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Review: Morphine Sulfate and Tramadol

This review analyzes the effectiveness and drug interactions between Morphine Sulfate and Tramadol. It is created by eHealthMe based on reports of 2,349 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Morphine Sulfate and Tramadol >>>

What are the drugs

Morphine sulfate (latest outcomes from 19,028 users) has active ingredients of morphine sulfate. It is used in pain.

Tramadol (latest outcomes from 41,403 users) has active ingredients of tramadol hydrochloride. It is used in pain.

On Aug, 19, 2014: 2,349 people who take Morphine Sulfate, Tramadol are studied

Morphine Sulfate, Tramadol outcomes

Drug combinations in study:
- Morphine Sulfate (morphine sulfate)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Morphine Sulfate is effective57.14%
(4 of 7 people)
(3 of 6 people)
(1 of 4 people)
(1 of 3 people)
(1 of 5 people)
(2 of 3 people)
(0 of 2 people)
(0 of 1 people)
Tramadol is effective25.00%
(1 of 4 people)
(0 of 1 people)
(0 of 4 people)
(1 of 5 people)
(2 of 9 people)
(2 of 5 people)
(0 of 2 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Confusional StateDyspnoeaRhabdomyolysisSomnolenceFatigueMemory ImpairmentHypotensionPain
PneumoniaPyrexiaSepsisHomicidal IdeationNausea And VomitingMigraineExhaustion, Fatigue, Lethargy, Tiredness, WearinessNausea
VomitingVomitingRenal Failure AcuteHepatosplenomegalySphincter Of Oddi DysfunctionPain - ElbowSweating - ExcessiveAnxiety
SomnolenceDysphagiaRespiratory FailureHepatic SteatosisPancreatitis ChronicExhaustion, Fatigue, Lethargy, Tiredness, WearinessDyspnoea
Respiratory ArrestMuscular WeaknessLiver Function Test AbnormalHyperphagiaCholecystitisPain - KneeBack Pain
Abdominal PainSpeech DisorderBack PainHypersexualityNightmareBone PainAsthenia
HypotensionRespiratory ArrestDyspnoeaLeft Ventricular HypertrophyHigh Blood PressureSleep DisorderFatigue
PyrexiaAsthmaComaIntentional OverdoseHyperlipasaemiaParanoia AggravatedHeadache
Muscular WeaknessTrismusHypocalcaemiaImpulse-control DisorderDyspnoeaConstipation AggravatedAnaemia
Renal Failure AcutePneumoniaPulmonary OedemaHepatic CirrhosisMultiple Drug OverdoseMood SwingsVomiting

Drug effectiveness by gender :

Morphine Sulfate is effective33.33%
(7 of 21 people)
(4 of 10 people)
Tramadol is effective18.18%
(4 of 22 people)
(2 of 10 people)

Most common drug interactions by gender * :

AnxietyBack Pain
Back PainConfusional State
HeadacheAbdominal Pain

Drug effectiveness by age :

Morphine Sulfate is effectiven/an/a100.00%
(1 of 1 people)
(2 of 7 people)
(2 of 21 people)
(6 of 28 people)
(1 of 4 people)
(0 of 8 people)
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
(0 of 5 people)
(3 of 14 people)
(2 of 21 people)
(1 of 5 people)
(0 of 8 people)

Most common drug interactions by age * :

HyperaesthesiaSepsisAnal FistulaAnxietyHeadachePainNauseaDyspnoea
CryingBone PainAnal AbscessHeadacheNauseaAnxietyArthralgiaPain
Discomfort NosArthralgiaCholecystitis ChronicDyspnoeaDepressionNauseaAstheniaFall
Anxiety NecTumour Lysis SyndromeCystChillsChest PainHypoaesthesiaBone DisorderAnaemia
DistressRespiratory FailureNauseaPainDrug Withdrawal SyndromeDiarrhoeaAnaemiaFatigue
Drug Exposure During PregnancyPneumoniaPancreatitisPneumoniaSuicidal IdeationDepressionDiarrhoeaConfusional State
Sudden DeathRenal FailureSphincter Of Oddi DysfunctionDrug AbusePainVomitingOsteoarthritisAsthenia
SomnolenceAbdominal PainAmnesiaArthralgiaBack PainPain In ExtremityWeight Decreased
Abdominal PainVomitingVision BlurredAnxietyFatigueDyspnoeaConstipation
Depressed Level Of ConsciousnessPainMusculoskeletal StiffnessAbdominal PainAbdominal PainDepressionBack Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Morphine Sulfate and Tramadol
- group for people who take Morphine Sulfate
- group for people who take Tramadol

Comments from related studies:

  • From this study (8 months ago):

  • want to find out of all my pain is a condition as well as my promary condition of back surgery and back pain


  • From this study (1 year ago):

  • I always had low blood pressure but have now discovered it is high and am wondering if it is related to recent med changes or just to deterioration in underlying condition. The steroids are new. Morphine is old but recently increased to 120mg every 12hrs slow release. Furosemide and Cetirizine have been introduced since I last used to keep a check on BP results 3yrs ago. Not sure if it is suddenly high now or has been for a while but not picked up until now.


  • From this study (1 year ago):

  • would like to know how morphine helps bipolar


    shannon on Apr, 13, 2013:

    Not sure exact mech. of action, however, could be to raise "Feel Good" endorphines and possibly keep you more at a "near but not fully" manic point, so to speak. I know a few with depression treated with morphine for that increases the available dopamine between the nerve cells called the synapsis, in turn, giving a feeling of "well being". This effct is opposite in some people...such as seems to make them more apt
    to do stranger stuff and hallucinate. Im just a paramedic that researches stuff like this and no physician by a long shot...just picked it up after researching a patient I thought was lying to me about a depression treatment plan with narcotic medication....I had to find it out for myself and the above explanation is the guts of the study....hope it helps....I research alot of "cases" I transport to the hospital with good stories...


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Complete drug side effects:

On eHealthMe, Morphine Sulfate (morphine sulfate) is often used to treat pain. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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