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Review: Novolog and Levemir

This review analyzes the effectiveness and drug interactions between Novolog and Levemir. It is created by eHealthMe based on 2,228 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 3, 2014: 2,228 people who reported to have interactions when taking Novolog, Levemir are studied

Trend of Novolog, Levemir's drug interactions, side effects and effectiveness reports (5486029)

Drug combinations in study:
- Novolog (insulin aspart recombinant)
- Levemir (insulin detemir recombinant)

eHealthMe real world results:

Most common interactions experienced by people in the use of Novolog, Levemir:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Blood Glucose Increased894
Hypoglycaemia (deficiency of glucose in the bloodstream)613
Dyspnoea (difficult or laboured respiration)310
Nausea (feeling of having an urge to vomit)270
Diabetes Mellitus Inadequate Control244
Blood Glucose Decreased244
Pain In Extremity200

Most common interactions experienced by people in long term use of Novolog, Levemir:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Hypoglycaemia (deficiency of glucose in the bloodstream)49
Blood Glucose Increased40
Hyperglycaemia (high blood sugar)34
Diabetes Mellitus Inadequate Control30
Atrial Fibrillation (fibrillation of the muscles of the atria of the heart)21
Anti-insulin Antibody Positive16
Blood Glucose Fluctuation14
Drug Exposure During Pregnancy14
Drug Eruption (adverse drug reaction of the skin)14
Sepsis (a severe blood infection that can lead to organ failure and death)12

How effective are the drugs:

not at allsomewhatmoderatehighvery high

Top conditions involved for these people * :

  1. Type 2 diabetes mellitus
  2. Type 1 diabetes mellitus
  3. Diabetes mellitus
  4. Hypertension
  5. Insulin-requiring type 2 diabetes mellitus

Top co-used drugs for these people * :

  1. Novorapid
  2. Aspirin
  3. Lasix
  4. Metformin hcl
  5. Lantus

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Related topic: Levemir, Novolog

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Complete drug side effects:

On eHealthMe, Novolog (insulin aspart recombinant) is often used to treat diabetes. Levemir (insulin detemir recombinant) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 weeks ago):

  • I started 18 units of levimir in january and my levothyroxine was raised from 112 mg to 125 at the same time. Levimir was raised from 15 to 34 units on feb 4 and since then to 38 units. I started novolog flex pen on feb. 4th. and my levothyroxine was elevated to alternating doses of 125 and 137. Since then I have been to the ER where they did ck test that was 726. The normal reference range is 30-200. My ckmb was4.9 with the normal reference range being 0.1-4.0. I had numbness on my left ear which has not gone away, it was coming and going, but is now more constant. Headaches, dizziness, difficulty breathing, loss of sleep, 3-4 hours a night max, can't catch my breath sitting or laying down, am better off when I'm on my feet,dizziness, fatigue, feels like a pressure or dizziness in both eyes. Have been in contact with endocrinologist and PCP. I stopped Testosterone injections, had my levothyroxine reduced to 112, quit taking novolog and got back on glimeperide, and stopped atorvastatin. Symptoms are not going away. It's been going on since the increases in medicine on feb 4. I had been getting test of ck and ckmb before and they were not high until the change in these medicines. I've been back to my PCP twice and shes trying to tell me it isn't the meds but I know it is. My blood pressure was high this week and that is never the case with me. I have had MRI on the chest and head, a brain scan MRI and carotid artery ultra sound that showed nothing out of the norm. I feel that these medicines are killing me. I can't go on like this much longer. My PCP does not seem to agree. Please advise!


  • From this study (4 months ago):

  • Patient was very talkative, eating well and walking a lot prior to this. Isn't talking much now.


  • From this study (5 months ago):

  • I am experiencing intentional movements when going to sleep. The movements follow what I am dreaming about.


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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