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Review: Methotrexate and Naproxen

This review analyzes the effectiveness and drug interactions between Methotrexate and Naproxen. It is created by eHealthMe based on reports of 2,960 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Methotrexate and Naproxen >>>

What are the drugs

Methotrexate (what 131,137 Methotrexate users reported?) has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis.

Naproxen (what 21,898 Naproxen users reported?) has active ingredients of naproxen. It is used in pain.

On Sep, 13, 2014: 2,960 people who take Methotrexate, Naproxen are studied

Methotrexate, Naproxen outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Naproxen (naproxen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a25.00%
(2 of 8 people)
0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
66.67%
(2 of 3 people)
50.00%
(2 of 4 people)
25.00%
(1 of 4 people)
n/a
Naproxen is effectiven/a42.86%
(3 of 7 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
25.00%
(1 of 4 people)
0.00%
(0 of 4 people)
57.14%
(4 of 7 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cytolytic HepatitisAnaemiaBlood Albumin DecreasedAbdominal PainDevice FailurePulmonary FibrosisDisseminated TuberculosisArthralgia
Transaminases IncreasedProstate CancerGastrointestinal HaemorrhageNauseaClavicle FractureDiverticulitisNeutropeniaPyrexia
PyrexiaPyrexiaRenal ImpairmentMalaiseImpaired HealingKlebsiella InfectionMeningitis TuberculousDrug Ineffective
ArthralgiaGastroenteritisCerebrovascular AccidentDizzinessFemur FractureFatigueLymph Node TuberculosisNausea
JaundiceTuberculosis Of Central Nervous SystemArthritisLiver Function Test AbnormalPneumoniaGeneral Physical Health DeteriorationImmune Reconstitution SyndromeRheumatoid Arthritis
Prothrombin Level DecreasedLymph Node TuberculosisRespiratory ArrestOedema PeripheralVomitingPolyneuropathyGenital UlcerationHeadache
CholestasisArthritisAnaemiaPneumonitisRespiratory FailureAnxietyTuberculosis Of Central Nervous SystemPain
Blood Bilirubin IncreasedMeningitis TuberculousNosocomial InfectionArthritisDeathEnterococcal InfectionRenal FailureDyspnoea
Autoimmune HepatitisDisseminated TuberculosisTachycardiaLiver InjuryToxic Epidermal NecrolysisInterstitial Lung DiseaseSeptic ShockVomiting
Herpes ZosterImmune Reconstitution SyndromeOccult Blood PositiveAbdominal MassAutoimmune HepatitisCandidiasisWoundInjection Site Pain

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective28.57%
(6 of 21 people)
33.33%
(2 of 6 people)
Naproxen is effective31.82%
(7 of 22 people)
16.67%
(1 of 6 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaDrug Ineffective
NauseaDyspnoea
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
HeadacheNausea
VomitingCough
Rheumatoid ArthritisOedema Peripheral
FatigueChest Pain
Injection Site PainPulmonary Fibrosis

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
7.14%
(1 of 14 people)
18.18%
(2 of 11 people)
57.14%
(4 of 7 people)
12.50%
(1 of 8 people)
Naproxen is effective0.00%
(0 of 1 people)
n/a0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
7.14%
(1 of 14 people)
33.33%
(3 of 9 people)
28.57%
(2 of 7 people)
12.50%
(1 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPyrexiaPyrexiaPainOedema PeripheralRheumatoid ArthritisArthralgiaDrug Ineffective
VomitingArthralgiaFlushingDiarrhoeaArthralgiaPyrexiaNausea
Hodgkin's DiseaseArthritisPyrexiaNauseaNauseaDrug IneffectiveArthralgia
Condition AggravatedInjection Site PainArthralgiaInjection Site PainDrug IneffectiveDyspnoeaPneumonia
HypoglycaemiaMulti-organ FailureHeadacheRheumatoid ArthritisPyrexiaNauseaPyrexia
HeadacheDisseminated Intravascular CoagulationNauseaCoughHeadachePainFatigue
HepatitisJuvenile ArthritisRespiratory FailurePyrexiaChest PainHeadacheCough
Juvenile ArthritisDiplopiaTachycardiaHypotensionOedema PeripheralInjection Site HaemorrhageAsthenia
Histiocytosis HaematophagicDrug Rash With Eosinophilia And Systemic SymptomsDrug IneffectiveGastrointestinal HaemorrhagePruritusVomitingPulmonary Fibrosis
ArthralgiaHistiocytosis HaematophagicAtrophyDyspnoeaPainMyalgiaRheumatoid Arthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Naproxen?

Get connected! Join a mobile support group:
- group for people who take Methotrexate and Naproxen
- group for people who take Methotrexate
- group for people who take Naproxen

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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