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Review: Methotrexate and Naproxen





Summary: drug interactions are reported among people who take Methotrexate and Naproxen together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Naproxen. It is created by eHealthMe based on reports of 2,960 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methotrexate and Naproxen >>>

What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (view latest outcomes from 131,201 users)

Naproxen has active ingredients of naproxen. It is often used in pain. (latest outcomes from Naproxen 21,930 users)

On Dec, 14, 2014: 2,960 people who take Methotrexate, Naproxen are studied

Methotrexate, Naproxen outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Naproxen (naproxen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a25.00%
(2 of 8 people)
0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
66.67%
(2 of 3 people)
50.00%
(2 of 4 people)
25.00%
(1 of 4 people)
n/a
Naproxen is effectiven/a42.86%
(3 of 7 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
25.00%
(1 of 4 people)
0.00%
(0 of 4 people)
57.14%
(4 of 7 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cytolytic HepatitisAnaemiaBlood Albumin DecreasedAbdominal PainDevice FailurePulmonary FibrosisDisseminated TuberculosisArthralgia
Transaminases IncreasedProstate CancerGastrointestinal HaemorrhageNauseaClavicle FractureDiverticulitisNeutropeniaPyrexia
PyrexiaPyrexiaRenal ImpairmentMalaiseImpaired HealingKlebsiella InfectionMeningitis TuberculousDrug Ineffective
ArthralgiaGastroenteritisCerebrovascular AccidentDizzinessFemur FractureFatigueLymph Node TuberculosisNausea
JaundiceTuberculosis Of Central Nervous SystemArthritisLiver Function Test AbnormalPneumoniaGeneral Physical Health DeteriorationImmune Reconstitution SyndromeRheumatoid Arthritis
Prothrombin Level DecreasedLymph Node TuberculosisRespiratory ArrestOedema PeripheralVomitingPolyneuropathyGenital UlcerationHeadache
CholestasisArthritisAnaemiaPneumonitisRespiratory FailureAnxietyTuberculosis Of Central Nervous SystemPain
Blood Bilirubin IncreasedMeningitis TuberculousNosocomial InfectionArthritisDeathEnterococcal InfectionRenal FailureDyspnoea
Autoimmune HepatitisDisseminated TuberculosisTachycardiaLiver InjuryToxic Epidermal NecrolysisInterstitial Lung DiseaseSeptic ShockVomiting
Herpes ZosterImmune Reconstitution SyndromeOccult Blood PositiveAbdominal MassAutoimmune HepatitisCandidiasisWoundInjection Site Pain

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective28.57%
(6 of 21 people)
33.33%
(2 of 6 people)
Naproxen is effective31.82%
(7 of 22 people)
16.67%
(1 of 6 people)

Most common drug interactions by gender * :

FemaleMale
ArthralgiaPyrexia
PyrexiaDrug Ineffective
NauseaDyspnoea
Drug IneffectiveArthralgia
PainRheumatoid Arthritis
HeadacheNausea
VomitingCough
Rheumatoid ArthritisOedema Peripheral
FatigueChest Pain
Injection Site PainPulmonary Fibrosis

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
7.14%
(1 of 14 people)
18.18%
(2 of 11 people)
57.14%
(4 of 7 people)
12.50%
(1 of 8 people)
Naproxen is effective0.00%
(0 of 1 people)
n/a0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
7.14%
(1 of 14 people)
33.33%
(3 of 9 people)
28.57%
(2 of 7 people)
12.50%
(1 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPyrexiaPyrexiaPainOedema PeripheralRheumatoid ArthritisArthralgiaDrug Ineffective
VomitingArthralgiaFlushingDiarrhoeaArthralgiaPyrexiaNausea
Hodgkin's DiseaseArthritisPyrexiaNauseaNauseaDrug IneffectiveArthralgia
Condition AggravatedInjection Site PainArthralgiaInjection Site PainDrug IneffectiveDyspnoeaPneumonia
HypoglycaemiaMulti-organ FailureHeadacheRheumatoid ArthritisPyrexiaNauseaPyrexia
HeadacheDisseminated Intravascular CoagulationNauseaCoughHeadachePainFatigue
HepatitisJuvenile ArthritisRespiratory FailurePyrexiaChest PainHeadacheCough
Juvenile ArthritisDiplopiaTachycardiaHypotensionOedema PeripheralInjection Site HaemorrhageAsthenia
Histiocytosis HaematophagicDrug Rash With Eosinophilia And Systemic SymptomsDrug IneffectiveGastrointestinal HaemorrhagePruritusVomitingPulmonary Fibrosis
ArthralgiaHistiocytosis HaematophagicAtrophyDyspnoeaPainMyalgiaRheumatoid Arthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Naproxen?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Naproxen
- support group for people who take Methotrexate
- support group for people who take Naproxen

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
  • Can long-term methadone use cause or increase the risk of colon cancer?
    I had a two-level spinal fusion at L4-S1 in 2000 after being injuried at work in Sept. 24, 1997. I lost everything after...the unjury, ability to do my job, my wife and family (couldn't take the strain) my home, my sense of self and purpose, direction and belonging...credit rating and ability to pay my bills.
    After a long period of waiting to settle my workmens' comp. case, I returned home, from the Bat Area back to Arizona to take of my mother with a yet un dianosed case of moderate dementia.
    Then, in 2011 I had a 2nd surgery to relieve spinal stenosis btwn. L2-L4, just above the fusion site.
    I've been taking methadone since early 2004, a little over ten years, now. I've had high blood pressure since my injury.

    Now, I waiting to be scheduled for a colonoscopy, with my father having had polyps and the way I've been feeling..drained, tired all the time, and stomach pains ( in addition to my chronic low back pain), I...
    find myself wondering if there is any relationtionship between the methadone and other meds and cancer?
  • What can i do to lessen the diarrhea i get while taking naprosyn?
    I am already using probiotics and trying to eat yogurt once a day. I also make sure to take medication on a full stomach.
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?
  • I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
    I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks

More questions for: Methotrexate, Naproxen

You may be interested at these reviews (Write a review):

  • Jaw pain and naproxen
    Taking naproxen for pain relief of mortons neuromas. 500 mg twice a day (cut in half) caused breathing problems. Now dose reduced to 125mg 2xdaily still causing intense jaw pain
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Eczema and birth control-microgestin
    I started getting eczema over the last year and recently decided it may be from the birth control as well, which I started taking @ 2 months before I got the eczema and skin started breaking out...weight gain, etc. I am on singulair, westcort cream, moisture/kenalog, exederm cream, cerevue wash, cetaphil moisturizer, and started using the black soap which is apparently helping. I started a vegetarian diet and eat mainly the same foods daily to monitor anything for allergies. I stopped taking the pill 3 days ago and I am optimistic. I am hoping others have had positive experiences.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Naproxen

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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