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Review: Trazodone and Methadone





Summary: drug interactions are reported among people who take Trazodone and Methadone together.

This review analyzes the effectiveness and drug interactions between Trazodone and Methadone. It is created by eHealthMe based on reports of 748 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Trazodone and Methadone >>>

What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from Trazodone hydrochloride 6,611 users)

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

On Dec, 14, 2014: 748 people who take Trazodone Hydrochloride, Methadone Hydrochloride are studied

Trazodone Hydrochloride, Methadone Hydrochloride outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective0.00%
(0 of 5 people)
25.00%
(1 of 4 people)
20.00%
(1 of 5 people)
n/a50.00%
(2 of 4 people)
60.00%
(3 of 5 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
Methadone Hydrochloride is effective33.33%
(1 of 3 people)
75.00%
(3 of 4 people)
66.67%
(2 of 3 people)
50.00%
(3 of 6 people)
66.67%
(2 of 3 people)
33.33%
(1 of 3 people)
100.00%
(3 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Head InjuryIris ColobomaNeuropathy PeripheralDysarthriaDepressionAnxietyHigh Blood Cholesterol And TriglyceridesPain
Grand Mal ConvulsionChoroidal ColobomaDiabetes MellitusDrug DependenceSuicide AttemptPancreatitisDepression SuicidalNausea
FallOptic Nerve DisorderDementiaDepressionDaydreamingDepressionDepression
Loss Of ConsciousnessMaternal Drugs Affecting FoetusHyperglycaemiaAbnormal BehaviourPoor Quality SleepOsteoporosisAnxiety
Vision BlurredMeningococcal InfectionFearTooth AbscessIrritabilityObesityWeight Decreased
Weight IncreasedMultiple Drug Overdose AccidentalHallucinationDental CariesParanoiaIrritable Bowel SyndromeAsthenia
Weight DecreasedTooth DisorderMajor DepressionOptic Nerve DisorderNightmarePainBack Pain
Ear InfectionInsomniaParanoid Personality DisorderIris ColobomaIntentional OverdosePancreatitis ChronicHeadache
Tongue BitingPneumoniaAbnormal BehaviourChoroidal ColobomaIncoherentSleep WalkingFall
DiplopiaHypotensionDrug DependenceDrug AbuseHypoventilationHyperlipidaemiaPyrexia

Drug effectiveness by gender :

FemaleMale
Trazodone Hydrochloride is effective35.71%
(5 of 14 people)
25.00%
(3 of 12 people)
Methadone Hydrochloride is effective75.00%
(9 of 12 people)
46.15%
(6 of 13 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
NauseaDepression
AnxietyPyrexia
Back PainTremor
Weight DecreasedFall
HeadacheConstipation
Neuropathy PeripheralOedema Peripheral
Weight IncreasedAsthenia
DepressionRash
AstheniaConfusional State

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Trazodone Hydrochloride is effectiven/an/an/a7.69%
(1 of 13 people)
66.67%
(2 of 3 people)
22.22%
(2 of 9 people)
13.64%
(3 of 22 people)
n/a
Methadone Hydrochloride is effectiven/an/an/a33.33%
(4 of 12 people)
50.00%
(2 of 4 people)
50.00%
(4 of 8 people)
22.73%
(5 of 22 people)
n/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Paraesthesia Oraln/aProgressive Multifocal LeukoencephalopathyOptic Nerve DisorderAstheniaDepressionNauseaPain
Tongue DiscolourationChoroidal ColobomaPainPainDepressionPain In Extremity
Hypoaesthesia OralIris ColobomaNauseaPyrexiaPainAnxiety
GlossodyniaLoss Of ConsciousnessNeuropathy PeripheralFallWeight IncreasedBack Pain
DysgeusiaMultiple Drug OverdoseDeathDiabetes MellitusWeight DecreasedRash
Gingival PainPyrexiaAnxietyConstipationFallOsteonecrosis Of Jaw
Drug Effect DecreasedInjection Site InfectionCardiac ArrestTremorAnxietyFistula
Respiratory DepressionConvulsionChest PainNeuropathy PeripheralHypoaesthesia
Injection Site InflammationDyspnoeaWeight DecreasedHeadacheImpaired Healing
Multiple Drug Overdose IntentionalRespiratory ArrestBack PainConfusional StateHyperplasia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Trazodone and Methadone?

You are not alone! Join a related mobile support group:
- support group for people who take Trazodone and Methadone
- support group for people who take Methadone Hydrochloride
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

  • I'm starting 7.5 mg remeron tonight , how can i expect to feal in the morning? (1 answer)
    Long period of depression desperate to find something that will work quik and give me some energy.
  • Do you have issues snoring from testosterone
    I was in an IED explosion in Afghanistan, had a TRAUMATIC BRAIN INJURY, 2005.JULY 28THlevels were extremely low. my V.A. doctor put me on testesterone 2011 BREAST CANCER, AUG 11TH 2012 HIT AND RUN ON MY MOTORCYCLE. DUE TO all the pain meds chemo, etcetera. MY testosterone. At first it was the best thing that had happened to me since I woke up in the hospital now I snore like a drunk Marined. and the culprit is the testosterone. I need to save my marriage and do something aboot this. any ideas what I can do
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • What causes it? and why is it so painful? (1 answer)
    I can lift my arm out in front of me but not out to the side!! The diclofenac doesn't seem to help. Any suggestions? Has anyone been on benlysta?
  • Can methadone cause my aynurism to burst?
    A doctor is lowering my dose of Methadone I take for severe back pain due to my aneurysm because he said the Methadone could cause a stroke w/my aneurysm. Has anyone else heard of this? Thank you!!!

More questions for: Methadone Hydrochloride, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Hit and miss sleep with dextroamphetamine
    Started drug 2 months ago and have seen an improvement in my focus. Ziprosidone for my depression causes me to get dead tired by 7 pm. Once I started taking Dextroamphetamine I started having insomnia 2 times a week. I think I would rather sleep early than stay up all night and then try and stay awake at work. So many drugs and even more side effects. Also Trazadone is no help for getting me to sleep. The only good side affect I have seen is I am down 26 pounds.
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.
  • Michael my son died as a result of kolopin & ambien (5 responses)
    My beautiful son to whom I depended upon took his Life by suicide on July 16, 2013. He had been struggling with a sleep disorder. It seemed to begin in his last year of high school 2010. Mike was very strong in mind and in body. He became a certified personal trainer. He encouraged everyone around him and all of his clients. How can someone so strong be so weak?
    He had been heavily medicated by a sleep doctor, for years this doctor gave him different medicines and he began to show other heath impairments..I could not see so many things that are very clear to me now, I never saw the effect the drugs had on him. he was growing more tired and withdrawn. He knew so much about medicines that I thought he knew what was happening he and I both trusted the doctors. With each new problem that occurred there was always a new drug to try and along with it a new set of side effects. A new doctor was added to his care and this doctor right away gave an RX for Kolopin. He was already taking Ambien and the two dont seem to play well together. Mean while he was growing sicker and sicker. We constantly were going for this test or that test, never once did the sleep doctor ever think that the drugs being given were the cause of all of his distress.
    At one point he was unable to keep food down and was throwing up every day. More test that always revealed the same result. No problem found. The visits to the sleep doctor were the same as well his condition was worsening and chronic. and yet never once did the sleep doctor ever give the drugs a second thought. The known side effects for both of these drugs were suicide for ages between 16 to 22. Until his death I never read about any of the products he was on.
    On July 16, 2013 the day began with Mike not sleeping, he seemed angry, exhausted. he was getting ready to help us out at our office. Once there it seemed like nothing went his way and at one point got into argument with his dad, told me he hated him and decided to go into his office to talk to him. He began to cry, I had to leave for an appointment and I waved to him through a window. I could see him crying. He got up and just left our office. Later we would find that he called his pastor, his cousins and a friend all did not reply. One girl friend of his did, she told him to meet her for drinks he told her what happened and he needed to save money and needed to be at his training job shortly. Within a 15 minute span wrote us a suicide letter, drove off and shot himself. a few minutes after he did a passer bye called 911. They took him to the hospital. The police came to our office to inform us we need to get to the hospital. The shock of all shock.... He passed away 1:04 am on the 17 of July. I never thought I could be so lost and broken as I am. I miss you so much Michael!

More reviews for: Methadone Hydrochloride, Trazodone Hydrochloride

Comments from related studies:

  • From this study (1 month ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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