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Review: Mucinex and Benadryl

This review analyzes the effectiveness and drug interactions between Mucinex and Benadryl. It is created by eHealthMe based on reports of 491 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Mucinex and Benadryl >>>

What are the drugs

Mucinex (what 5,822 Mucinex users reported?) has active ingredients of guaifenesin. It is used in cough.

Benadryl (what 29,327 Benadryl users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in allergies.

On Aug, 13, 2014: 491 people who take Mucinex, Benadryl are studied

Mucinex, Benadryl outcomes

Drug combinations in study:
- Mucinex (guaifenesin)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Mucinex is effective26.67%
(4 of 15 people)
(2 of 5 people)
(0 of 3 people)
(0 of 1 people)
(0 of 2 people)
Benadryl is effective25.00%
(3 of 12 people)
(1 of 2 people)
(1 of 1 people)
(2 of 5 people)
(1 of 4 people)
(1 of 1 people)
(1 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pleural EffusionDepressed MoodBlood Potassium IncreasedBlood Potassium IncreasedIleusn/an/aDyspnoea
Confusional StateDysarthriaBronchospasmAllergic ReactionsFebrile NeutropeniaNausea
Decubitus UlcerHomicideDiplopiaConstipationBack Pain
EpistaxisHypotensionMuscle CrampsAnxiety
Cardiorenal SyndromePostpartum DepressionBronchospasmPain
Atrial FibrillationMental DisorderType 2 Diabetes MellitusPyrexia
AnaemiaDiplopiaDiabetes Mellitus Inadequate ControlChest Pain
AstheniaMuscle CrampsDiabetic NephropathyOsteoarthritis
GangreneAggressionGlucose Tolerance ImpairedCough
CardiomegalyDisorientationHypoglycaemiaOedema Peripheral

Drug effectiveness by gender :

Mucinex is effective22.22%
(4 of 18 people)
(2 of 8 people)
Benadryl is effective36.84%
(7 of 19 people)
(3 of 8 people)

Most common drug interactions by gender * :

Back PainPneumonia
PainChest Pain
Oedema PeripheralAsthenia
CardiomegalyPain In Extremity

Drug effectiveness by age :

Mucinex is effectiven/a33.33%
(1 of 3 people)
(0 of 1 people)
(0 of 3 people)
(4 of 9 people)
(1 of 4 people)
(0 of 4 people)
(0 of 3 people)
Benadryl is effectiven/a0.00%
(0 of 3 people)
(1 of 3 people)
(0 of 2 people)
(5 of 10 people)
(3 of 4 people)
(0 of 4 people)
(1 of 3 people)

Most common drug interactions by age * :

InfectionDrug Screen PositiveInfectionNauseaDyspnoeaNauseaAnxietyDyspnoea
Respiratory DistressCardio-respiratory ArrestHepatomegalyUpper Respiratory Tract InfectionPneumoniaVomitingCoughBack Pain
Therapeutic Response DecreasedAdverse ReactionHepatitisInsomniaPyrexiaBack PainAtelectasisAsthenia
Transplant RejectionKawasaki's DiseaseCondition AggravatedChest PainDyspnoeaPainConstipation
HypertensionPenile SwellingUrinary Tract InfectionArthralgiaPyrexiaGastritisPleural Effusion
Hyperparathyroidism SecondaryViral RashBronchitisBlood Pressure IncreasedAnaemiaOsteoarthritisPneumonia
ConvulsionScarlet FeverCardiac Failure CongestiveDizzinessPainInjuryAnxiety
Cerebral InfarctionHepatic Enzyme IncreasedHeadacheOtorrhoeaUrinary Tract InfectionDiarrhoeaOsteoarthritis
EncephalomalaciaOropharyngeal PainInfluenza Like IllnessStaphylococcal InfectionAnxietyToothacheChest Pain
ThrombocytopeniaGianotti-crosti SyndromeCholecystitisHypoacusisDepressionTooth FractureNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group of people like you:
- group for people who take Mucinex and Benadryl
- group for people who take Benadryl
- group for people who take Mucinex

Comments from related studies:

  • From this study (7 months ago):

  • Starting having severe muscle cramps and fasciculations. Cramping to all muscles- even my neck and abdomen


  • From this study (2 years ago):

  • carmen on Nov, 16, 2012:

    I am 25yr. Old female I was prescribed a muscle relaxer 500mg, mucinex 600mg, ibuprofen 600mg,is it ok to take all meds at the same time or should I wait some time before taking the next med.


  • From this study (5 years ago):

  • Do any of these medications contain any form of mercury? My son can't excrete mercury well. Do any contain sulfa? He is allergic to sulfa.


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Benadryl, Mucinex

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  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Benadryl, Mucinex

Complete drug side effects:

On eHealthMe, Mucinex (guaifenesin) is often used to treat cough. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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