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Review: taking Methotrexate and Naproxen together

Summary: drug interactions are reported among people who take Methotrexate and Naproxen together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Naproxen. It is created by eHealthMe based on reports of 2,960 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Methotrexate and Naproxen >>>

What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,224 Methotrexate users)

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from 21,944 Naproxen users)

On Jan, 13, 2015: 2,960 people who take Methotrexate, Naproxen are studied

Methotrexate, Naproxen outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Naproxen (naproxen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a25.00%
(2 of 8 people)
0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
66.67%
(2 of 3 people)
50.00%
(2 of 4 people)
25.00%
(1 of 4 people)
n/a
Naproxen is effectiven/a42.86%
(3 of 7 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
25.00%
(1 of 4 people)
0.00%
(0 of 4 people)
57.14%
(4 of 7 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cytolytic HepatitisAnaemiaBlood Albumin DecreasedAbdominal PainDevice FailurePulmonary FibrosisDisseminated TuberculosisArthralgia
Transaminases IncreasedProstate CancerGastrointestinal HaemorrhageNauseaClavicle FractureDiverticulitisNeutropeniaPyrexia
PyrexiaPyrexiaRenal ImpairmentMalaiseImpaired HealingKlebsiella InfectionMeningitis TuberculousDrug Ineffective
ArthralgiaGastroenteritisCerebrovascular AccidentDizzinessFemur FractureFatigueLymph Node TuberculosisNausea
JaundiceTuberculosis Of Central Nervous SystemArthritisLiver Function Test AbnormalPneumoniaGeneral Physical Health DeteriorationImmune Reconstitution SyndromeRheumatoid Arthritis
Prothrombin Level DecreasedLymph Node TuberculosisRespiratory ArrestOedema PeripheralVomitingPolyneuropathyGenital UlcerationHeadache
CholestasisArthritisAnaemiaPneumonitisRespiratory FailureAnxietyTuberculosis Of Central Nervous SystemPain
Blood Bilirubin IncreasedMeningitis TuberculousNosocomial InfectionArthritisDeathEnterococcal InfectionRenal FailureDyspnoea
Autoimmune HepatitisDisseminated TuberculosisTachycardiaLiver InjuryToxic Epidermal NecrolysisInterstitial Lung DiseaseSeptic ShockVomiting
Herpes ZosterImmune Reconstitution SyndromeOccult Blood PositiveAbdominal MassAutoimmune HepatitisCandidiasisWoundInjection Site Pain

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective28.57%
(6 of 21 people)
33.33%
(2 of 6 people)
Naproxen is effective31.82%
(7 of 22 people)
16.67%
(1 of 6 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaDrug Ineffective
NauseaDyspnoea
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
HeadacheNausea
VomitingCough
Rheumatoid ArthritisOedema Peripheral
FatigueChest Pain
Injection Site PainPulmonary Fibrosis

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
7.14%
(1 of 14 people)
18.18%
(2 of 11 people)
57.14%
(4 of 7 people)
12.50%
(1 of 8 people)
Naproxen is effective0.00%
(0 of 1 people)
n/a0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
7.14%
(1 of 14 people)
33.33%
(3 of 9 people)
28.57%
(2 of 7 people)
12.50%
(1 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPyrexiaPyrexiaPainOedema PeripheralRheumatoid ArthritisArthralgiaDrug Ineffective
VomitingArthralgiaFlushingDiarrhoeaArthralgiaPyrexiaNausea
Hodgkin's DiseaseArthritisPyrexiaNauseaNauseaDrug IneffectiveArthralgia
Condition AggravatedInjection Site PainArthralgiaInjection Site PainDrug IneffectiveDyspnoeaPneumonia
HypoglycaemiaMulti-organ FailureHeadacheRheumatoid ArthritisPyrexiaNauseaPyrexia
HeadacheDisseminated Intravascular CoagulationNauseaCoughHeadachePainFatigue
HepatitisJuvenile ArthritisRespiratory FailurePyrexiaChest PainHeadacheCough
Juvenile ArthritisDiplopiaTachycardiaHypotensionOedema PeripheralInjection Site HaemorrhageAsthenia
Histiocytosis HaematophagicDrug Rash With Eosinophilia And Systemic SymptomsDrug IneffectiveGastrointestinal HaemorrhagePruritusVomitingPulmonary Fibrosis
ArthralgiaHistiocytosis HaematophagicAtrophyDyspnoeaPainMyalgiaRheumatoid Arthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Naproxen?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Naproxen
- support group for people who take Methotrexate
- support group for people who take Naproxen

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Why would naproxen be chosen above other anti-inflammatory drugs ?
    I had Kidney stones Years ago and they were removed over 18 months slowly by monthly appointments for Lithotrypsy ( Ultrasound ) Over all this time I had a jj Stent tied off from inside my Kidney to inside my Bladder ( To keep Kidney from blocking again ) In the years since then I have sufferred intense pain in Kidney region and have ben told there are now cysts in my kidney. Occasionally these cysts burst and bleed thus blocking my urethra with clot.
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methotrexate, Naproxen

You may be interested at these reviews (Write a review):

  • Jaw pain and naproxen
    Taking naproxen for pain relief of mortons neuromas. 500 mg twice a day (cut in half) caused breathing problems. Now dose reduced to 125mg 2xdaily still causing intense jaw pain
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Eczema and birth control-microgestin
    I started getting eczema over the last year and recently decided it may be from the birth control as well, which I started taking @ 2 months before I got the eczema and skin started breaking out...weight gain, etc. I am on singulair, westcort cream, moisture/kenalog, exederm cream, cerevue wash, cetaphil moisturizer, and started using the black soap which is apparently helping. I started a vegetarian diet and eat mainly the same foods daily to monitor anything for allergies. I stopped taking the pill 3 days ago and I am optimistic. I am hoping others have had positive experiences.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Naproxen

Comments from related studies:

  • From this study (1 year ago):

  • I am having most of the symptoms of Hypothyroid, weight gain, very dry skin & hair, easily stressed, palpitations yet my doctor tells me my bloods are normal. No one seems to know why I am feeling so bad all the time.

    Reply

  • From this study (3 years ago):

  • I have only been taking Mavik for 5 days. Today my stomach is in consistent pain, my lower center back is aching.

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  • From this study (6 years ago):

  • Extreme constipation not responding to daily dose of Miralax fiber laxative with 3 Dulcolax tabs and water enema, for over one week. Trying to find nuke or rocket-propelled grenade, but I'm a middle-aged accountant and don't have the contacts. Am considering eating nothing but raisins for a week but not sure I can survive long enough for this to work. Also extremely depressed to the point of disorientation and almost constant suicidal ideation.

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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