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Review: taking Neurontin and Methadone together

Summary: drug interactions are reported among people who take Neurontin and Methadone together.

This review analyzes the effectiveness and drug interactions between Neurontin and Methadone. It is created by eHealthMe based on reports of 1,969 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Neurontin and Methadone >>>

On Apr, 17, 2015: 1,969 people who take Neurontin, Methadone Hydrochloride are studied

Neurontin, Methadone Hydrochloride outcomes

Drug combinations in study:
- Neurontin (gabapentin)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Neurontin is effective22.22%
(2 of 9 people)
(0 of 4 people)
(0 of 6 people)
(5 of 14 people)
(3 of 14 people)
(5 of 12 people)
(3 of 4 people)
Methadone Hydrochloride is effective30.00%
(3 of 10 people)
(6 of 10 people)
(0 of 3 people)
(5 of 7 people)
(5 of 12 people)
(7 of 11 people)
(4 of 7 people)
(0 of 1 people)

Drug effectiveness by gender :

Neurontin is effective29.73%
(11 of 37 people)
(7 of 26 people)
Methadone Hydrochloride is effective51.28%
(20 of 39 people)
(10 of 22 people)

Drug effectiveness by age :

Neurontin is effectiven/an/an/a18.18%
(2 of 11 people)
(7 of 40 people)
(4 of 36 people)
(1 of 44 people)
(4 of 14 people)
Methadone Hydrochloride is effectiven/an/an/a36.36%
(4 of 11 people)
(10 of 44 people)
(9 of 35 people)
(6 of 45 people)
(1 of 11 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Withdrawal SyndromeLoss Of ConsciousnessDepressionDepressionDrug IneffectiveDiarrhoeaWeaknessPain
OverdoseMusculoskeletal StiffnessInfluenza Like IllnessDysarthriaDiarrhoeaNeutropeniaBack PainAnxiety
DehydrationCompleted SuicidePain In ExtremityTooth AbscessOedema PeripheralDehydrationBone PainDyspnoea
FallNeoplasm MalignantGoutDental CariesPeriodontal DiseaseHypotensionAnxiety DisorderOsteonecrosis Of Jaw
DysarthriaDrug IneffectiveDrug IneffectiveAbnormal BehaviourJaw DisorderConfusional StateSleepiness - During The DayBack Pain
Electrocardiogram Qt ProlongedVision BlurredFallDrug DependenceHiatus HerniaPain In ExtremityInsomniaNausea
Pneumonia Respiratory Syncytial ViralRenal FailureBlood Creatinine IncreasedDrug IneffectiveHallucinationPlatelet Count DecreasedSleep Disorder Due To General Medical Condition, Insomnia TypeOedema Peripheral
HypotensionHaematuriaBlood Urea IncreasedOverdoseOsteomyelitisWhite Blood Cell Count DecreasedDepression AggravatedFatigue
Blood Bilirubin IncreasedUrinary Tract InfectionArrhythmia NosDrug AbuseCoordination AbnormalHaemoglobin DecreasedAnxietyArthralgia
PneumonitisOverdoseLethargyPartner StressWeight IncreasedHaematocrit DecreasedBipolar DisorderHypoaesthesia

Most common drug interactions by gender * :

NauseaBack Pain
Osteonecrosis Of JawAsthenia
Back PainHeadache
Oedema PeripheralPyrexia
HypoaesthesiaOedema Peripheral
Emotional DistressOsteonecrosis Of Jaw

Most common drug interactions by age * :

n/aRespiratory DistressHaematocrit DecreasedDeep Vein ThrombosisAnxietyPainPainPain
Febrile NeutropeniaHypotensionWeight DecreasedPainDyspnoeaAnxietyDyspnoea
White Blood Cell Count DecreasedPyrexiaHypokalaemiaOsteonecrosis Of JawFatigueArthralgiaBack Pain
NeuroblastomaCompleted SuicideOedema PeripheralNauseaAnxietyOsteonecrosis Of JawOsteonecrosis Of Jaw
Neoplasm ProgressionCardiac ArrestParaesthesiaBack PainOedema PeripheralEmotional DistressAnxiety
Rhabdomyosarcoma RecurrentRespiratory ArrestPainDyspnoeaDepressionPyrexiaImpaired Healing
Oxygen Saturation DecreasedFebrile NeutropeniaConstipationBone DisorderNauseaBack PainWeight Decreased
Pain In ExtremityHeadacheVomitingOedema PeripheralBack PainInjuryOsteoarthritis
Disease ProgressionHaemoglobin DecreasedPain In ExtremityFatigueVomitingNauseaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Neurontin and Methadone?




You are not alone! Join a related support group:
- support group for people who take Methadone Hydrochloride
- support group for people who take Neurontin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Neurontin (gabapentin) is often used to treat pain. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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