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Review: Naproxen and Oxycodone

This review analyzes the effectiveness and drug interactions between Naproxen and Oxycodone. It is created by eHealthMe based on reports of 1,167 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Naproxen (latest outcomes from 21,910 users) has active ingredients of naproxen. It is often used in pain.

Oxycodone (latest outcomes from 27,252 users) has active ingredients of oxycodone hydrochloride. It is often used in pain.

On Oct, 26, 2014: 1,167 people who take Naproxen, Oxycodone are studied

Naproxen, Oxycodone outcomes

Drug combinations in study:
- Naproxen (naproxen)
- Oxycodone (oxycodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Naproxen is effective50.00%
(1 of 2 people)
(1 of 4 people)
(2 of 3 people)
(1 of 1 people)
(0 of 2 people)
(0 of 2 people)
(0 of 1 people)
Oxycodone is effective80.00%
(4 of 5 people)
(2 of 4 people)
(2 of 3 people)
(1 of 1 people)
(0 of 1 people)
(0 of 2 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaHepatic Function AbnormalDrug Withdrawal SyndromeCholecystitis ChronicAnxietyChest PainPainPain
Hepatic Function AbnormalC-reactive Protein IncreasedConstipationGallbladder InjuryPainMalaiseDrug DependenceAnxiety
HeadacheNauseaDepressionAnxietyDepressionMuscle SpasmsAnxietyDepression
AnaemiaRenal ImpairmentNauseaPancreatitisDrug Withdrawal SyndromeNauseaBrain InjuryOsteonecrosis Of Jaw
HypoalbuminaemiaAnaemiaDysmenorrhoeaGeneral Physical Health DeteriorationDrug DependenceInsomniaSubstance AbuseNausea
Renal ImpairmentHypoalbuminaemiaAnxietyEmotional DistressNauseaHeadacheConfusional StateArthralgia
C-reactive Protein IncreasedMalignant Neoplasm ProgressionDrug DependenceInjuryDysmenorrhoeaDry MouthDizzinessInjury
FallPlatelet Count DecreasedFatiguePainFatigueDyspepsiaMemory ImpairmentFall
Vomiting NosTumour Lysis SyndromeFungal Infection NosAnhedoniaInjuryEmotional DistressMultiple Drug OverdoseBack Pain
Platelet Count DecreasedHepatic Neoplasm MalignantAbdominal DistensionConfusional StateConstipationHyperhidrosisGeneral Physical Health DeteriorationDyspnoea

Drug effectiveness by gender :

Naproxen is effective40.00%
(2 of 5 people)
(3 of 10 people)
Oxycodone is effective71.43%
(5 of 7 people)
(5 of 11 people)

Most common drug interactions by gender * :

FallOsteonecrosis Of Jaw
Osteonecrosis Of JawNausea
Back PainArthralgia
InjuryBack Pain

Drug effectiveness by age :

Naproxen is effectiven/an/an/an/a28.57%
(2 of 7 people)
(0 of 4 people)
(2 of 3 people)
(1 of 2 people)
Oxycodone is effectiven/an/an/a100.00%
(1 of 1 people)
(4 of 9 people)
(2 of 4 people)
(1 of 2 people)
(2 of 11 people)

Most common drug interactions by age * :

n/aRespiratory ArrestPulmonary EmbolismAnxietyPainPainPainPain
Accidental Drug Intake By ChildStatus MigrainosusPainDepressionAnxietyArthralgiaAnxiety
Cardiac ArrestDeep Vein ThrombosisDysmenorrhoeaAnxietyDepressionOsteonecrosis Of JawBone Disorder
Drug ToxicityPleural EffusionNauseaAccidental OverdoseDrug DependenceNauseaDyspnoea
DeathChest PainDrug Withdrawal SyndromeDrug Withdrawal SyndromeDrug Withdrawal SyndromeAnxietyOsteonecrosis Of Jaw
Unresponsive To StimuliNon-cardiac Chest PainOvarian CystNauseaChest PainOsteoarthritisFall
SomnolenceAbdominal PainWeight DecreasedBronchitisInjuryFallAsthenia
Drug AbuseCholelithiasisDrug DependenceArthralgiaHypoaesthesiaFatigueConfusional State
PoisoningGallbladder PainDyspepsiaAgitationArthralgiaDecreased AppetiteImpaired Healing
Gallbladder DisorderAbdominal Pain UpperDepressed Level Of ConsciousnessNauseaDiarrhoeaOsteomyelitis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Naproxen and Oxycodone?

Get connected! Join a related mobile support group:
- support group for people who take Naproxen and Oxycodone
- support group for people who take Naproxen
- support group for people who take Oxycodone

Comments from related studies:

  • From this study (2 years ago):

  • With such a mixture I experience many side effects - fatigue,disorientation, memory loss, constipation, nausea - the list goes on..... I am totally unsure which side effects are from which medication and which symptoms are caused by my medical condition and which are produced by drugs taken.


    noname on Jan, 15, 2013:

    My Mother was was taking prednisone for a couple years. She passed away from stomach cancer.


  • From this study (2 years ago):

  • Since an increase in back pain, vomitting has become common


  • From this study (2 years ago):

  • I used to have sex every day some times twice when possible ,after about 2yrs on the meds testosrone level is .025 (none)Starting about june 2005 I lost all body hair including pubic and facial hair,in about 3 mnts went from daily shaving to once a month ,was started on testosrone therapy presently using 20 mgs a day.Still sex drive is very low I realy don't care if I have it but partner wants to. I am presently waiting to have both knees replaced . I also have 5 herneated discs in back 3in the neck that are inoperatal 2 in lower back are bad ,I can have them fused but am waiting as long as i can . The ones in neck make my hands swell and get very hot as high as 105 fairenhite this extremly painfull and i frequently end up sleeping in a chair.Ican give more info if required thankyou mc


    Jim on May, 13, 2012:

    I have chronic pain and degenerative disc disease. I have undergone 8 back surgeries. I am now 52 years old. I always loved sex and it was important part of my marriage. I can tell you from experience, your lack of sexual desire is partly from the drugs but in large measure it is simply the result of being in horrible pain all the time. My best advice is to make sure your testosterone levels are at top of the normal range. Second and most importantly, I can have super high testosterone but without sleep, it is as if it doesn't metabolize into my system. You MUST figure out how to sleep well. DO NOT wake yourself in the morning simply because you feel guilty being in bed so late. If you have a job and have to be there early, I have no advice. I am self employed so I have moved my schedule around. I only get good sleep between 5 am and 10am. I have no idea why but this seems to be a trend with individuals like you and me. I have taken methadone for pain for 10yrs. Follow my advice and it should help.


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More reviews for: Naproxen, Oxycodone

Complete drug side effects:

On eHealthMe, Naproxen (naproxen) is often used to treat pain. Oxycodone (oxycodone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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