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Review: Methotrexate and Oxycontin





Summary: drug interactions are reported among people who take Methotrexate and Oxycontin together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Oxycontin. It is created by eHealthMe based on reports of 1,265 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Methotrexate and Oxycontin >>>

What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 131,201 users)

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. (latest outcomes from Oxycontin 42,284 users)

On Nov, 26, 2014: 1,265 people who take Methotrexate, Oxycontin are studied

Methotrexate, Oxycontin outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Oxycontin (oxycodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effective100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
n/a100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
n/a
Oxycontin is effective100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
40.00%
(2 of 5 people)
n/a0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug IneffectiveSepsisSquamous Cell CarcinomaPsoriasisTremorBacteraemiaIntervertebral DiscitisPain
AnaemiaRenal Failure AcutePyrexiaIncision Site PainDrug DependenceThrombocytopeniaIntervertebral Disc DisorderNausea
VomitingEndocarditis BacterialFeeling AbnormalProcedural PainDrug Withdrawal SyndromePyrexiaParaparesisOedema Peripheral
RashCellulitisFatigueBreast TendernessSuicidal IdeationPneumonia BacterialStaphylococcal SepsisArthralgia
PancytopeniaRheumatoid ArthritisFallUterine SpasmPainDysphagiaAnaemiaPyrexia
Malignant Neoplasm ProgressionAnaemiaDyspepsiaEctopic PregnancyMental DisorderVenous Thrombosis LimbHyponatraemiaAnaemia
NeutropeniaLung NeoplasmDyspnoea ExertionalPainNauseaSkin UlcerSeptic ShockAnxiety
ThrombocytopeniaSquamous Cell CarcinomaEar PainPostpartum DepressionFlatulenceRed Blood Cell Count AbnormalEmpyemaDyspnoea
White Blood Cell Count DecreasedPainFlushingIntermittent ClaudicationArthralgiaFallArthritis BacterialBack Pain
Bone Marrow FailureDecreased AppetiteMental DisorderOedema PeripheralDry MouthPneumonia PneumococcalBack PainFatigue

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective40.00%
(2 of 5 people)
0.00%
(0 of 2 people)
Oxycontin is effective62.50%
(5 of 8 people)
100.00%
(2 of 2 people)

Most common drug interactions by gender * :

FemaleMale
PainOedema Peripheral
NauseaPain
ArthralgiaWeight Decreased
Oedema PeripheralCellulitis
VomitingChest Pain
AnaemiaArthralgia
AnxietyDepression
FatigueConstipation
PyrexiaAsthenia
FallBack Pain

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/an/an/a0.00%
(0 of 1 people)
14.29%
(1 of 7 people)
n/a50.00%
(1 of 2 people)
Oxycontin is effectiven/an/an/an/a100.00%
(1 of 1 people)
30.00%
(3 of 10 people)
3.70%
(1 of 27 people)
100.00%
(2 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPancreatitisMulti-organ FailureDyspnoeaNauseaPainFatiguePain
StomatitisTransfusion ReactionWhite Blood Cell Count DecreasedDrug IneffectivePyrexiaPainOedema Peripheral
Anorectal DisorderMyeloid LeukaemiaHyponatraemiaVomitingOedema PeripheralNauseaArthralgia
Clostridium Test PositiveSeptic ShockCardiac Failure CongestiveDiarrhoeaRheumatoid ArthritisOedema PeripheralFall
HypophagiaAcute Monocytic LeukaemiaPlatelet Count DecreasedPainChest PainArthralgiaNausea
Mucosal InflammationDecreased AppetiteLeukopeniaHeadacheWeight DecreasedOsteoarthritisDyspnoea
Vaginal DisorderHeadacheMulti-organ FailureLoss Of ConsciousnessTremorAnaemiaAnxiety
VomitingVomitingCatheter Related InfectionPyrexiaBack PainPyrexiaFatigue
Abdominal PainCrohn's DiseasePneumonia StreptococcalMalaiseAnaemiaSinusitisBack Pain
Blood Culture PositivePyrexiaPyrexiaInjection Site PainDepressionHeadacheAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Oxycontin?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Oxycontin
- support group for people who take Methotrexate
- support group for people who take Oxycontin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
  • Do you have issues snoring from testosterone
    I was in an IED explosion in Afghanistan, had a TRAUMATIC BRAIN INJURY, 2005.JULY 28THlevels were extremely low. my V.A. doctor put me on testesterone 2011 BREAST CANCER, AUG 11TH 2012 HIT AND RUN ON MY MOTORCYCLE. DUE TO all the pain meds chemo, etcetera. MY testosterone. At first it was the best thing that had happened to me since I woke up in the hospital now I snore like a drunk Marined. and the culprit is the testosterone. I need to save my marriage and do something aboot this. any ideas what I can do
  • Can you get chills with multiple myeloma?
    Do multiple myeloma patients have the chills without fever? My husband was diagnosed 2 months ago and has had 2 months of chemo 2x weekly for 3 weeks. He has Velacade and a steroid Decadron. He has also had 3 rounds of cytoxan. Why is he getting chills?
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?
  • I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
    I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks

More questions for: Methotrexate, Oxycontin

You may be interested at these reviews (Write a review):

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    I have severe back injuries. When I lived in another state, I was put on oxycontin and immediately my menstrual cycle (period] stopped for 1 year. When I moved to another state, I stopped taking this drug and my period returned normal. I eventually had to go back on this drug, (oxycontin) and since this time, 2 years now, I again have not had a period since beginning. If you are on this drug and are worried about your period stopping, fear not, it is a normal side effect. Hope this helps. ..
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Which issue has caused my periodontitis, my fibromyalgia or spinal stenosis? (2 responses)
    At the age of 38 yrs old, I was diagnosed with Fibromyalgia and Spinal Stenosis. Obviously I had both of the disease for some years, and was struggling with the pain and symptoms for some time before I finally got checked, went through years being told they didn't find anything, told I had Herniated disks in My back only. Now with all the findings, there are 7 Herniated disks from My neck to My lower back.
    Also since 2010, I was diagnosed with Periodontitis and have been losing all of My teeth in the top of My mouth.
    I am 44 yrs old now, have been on disability for the last 4 years. I am down to 6 teeth in the top of My mouth, since having 1 removed just last week. They are telling Me that 3 more need to come out, and I am trying not to sink into total depression, especially since these are now My front teeth. I have a appointment today for a Denture Exam.

    I started researching today to see if this Periodontitis is related to either My Spinal Stenosis or My Fibromyalgia. Especially since I once again looked up the definition for Periodontitis. Which States;

    **Periodontal Disease and Bone Health. Periodontitis is a chronic infection that affects the gums and the bones that support the teeth. Bacteria and the body's own immune system break down the bone and connective tissue that hold teeth in place.

    Of course with My disease of Spinal Stenosis and the bone loss as well as the nerve narrowing, I thought the breaking down of the bone in the gums might have a connection. Research didnt find any linking.

    Now with Fibromyalgia, research showed 6 out of 17 thousand that they found. LOL Wow.. Well I guess I am "Number 7". Lucky Me! But it does make more sense now that looking at the definition. It is a Chronic infection (which Fibromyalia does create these) that effects the gums and bones. Bacteria and The Body's own Immune System break down the bone and connective tissue that hold the teeth. Which with Fibromyalgia, our Immune System is always all kinds of "Crazy"!

    Oh course you can not have any of these diseases, or any other health issues and wind up with Periodontitis. It happens. But I know from lots of reading, researching and living with Fibromyalgia, that it is "Very Possible"!

    I would sure like to know what others with these 2 diseases are experiencing.
    Have a Blessed Day.
  • Who cares about the patient? (1 response)
    I can't believe I'm still alive but quality of life is greatly diminished and no one cares. Not one doctor cares about how this one dr. prescribed all these drugs over a period of 5 years and I lost everything. I flat-lined sept 18, 2005 and was told by dr there in er that I would live 1-5 years and I had just lost my job as letter-carrier of over 17 years and my daughter was killed in dec of 2000, which I will always feel great responsibility because I knew I should have called her, it would have saved her life as she was killed in the firdale village apt fire and she didn't live there, she lived with me she was only 20 years old. So this crappy dr steven a creelman of seattle just kept throwing pills at me, telling me there was nothing wrong with any of the pills just me. I feared dr's and still do, I know they are just people and most people are good and caring but a lot are not. The Celebrex started after I was hit by a truck on the job in march of 2000. I will admit it relieved some pain but I had side affects immediately, within days to weeks. I was told by the crappy dr to shut up and take them as he originally told me they were not anti-inflamatorys but a new drug that did not upset stomach but they did. I felt trapped because it was an L&I and I didn't want to lose my job and so healthy and strong figured w/PT and rest I could overcome the accident pain which was lower back and neck well I couldn't sleep from pain and stomach but I couldn't tell crappy dr it would do no good. My daughter was killed Christmas night and that's a very hard one. I went back to work because my job was most of my life and I had friends at work. I continued to have more problems from Celebrex and I thought my stomach was on fire, it was blood clots that broke lose and I had to have an operation on my small instestine and what was worse is creelman, the crappy dr, when he told me it was an emergency umbililical hernia I told him I was going to get papers from owcp DOL as I would be off work at least 6 weeks. He said NO!!!!!!!!!! He closed the door and told me no, no I won't say it's from Celebrex when He really did know it was. I had an endoscopy 6 months later and that specialist said no more Celebrex. After that operation I just never felt good again I was swelling up my legs etc and fatique all kinds of not feeling good things and I was pissed at the crappy dr who by the said to me that no other dr would diagnose any different or believe me. So, it was in July of 04 and I was so sick I just went in there andhe was on vaction so another dr ran a bunch of blood tests for hiv which I told her was impossible and lupus and a few other things but no one there looked at any of the drugs except the pain medication which ironically was one of the only ones that didn't contribute to dvt & PE. when creelman got back I was still so sick I had left work and said I would be back in 2 weeks after I had some PT and rest. I couldn't sleep. That's when he prescribed REMERON. It was for sleep which it did help but I gained 50 lbs and within a couple months acquired tonsillitis, bhroinchitis, pneumonia, Phlebitis and a dvt which instead of referring me to a specialist he just presibed me an anti-inflammatory and another anti-depressant plus all the drugs He gave tons of samples which were never in noted in my files. I think he should have to pay me MONEY!! I have none since I have no job and I feel so terrible I wish I could just have my job back. And my Daughter but my health has been a Hematologist and injectable blood thinners. I hate the state of wash medical care about doctors but not the patients and I have no money to sue and it has been my experience not to mention crappy doctor SO WHO DO THE PATIENTS THAT ARE BADLY AFFECTED BY CRAPPY DCTORS GO TO? Oh I also couldn't be in the class-action suit because I didn't flat-line from heart attack. REALLY?
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine

More reviews for: Methotrexate, Oxycontin

Comments from related studies:

  • From this study (4 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

    Lisa on Sep, 4, 2014:

    Female 55 I have bechets. Diagnosed at 39. I take every medication on that list except I dropped methotrexate. I worse since I dropped it. And I have every symptom including ganglion cyst which needs to be surgically removed to the throat lesion. I can barely function. The only 5hing I dont have is the allergic cough. I did have mrsa phenomia once. Oh most recently plursey. I have been ivig dependent for 13 years.

    Reply

  • From this study (11 months ago):

  • want to find out if these drugs would cause semen discolouration (yellow, greenish)

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Oxycontin (oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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