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Review: taking Naproxen and Bactrim together

Summary: drug interactions are reported among people who take Naproxen and Bactrim together.

This review analyzes the effectiveness and drug interactions between Naproxen and Bactrim. It is created by eHealthMe based on reports of 646 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 23, 2015: 646 people who take Naproxen Sodium, Bactrim are studied

Naproxen Sodium, Bactrim outcomes

Drug combinations in study:
- Naproxen Sodium (naproxen)
- Bactrim (sulfamethoxazole; trimethoprim)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Naproxen Sodium is effective0.00%
(0 of 2 people)
(1 of 1 people)
(1 of 2 people)
(1 of 1 people)
Bactrim is effective33.33%
(1 of 3 people)

Drug effectiveness by gender :

Naproxen Sodium is effective40.00%
(2 of 5 people)
(1 of 1 people)
Bactrim is effective33.33%
(1 of 3 people)

Drug effectiveness by age :

Naproxen Sodium is effectiven/an/a0.00%
(0 of 1 people)
(1 of 2 people)
(1 of 1 people)
(0 of 1 people)
(1 of 1 people)
Bactrim is effectiven/an/an/a100.00%
(1 of 1 people)
(0 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPruritusn/aEmotional DistressAnxietyAnxietyTachyarrhythmiaPain
PruritusInsomniaInjuryAgitationSuicide AttemptDyspepsiaAnxiety
InsomniaRespiratory FailurePainDepressionDepressionAcute Myocardial InfarctionInjury
RashDrug EruptionMyocardial InfarctionSuicidal IdeationAgitationArteriospasm CoronaryBack Pain
Renal Failure AcuteJaundiceDepressionBipolar DisorderAggressionWeight IncreasedArthralgia
Bone Marrow FailurePyrexiaThrombophlebitis SuperficialEmotional DistressPost-traumatic Stress DisorderMitral Valve IncompetenceDyspnoea
VomitingNauseaPathological GamblingInjuryIntentional OverdoseNeuralgiaNausea
NauseaInjuryAlcohol AbusePainHostilityTricuspid Valve IncompetenceEmotional Distress
White Blood Cell Count IncreasedDiarrhoeaObsessive-compulsive DisorderIrritabilityBorderline Personality DisorderSacroiliitisDepression
Mental Status ChangesEscherichia InfectionRespiratory DistressHostilityHallucination, AuditoryIntervertebral Disc DisplacementAnaemia

Most common drug interactions by gender * :

Back PainInjury
Urinary Tract InfectionDepression
ArthralgiaBack Pain
Emotional DistressRenal Failure Acute
DyspnoeaOsteonecrosis Of Jaw
NauseaEmotional Distress

Most common drug interactions by age * :

Neural Tube DefectPyrexiaAbdominal Pain UpperNauseaPalpitationsChest PainAnxietyPain
Spina BifidaInfusion Related ReactionCholelithiasisPainHyperhidrosisInjuryPainAnxiety
TalipesBone Marrow FailureVomitingVomitingCoughNauseaBack PainWeight Decreased
MeningomyeloceleUpper Respiratory Tract InfectionCholecystitisCholecystitis ChronicDyspnoeaWeight IncreasedArthralgiaAnhedonia
Maternal Drugs Affecting FoetusChillsNauseaAbdominal Pain UpperNauseaArthralgiaOsteonecrosis Of JawBone Disorder
Congenital Central Nervous System AnomalyPneumocystis Jiroveci PneumoniaDiarrhoeaPulmonary EmbolismDizzinessDyspepsiaInjuryInjury
Congenital HydrocephalusHistiocytosis HaematophagicPainCholelithiasisTremorPruritusEmotional DistressOsteonecrosis Of Jaw
Abortion InducedWhite Blood Cell Count IncreasedCholecystitis ChronicAbdominal PainMalaiseVomitingBone DisorderTooth Disorder
Cerebral HaemorrhageWeight DecreasedAnxietyCardiac Valve DiseaseMyalgiaAnaemiaBack Pain
Protein Urine PresentPain NosEmotional DistressDehydrationPainImpaired HealingSpinal Osteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Naproxen and Bactrim?




You are not alone! Join a related support group:
- support group for people who take Bactrim
- support group for people who take Naproxen Sodium

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Naproxen Sodium (naproxen) is often used to treat pain. Bactrim (sulfamethoxazole; trimethoprim) is often used to treat urinary tract infection. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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