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Review: taking Methotrexate and Niacin together

Summary: drug interactions are reported among people who take Methotrexate and Niacin together. This review analyzes the effectiveness and drug interactions between Methotrexate and Niacin. It is created by eHealthMe based on reports of 320 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,279 Methotrexate users)

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. (latest outcomes from 6,319 Niacin users)

On May, 12, 2015: 320 people who take Methotrexate, Niacin are studied

Methotrexate, Niacin outcomes

Drug combinations in study:
- Methotrexate (methotrexate sodium)
- Niacin (niacin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Methotrexate is effectiven/a0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 1 people)
(1 of 1 people)
(2 of 2 people)
Niacin is effectiven/a0.00%
(0 of 1 people)
(1 of 2 people)
(0 of 2 people)

Drug effectiveness by gender :

Methotrexate is effective66.67%
(2 of 3 people)
(2 of 3 people)
Niacin is effective50.00%
(1 of 2 people)
(0 of 3 people)

Drug effectiveness by age :

Methotrexate is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
(2 of 5 people)
(2 of 2 people)
Niacin is effectiven/an/an/an/an/an/a0.00%
(0 of 5 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FlushingFlushingSinusitisPruritusPruritus GeneralisedRetinal Artery Occlusionn/aFlushing
VomitingBurning SensationPyrexiaFlushingRashCerebral Artery EmbolismFall
PruritusPruritusSinus CongestionRheumatoid ArthritisOsteolysisAtrial Septal DefectPruritus
RetchingImpatienceNasopharyngitisErythemaHepatitisDizziness PosturalDizziness
Burning SensationPain Of SkinNasal CongestionBreast CancerHeadacheAnaemiaNausea
Abdominal PainIrritabilityHeadacheRashErectile DysfunctionDuodenal UlcerDiarrhoea
Muscle SpasmsRashSyncopeTachycardiaDyspnoea
StomatitisDiarrhoeaMalaiseIntestinal UlcerMyalgia
Skin Burning SensationFearInsomniaHaemodynamic InstabilityVomiting
NauseaAstheniaC-reactive Protein IncreasedMalaiseDrug Ineffective

Most common drug interactions by gender * :

FallDrug Ineffective
Back PainPruritus
DiarrhoeaPain In Extremity
HeadacheFeeling Hot
Road Traffic AccidentInjection Site Haematoma
MyalgiaBlood Glucose Increased

Most common drug interactions by age * :

n/an/an/an/aVomitingInjection Site PainFlushingFlushing
DiarrhoeaFeeling HotDrug IneffectivePain
DizzinessInjection Site HaemorrhagePruritusDrug Ineffective
MenopauseAbdominal PainPain In ExtremityPruritus
Meniscus LesionStomatitisPulmonary TuberculosisFall
Mechanical UrticariaRetchingDry SkinBack Pain
BursitisVomitingDizzinessOedema Peripheral
Breast PainMuscle SpasmsChest PainCellulitis
Morton's NeuromaInjection Site HaematomaB-cell LymphomaRash
MononeuropathyErythemaStomatitisTooth Extraction

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Methotrexate and Niacin on

Do you take Methotrexate and Niacin?


You are not alone! Join a related support group:
- support group for people who take Methotrexate
- support group for people who take Niacin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Methotrexate, Niacin

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Complete drug side effects:

On eHealthMe, Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Niacin (niacin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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