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Review: Methadone and Lorazepam





Summary: drug interactions are reported among people who take Methadone and Lorazepam together.

This review analyzes the effectiveness and drug interactions between Methadone and Lorazepam. It is created by eHealthMe based on reports of 1,193 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methadone and Lorazepam >>>

What are the drugs

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. (latest outcomes from Lorazepam 47,090 users)

On Dec, 2, 2014: 1,193 people who take Methadone Hydrochloride, Lorazepam are studied

Methadone Hydrochloride, Lorazepam outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Lorazepam (lorazepam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective42.86%
(3 of 7 people)
75.00%
(3 of 4 people)
25.00%
(1 of 4 people)
33.33%
(1 of 3 people)
42.86%
(3 of 7 people)
33.33%
(1 of 3 people)
66.67%
(2 of 3 people)
n/a
Lorazepam is effective16.67%
(1 of 6 people)
50.00%
(3 of 6 people)
60.00%
(3 of 5 people)
50.00%
(2 of 4 people)
33.33%
(2 of 6 people)
n/a50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SomnolenceAcute Respiratory Distress SyndromeHyperglycaemiaDepressionBack PainDementia Of The Alzheimer's Type, With DelusionsAnaemiaAnxiety
Drug Withdrawal SyndromeConstipationNeuropathy PeripheralNeuropathy PeripheralDepressionRadiculitis CervicalPain
HypotensionDrug DependenceDementiaHyperglycaemiaInsomniaRadiculitis LumbosacralNausea
Electrocardiogram Qt ProlongedHepatic NecrosisDiabetes MellitusDiabetes MellitusRoad Traffic AccidentPolypOsteonecrosis Of Jaw
Acute Respiratory Distress SyndromePneumoniaFearDysarthriaConvulsionPanic AttackDepression
Abnormal BehaviourCoeliac Artery Compression SyndromeHallucinationDrug DependenceAmnesiaMusculoskeletal PainDyspnoea
Blood Bilirubin IncreasedBlood Bilirubin IncreasedDrug DependenceDental CariesAnxietyOropharyngeal PainHeadache
Drug DependenceHypernatraemiaMajor DepressionAbnormal BehaviourCognitive DisorderPancreatitisBack Pain
HeadachePneumonia Respiratory Syncytial ViralParanoid Personality DisorderDementiaDental CariesSinusitisFatigue
Pneumonia Respiratory Syncytial ViralPneumonitisConstipationTooth AbscessMultiple InjuriesSuicidal IdeationAsthenia

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective40.00%
(8 of 20 people)
54.55%
(6 of 11 people)
Lorazepam is effective42.11%
(8 of 19 people)
40.00%
(4 of 10 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
AnxietyDepression
NauseaPain
Osteonecrosis Of JawAsthenia
DyspnoeaOsteonecrosis Of Jaw
HeadacheDyspnoea
DepressionConstipation
Back PainFatigue
FatigueWeight Decreased
Oedema PeripheralMental Status Changes

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/a28.57%
(2 of 7 people)
40.00%
(4 of 10 people)
25.00%
(3 of 12 people)
36.36%
(4 of 11 people)
20.00%
(1 of 5 people)
Lorazepam is effectiven/an/an/a0.00%
(0 of 6 people)
50.00%
(3 of 6 people)
21.43%
(3 of 14 people)
71.43%
(5 of 7 people)
20.00%
(1 of 5 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PriapismOverdoseVomitingCompleted SuicideAnxietyAnxietyPainAnxiety
Application Site DiscolourationConstipationHypotensionPain In ExtremityHeadachePainAnxietyPain
StillbirthDroolingNauseaHeadacheNauseaDepressionDepressionBack Pain
Premature Separation Of PlacentaDysphagiaHaematemesisPainOsteonecrosis Of JawDyspnoeaArthralgiaOsteonecrosis Of Jaw
InjuryBulbar PalsyPyrexiaHypokalaemiaDyspnoeaBack PainNauseaBone Pain
Renal FailureDrug IneffectiveBlood Bilirubin IncreasedVomitingFatigueFatigueOsteonecrosis Of JawWeight Decreased
Renal Failure AcuteAreflexiaAcute Respiratory Distress SyndromePneumoniaPainConstipationInjuryEmotional Distress
DeathAstheniaHaematocrit DecreasedWeight DecreasedAstheniaDizzinessEmotional DistressMetastases To Bone
Renal InjuryApnoeaHypertensionParaesthesiaConstipationNauseaHeadacheDyspnoea
PainMuscular WeaknessRenal DisorderOedema PeripheralPneumoniaAstheniaInsomniaPain In Extremity

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Lorazepam?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Lorazepam
- support group for people who take Lorazepam
- support group for people who take Methadone Hydrochloride

Can you answer these questions (Ask a question):

  • Can i take my ativan if i'm taking phenteremine? (1 answer)
    I just started taking phenteremine and I can't sleep. I take it at 6 am
    Am I able to take an Ativan at bed time?
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • What could be causing eye pain and headacne and bright glaring light on the right side only?
    Senitive to light, can't spend long on computer or cell phone. Diagnosed with anklylosing spondylosis
  • Have you or someone who has taken ativan, lorazepam or orfidal developed and form of cancer? esp. esophageal or stomach cancer
    suspect long term prescription (years) of Lorazepam may have been causal to esophageal cancer Ativan, Lorazepam or Orfidal are all basically the same formula - please be specific in your answer
  • Should a person with the history of itp take the drug meloxicam
    I am the one in the books on the study of ITP. in 1976 I had my spleen removed as the result of the disease. at that time I was 16. now I am 54 and scarred that if I take any kind of blood thinner this may cause the disease to return. Should I be taking Meloxicam with it being somewhat of a blood thinner?

More questions for: Lorazepam, Methadone Hydrochloride

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Lorazepam nearly killed me during cancer treatment
    Day 31 of cold turkey and I want to die. It is a roller coaster from body tics and sweats to rage and crying in one day. I felt so good the 4h day of c/t. It was like before my cancer diagnosis. My bowels are better off Lorazepam. I threw up during bowel movements from the pain. Off Lorazepam first normal bowel movement in over 2 years. Stomach so damaged by Lorazepam that I have absolutely no appetite. I force myself to eat. Neuropathy in hands nearly gone. Feet are better but slower. Lymphedema that appeared after one year on Lorazepam is now gone. I have full range of motion.
  • Sleep apnea and vertigo
    Previous to Lorazepam, I was taking Mekclezine. Both makes me feel worst longer with vertigo. Usually when I fall asleep without my mouth guard, I get a serious bout of Vertigo for several days and the medications just cause more dizziness and the problem last even longer. I also find when I am under extreme stress, I acquire a bout vertigo as well. I am getting a better mouth guard made because the sleep apnea gets worse, the guard has gotten worn and my air way is getting blocked again, causes lack of oxygen and lack of oxygen causes dizziness. Which means to me one causes the other.
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.

More reviews for: Lorazepam, Methadone Hydrochloride

Comments from related studies:

  • From this study (8 months ago):

  • My mother has taken methadone for ten years and was diagnosed with alzheimers informally in a neurologists office while she was still taking the methadone. She only takes lortab now

    Reply

  • From this study (1 year ago):

  • Sudden onset of electric shocks and muscle stiffness

    Reply

  • From this study (2 years ago):

  • Although some of the adverse outcomes tend to wax and wane as my mood shifts with bipolar disorder, the bed wetting is of extreme urgency. I'm looking for answers more for the bed wetting but would be happy to find reasons for the others as well.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Lorazepam (lorazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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