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Review: taking Methadone and Wellbutrin together

Summary: drug interactions are reported among people who take Methadone and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Methadone and Wellbutrin. It is created by eHealthMe based on reports of 675 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Methadone and Wellbutrin >>>

What are the drugs

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from 2,848 Methadone hydrochloride users)

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from 55,068 Wellbutrin users)

On Feb, 11, 2015: 675 people who take Methadone Hydrochloride, Wellbutrin are studied

Methadone Hydrochloride, Wellbutrin outcomes

Drug combinations in study:
- Methadone Hydrochloride (methadone hydrochloride)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadone Hydrochloride is effective25.00%
(1 of 4 people)
100.00%
(4 of 4 people)
50.00%
(3 of 6 people)
55.56%
(5 of 9 people)
72.73%
(8 of 11 people)
50.00%
(3 of 6 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
Wellbutrin is effective0.00%
(0 of 1 people)
33.33%
(3 of 9 people)
0.00%
(0 of 5 people)
25.00%
(1 of 4 people)
22.22%
(2 of 9 people)
55.56%
(5 of 9 people)
50.00%
(2 of 4 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionCataractDepressionTooth AbscessDepressionDepressionAngerPain
NauseaFibromyalgiaMyocardial InfarctionDepressionHeadacheHigh Blood PressureNauseaAnxiety
DysarthriaThyroid NeoplasmPainDrug DependenceAnxietyAnxietyWeight Gain - UnintentionalDepression
Tooth AbscessImmune System DisorderCataractDysarthriaConvulsionHeart InjuryAnorgasmiaNausea
Memory ImpairmentDrug IneffectiveArthralgiaDental CariesBack PainSeasonal AllergyDry MouthOsteonecrosis Of Jaw
Dental CariesPainOedema PeripheralAbnormal BehaviourInsomniaHerniated Intervertebral DiskWeight GainOedema Peripheral
Drug DependenceJoint SwellingHerpes ZosterDrug AbuseRoad Traffic AccidentFailed Back Surgery SyndromePyrexia
VomitingMyocardial InfarctionThyroid NeoplasmTooth LossAmnesiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessAnaemia
Abnormal BehaviourArthralgiaDrug IneffectivePartner StressMultiple InjuriesHeadacheBack Pain
HyperglycaemiaOedema PeripheralImmune System DisorderOverdoseSyncopeAches - LegDyspnoea

Drug effectiveness by gender :

FemaleMale
Methadone Hydrochloride is effective63.33%
(19 of 30 people)
57.14%
(8 of 14 people)
Wellbutrin is effective31.03%
(9 of 29 people)
30.77%
(4 of 13 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
AnxietyPain
DepressionPyrexia
NauseaCellulitis
Oedema PeripheralAsthenia
ArthralgiaBone Disorder
Osteonecrosis Of JawHeadache
DyspnoeaBack Pain
FatigueDrug Abuse
Intervertebral Disc ProtrusionAnxiety

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadone Hydrochloride is effectiven/an/an/a28.57%
(2 of 7 people)
46.15%
(12 of 26 people)
42.86%
(9 of 21 people)
14.29%
(3 of 21 people)
25.00%
(1 of 4 people)
Wellbutrin is effectiven/an/an/a0.00%
(0 of 7 people)
12.50%
(3 of 24 people)
20.00%
(4 of 20 people)
19.05%
(4 of 21 people)
100.00%
(2 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Hypoglycaemian/aRoad Traffic AccidentRespiratory ArrestDepressionPainAnxietyDepression
Diabetes Mellitus Inadequate ControlPolysubstance AbuseMultiple Drug OverdoseAnxietyAnxietyPainNausea
Impaired Driving AbilityCompleted SuicideHeadacheAnaemiaPyrexiaLipase Increased
Cardiac ArrestCompleted SuicideDepressionOedema PeripheralDeath
Drug ToxicityConvulsionOedema PeripheralArthralgiaPleural Effusion
ConvulsionImpaired HealingNauseaDepressionHaemoglobin Decreased
DeliriumType 2 Diabetes MellitusOsteonecrosis Of JawPain In ExtremityFluid Overload
HypotensionOsteomyelitisDizzinessOsteoarthritisPain
PainBone DisorderFatigueBack PainDyspnoea
Body Temperature IncreasedOsteonecrosis Of JawChest PainInjuryVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadone and Wellbutrin?

You are not alone! Join a related mobile support group:
- support group for people who take Methadone and Wellbutrin
- support group for people who take Methadone Hydrochloride
- support group for people who take Wellbutrin

Can you answer these questions (Ask a question):

  • How does a person get this awful facial pain?
    it seems like my teeth hurt real bad when I get an attack, and its hard to eat, it hurts when I chew.drink anything hot or cold.
  • Why is restoril showing poaitive in my urin when i never took this drug (1 answer)
    I have been ill for 15 years, taking Methadone all the while along with Soma and Hydrocodone for break thru pain. I now include Lyrica daily.I have had 2 back surgeries, one detailing rod and cage around L4 L5 in 2007. Most recent Nov 2013 at the Laser Spine Institute for spine decompression in that same area. Diagnosed w/ Arachnoiditis 15 yrs ago when working full time and since Methadone seems to be my only safe bet to take so that I can function. 4 years on Hizentra IVG home treatment every week. Lorazapam was prescribed for panic. Tried Diazapam more than 8-9 months ago, however that drug seems to back up in my system therefore I get no immediate relief but sort of a knock out sleep 8 hours later so we went back to Lorazapam. I am now unfortunately disabled, mostly homebound and 60 yrs old. Since this past August my urin specimen has come back positive for Restoril. This past month Restoril is still positive and described as habitual use. I am staring down a discharge from my physician who I care for, respect and admire, I never ever thought this would happen. We just took another test I offered to get another different Lab test she told me to wait so I am but its killing me. I never took a sleeping other than Unisom OTC in my Entire life. Never been prescribed Restoril, no offense but would never take it on top of what I already take and Lord knows how I would react to this drug. If I am awake all night that's just the way it is and I live with it. Why is this foreign drug showing up in my system? Please help. Thank you kindly, Louise
  • What are the side effects of taking methadone and cefdinir
    I know there are some antibiotics that do not go well with methadone. I need to know if anyone has ever had these two together and how well it worked or not
  • Can i take ketorolac if i am already taking methadone everyday?
    I take methadone everyday and I have a tooth ache so can I take ketorolac with methadone?
  • I am on 2 x daily rifampin and 4 x daily cephalixin 500mg and and awake exhausted after 8-9 hours sleep and the fatigue is unbelievable all day every day, is this "normal" or should i investigate ore (1 answer)
    Had total knee replacement 11/12, bad from the start, knee swollen/hot/painful/unstable for most of 2 years before a mechanically successful Revision that found a loose patella and both ends of the prostheses loose. In spite of 10-12 aspirations and almost as many samples sent to labs for testing the result was always "no growth after a week". Following the revision, 10 days after, surgeons office called and says yes you have a staph E infection. Immediate therapy with 6 weeks of 3 X day IV PLUS 2 x per day oral Rifampin.
    IV over but now on the 2 X day Rifampin PLUS 4 X day 500mg cephalexin and the fatigue is unbelievable. Wake up exhausted after 8 hours sleep, daily hour plus mid afternoon naps.

More questions for: Methadone Hydrochloride, Wellbutrin

You may be interested at these reviews (Write a review):

  • Are you mental on methadone
    My doctor changed my pain medication back in May of 2014 . I was pleased with how well it handle my back pain and was pleased with how inexpensive it was. My husband had been using the same drug with great results. It wasn't until about a month later I started to notice just feelings of sadness. I didn't think too much of it but then I would get such strong feelings of despair really bad that I would just cry. I also started getting a lot of panic attacks I had so much anxiety at times it prevented me from doing things. At one point I really thought I was having some sort of break down, but the feelings would have highs and lows and sometimes I would have a day with out them. Eventually after being on them for 7 months I went to my doctor and asked if it were possible I was experiencing these feelings from the Methadone. He wasn't sure but with it all happening right after I started taking them he decided to put me on something else. It's been about three weeks and even though the feelings are still there they are not as strong and seem to be passing. I hope as time goes I will feel like myself again and hope never to have to experience something like that again.
  • Methadone and forgetting basic things.
    I have been in MMT (Methadone Maintenance Treatment) for around 7 1/2 years for chronic pain. I have gotten to where I forget things that I never would or did before and the longer in time the worse it has gotten I am currently looking at some different meds for treatment. The loss of memory is everything from childhood memories to what I did yesterday I may pay something and if I dont write it diwn I will forget it things I have known all my life I have forgotten. I can't say 100% it is from the MMT or not however I will sag I had no such problems before and I am at age 38 so I believe I am much too young to have severe memory loss that I am currently experiencing and whats scary is what if it never comes back and continues to decline?
  • Lamotrigine severe rash
    I started taking 100mg of Teva-Lamotrigine Nov 22 once daily. I got a refill on Dec 5 that was Mylan-Lamotrigine. Two days later I woke up with an odd hot feeling rash all over my body and severe fatigue. I went back to bed 1/2 hour later after taking my regular Wellbutrin and the Lamotrigine. I woke up late morning. It got progressively worse during the day and I had a headache,fever and chills. I took the anti-histimine Aerius later that day which didn't help. The next day I went to a walk in clinic and they said it wasn't the Lamotrigine and thought it was a virus and did a throat swab. The fever and chills went away after a few days but I still have the rash. Finally after a week I saw a doctor that agreed it was the drug and I am now on the second week of Prednisone steroid treatment and prescription Reactin which is helping slowly. I have reported it to the Mylan drug company.
  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.

More reviews for: Methadone Hydrochloride, Wellbutrin

Comments from related studies:

  • From this study (4 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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