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Review: taking Nortriptyline and Zyban together

Summary: drug interactions are reported among people who take Nortriptyline and Zyban together.

This review analyzes the effectiveness and drug interactions between Nortriptyline and Zyban. It is created by eHealthMe based on reports of 518 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Nortriptyline and Zyban >>>

What are the drugs

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in depression. (latest outcomes from 1,508 Nortriptyline hydrochloride users)

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. (latest outcomes from 7,089 Zyban users)

On Feb, 1, 2015: 518 people who take Nortriptyline Hydrochloride, Zyban are studied

Nortriptyline Hydrochloride, Zyban outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Zyban (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 4 people)
(0 of 2 people)
(2 of 7 people)
(1 of 5 people)
(1 of 5 people)
(3 of 5 people)
(2 of 4 people)
(1 of 1 people)
Zyban is effective0.00%
(0 of 2 people)
(1 of 4 people)
(0 of 5 people)
(2 of 9 people)
(3 of 9 people)
(3 of 5 people)
(2 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationDrug IneffectiveSuicidal IdeationSuicidal IdeationAbdominal PainSuicide AttemptTinnitusPain
DysarthriaDrug Withdrawal SyndromeRash ErythematousNeuropathy PeripheralCholelithiasisDepressionNauseaAnxiety
Emotional DistressTherapeutic Response DecreasedNeuropathy PeripheralType 2 Diabetes MellitusCholecystitis ChronicIntentional OverdoseVertigoDepression
InsomniaGrand Mal ConvulsionHyperglycaemiaDiabetes MellitusAnxietyAnxietyHypoaesthesia
Cerebral IschaemiaMultiple SclerosisDiabetes MellitusHerniaInjuryAngerArthralgia
Electrocardiogram Qrs Complex ProlongedSubstance AbuseHerniaHyperglycaemiaEmotional DistressAmnesiaWeight Increased
Electrocardiogram T Wave PeakedDrug DependenceSkin UlcerFatigueNauseaAggressionParaesthesia
Electroencephalogram AbnormalConstipationType 2 Diabetes MellitusLiver DisorderVertigoAbnormal BehaviourBack Pain
Family StressGenital DischargeImpaired HealingInguinal HerniaType 2 Diabetes MellitusGrand Mal ConvulsionDiarrhoea
AnorexiaTirednessScarMemory LossDiabetes MellitusMiscarriageSpinal Osteoarthritis

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective32.00%
(8 of 25 people)
(2 of 8 people)
Zyban is effective29.63%
(8 of 27 people)
(3 of 10 people)

Most common drug interactions by gender * :

Weight IncreasedInsomnia
HypoaesthesiaType 2 Diabetes Mellitus
Back PainFatigue
Spinal OsteoarthritisPain In Extremity
OsteomyelitisSuicidal Ideation

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a33.33%
(2 of 6 people)
(1 of 7 people)
(2 of 11 people)
(3 of 6 people)
(2 of 8 people)
Zyban is effectiven/an/an/a28.57%
(2 of 7 people)
(0 of 9 people)
(3 of 11 people)
(3 of 7 people)
(3 of 8 people)

Most common drug interactions by age * :

Type 2 Diabetes MellitusSudden DeathAgitationAnxietyDepressionDepressionPainOedema Peripheral
Suicide AttemptSomnolenceEmotional DistressBack PainAnxietyAnxietyDrug Ineffective
Hepatitis CDisturbance In AttentionHypoaesthesiaParaesthesiaPainDiarrhoeaDyspnoea
HaematocheziaFatigueWeight IncreasedPyrexiaType 2 Diabetes MellitusParaesthesiaThrombosis
FallInfluenzaConstipationWeight IncreasedFatigueHypoaesthesiaNeuropathy Peripheral
DeafnessFatigueFatigueChest PainArthralgiaHypoaesthesia
Memory ImpairmentFallPain In JawNauseaNeuropathy PeripheralArthritis
Muscle SpasmsMuscle SpasmsHypoaesthesiaAstheniaGeneral Physical Health DeteriorationCoronary Artery Disease
Drug IneffectiveSedationPainBlood Cholesterol IncreasedLymphadenopathyArthralgia
Rectal HaemorrhageDrug DependenceAnxietyWeight IncreasedErythemaBone Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nortriptyline and Zyban?

You are not alone! Join a related mobile support group:
- support group for people who take Nortriptyline and Zyban
- support group for people who take Nortriptyline Hydrochloride
- support group for people who take Zyban

Can you answer these questions (Ask a question):

More questions for: Nortriptyline Hydrochloride, Zyban

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    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.

More reviews for: Nortriptyline Hydrochloride, Zyban

Comments from related studies:

  • From this study (2 years ago):

  • have been having a high resting heart rate (over 100) and with just small amounts of physical activity it jumps high. I spent 10 minutes on the treadmill and it climbed to 180. I am 54 years old and just slightly overweight around the middle. I feel tired and weak when this happens but anxious. I can feel the pulse in my neck jumping. I've had a cardiac stress test and ultrasound and there is nothing wrong with my heart. I think it may be be one of the medications I'm on. Synthroid is most recent. Could it be that?


  • From this study (5 years ago):

  • Every year in January I try and get off each of the medications, one at a time and the symptoms come back and I have to start taking them again.


Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat depression. Zyban (bupropion hydrochloride) is often used to treat quit smoking. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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