DischargeHaematocrit DecreasedChronic PainNausea
Tooth AbscessGrand Mal ConvulsionInfluenza Like IllnessDrug AbuseDevice Related InfectionChillsSleep Disorder Due To General Medical Condition, Insomnia TypeOedema Peripheral
Drug DependenceAnxietyFallOverdosePeriodontal DiseaseHaemoglobin DecreasedDepression AggravatedFatigue
Drug IneffectivePetit Mal EpilepsyArrhythmia NosDrug IneffectiveTooth DisorderPlatelet Count DecreasedBack PainArthralgia
LethargyAstheniaIntentional OverdosePartner StressNeck InjuryPain In ExtremityInsomniaHypoaesthesia

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective51.28%
(20 of 39 people)
42.86%
(9 of 21 people)
Gabapentin is effective29.73%
(11 of 37 people)
28.00%
(7 of 25 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyAnxiety
DyspnoeaDyspnoea
NauseaBack Pain
Osteonecrosis Of JawAsthenia
Back PainHeadache
FatigueArthralgia
Oedema PeripheralPyrexia
HypoaesthesiaOedema Peripheral
Emotional DistressOsteonecrosis Of Jaw

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/a36.36%
(4 of 11 people)
22.73%
(10 of 44 people)
25.71%
(9 of 35 people)
11.36%
(5 of 44 people)
9.09%
(1 of 11 people)
Gabapentin is effectiven/an/an/a18.18%
(2 of 11 people)
17.50%
(7 of 40 people)
11.11%
(4 of 36 people)
2.33%
(1 of 43 people)
28.57%
(4 of 14 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aRespiratory DistressHaematocrit DecreasedDeep Vein ThrombosisAnxietyPainPainPain
Febrile NeutropeniaHypotensionWeight DecreasedPainDyspnoeaAnxietyDyspnoea
White Blood Cell Count DecreasedPyrexiaHypokalaemiaOsteonecrosis Of JawFatigueArthralgiaBack Pain
NeuroblastomaCompleted SuicideOedema PeripheralNauseaAnxietyOsteonecrosis Of JawOsteonecrosis Of Jaw
Neoplasm ProgressionCardiac ArrestParaesthesiaBack PainOedema PeripheralEmotional DistressAnxiety
TachycardiaCaecitisAstheniaDyspnoeaNauseaPyrexiaOsteomyelitis
Rhabdomyosarcoma RecurrentRespiratory ArrestPainAstheniaInsomniaDyspnoeaWeight Decreased
Oxygen Saturation DecreasedFebrile NeutropeniaConstipationBone DisorderDepressionBack PainOsteoarthritis
Pain In ExtremityHeadacheVomitingOedema PeripheralBack PainInjuryImpaired Healing
Disease ProgressionHaemoglobin DecreasedPain In ExtremityFatigueVomitingNauseaBone Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Gabapentin?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Gabapentin
- support group for people who take Gabapentin
- support group for people who take Methadone Hydrochloride

Can you answer these questions (Ask a question):

  • Requip cause dysphagia
    an increase caused me not to be able to swallow at all
  • Does anyone else have peripheral neuropathy? anyone have pn with lichen sclerosus? i have pain in hands, feet and face.
    Pain much worse at end of day and when I overdo. Sleep difficult - but essential! Feel so much better if I get 6+ hours. At the moment, very distressed by swollen lips (mostly inside mouth) and tissue surrounding eyes. I'm sure I have some arthritis in my fingers and toes. I also have had lichen sclerosus on my skin for nearly 20 years. Have had the PN for 15 years or so. I'm afraid that the medications can actually make the condition worse. If anyone has any suggestions, I'm all ears!
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • Does nexplanon have nickel in it?
    I have a severe nickel allergy and I have epilepsy. I am considering explain to reduce periodes since my seizures are worse that time of the month. I need to know if nexplanon has nickel because I need to avoid it if it does.
  • Can gabapentin cause bladder distension? there is no urinary symptom .
    Existing illness are Chronic renal failure (after hydro uretero nephrosis due to BPH) and peripheral neuropathy (vit B6 deficiency ) after ATT are the major problems along with BP .At present , the problem is that creatinine gas risen from 1,1 to 1.5 in 6 months .Since 6 months , I am taking medicines for neuropathy so I doubt some side effect of these medicines as Ultrasound has shown bladder distension but I do not feel any urinary problem at present. I also have kidney stones but seeing the ultrasound report , doctor said it is not hindering with urine passage . I feel some tightness , fullness and protruded lower abdomen part. I am aged 72 from India and am vegetarian.I also take some drugs for controlling blood pressure . I have elevated Blood urea at present (52) . I was given medicine to relax prostrate muscles for last 20 days but I did not feel any improvement in my bladder size. I had had my prostrate operated 2 years back.

More questions for: Gabapentin, Methadone Hydrochloride

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Ranexa and erectile dysfunction
    I have experienced moderate ED with taking multiple heart and NO meds. This has been manageable and acceptable. Cardiologist added Ranexa (Ranalozine) 3 weeks ago and I am now experiencing complete erectile and ejaculatory failure.
  • Cough and gabapentin
    Have chronic cough for 6 yr's at least.3 yr's ago it got bad enough to seek doc. Help. Took all the tests . Tried to tell me I had asthma,copd, ect. Put me on sprivia, symbicort, singular, helped a little for awhile. Long story short. Went to one doc. He asked me some questions about my cough. Figured out it usually started with a tickle on the left side of my throat. And he put me on gabapentin 300mg. 3 times Aday. Which is for nerve damage. It took about 7days to see some change. And about 35days To stop the chronic cough. I still cough once in awhile. But no chronic coughing. Now I am going to try and see if I can stop the other med,s one at a time and see what happens
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Gabapentin, Methadone Hydrochloride

Comments from related studies:

  • From this study (2 weeks ago):

  • Rosacea appeared after a few months on Methadone.

    Reply

  • From this study (2 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Gabapentin (gabapentin) is often used to treat neuralgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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