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Review: Methadose and Propranolol





Summary: drug interactions are reported among people who take Methadose and Propranolol together.

This review analyzes the effectiveness and drug interactions between Methadose and Propranolol. It is created by eHealthMe based on reports of 223 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methadose and Propranolol >>>

What are the drugs

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadose 2,391 users)

Propranolol hydrochloride has active ingredients of propranolol hydrochloride. It is often used in migraine. (view latest outcomes from 3,322 users)

On Dec, 20, 2014: 223 people who take Methadose, Propranolol Hydrochloride are studied

Methadose, Propranolol Hydrochloride outcomes

Drug combinations in study:
- Methadose (methadone hydrochloride)
- Propranolol Hydrochloride (propranolol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methadose is effective0.00%
(0 of 2 people)
n/an/a100.00%
(2 of 2 people)
50.00%
(1 of 2 people)
n/a66.67%
(2 of 3 people)
n/a
Propranolol Hydrochloride is effectiven/an/a100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
66.67%
(2 of 3 people)
n/a50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaMiosisDrowsinessBreakthrough PainDepressionn/aGastrooesophageal Reflux DiseasePain
HypervolaemiaNarcotic IntoxicationFlatulenceTachycardiaPoor Peripheral CirculationGeneral Physical Health DeteriorationAnxiety
HypotensionRespiratory DepressionShort-term Memory LossSupraventricular TachycardiaSuicide AttemptAbdominal PainNausea
PainDepressed Level Of ConsciousnessFeeling JitteryPhantom PainInjuryConvulsion
Cardio-respiratory ArrestUnresponsive To StimuliWeight IncreasedParanoiaGastric DisorderHeadache
Blood Creatinine IncreasedDrug Withdrawal SyndromeSweating IncreasedMood SwingsAnxietyFibromyalgia
FlatulenceOverdoseWithdrawal SyndromePostherpetic NeuralgiaPainDepression
Acute Pulmonary OedemaDecreased AppetiteOedema PeripheralAbdomen - SwollenVomitingInsomnia
Abdominal PainMusculoskeletal PainConstipationCholecystitis ChronicPain In Jaw
SedationBlood Triglycerides IncreasedPanic AttacksCholelithiasisCompleted Suicide

Drug effectiveness by gender :

FemaleMale
Methadose is effective50.00%
(3 of 6 people)
66.67%
(2 of 3 people)
Propranolol Hydrochloride is effective60.00%
(3 of 5 people)
66.67%
(2 of 3 people)

Most common drug interactions by gender * :

FemaleMale
PainCompleted Suicide
FibromyalgiaCardiac Arrest
NauseaRespiratory Arrest
ConvulsionDepression
AnxietyAnxiety
HeadacheInsomnia
Gastrooesophageal Reflux DiseaseHeadache
InjuryLoss Of Consciousness
Oedema PeripheralConfusional State
Emotional DistressNausea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methadose is effectiven/an/an/a100.00%
(2 of 2 people)
0.00%
(0 of 11 people)
100.00%
(1 of 1 people)
66.67%
(2 of 3 people)
n/a
Propranolol Hydrochloride is effectiven/an/an/a100.00%
(1 of 1 people)
16.67%
(2 of 12 people)
n/a66.67%
(2 of 3 people)
n/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Deathn/aCompleted SuicideDifferential White Blood Cell Count AbnormalMulti-organ FailureConvulsionDepressionSedation
Renal Failure AcuteRespiratory ArrestNauseaPneumonitisPainNauseaHypervolaemia
Renal InjuryCardiac ArrestNeutrophil Count DecreasedOverdoseAnxietyHeadacheHypotension
PainCardio-respiratory ArrestSalivary Gland PainEmotional DistressFibromyalgiaOedema PeripheralBlood Creatinine Increased
Renal FailureUnresponsive To StimuliVomitingVentricular FibrillationAstheniaHypertensionCardio-respiratory Arrest
InjuryPulseless Electrical ActivityParotid Gland EnlargementMalaiseHeadacheCompleted SuicideAbdominal Pain
Poisoning DeliberateAggressionMyocardial InfarctionPain In ExtremityCoughHallucination
DeathThinking AbnormalShort-term Memory LossInsomniaAnxietyNausea
Sinus TachycardiaPersecutory DelusionCardiac ArrestFatigueInsomniaAcute Pulmonary Oedema
Electrocardiogram Qt Corrected Interval ProlongedHallucination, AuditoryIntentional OverdoseDepressionCardiac ArrestPain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methadose and Propranolol?

You are not alone! Join a related mobile support group:
- support group for people who take Methadose and Propranolol
- support group for people who take Methadose
- support group for people who take Propranolol Hydrochloride

Can you answer these questions (Ask a question):

  • Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
    1)Coughing up Mucus
    2)Shortness of Breath
    3)Tightness in the Chest"

    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos
  • I am on propranolol 10mg 3tad i now have a stomach bug and have been prescribed vancomycin, is it safe to take both together
    I have a very bad stomach bug, can this be caused by use propranolol, and is it safe and will the vancomycin work, while i am taken propranolol
  • Should i go to the emergency room for severe leg pain. i'm taking propranlol (1 answer)
    Extremely soar legs. Soar throat, swollen thyroid, and headache.;
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • Propranolo & pregabalin - do they produce heart troubles? my meds mix has
    Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!

More questions for: Methadose, Propranolol Hydrochloride

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
  • Extreme tooth sensitivity after 5 years on lyrica
    One year ago, after being on Lyrica for 5 years, I developed extreme tooth sensitivity. It came on very quickly to one tooth, then quickly spread to all of my top front 6 teeth and now the rest of my teeth are sensitive too. When I say sensitive, I mean that I can't even bite a banana using my front teeth!!! I ended up having root canals on my top front 4 teeth and then had to have two of them pulled because even after the root canals, they were extremely sensitive to any sort of touch at all!!! I now have implants for those two teeth and yet the sensitivity continues in the rest of my teeth. The dentist, endodontist, periodontist and family physician can find nothing 'physically' wrong. My gums are healthy. I feel that it is somehow nerve related and that there has been some damage done. I can not even form words properly because my tongue hits the back of my front teeth as I talk (which is normal), but even THAT causes me pain. I have to constantly use Tylenol and Advil (although they really don't give me any relief.) I have gone through no less than 20 tubes of Orajel and Ambesol in the past year. It is pretty much the only thing that gives me any sort of relief. It has completely affected my quality of life, (as if the reason I needed the Lyrica in the first place didn't already do that enough!!) I am confident that it is the Lyrica as I can find no other literature on the Propranolol causing any side effects such as this. I am a very fit, active lady. I happen to have P.O.T.S which is why I am on the Beta Blocker and Lyrica in the first place. I sure hope that if I stop taking the Lyrica, the sensitivity will decrease. At this rate, I'm going to lose all of my teeth! Incidentally, two of my otherwise healthy teeth now feel wiggly as well! Up until recently, I had only typical, age related dental issues. My dentist is perplexed as to what is going on with me. This is so frustrating!
  • Xanax bed wetting will it stop and do i wear diapers or die (1 response)
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.

More reviews for: Methadose, Propranolol Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Can I have seizures by stopping Xanax if I have weaned myself down to 1 mg a day for a month?

    Reply

  • From this study (3 years ago):

  • I just wanted to check to see if there is any known interaction with my medication....

    Reply

  • From this study (5 years ago):

  • I've been on the methadone treatment for my opiate addiction and the klonopin for my panic attacks for around two years and they both have saved my life in more ways then one. But my doctor wanted to put me on propranolol to help with the panic attacks cause my blood pressure was high. I know the propranolol is safe with the klonopin because she gave me the two on the same prescription, but I was wondering if the propranolol is safe to take with the methadone?

    Reply

Complete drug side effects:

On eHealthMe, Methadose (methadone hydrochloride) is often used to treat pain. Propranolol Hydrochloride (propranolol hydrochloride) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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