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Review: taking Methotrexate and Oxycontin together

Summary: drug interactions are reported among people who take Methotrexate and Oxycontin together.

This review analyzes the effectiveness and drug interactions between Methotrexate and Oxycontin. It is created by eHealthMe based on reports of 1,265 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Methotrexate and Oxycontin >>>

What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,236 Methotrexate users)

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. (latest outcomes from 42,298 Oxycontin users)

On Feb, 26, 2015: 1,265 people who take Methotrexate, Oxycontin are studied

Methotrexate, Oxycontin outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Oxycontin (oxycodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effective100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
n/a100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
n/a
Oxycontin is effective100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
40.00%
(2 of 5 people)
n/a0.00%
(0 of 1 people)
n/a

Drug effectiveness by gender :

FemaleMale
Methotrexate is effective40.00%
(2 of 5 people)
0.00%
(0 of 2 people)
Oxycontin is effective62.50%
(5 of 8 people)
100.00%
(2 of 2 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Methotrexate is effectiven/an/an/an/a0.00%
(0 of 1 people)
14.29%
(1 of 7 people)
n/a50.00%
(1 of 2 people)
Oxycontin is effectiven/an/an/an/a100.00%
(1 of 1 people)
30.00%
(3 of 10 people)
3.70%
(1 of 27 people)
100.00%
(2 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug IneffectiveSepsisSquamous Cell CarcinomaPsoriasisTremorBacteraemiaIntervertebral DiscitisPain
AnaemiaRenal Failure AcutePyrexiaIncision Site PainDrug DependenceThrombocytopeniaIntervertebral Disc DisorderNausea
VomitingEndocarditis BacterialFeeling AbnormalProcedural PainDrug Withdrawal SyndromePyrexiaParaparesisOedema Peripheral
RashCellulitisFatigueBreast TendernessSuicidal IdeationPneumonia BacterialStaphylococcal SepsisArthralgia
PancytopeniaRheumatoid ArthritisFallUterine SpasmPainDysphagiaAnaemiaPyrexia
Malignant Neoplasm ProgressionAnaemiaDyspepsiaEctopic PregnancyMental DisorderVenous Thrombosis LimbHyponatraemiaAnaemia
NeutropeniaLung NeoplasmDyspnoea ExertionalPainNauseaSkin UlcerSeptic ShockAnxiety
ThrombocytopeniaSquamous Cell CarcinomaEar PainPostpartum DepressionFlatulenceRed Blood Cell Count AbnormalEmpyemaDyspnoea
White Blood Cell Count DecreasedPainFlushingIntermittent ClaudicationArthralgiaFallArthritis BacterialBack Pain
Bone Marrow FailureDecreased AppetiteMental DisorderOedema PeripheralDry MouthPneumonia PneumococcalBack PainFatigue

Most common drug interactions by gender * :

FemaleMale
PainOedema Peripheral
NauseaPain
ArthralgiaWeight Decreased
Oedema PeripheralCellulitis
VomitingChest Pain
AnaemiaArthralgia
AnxietyDepression
FatigueConstipation
PyrexiaAsthenia
FallBack Pain

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPancreatitisMulti-organ FailureDyspnoeaNauseaPainFatiguePain
StomatitisTransfusion ReactionWhite Blood Cell Count DecreasedDrug IneffectivePyrexiaPainOedema Peripheral
Anorectal DisorderMyeloid LeukaemiaHyponatraemiaVomitingOedema PeripheralNauseaArthralgia
Clostridium Test PositiveSeptic ShockCardiac Failure CongestiveDiarrhoeaRheumatoid ArthritisOedema PeripheralFall
HypophagiaAcute Monocytic LeukaemiaPlatelet Count DecreasedPainChest PainArthralgiaNausea
Mucosal InflammationDecreased AppetiteLeukopeniaHeadacheWeight DecreasedOsteoarthritisDyspnoea
Vaginal DisorderHeadacheMulti-organ FailureLoss Of ConsciousnessTremorAnaemiaAnxiety
VomitingVomitingCatheter Related InfectionPyrexiaBack PainPyrexiaFatigue
Abdominal PainCrohn's DiseasePneumonia StreptococcalMalaiseAnaemiaSinusitisBack Pain
Blood Culture PositivePyrexiaPyrexiaInjection Site PainDepressionHeadacheAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Methotrexate and Oxycontin?

You are not alone! Join a related mobile support group:
- support group for people who take Methotrexate and Oxycontin
- support group for people who take Methotrexate
- support group for people who take Oxycontin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • What are safe alternatives to oxycontin? since moving to florida., no pharmacy stocks or can order it. suggestions?
    I've been on OxyContin for several years with pretty good results managing severe pain. Since moving south I'm finding that pharmacies cannot/will not carry it. Sent ex fr. Local md to mail order--one week later, still waiting.
    I'm desperate to find an effective alternative. Ideas?
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methotrexate, Oxycontin

You may be interested at these reviews (Write a review):

  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Oxycontin induced low blood pressure.
    Have taken for 10+ years (Oxycontin). Recently had dose raised by 50%. I now take 140mg 3xdaily and 60mg (immediate Release) x4 daily as needed. Almost immediately after changing dosing (3-5 days later) I began to feel dizzy and light headed. BP began to lower and is now at 89/58. I have been treated in the past for having high BP so this is significantly lower than usual. The ONLY other change in diet, medication and lifestyle is at the same time I stopped consuming regular Coke and have switched to Diet Dr. pepper. Same caffeine levels but not same sugar levels.
  • Mensis cycle and oxycontin
    I have severe back injuries. When I lived in another state, I was put on oxycontin and immediately my menstrual cycle (period] stopped for 1 year. When I moved to another state, I stopped taking this drug and my period returned normal. I eventually had to go back on this drug, (oxycontin) and since this time, 2 years now, I again have not had a period since beginning. If you are on this drug and are worried about your period stopping, fear not, it is a normal side effect. Hope this helps. ..
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Methotrexate, Oxycontin

Comments from related studies:

  • From this study (6 months ago):

  • All lesions necrosis
    Painful granulomas
    I live in chronic pain and fatigue

    Reply

    Lisa on Sep, 4, 2014:

    Female 55 I have bechets. Diagnosed at 39. I take every medication on that list except I dropped methotrexate. I worse since I dropped it. And I have every symptom including ganglion cyst which needs to be surgically removed to the throat lesion. I can barely function. The only 5hing I dont have is the allergic cough. I did have mrsa phenomia once. Oh most recently plursey. I have been ivig dependent for 13 years.

    Reply

  • From this study (13 months ago):

  • want to find out if these drugs would cause semen discolouration (yellow, greenish)

    Reply

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Oxycontin (oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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