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Review: taking Nortriptyline and Zyban together

Summary: drug interactions are reported among people who take Nortriptyline and Zyban together.

This review analyzes the effectiveness and drug interactions between Nortriptyline and Zyban. It is created by eHealthMe based on reports of 518 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 11, 2015: 518 people who take Nortriptyline Hydrochloride, Zyban are studied

Nortriptyline Hydrochloride, Zyban outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Zyban (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 4 people)
(0 of 2 people)
(2 of 7 people)
(1 of 5 people)
(1 of 5 people)
(3 of 5 people)
(2 of 4 people)
(1 of 1 people)
Zyban is effective0.00%
(0 of 2 people)
(1 of 4 people)
(0 of 5 people)
(2 of 9 people)
(3 of 9 people)
(3 of 5 people)
(2 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective32.00%
(8 of 25 people)
(2 of 8 people)
Zyban is effective29.63%
(8 of 27 people)
(3 of 10 people)

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a33.33%
(2 of 6 people)
(1 of 7 people)
(2 of 11 people)
(3 of 6 people)
(2 of 8 people)
Zyban is effectiven/an/an/a28.57%
(2 of 7 people)
(0 of 9 people)
(3 of 11 people)
(3 of 7 people)
(3 of 8 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationDrug IneffectiveSuicidal IdeationSuicidal IdeationAbdominal PainSuicide AttemptTinnitusPain
DysarthriaDrug Withdrawal SyndromeRash ErythematousNeuropathy PeripheralCholelithiasisDepressionNauseaAnxiety
Emotional DistressTherapeutic Response DecreasedNeuropathy PeripheralType 2 Diabetes MellitusCholecystitis ChronicIntentional OverdoseVertigoDepression
InsomniaGrand Mal ConvulsionHyperglycaemiaDiabetes MellitusAnxietyAnxietyHypoaesthesia
Cerebral IschaemiaMultiple SclerosisDiabetes MellitusHerniaInjuryAngerArthralgia
Electrocardiogram Qrs Complex ProlongedSubstance AbuseHerniaHyperglycaemiaEmotional DistressAmnesiaWeight Increased
Electrocardiogram T Wave PeakedDrug DependenceSkin UlcerFatigueNauseaAggressionParaesthesia
Electroencephalogram AbnormalConstipationType 2 Diabetes MellitusLiver DisorderVertigoAbnormal BehaviourBack Pain
Family StressGenital DischargeImpaired HealingInguinal HerniaType 2 Diabetes MellitusGrand Mal ConvulsionDiarrhoea
AnorexiaTirednessScarMemory LossDiabetes MellitusMiscarriageSpinal Osteoarthritis

Most common drug interactions by gender * :

Weight IncreasedInsomnia
HypoaesthesiaType 2 Diabetes Mellitus
Back PainFatigue
Spinal OsteoarthritisPain In Extremity
OsteomyelitisSuicidal Ideation

Most common drug interactions by age * :

Type 2 Diabetes MellitusSudden DeathAgitationAnxietyDepressionDepressionPainOedema Peripheral
Suicide AttemptSomnolenceEmotional DistressBack PainAnxietyAnxietyDrug Ineffective
Hepatitis CDisturbance In AttentionHypoaesthesiaParaesthesiaPainDiarrhoeaDyspnoea
HaematocheziaFatigueWeight IncreasedPyrexiaType 2 Diabetes MellitusParaesthesiaThrombosis
FallInfluenzaConstipationWeight IncreasedFatigueHypoaesthesiaNeuropathy Peripheral
DeafnessFatigueFatigueChest PainArthralgiaHypoaesthesia
Memory ImpairmentFallPain In JawNauseaNeuropathy PeripheralArthritis
Muscle SpasmsMuscle SpasmsHypoaesthesiaAstheniaGeneral Physical Health DeteriorationCoronary Artery Disease
Drug IneffectiveSedationPainBlood Cholesterol IncreasedLymphadenopathyArthralgia
Rectal HaemorrhageDrug DependenceAnxietyWeight IncreasedErythemaBone Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Nortriptyline Hydrochloride
- support group for people who take Zyban

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat depression. Zyban (bupropion hydrochloride) is often used to treat quit smoking. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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