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Review: Nortriptyline and Pregabalin

This review analyzes the effectiveness and drug interactions between Nortriptyline and Pregabalin. It is created by eHealthMe based on reports of 509 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Nortriptyline and Pregabalin >>>

What are the drugs

Nortriptyline hydrochloride (latest outcomes from 1,468 users) has active ingredients of nortriptyline hydrochloride. It is often used in migraine.

Pregabalin (latest outcomes from 4,453 users) has active ingredients of pregabalin. It is often used in fibromyalgia.

On Jul, 12, 2014: 509 people who take Nortriptyline Hydrochloride, Pregabalin are studied

Nortriptyline Hydrochloride, Pregabalin outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Pregabalin (pregabalin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 3 people)
(0 of 4 people)
(1 of 5 people)
(0 of 5 people)
(2 of 3 people)
(1 of 1 people)
(3 of 5 people)
Pregabalin is effective0.00%
(0 of 3 people)
(3 of 5 people)
(1 of 5 people)
(1 of 2 people)
(4 of 8 people)
(0 of 2 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Oedema PeripheralPainCerebral InfarctionVision BlurredDiabetes MellitusWeight Above NormalLoss Of LibidoPain
PainWeight IncreasedPain In ExtremityInsomniaPancreatitisPeripheral NeuropathyAbdominal Pain AggravatedNausea
Feeling AbnormalOedema PeripheralPainDrug IneffectiveWithdrawal SyndromeMigraine With AuraPain In Extremity
NauseaNauseaIntestinal ObstructionChest PainConstipation AggravatedCataractArthralgia
Memory ImpairmentVomitingWeight IncreasedPainDry Eyes AggravatedConstipationFatigue
InsomniaDepressionCerebral AtrophyWeight IncreasedChest PainWeight IncreasedOsteoarthritis
DizzinessLiver Function Test AbnormalAbdominal Pain UpperHyperhidrosisDrug Withdrawal SyndromeShortness Of BreathPain In Jaw
RashAbdominal DistensionBlood Pressure IncreasedFeeling AbnormalDry MouthPeripheral NeuropathyAnxiety
DisorientationBalance DisorderDizzinessBalance DisorderJoint SwellingChest PainWeight Increased
SomnolenceSyncopeFace OedemaPruritusUrinary RetentionPain - MusclesDepression

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective33.33%
(5 of 15 people)
(2 of 10 people)
Pregabalin is effective31.25%
(5 of 16 people)
(4 of 10 people)

Most common drug interactions by gender * :

Pain In ExtremityAnxiety
Weight IncreasedDepression
Drug IneffectiveNeuropathy Peripheral
ParaesthesiaDecreased Appetite
FallEmotional Distress

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 4 people)
(0 of 4 people)
(2 of 15 people)
(4 of 29 people)
(1 of 10 people)
Pregabalin is effectiven/an/an/a50.00%
(2 of 4 people)
(0 of 4 people)
(3 of 15 people)
(4 of 29 people)
(1 of 10 people)

Most common drug interactions by age * :

n/an/aBlisterMultiple SclerosisWeight IncreasedOedema PeripheralPainPain
Mood AlteredSkin Burning SensationHiatus HerniaFatigueNauseaNausea
MalaisePain Of SkinIleusVision BlurredPain In JawOsteoarthritis
Suicidal IdeationGastritisFallParaesthesiaDyspnoea
HypoglycaemiaInflammatory Bowel DiseaseAmnesiaArthralgiaBack Pain
Sleep DisorderGastrooesophageal Reflux DiseaseImmune Reconstitution SyndromeDrug IneffectivePain In Jaw
TremorIntestinal ObstructionConfusional StateWeight IncreasedDecreased Interest
InsomniaPainProgressive Multifocal LeukoencephalopathyPneumoniaOral Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Nortriptyline and Pregabalin
- group for people who take Nortriptyline Hydrochloride
- group for people who take Pregabalin

Comments from related studies:

  • From this study (9 months ago):

  • I have quit taking cymbalta, lyrica and nortriptyline over the last 10 weeks and the hives are not nearly as severe as they were. I have removed and reintroduced different food items from my diet without any changes to my condition.
    It is not the laundry detergent or soaps. I have 2 cats but I keep both the cats brushed and the place clean so I know it's not them.
    The only thing left that would indicate this may be an allergy is the substitution of the percocet to another pain medication.
    Do you think this is an allergy or is it a condition?


  • From this study (1 year ago):

  • This is my 3rd year for the Reclast IV. The first year I had no side effects. The second, I had flu-like symptoms for a few days. This year, I began to experience severe musculoskeletal pain the day after I received the infusion. I have migratory pain that affects my ability to walk and perform daily activities. All lab tests came back negative and my doctor concluded that I had an adverse reaction to the Reclast. He says it should have been out of my system within a few weeks, but it has now been 3 months. Is there any hard data on long-term side effects for Reclast beyond anecdotal reports? My doctor has diagnosed me with myoligamentous pain, but Lyrica has limited effectiveness. I am not sure where to go from here. My life has changed dramatically and I have had to give up almost all of my normal activities.


  • From this study (2 years ago):

  • Right hand and foot are painfully cold, not only in terms of sensation but also actual skin temperature.


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • Can droopy eyelid be caused by a bump and/or pregabalin?
    Had a bad bump on my forehead a couple of weeks ago and my whole face went black. Mostly better now but Im let with a badly drooping eyelid (right) which the doctors tell me will go away. No sign of that at the moment but Ive read that pregabalin (which I take in small doses, can cause this. It ...

  • Is anyone else with ms having problems getting off of lyrica?
    I am on 1.5 mg clonazepam and I take Betaseron injectables for my MS. I take 50 mg of Ellaville and one Prilosec that's it. I was on Lyrica for about three months and am having a horrible time trying to come down off of it. I would really like to know if anyone has tried the Lyrica oral suspension. ...

  • Can a person with hear problems that took lyrica have sudden death
    my husband took lyrica in dec 2007 swelled up the md prescribed more and he died suddenly on March 17 2008 i wrote to pfziers legal department for answers as they directed me and i never heard from them.

More questions for: Nortriptyline Hydrochloride, Pregabalin

You may be interested at these reviews (what is this?):

  • Review: could lyrica cause intracranial pressure increased?
    One dose (75mg) caused severe head pain (increased intracranial pressure) and nausea.

  • Lyrica caused my kidneys to shut down
    I was on Lyrica for 6 weeks and it almost killed me. I was so weak at the end that my daughter had to help me get out of bed go to the bathroom. I gained 22 lbs in 10 days. I gained over 40 lbs in 6 weeks. My ankles and feet were so swollen that the skin was starting to break open. I was in and out ...

  • Sleepwalking while on lyrica
    I have never had issues with sleepwalking until taking Lyrica. I have had some terrifying experiences like walking up in a hotel lobby in my short nightie. After several episodes, I stopped taking lyrica and stopped sleepwalking. Recently my doctor put me back on this drug and the first night I took ...

More reviews for: Nortriptyline Hydrochloride, Pregabalin

Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat depression. Pregabalin (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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