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Review: Morphine Sulfate and Tramadol





Summary: drug interactions are reported among people who take Morphine Sulfate and Tramadol together.

This review analyzes the effectiveness and drug interactions between Morphine Sulfate and Tramadol. It is created by eHealthMe based on reports of 2,349 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Morphine Sulfate and Tramadol >>>

What are the drugs

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. (latest outcomes from Morphine sulfate 19,045 users)

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 41,511 users)

On Nov, 25, 2014: 2,349 people who take Morphine Sulfate, Tramadol are studied

Morphine Sulfate, Tramadol outcomes

Drug combinations in study:
- Morphine Sulfate (morphine sulfate)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Morphine Sulfate is effective57.14%
(4 of 7 people)
50.00%
(3 of 6 people)
25.00%
(1 of 4 people)
33.33%
(1 of 3 people)
20.00%
(1 of 5 people)
66.67%
(2 of 3 people)
0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
Tramadol is effective25.00%
(1 of 4 people)
0.00%
(0 of 1 people)
0.00%
(0 of 4 people)
20.00%
(1 of 5 people)
22.22%
(2 of 9 people)
40.00%
(2 of 5 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Confusional StateDyspnoeaRhabdomyolysisSomnolenceFatigueMemory ImpairmentHypotensionPain
PneumoniaPyrexiaSepsisHomicidal IdeationNausea And VomitingMigraineExhaustion, Fatigue, Lethargy, Tiredness, WearinessNausea
VomitingVomitingRenal Failure AcuteHepatosplenomegalySphincter Of Oddi DysfunctionPain - ElbowSweating - ExcessiveAnxiety
SomnolenceDysphagiaRespiratory FailureHepatic SteatosisPancreatitis ChronicExhaustion, Fatigue, Lethargy, Tiredness, WearinessDyspnoea
Respiratory ArrestMuscular WeaknessLiver Function Test AbnormalHyperphagiaCholecystitisPain - KneeBack Pain
Abdominal PainSpeech DisorderBack PainHypersexualityNightmareBone PainAsthenia
HypotensionRespiratory ArrestDyspnoeaLeft Ventricular HypertrophyHigh Blood PressureSleep DisorderFatigue
PyrexiaAsthmaComaIntentional OverdoseHyperlipasaemiaParanoia AggravatedHeadache
Muscular WeaknessTrismusHypocalcaemiaImpulse-control DisorderDyspnoeaConstipation AggravatedAnaemia
Renal Failure AcutePneumoniaPulmonary OedemaHepatic CirrhosisMultiple Drug OverdoseMood SwingsVomiting

Drug effectiveness by gender :

FemaleMale
Morphine Sulfate is effective33.33%
(7 of 21 people)
40.00%
(4 of 10 people)
Tramadol is effective18.18%
(4 of 22 people)
20.00%
(2 of 10 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
NauseaPain
AnaemiaDyspnoea
DyspnoeaNausea
FatigueVomiting
AnxietyBack Pain
AstheniaDepression
Back PainConfusional State
HeadacheAbdominal Pain
ArthralgiaSomnolence

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Morphine Sulfate is effectiven/an/a100.00%
(1 of 1 people)
28.57%
(2 of 7 people)
9.52%
(2 of 21 people)
21.43%
(6 of 28 people)
25.00%
(1 of 4 people)
0.00%
(0 of 8 people)
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 5 people)
21.43%
(3 of 14 people)
9.52%
(2 of 21 people)
20.00%
(1 of 5 people)
0.00%
(0 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
HyperaesthesiaSepsisAnal FistulaAnxietyHeadachePainNauseaDyspnoea
CryingBone PainAnal AbscessHeadacheNauseaAnxietyArthralgiaPain
Discomfort NosArthralgiaCholecystitis ChronicDyspnoeaDepressionNauseaAstheniaFall
Anxiety NecTumour Lysis SyndromeCystChillsChest PainHypoaesthesiaBone DisorderAnaemia
DistressRespiratory FailureNauseaPainDrug Withdrawal SyndromeDiarrhoeaAnaemiaFatigue
Drug Exposure During PregnancyPneumoniaPancreatitisPneumoniaSuicidal IdeationDepressionDiarrhoeaConfusional State
Sudden DeathRenal FailureSphincter Of Oddi DysfunctionDrug AbusePainVomitingOsteoarthritisAsthenia
SomnolenceAbdominal PainAmnesiaArthralgiaBack PainPain In ExtremityWeight Decreased
Abdominal PainVomitingVision BlurredAnxietyFatigueDyspnoeaConstipation
Depressed Level Of ConsciousnessPainMusculoskeletal StiffnessAbdominal PainAbdominal PainDepressionBack Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Morphine Sulfate and Tramadol?

You are not alone! Join a related mobile support group:
- support group for people who take Morphine Sulfate and Tramadol
- support group for people who take Morphine Sulfate
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (3 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.
  • Can you loose weight while taking hydroxyzine?
    Hydroxyzine has been my life saver but I have noticed a gradual increase in weight. My blood pressure has also gone up. I don't have the increased hunger but what scares me is I am not eating more than I normally do. I do not eat breakfast. I have a Glucerna at lunch and then dinner, protein potatoes/rice and veggies, sometimes pasta nothing huge and a snack at night. Maybe a small bowl of ice cream but not every night. I do not drink soda, lots of water and with dinner a large glass of apple juice. I have noticed every year I put on a little bit more weight. I was tested for my thyroid and it is normal. I haven't started an avid work out program. Doing high intense impact will not work due to my IC. I would like to try power walking. Anyone else experience any of these issues?
  • Is vomiting all liquids common while taking morphine
    I Recently started taking 6mg of Hydro-Morphine per day for pain. Every time i take the drug i vomit up any liquids I drink. i fell just fine without anything in my stomach but as soon as i eat or drink I instantly become nauseated and vomit everything. It is hard not to drink because the drug is making me very thirsty. So i try to drink and my body rejects it over and over again.. this goes on for hours (3-5)because i am sooo thirsty that I can not stop drinking.

More questions for: Morphine Sulfate, Tramadol

You may be interested at these reviews (Write a review):

  • Prostatitis and prostate cancer acceleration due to anaesthetics
    Caught Chlamydia in 1978. Interestingly, the partnered girl's sister worked in an aviary; and I found out later that Chlamydia originates from handling birdshit and birds are the carriers. Chlamydia was undiagnosed at the time, so it was listed under 'Non-specific urethritis'. Chlamydia wasn't named until about 8 years later. I was given tetracycline and told to stay off alcohol and sex. Yeah, really?

    I was 24; highly sexed, and in night clubs and pubs most nights. I laid off the alcohol and after two weeks, I was good. The laying off sex, I understood, because of contamination of others (condoms were little used in 1978 in the singles arena); so I masturbated one night... and that caused me immense in my prostate, and pain and suffering for the rest of my life.

    The ejaculation was extremely painful, and chronic prostatitis started. I was on and off medication for two years. I got light-sensitivity, which means in sunlight, I came out in burning rashes. I became allergic to tetracycline.

    The message? Consultants are generally poor at communicating what not to do, and why not. Lay off sex he said. All he had to say was no sex, no masturbation; or you may suffer for the rest of your life. That would have done it.

    No-one has been able to help me with this chronic prostatitis. In the early years it would come and go, but as the years have gone on, it has become more frequent, and now it is constant.

    Four years ago I went in for major foot surgery, and flat-lined. I was in intensive care for 2 days, on a morphine drip for the pain.
    When I awoke, I knew immediately I was suffering with my prostate. It was aching badly and I was urinating frequently. The nurses were amazed with how many 'bottles' I filled in such a short time.
    For the next few months, I was in agony. I have tried every possible drug going, as well as prostate massage and the indignancy of a urethragram whilst female students were watching.

    In November 2011 I went to see another consultant, who suggested a biopsy. I was diagnosed with prostate cancer. After much research, I now know that my diet and lifestyle, coupled with inflammation of the prostate with prostatitis, has caused prostate cancer. Yes, there is a direct relationship between prostatitis and prostate cancer.

    I am now beating it, without drugs and without surgery. I have changed my diet to a vegan diet, no sugar, very little alcohol, and a lot of supplementation.

    In December 2013, I went in for more foot surgery. I was unaware about the morphine at this time, so didn't consider it being a problem. I talk to the anaesthetist, who wanted me to have an epidural (injection in the spine to numb my lower body). At no point did he talk to me about my prostate history.
    In recovery, I sensed a problem as soon as the anaesthetic began to wear off. It was like my prostate and testicles wanted to explode. I knew I was going to have problems. My intuition reminded me of three years ago with the morphine, so I asked the surgeon if he knew of these complications with morphine, but he didn't.

    I spoke to the head of the post-operative ward and asked her if she had any experience of post-operative patients who suffered with prostatitis after surgery, and she confirmed she had. So here was a nurse who knew of the problems, but the surgeon and anaesthetist didn't. This is typical in the health service... the lack of sharing.

    Not only did I suffer with the chronic prostatitis (and still am 11 month later) I was incontinent. It took 6 months of 4-times daily legal exercises to get back control of my bladder.
    For me, morphine has a dire effect on my prostate.

    Bear in mind that your prostate is designed to eliminate toxins, so it is flooded with morphine. I will do my best to ensure I check for morphine in any drugs or anaesthetics in future.

    My first PSA level was 18, 3 ears ago. I brought it down to 13.5, then 10.4, 10.3, 10.9, 11.3, 14.3 and after the last surgery it spiked at 17.5. As a result, I have gone back to a stricter, greener raw diet to bring it down again.

    Oh, and anther tip; you need to get your vitamin D3 blood count above 200n/mols (UK measure) to have any chance of not getting prostate cancer. Mine was 32 when I was diagnosed. Today it is over 200, from supplementation of 10000 ius a day. Minimum in the UK, recommended by scientists, is 75n/mols, and it's too low. OK if you have a great immune system, but not if you want to fight prostate cancer and prostatitis.

    Black African males in the Northern US states and in Europe have twice as much risk, due to lack of sunlight. Sunlight on skin promotes vitamin D3, which is essential for the immune system and production of calcium.

    Black African males need more sunlight to produce the same amount of vitamin D3 as a caucasian male. Also, any male who is bald and fat has a higher risk, so a Black African, obese bald male, has an extremely high risk of prostate cancer, unless they get their immune system in order.

    The main way to fight all this, is on a clean, raw vegetable diet, pure water, no alcohol, sugar, processed or refined food, no meat, no dairy, no vegetable oil, no exceptions, and some breath-taking regular exercise. Just like we did 100 years ago. Go figure! Look at chronic disease studies of 100 years ago. 85% of all disease was from infection. Today 85% is from chronic disease.

    Your prostate eliminates toxins, and today, we are overloading it. Remove the toxins (and the stress and anxiety) and things will improve. It's a hard road; but with it is you want to be healthier and live longer.

    Good luck.
    Glenn.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.

More reviews for: Morphine Sulfate, Tramadol

Comments from related studies:

  • From this study (12 months ago):

  • want to find out of all my pain is a condition as well as my promary condition of back surgery and back pain

    Reply

  • From this study (2 years ago):

  • I always had low blood pressure but have now discovered it is high and am wondering if it is related to recent med changes or just to deterioration in underlying condition. The steroids are new. Morphine is old but recently increased to 120mg every 12hrs slow release. Furosemide and Cetirizine have been introduced since I last used to keep a check on BP results 3yrs ago. Not sure if it is suddenly high now or has been for a while but not picked up until now.

    Reply

  • From this study (2 years ago):

  • would like to know how morphine helps bipolar

    Reply

    shannon on Apr, 13, 2013:

    Not sure exact mech. of action, however, could be to raise "Feel Good" endorphines and possibly keep you more at a "near but not fully" manic point, so to speak. I know a few with depression treated with morphine for that reason...it increases the available dopamine between the nerve cells called the synapsis, in turn, giving a feeling of "well being". This effct is opposite in some people...such as scizophrenics...it seems to make them more apt
    to do stranger stuff and hallucinate. Im just a paramedic that researches stuff like this and no physician by a long shot...just picked it up after researching a patient I thought was lying to me about a depression treatment plan with narcotic medication....I had to find it out for myself and the above explanation is the guts of the study....hope it helps....I research alot of "cases" I transport to the hospital with good stories...

    Reply

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Complete drug side effects:

On eHealthMe, Morphine Sulfate (morphine sulfate) is often used to treat pain. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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