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Review: taking Nortriptyline and Pregabalin together

Summary: drug interactions are reported among people who take Nortriptyline and Pregabalin together. This review analyzes the effectiveness and drug interactions between Nortriptyline and Pregabalin. It is created by eHealthMe based on reports of 510 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in depression. (latest outcomes from 1,515 Nortriptyline hydrochloride users)

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from 4,493 Pregabalin users)

On May, 14, 2015: 510 people who take Nortriptyline Hydrochloride, Pregabalin are studied

Nortriptyline Hydrochloride, Pregabalin outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Pregabalin (pregabalin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 3 people)
(0 of 4 people)
(1 of 5 people)
(0 of 5 people)
(2 of 4 people)
(1 of 1 people)
(3 of 5 people)
Pregabalin is effective0.00%
(0 of 3 people)
(3 of 5 people)
(1 of 5 people)
(1 of 2 people)
(4 of 9 people)
(0 of 2 people)
(1 of 1 people)

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective31.25%
(5 of 16 people)
(2 of 10 people)
Pregabalin is effective29.41%
(5 of 17 people)
(4 of 10 people)

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a0.00%
(0 of 4 people)
(0 of 4 people)
(2 of 16 people)
(4 of 29 people)
(1 of 10 people)
Pregabalin is effectiven/an/an/a50.00%
(2 of 4 people)
(0 of 4 people)
(3 of 16 people)
(4 of 29 people)
(1 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Oedema PeripheralPainCerebral InfarctionVision BlurredDiabetes MellitusWeight Above NormalLoss Of LibidoPain
PainWeight IncreasedPain In ExtremityInsomniaPancreatitisPeripheral NeuropathyAbdominal Pain AggravatedNausea
Feeling AbnormalOedema PeripheralPainDrug IneffectiveWithdrawal SyndromeMigraine With AuraPain In Extremity
NauseaNauseaIntestinal ObstructionChest PainConstipation AggravatedCataractArthralgia
Memory ImpairmentVomitingWeight IncreasedPainDry Eyes AggravatedConstipationFatigue
InsomniaDepressionCerebral AtrophyWeight IncreasedChest PainWeight IncreasedOsteoarthritis
DizzinessLiver Function Test AbnormalAbdominal Pain UpperHyperhidrosisDrug Withdrawal SyndromeShortness Of BreathPain In Jaw
RashAbdominal DistensionBlood Pressure IncreasedFeeling AbnormalDry MouthPeripheral NeuropathyAnxiety
DisorientationBalance DisorderDizzinessBalance DisorderJoint SwellingChest PainWeight Increased
SomnolenceSyncopeFace OedemaPruritusUrinary RetentionPain - MusclesDepression

Most common drug interactions by gender * :

Pain In ExtremityAnxiety
Weight IncreasedDepression
Drug IneffectiveNeuropathy Peripheral
ParaesthesiaDecreased Appetite
FallEmotional Distress

Most common drug interactions by age * :

n/an/aBlisterMultiple SclerosisWeight IncreasedOedema PeripheralPainPain
Mood AlteredSkin Burning SensationHiatus HerniaFatigueNauseaNausea
MalaisePain Of SkinIleusPainPain In JawOsteoarthritis
CryingFatigueHaematocheziaVision BlurredHeadacheAnxiety
Suicidal IdeationGastritisFallParaesthesiaDyspnoea
HypoglycaemiaInflammatory Bowel DiseaseAmnesiaArthralgiaBack Pain
Sleep DisorderGastrooesophageal Reflux DiseaseImmune Reconstitution SyndromeDrug IneffectivePain In Jaw
TremorIntestinal ObstructionConfusional StateWeight IncreasedDecreased Interest
InsomniaPainProgressive Multifocal LeukoencephalopathyPneumoniaOral Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Nortriptyline and Pregabalin on

Do you take Nortriptyline and Pregabalin?


You are not alone! Join a related support group:
- support group for people who take Nortriptyline Hydrochloride
- support group for people who take Pregabalin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

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More questions for: Nortriptyline Hydrochloride, Pregabalin

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Comments from related studies:

  • From this study (2 years ago):

  • I have quit taking cymbalta, lyrica and nortriptyline over the last 10 weeks and the hives are not nearly as severe as they were. I have removed and reintroduced different food items from my diet without any changes to my condition.
    It is not the laundry detergent or soaps. I have 2 cats but I keep both the cats brushed and the place clean so I know it's not them.
    The only thing left that would indicate this may be an allergy is the substitution of the percocet to another pain medication.
    Do you think this is an allergy or is it a condition?


  • From this study (2 years ago):

  • This is my 3rd year for the Reclast IV. The first year I had no side effects. The second, I had flu-like symptoms for a few days. This year, I began to experience severe musculoskeletal pain the day after I received the infusion. I have migratory pain that affects my ability to walk and perform daily activities. All lab tests came back negative and my doctor concluded that I had an adverse reaction to the Reclast. He says it should have been out of my system within a few weeks, but it has now been 3 months. Is there any hard data on long-term side effects for Reclast beyond anecdotal reports? My doctor has diagnosed me with myoligamentous pain, but Lyrica has limited effectiveness. I am not sure where to go from here. My life has changed dramatically and I have had to give up almost all of my normal activities.


  • From this study (2 years ago):

  • Right hand and foot are painfully cold, not only in terms of sensation but also actual skin temperature.


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Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat migraine. Pregabalin (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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