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Review: Nortriptyline and Zyban

This review analyzes the effectiveness and drug interactions between Nortriptyline and Zyban. It is created by eHealthMe based on reports of 518 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Nortriptyline and Zyban >>>

What are the drugs

Nortriptyline hydrochloride (latest outcomes from 1,474 users) has active ingredients of nortriptyline hydrochloride. It is often used in depression.

Zyban (latest outcomes from 7,087 users) has active ingredients of bupropion hydrochloride. It is often used in quit smoking.

On Aug, 25, 2014: 518 people who take Nortriptyline Hydrochloride, Zyban are studied

Nortriptyline Hydrochloride, Zyban outcomes

Drug combinations in study:
- Nortriptyline Hydrochloride (nortriptyline hydrochloride)
- Zyban (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nortriptyline Hydrochloride is effective0.00%
(0 of 4 people)
(0 of 2 people)
(2 of 7 people)
(1 of 5 people)
(1 of 5 people)
(3 of 5 people)
(2 of 4 people)
(1 of 1 people)
Zyban is effective0.00%
(0 of 2 people)
(1 of 4 people)
(0 of 5 people)
(2 of 9 people)
(3 of 9 people)
(3 of 5 people)
(2 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationDrug IneffectiveSuicidal IdeationSuicidal IdeationAbdominal PainSuicide AttemptTinnitusPain
DysarthriaDrug Withdrawal SyndromeRash ErythematousNeuropathy PeripheralCholelithiasisDepressionNauseaAnxiety
Emotional DistressTherapeutic Response DecreasedNeuropathy PeripheralType 2 Diabetes MellitusCholecystitis ChronicIntentional OverdoseVertigoDepression
InsomniaGrand Mal ConvulsionHyperglycaemiaDiabetes MellitusAnxietyAnxietyHypoaesthesia
Cerebral IschaemiaMultiple SclerosisDiabetes MellitusHerniaInjuryAngerArthralgia
Electrocardiogram Qrs Complex ProlongedSubstance AbuseHerniaHyperglycaemiaEmotional DistressAmnesiaWeight Increased
Electrocardiogram T Wave PeakedDrug DependenceSkin UlcerFatigueNauseaAggressionParaesthesia
Electroencephalogram AbnormalConstipationType 2 Diabetes MellitusLiver DisorderVertigoAbnormal BehaviourBack Pain
Family StressGenital DischargeImpaired HealingInguinal HerniaType 2 Diabetes MellitusGrand Mal ConvulsionDiarrhoea
AnorexiaTirednessScarMemory LossDiabetes MellitusMiscarriageSpinal Osteoarthritis

Drug effectiveness by gender :

Nortriptyline Hydrochloride is effective32.00%
(8 of 25 people)
(2 of 8 people)
Zyban is effective29.63%
(8 of 27 people)
(3 of 10 people)

Most common drug interactions by gender * :

Weight IncreasedInsomnia
HypoaesthesiaType 2 Diabetes Mellitus
Back PainFatigue
Spinal OsteoarthritisPain In Extremity
OsteomyelitisSuicidal Ideation

Drug effectiveness by age :

Nortriptyline Hydrochloride is effectiven/an/an/a33.33%
(2 of 6 people)
(1 of 7 people)
(2 of 11 people)
(3 of 6 people)
(2 of 8 people)
Zyban is effectiven/an/an/a28.57%
(2 of 7 people)
(0 of 9 people)
(3 of 11 people)
(3 of 7 people)
(3 of 8 people)

Most common drug interactions by age * :

Type 2 Diabetes MellitusSudden DeathAgitationAnxietyDepressionDepressionPainOedema Peripheral
Suicide AttemptSomnolenceEmotional DistressBack PainAnxietyAnxietyDrug Ineffective
Hepatitis CDisturbance In AttentionHypoaesthesiaParaesthesiaPainDiarrhoeaDyspnoea
HaematocheziaFatigueWeight IncreasedPyrexiaType 2 Diabetes MellitusParaesthesiaThrombosis
FallInfluenzaConstipationWeight IncreasedFatigueHypoaesthesiaNeuropathy Peripheral
DeafnessFatigueFatigueChest PainArthralgiaHypoaesthesia
Memory ImpairmentFallPain In JawNauseaNeuropathy PeripheralArthritis
Muscle SpasmsMuscle SpasmsHypoaesthesiaAstheniaGeneral Physical Health DeteriorationCoronary Artery Disease
Drug IneffectiveSedationPainBlood Cholesterol IncreasedLymphadenopathyArthralgia
Rectal HaemorrhageDrug DependenceAnxietyWeight IncreasedErythemaBone Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nortriptyline and Zyban?

Comments from related studies:

  • From this study (2 years ago):

  • have been having a high resting heart rate (over 100) and with just small amounts of physical activity it jumps high. I spent 10 minutes on the treadmill and it climbed to 180. I am 54 years old and just slightly overweight around the middle. I feel tired and weak when this happens but anxious. I can feel the pulse in my neck jumping. I've had a cardiac stress test and ultrasound and there is nothing wrong with my heart. I think it may be be one of the medications I'm on. Synthroid is most recent. Could it be that?


  • From this study (4 years ago):

  • Every year in January I try and get off each of the medications, one at a time and the symptoms come back and I have to start taking them again.


Can you answer these questions (what is this?):

  • I'm on 1 1/12 mg of suboxone. would i have to go off of it if i need major surgery?
    I was taking about 5 to 15 mg of Percocet a day and wanted to get off them. If I don't take suboxone at night I get EXTREME discomfort down my left leg & can not sleep due to pressure on my lower back (that's why I had to take Percocet). I have tried NUMEROUS meds over the past 20 yrs & nothing work ...

  • Is dramamine ok to take with afib
    I want to take Dramamine for it ok with all these other meds. I have afib

  • Exercise intolerance
    I've been running for 2 years and recently it has become harder to run and I've lost 45 seconds off my pace. It's harder becuase my hips/.thighs hurt and not because of reduced lung capacity. It isn't temperature related. I've been taking 40 mg Prozac, 450 mg Wellbutrin, and .5 mg Xanax XR for 4 y ...

More questions for: Nortriptyline Hydrochloride, Zyban

You may be interested at these reviews (what is this?):

  • Chills associated with ibuprophen
    I generally respond well to medication. I am a senior who has chronic pain from a c1-c2 fusion. Codeine works well, and I don't use a lot. Still, I sought alternatives to opiates for nerve pain. I lice in a colder climate. It took me quite a while to associate susceptibility to becoming chilled w ...

  • Xanax bed wetting will it stop and do i wear diapers or die
    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts. Just want to bleed out and not hur ...

  • Wellbutrin buproprion two suicide attempts
    Started taking Buproprion and almost immediately had suicide ideation but didn't connect it to the med. Did not want to be here anymore and one week later tried to OD but woke up in the morning. Two weeks later wrote a suicide note to my therapist and again tried to OD. She called the police and t ...

More reviews for: Nortriptyline Hydrochloride, Zyban

Complete drug side effects:

On eHealthMe, Nortriptyline Hydrochloride (nortriptyline hydrochloride) is often used to treat migraine. Zyban (bupropion hydrochloride) is often used to treat quit smoking. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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