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Related topic: Morphine Sulfate, Oxycodone

Review: Morphine Sulfate and Oxycodone

This review analyzes the effectiveness and drug interactions between Morphine Sulfate and Oxycodone. It is created by eHealthMe based on 5,131 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 3, 2014: 5,131 people who reported to have interactions when taking Morphine Sulfate, Oxycodone are studied

Trend of Morphine Sulfate, Oxycodone's drug interactions, side effects and effectiveness reports (4098646)

Drug combinations in study:
- Morphine Sulfate (morphine sulfate)
- Oxycodone (oxycodone hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Morphine Sulfate, Oxycodone:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety4,153
Pain3,500
Dyspnoea (difficult or laboured respiration)2,816
Vomiting2,587
Osteonecrosis Of Jaw (death of bone of jaw)2,230
Back Pain2,169
Nausea (feeling of having an urge to vomit)1,968
Fatigue (feeling of tiredness)1,881
Injury1,567
Anaemia (lack of blood)1,547

Most common interactions experienced by people in long term use of Morphine Sulfate, Oxycodone:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety113
Drug Dependence113
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)98
Memory Impairment97
Pain87
Vomiting77
Insomnia (sleeplessness)68
Depression58
Nausea (feeling of having an urge to vomit)54
Suicidal Ideation49

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Morphine Sulfate8.33%8.33%41.67%41.67%0.00%
Oxycodone9.09%9.09%27.27%36.36%18.18%

Top conditions involved for these people * :

  1. Pain
  2. Multiple myeloma
  3. Cancer pain
  4. Back pain
  5. Metastases to bone

Top co-used drugs for these people * :

  1. Oxycontin
  2. Zometa
  3. Ms contin
  4. Aredia
  5. Neurontin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Complete drug side effects:

On eHealthMe, Morphine Sulfate (morphine sulfate) is often used to treat pain. Oxycodone (oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (2 months ago):

  • During the past five years all of my relationships have become strained and most are currently non-existent. I have occasional outbursts where I become extremely angry and often scream and yell at those around me. I am also, and have been, for ten or more years very emotional, crying at the slightest thing from conversations to TV shows. The depression has also worsened over the past several years to the point that I no longer enjoy leaving my house for any reason and when I have no alternative but to go into public, I do so and get home as quickly as possible. In addition to the depressed mood and anger outbursts, I suffer from chronic fatigue that is so severe I can go an entire week without leaving my rocking chair, going so far as to not even want to shower. I am obsessive about things as well, so much so that if I begin watching a TV series, I can not stop until ALL episodes are watched, even if it is hundreds of episodes. I used to work out in a gym, have friends, a career and now I have NOTHING left. Even my relationships with my adult children (ages 19 and 20) are strained and both of my children have been asked by me to leave my home and move out which is totally out of character for me as I was a single mom who raised them myself, always having a very close relationship with them both. Now, I barely EVER speak to either of them on the phone and even less in person. The stress in my life is also very real. I was divorced after ten years due to my first husband cheating on me multiple times after which he left and started a family with the woman he cheated with, never coming back to even see his children. After that I dated a drunk for three years and then separated only to end up marrying a man who I thought was in recovery from heroin addiction but actually he began using again. Prior to the deterioration of my second marriage, my second husband had 9 strokes in a 3 month span after which he was diagnosed with CADASILL, leaving me to raise my two children and be a step-mother to his two children whose mother HATED me. In addition, I come from a family with an older brother who is an alcoholic and a second brother who is a cocaine/heroin addict who is often times verbally abusive to all of those around him. My mother and father are elderly; however, my mother has always been a enabler, choosing to ignore their bad behavior, often times "siding" with them. However, due to their old age and the fact that I am the only child who does not suffer from a substance abuse problem, I must always be their caretaker. Finally, I have an older sister who was diagnosed with MR as a child and I also take care of her both as a job and as a sister. This puts considerable stress on me and often times all of this drama leaves me feeling stressed out and angry and exhausted. Recently, I went off of the MS Contin and only take the water pills on an every other day basis.

    Reply

    julie on Mar, 4, 2014:

    ,i will be honest with you,and not lie,no reason too,you better get a grip on your own life,some kind of enjoyment every other day,you are a finatic hung up on issues,but you should not take it out on your childeren,not their fault you are such a bad person in your own mind,you can change all this,or you can drown in it,pray about it,ask god to help you,you need to change your outlook your attitude,and you need to meet people get out,stop blaming your family get with it,stop being a baby,be a soldier,pray,eat,sleep,work,have enjoy life,one day,you will be out of here,you need to get a grip on your life,family are druggies,get away from them,change your world you know how to do it,with gods help,get rid of the attitude,and stop blaming your kids,your fault,do something about it,get your hormones checked too while you are at it.,but stop blaming people around you,you are you,you can change you,and be a better person,or you can just die with an attitude,you are what you do and eat,you can procrastinate,and roll in the muck,or do something about it,stop blaming others and hurting others,change your life,abc,,123

    Reply

  • From this study (6 months ago):

  • severe RSD pain to upper right extremity with blisters, sores, pustules, coughing with spitting up blood and chronic pulmonary emboli, weight loss, loss of appetite, frail.

    Reply

  • From this study (11 months ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

    Reply

    jimmy on Apr, 29, 2013:

    Susan,
    Finally, I'd been reading thru here and finnaly, what doctor in the U.S. still prescribes cocaine? LOL

    Reply

    jimmy on Apr, 29, 2013:

    IF you donT see my other comments, Never take Cymbalta or anything containing same ingrediants or speeding thru the same side effects durring their enjoyable living advertizements!

    Reply

    Jmsrocks on Jul, 25, 2012:

    Probably death. Cocain and opiates together = speed ball.

    Reply

    Hebe on Jul, 31, 2012:

    I have had two close relatives on prednisone, and for both of them it alone can make them feel really speedy. Combined with cocaine and wellbutrin would probably make sleeping very difficult. As the previous commenter mentioned, combining oxys into this is probably a bit dangerous.

    Reply

    Patty O'Neill on Aug, 10, 2012:

    The comments about death in combination with cocaine and opiates or any other drug is possible
    depending on how much and the situation. Frightening people is not the key here. Basically any drug in combination with another could cause a major health problem as we are all very much not the same makeup. Cheers,

    Reply

    ken on Aug, 17, 2012:

    If she continues with this type of treatment, its kinda scary in all reality. Why not see a doctor, that's where the healing may start.

    Reply

    Jackie on Apr, 30, 2013:

    I am wondering if you were diagnosed because you had pain and found out you had a neurological message going on.... or just a process of elimination over the pain after you were taking your anti psychotic medication? I've been taking oxycone for my pain my back and neck disc issues um for about a year now, was having joint pain and stiffness all over my body the Dr put me on cymbalta and now three weeks later he put me on wellbutrin and I'm wondering about seratonin syndrome... I'm having muscle twitching also lump on top of my head and vision problems.

    Reply

    iCaNtCaLlIt on Oct, 24, 2012:

    Please coke for arthrit.? take your fish oils 2 each meal and take your perscribed pain meds(careful very addicting) stop the coke thats being silly for real. goodluck, lifes a bych and ya die thats why we get high .. p.s ankle 9 surgerys plates screws never walk normal again, fight thru it..i got hurt at work btw 7 ton crushed my leg instead of me....jus always think thingd can be worse, be a gpod person dont let this bring u dwn n b miserable..pul thru keep head up n watch those pain meds..goodluck...email if u wana talk but dont come with negatibity. buhbye

    Reply

    susan on Jan, 3, 2013:

    have vit d blood levles ck, and supplenment. vit d is an amazing pain control helper.

    Reply

    nefariouson3 on Nov, 7, 2012:

    I too am a chronic pain sufferer, I drove over a explosive in the middle-east. I don't understand what or why this thread was written up like a true medical study, to me it looks more like a recreational train wreck, some listed drugs have reverse reactions and others simply have no medical need what so ever, personally I would seek professional help and attempt to get off the unneeded drugs and concentrate on the true medical issues. At your age 51, you run the risk of many complications and possibility death from the listed drugs, though who am I to judge, life is way too short enjoy it when your still alive.

    Th3

    Reply

    Had'em all on Nov, 14, 2012:

    Prison and/or death. Comparing taking coke by inhalation and oxycontin orally is NOT the same thing as speed ball. Kindergarten speed ball maybe. Addiction threshold of oxy is 60mg/day. She should try to stay below that.
    Get her the hell off Pristine/Ketoconazole unless it is absolutely positively necessary. If necessary, try to get a lower dose. Stuff fries the liver & with all the other crap--BAD idea.
    Is there a reason she isn't taking an NSAID? I see prednisone. Would help more than oxy.

    Reply

    kobe77 on Jan, 3, 2013:

    Lmao! Lmao! You sound like your high ......enjoy your trip!

    Reply

    knowledgable on Jan, 7, 2013:

    Death bed us what they should expect. Mixing cocaine and oxy, are they brainless!!!!

    Reply

    Sydney on Jan, 9, 2013:

    Tell your friend to GET OFF WHEAT. The wheat products in this country are GMO which are very bad for us and cause arthritis. Tell your friend to research. Never let the Dr.s try and figure out what's wrong with you. They won't. And they'll kill you trying.

    Reply

    nursing101 on Jan, 28, 2013:

    Well, NSAID, you say? Hmmm....I see motrin, naproxen and aspirin on the list....all NSAID's

    Reply

    Billy on Feb, 2, 2013:

    It is a wonder that your wife is at all coherent taking that cocktail of medications. I would try to find a new doctor that has a better grasp of toxicology and drug interactions. Cocaine and Oxycotin--can't belief any reputable doctor would prescribe that combination.

    Reply

    High depression low motivation on Feb, 8, 2013:

    I take fish oils and centrum vitamins for depression replacing latuda and Lexapro wich was messing with my school I was out of phase sleeping all day and cloudy thinking. Now I just take Adderall and Xanax for agoraphobia and I feel a lot better and Im actually doing homework!! I scored high on my test than on the antidepressants with low scores.

    Reply

    AdoreTu on Mar, 4, 2013:

    Well, I just stopped at your post, and who ever is taking all of that stuff needs to take some Milk Thistle to help restore their liver.

    Reply

    Sam on Mar, 11, 2013:

    Way back in the late 1960's I heard it called a combination of cocaine and opiate type drugs a speedball. My best guess is your friend is on the way out of this world, unless there is an intervention. In short, death is the end result/side effect of taking such a combination of drugs....

    Deo Vindece,

    Sam

    Reply

    BCS on Mar, 12, 2013:

    Honestly. She can expect to die very young.

    Everything from heart, kidney, liver, stomach, brain, lungs, immune system, etc. will began to shut down.
    She will most likely become increasingly weak, finding herself in the hospital more often, and eventually die of organ failure. that is unless she dies from an overdoes first.

    Reply

    bcs on Mar, 12, 2013:

    Yeah, hybrid wheat is causing all the problems. not the cocaine and oxy, mixed with other prescription drugs.

    I agree Hybrid wheat is harmful and best left out of ones diet, but it's not the biggest problem here. (it hybrid not gmo) they haven't released that yet.

    Reply

    Susan on Mar, 12, 2013:

    Are you guys really this dumb? She meant to say her friend was taking Codeine not cocaine. I'm not even going to bother asking a question on this website if you're that dumb! LOL

    Reply

    Jenn on Mar, 15, 2013:

    I know that I am super sensitive to both codeine and oxy. They actually make me more nauseous and dizzy and i find regular tylenol or ibuprophen to be more effective against pain. I have heard some good things about omega fish oil and gluten free diets. My sister has RA too and when she flares up even pain meds dont help much. She is also gluten intolerant and can feel a marked difference in symptoms when she "slips" and eats gluten-y things. Steroids make your blood pressure high, she takes them when she gets flare ups but tries to ween herself off as the flare up dissipates. She gets weird skin breakouts because steroids also mess with the natural flora of your body. RA sux!!!!

    Reply

    doc moc on Mar, 25, 2013:

    have tou tried cocaine? pretty sure its gluten free our previous inquisitor seemed to have some luck with its administration in combination with an assortment of other medications to treat her condition also as far as the flora issue goes i dont think cocaine is an antagonist

    Reply

    doc moc on Mar, 30, 2013:

    oh yes BCS i agree hybrid wheat is a very dangerous substance especially when compared to the rather inocuous substances of cocaine and oxycontin! just what are your qualifications to dispense such well researched and supported opinions? You are truly a fool

    Reply

    Stephanie on Apr, 1, 2013:

    Yeah I'm pretty sure she ment codeine. i dont visit these sites often anymore becasue my questions never get answered and everything gets way off topic.

    Reply

    really on Apr, 10, 2013:

    people like you should visit your local humane society and have yourself spayed or neutered because the human race does not need less intelligent, human-jackass hybrid beings breeding with those of greater intellect. Cocaine was clearly written, not codeine. and please don't post your questions, prefer you be the guinea pig and take risks alerting the people who matter of potential risk factors. :)

    Reply

    Robert on Apr, 12, 2013:

    I just wish the federal government would overhaul Richard Nixon's war on drugs and the whole controlled drug act. I have had my share of pain and you can consider yourself lucky to be able to cope with it. It is the sorry folk out there who have psychiatric disorders which affect the brain's ability to "deal" and cope, and is at a chemical level with them, a neurological mess-up. I know personally, I have phases of time when it is dangerous for me to try and tough it out when my brain sometimes slows down production and release of the natural chemicals like beta endorphin, dopamine, Gammaaminobuteric Acid, and I can find my body aches because Im not making enough natural opiate substances. SO I take drugs given by MD to make me feel normal, like clonazepam, prozac, and sometimes amphetamine in low doses. It is frustrating because people still don't understand and think I am a schmuck for taking drugs to feel normal happiness, calm, joy, relaxation, and to enjoy life's natural pleasures I periodically am unable to feel or appreciate.

    Reply

    Robert on Apr, 12, 2013:

    It is true that speedballs, containing opiates and any stimulant. The "speed" in speedball likely refers to amphetamine, which was, prior to 1970, the original or at least most widely used upper in the 1960's. When the Controlled Drug Act was made official, cocaine became hugely popular, as an easier and more available alternative. SO strangely enough it became easier to get a totally outlawed drug than legal controlled drugs, because the new DEA and their most overzealous zealots were too busy finally settling old scores and getting the "dopeheads" and "speedfreeks" with the new Nixonian legislation backing them up like the word of God

    Reply

    Michele on Apr, 12, 2013:

    I totally understand where you are coming from. Your comment at the end there helped me understand that I am not "a druggy" as my husband calls me because I need medications to feel an enjoy simple life activities. You're lucky to have found the right combination of medicines to treat your depression. I feel like I've been on a roller coaster for the last 20 years. If I find the "right" combination to treat my severe depression/bipolar2 disorders, then I find myself with one or more intolerable side effects that I must live with, like extreme teeth pain/bruxism. I look at people all the time and say to myself "That person is "normal." "That person is enjoying life." "That person sleeps normally and doesn't need help." "That person is a good mom for doing activities with her child/children." I get sorta jealous, then I start believing what my husband says about me being a druggy and that I am not a good teacher/mom/wife. That I shouldn't need medicine to just have energy to get up and get dressed. But when I read your post it made me feel good, not that you were dealing with depression, but that someone else out there understands how it feels, that my husband is dead wrong and out of line, that my depression is a real disorder and not my fault. Thank you for your post.

    Reply

    shannon on Apr, 13, 2013:

    What shouldnt the expexation be...yes, cocaone is an antisthetic...only local, dentists "pink" mouth swab is cocaine based to numb the area and costrict blood vessels toz reduce swelling and bleeding....not for arthritis!..sounds like its a way to find a way out faster by destroying the heart muscle fro. The cocke's super stimulative effect and leave this world. There are other means to treat pain than death and mega doses of narcotics to mask the pain and increase the tolernance of the mds to the point that either there are no interior sinuses lrft by coke use or not enough pain meds to overcome the tolerance....ven IV cocaine use will burn the veins you shoot it in...its a loosing battle...and a painful one from damag thats beendone...Im praying for you guys...

    Reply

    mtntexas on Jun, 13, 2013:

    So, Dawn: When you say 'we're all stupid" do you mean all of us on this page or all of us on this planet? Cause I know a girl in Florida that can yodel while playing the piano.

    Reply

    Russ on May, 7, 2013:

    Formally of you bashing the cocaine for pain, do some research! Brompton's Cocktail is a chronic pain medicine in liquid form that contains cocaine, opiates, and some other meds. It is an evidenced based treatment for chronic pain, so please don't assume just because it has cocaine in it means it's gonna kill you. People suffering from chronic.pain need relief. if Brompton's works, then let them get their much needed relief!!! Without judgement!!

    Reply

    Big Balla on Jun, 1, 2013:

    Just kidding about all that stuff. Who's the doctor that prescribed all that? They probably shouldn't have a license.

    Reply

    Alicia on May, 30, 2013:

    I'm intrigued by your comment on cymbalta. I've been taking it for 2 years and since then I've had sugar disorders, irregular heart palpations and know I just feel like I'm on an adrenaline rush. It's scary. But I would like your opinion on this med I would really appreciate it and maybe then I can get some relief. I'm 33yrs old a mother of 3 boys and unfortunately my health is not the best so I'm trying to get as much info as I can from others that take the same meds I do or know of them. Thanks.. Alicia..

    Reply

    Big Balla on Jun, 1, 2013:

    Cocaine and oxy? Really??? Okay, have your friend continue the cocaine and oxy regimen. Replace the Wellbutrin with 20 mg of MDMA. They're going to want to add a few drops of LSD as well. At bedtime take 5mg Xanax with a marijuana cigarette dipped in embalming fluid. Don't forget to sprinkle some of the cocaine on it.

    Reply

    dawn on Jun, 13, 2013:

    how do you know what she meant??? She didn't correct herself, which probably means imo that she wrote it for shock value in the first place!! (in response to the person that said were all stupid!)

    Reply

    Girl_narcolepsy on Jun, 15, 2013:

    Female 32

    Hi, I would be worried about Serotonin but it usually has specific stages of symptoms. So starts with immediate symptoms like severe headache, dizziness etc.. then progresses- delirium, high fever etc..

    If you were having sensitivity I would look into sensitization or fibro.I had it and went away with Savella... (after neurosurgery)

    Reply

    Hypoglycemic on Jun, 16, 2013:

    @ Alicia - those sound like symptoms of Hypoglycemia. Do you feel better at night and then sometimes have trouble getting to sleep ?

    If it is hypoglycemia - the only treatment I know of is diet related. Removing all sugar and processed carbs from the diet and avoiding caffeine and alcohol. There are many names for sugar - and don't be duped by agave - not much better than corn syrup, which is the same as having sugar! Eat regularly - smaller meals every 3 hours and eat soon after waking up. High protein breakfast is a good start too. I'm vegan so I rely on soybeans a lot for protein. Diet will be much easier for a meat eater as no carbs in meat, but avoid high carb vegies too - like potatoes. Not too much fruit, avoid all dried fruit. I have to avoid bananas and most other fruits too, but can tolerate small amounts of berries. Go stricter in the beginning and then you can experiment and see what affects you and what doesn't. Think of it as a carb intolerance, which is what some refer to it as.

    Reply

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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