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Review: Morphine and Methadone

This review analyzes the effectiveness and drug interactions between Morphine and Methadone. It is created by eHealthMe based on 1,530 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 5, 2014: 1,530 people who reported to have interactions when taking Morphine, Methadone Hydrochloride are studied

Trend of Morphine, Methadone Hydrochloride's drug interactions, side effects and effectiveness reports (8630120)

Drug combinations in study:
- Morphine (morphine sulfate)
- Methadone Hydrochloride (methadone hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Morphine, Methadone Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)1,094
Osteonecrosis Of Jaw (death of bone of jaw)834
Arthralgia (joint pain)807
Back Pain724
Bone Disorder558
Nausea (feeling of having an urge to vomit)518
Osteoarthritis (a joint disease caused by cartilage loss in a joint)508

Most common interactions experienced by people in long term use of Morphine, Methadone Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Dental Caries38
Hiatus Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)27
Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)27
Osteonecrosis Of Jaw (death of bone of jaw)22
Osteomyelitis (infection of bone)22
Back Pain20
Rib Fracture18
Arthritis (form of joint disorder that involves inflammation of one or more joints)18

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Methadone Hydrochloride0.00%11.11%44.44%44.44%0.00%

Top conditions involved for these people * :

  1. Pain
  2. Multiple myeloma
  3. Back pain
  4. Nausea
  5. Cancer pain

Top co-used drugs for these people * :

  1. Methadone hcl
  2. Zometa
  3. Oxycontin
  4. Neurontin
  5. Ms contin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methadone Hydrochloride, Morphine

You can also:

Complete drug side effects:

On eHealthMe, Morphine (morphine sulfate) is often used to treat pain. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 year ago):

  • I hurt my back lifting a patient at work. I have had three back surgeries, two dural tears. I get migraines a lot, sometimes w numbness in limbs especially left side. I also was diagnosed with limes disease a yrs ago, I took antibiotics but I think I still have due to fluid build up, knee an joint pain an I am severely fatigued. I keep having mental clarity issues, trouble focusing. Also I recently again have had chest pain, tightness, coughing attacks, where it feels like I can't swallowat times. I am only 28 yrs old my back has been hurt since 07, but Iam at witts end w always feeling bad. Also around time of limes detection a yr ago, had the implanon put in my ARM, I ended up gaining 40 pds an couldn't breath so went to er, had it removed but found out it had broken in blood stream. Then I went on depo for 6 months. Havent been on for two month.


  • From this study (2 years ago):

  • I just want to know what the potential dangerous side effects could be from taking methadone, morphine and ritalin together???


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More reviews for: Methadone Hydrochloride, Morphine

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related studies

- Methadone Hydrochloride side effects
- Morphine side effects



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