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Review: taking Trazodone and Methadone together

Summary: drug interactions are reported among people who take Trazodone and Methadone together.

This review analyzes the effectiveness and drug interactions between Trazodone and Methadone. It is created by eHealthMe based on reports of 748 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 12, 2015: 748 people who take Trazodone Hydrochloride, Methadone Hydrochloride are studied

Trazodone Hydrochloride, Methadone Hydrochloride outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective0.00%
(0 of 5 people)
(1 of 4 people)
(1 of 5 people)
(2 of 4 people)
(3 of 5 people)
(1 of 2 people)
(0 of 1 people)
Methadone Hydrochloride is effective33.33%
(1 of 3 people)
(3 of 4 people)
(2 of 3 people)
(3 of 6 people)
(2 of 3 people)
(1 of 3 people)
(3 of 3 people)

Drug effectiveness by gender :

Trazodone Hydrochloride is effective35.71%
(5 of 14 people)
(3 of 12 people)
Methadone Hydrochloride is effective75.00%
(9 of 12 people)
(6 of 13 people)

Drug effectiveness by age :

Trazodone Hydrochloride is effectiven/an/an/a7.69%
(1 of 13 people)
(2 of 3 people)
(2 of 9 people)
(3 of 22 people)
Methadone Hydrochloride is effectiven/an/an/a33.33%
(4 of 12 people)
(2 of 4 people)
(4 of 8 people)
(5 of 22 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Head InjuryIris ColobomaNeuropathy PeripheralDysarthriaDepressionAnxietyHigh Blood Cholesterol And TriglyceridesPain
Grand Mal ConvulsionChoroidal ColobomaDiabetes MellitusDrug DependenceSuicide AttemptPancreatitisDepression SuicidalNausea
FallOptic Nerve DisorderDementiaDepressionDaydreamingDepressionDepression
Loss Of ConsciousnessMaternal Drugs Affecting FoetusHyperglycaemiaAbnormal BehaviourPoor Quality SleepOsteoporosisAnxiety
Vision BlurredMeningococcal InfectionFearTooth AbscessIrritabilityObesityWeight Decreased
Weight IncreasedMultiple Drug Overdose AccidentalHallucinationDental CariesParanoiaIrritable Bowel SyndromeAsthenia
Weight DecreasedTooth DisorderMajor DepressionOptic Nerve DisorderNightmarePainBack Pain
Ear InfectionInsomniaParanoid Personality DisorderIris ColobomaIntentional OverdosePancreatitis ChronicHeadache
Tongue BitingPneumoniaAbnormal BehaviourChoroidal ColobomaIncoherentSleep WalkingFall
DiplopiaHypotensionDrug DependenceDrug AbuseHypoventilationHyperlipidaemiaPyrexia

Most common drug interactions by gender * :

Back PainTremor
Weight DecreasedFall
Neuropathy PeripheralOedema Peripheral
Weight IncreasedAsthenia
AstheniaConfusional State

Most common drug interactions by age * :

Paraesthesia Oraln/aProgressive Multifocal LeukoencephalopathyOptic Nerve DisorderAstheniaDepressionNauseaPain
Tongue DiscolourationChoroidal ColobomaPainPainDepressionPain In Extremity
Hypoaesthesia OralIris ColobomaNauseaPyrexiaPainAnxiety
GlossodyniaLoss Of ConsciousnessNeuropathy PeripheralFallWeight IncreasedBack Pain
DysgeusiaMultiple Drug OverdoseDeathDiabetes MellitusWeight DecreasedRash
Gingival PainPyrexiaAnxietyConstipationFallOsteonecrosis Of Jaw
Drug Effect DecreasedInjection Site InfectionCardiac ArrestTremorAnxietyFistula
Respiratory DepressionConvulsionChest PainNeuropathy PeripheralHypoaesthesia
Injection Site InflammationDyspnoeaWeight DecreasedHeadacheImpaired Healing
Multiple Drug Overdose IntentionalRespiratory ArrestBack PainConfusional StateHyperplasia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Trazodone and Methadone?




You are not alone! Join a related mobile support group:
- support group for people who take Methadone Hydrochloride
- support group for people who take Trazodone Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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