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Review: Nortriptyline and Pregabalin

This review analyzes the effectiveness and drug interactions between Nortriptyline and Pregabalin. It is created by eHealthMe based on reports of 509 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Nortriptyline and Pregabalin >>>

What are the drugs

Nortriptyline hydrochloride (latest outcomes from 1,474 users) has active ingredients of nortriptyline hydrochloride. It is often used in depression.

Pregabalin (latest outcomes from 4,464 users) has active ingredients of pregabalin. It is often used in fibromyalgia.

On Oct, 13, 2014: 509 people who take Nortriptyline Hydrochloride, Pregabalin are studied

Nortriptyline Hydrochloride, Pregabalin outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Pregabalin (pregabalin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 3 people)
(0 of 4 people)
(1 of 5 people)
(0 of 5 people)
(2 of 3 people)
(1 of 1 people)
(3 of 5 people)
Pregabalin is effective0.00%
(0 of 3 people)
(3 of 5 people)
(1 of 5 people)
(1 of 2 people)
(4 of 8 people)
(0 of 2 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Oedema PeripheralPainCerebral InfarctionVision BlurredDiabetes MellitusWeight Above NormalLoss Of LibidoPain
PainWeight IncreasedPain In ExtremityInsomniaPancreatitisPeripheral NeuropathyAbdominal Pain AggravatedNausea
Feeling AbnormalOedema PeripheralPainDrug IneffectiveWithdrawal SyndromeMigraine With AuraPain In Extremity
NauseaNauseaIntestinal ObstructionChest PainConstipation AggravatedCataractArthralgia
Memory ImpairmentVomitingWeight IncreasedPainDry Eyes AggravatedConstipationFatigue
InsomniaDepressionCerebral AtrophyWeight IncreasedChest PainWeight IncreasedOsteoarthritis
DizzinessLiver Function Test AbnormalAbdominal Pain UpperHyperhidrosisDrug Withdrawal SyndromeShortness Of BreathPain In Jaw
RashAbdominal DistensionBlood Pressure IncreasedFeeling AbnormalDry MouthPeripheral NeuropathyAnxiety
DisorientationBalance DisorderDizzinessBalance DisorderJoint SwellingChest PainWeight Increased
SomnolenceSyncopeFace OedemaPruritusUrinary RetentionPain - MusclesDepression

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective33.33%
(5 of 15 people)
(2 of 10 people)
Pregabalin is effective31.25%
(5 of 16 people)
(4 of 10 people)

Most common drug interactions by gender * :

Pain In ExtremityAnxiety
Weight IncreasedDepression
Drug IneffectiveNeuropathy Peripheral
ParaesthesiaDecreased Appetite
FallEmotional Distress

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 4 people)
(0 of 4 people)
(2 of 15 people)
(4 of 29 people)
(1 of 10 people)
Pregabalin is effectiven/an/an/a50.00%
(2 of 4 people)
(0 of 4 people)
(3 of 15 people)
(4 of 29 people)
(1 of 10 people)

Most common drug interactions by age * :

n/an/aBlisterMultiple SclerosisWeight IncreasedOedema PeripheralPainPain
Mood AlteredSkin Burning SensationHiatus HerniaFatigueNauseaNausea
MalaisePain Of SkinIleusVision BlurredPain In JawOsteoarthritis
Suicidal IdeationGastritisFallParaesthesiaDyspnoea
HypoglycaemiaInflammatory Bowel DiseaseAmnesiaArthralgiaBack Pain
Sleep DisorderGastrooesophageal Reflux DiseaseImmune Reconstitution SyndromeDrug IneffectivePain In Jaw
TremorIntestinal ObstructionConfusional StateWeight IncreasedDecreased Interest
InsomniaPainProgressive Multifocal LeukoencephalopathyPneumoniaOral Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nortriptyline and Pregabalin?

Get connected! Join a related mobile support group:
- support group for people who take Nortriptyline and Pregabalin
- support group for people who take Nortriptyline Hydrochloride
- support group for people who take Pregabalin

Comments from related studies:

  • From this study (13 months ago):

  • I have quit taking cymbalta, lyrica and nortriptyline over the last 10 weeks and the hives are not nearly as severe as they were. I have removed and reintroduced different food items from my diet without any changes to my condition.
    It is not the laundry detergent or soaps. I have 2 cats but I keep both the cats brushed and the place clean so I know it's not them.
    The only thing left that would indicate this may be an allergy is the substitution of the percocet to another pain medication.
    Do you think this is an allergy or is it a condition?


  • From this study (2 years ago):

  • This is my 3rd year for the Reclast IV. The first year I had no side effects. The second, I had flu-like symptoms for a few days. This year, I began to experience severe musculoskeletal pain the day after I received the infusion. I have migratory pain that affects my ability to walk and perform daily activities. All lab tests came back negative and my doctor concluded that I had an adverse reaction to the Reclast. He says it should have been out of my system within a few weeks, but it has now been 3 months. Is there any hard data on long-term side effects for Reclast beyond anecdotal reports? My doctor has diagnosed me with myoligamentous pain, but Lyrica has limited effectiveness. I am not sure where to go from here. My life has changed dramatically and I have had to give up almost all of my normal activities.


  • From this study (2 years ago):

  • Right hand and foot are painfully cold, not only in terms of sensation but also actual skin temperature.


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Nortriptyline Hydrochloride, Pregabalin

You may be interested at these reviews (what is this?):

  • Nightmare on lyrica st.
    r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyri ...

  • Lyrica varied widely
    I was prescribed Lyrica for treatment of chronic pain. It was ineffective, but it knocked out the symptoms of interstitial. However, it also caused rapid weight gain (I went from 110 to 130 lbs. in just a few weeks) and my ankles started to swell. The pain doctor advised me to discontinue the dru ...

  • Lyrica photosensitivity
    Spent several hours outside in partly sunny conditions on Sat. Swelling started a little on Sun. But by Monday my face was ver swollen and red with small bumps most noticeable across the cheeks, nose and area of the forehead where bangs did not cover. I have only been using for (6) months. Un ...

More reviews for: Nortriptyline Hydrochloride, Pregabalin

Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat depression. Pregabalin (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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