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Review: Nuvigil and Benadryl

This review analyzes the effectiveness and drug interactions between Nuvigil and Benadryl. It is created by eHealthMe based on reports of 44 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Nuvigil and Benadryl >>>

What are the drugs

Nuvigil (latest outcomes from 4,388 users) has active ingredients of armodafinil. It is often used in narcolepsy.

Benadryl (latest outcomes from 29,348 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Oct, 29, 2014: 44 people who take Nuvigil, Benadryl are studied

Nuvigil, Benadryl outcomes

Drug combinations in study:
- Nuvigil (armodafinil)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nuvigil is effective50.00%
(1 of 2 people)
(1 of 2 people)
Benadryl is effectiven/an/an/an/a66.67%
(2 of 3 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Skin Exfoliationn/an/an/aFood Intolerancen/aFood IntoleranceOsteopenia
Eye IrritationDepression AggravatedDepression AggravatedPain In Extremity
Heat RashSuicidal IdeationSuicidal IdeationPain
BlisterDecreased InterestDecreased InterestOsteonecrosis Of Jaw
ChillsDecreased AppetiteDecreased AppetiteUrinary Tract Infection
Cerebrovascular AccidentNasal UlcerNasal UlcerOsteoarthritis
ScabDry ThroatDry ThroatArthralgia
Lip DisorderDry MouthDry MouthChronic Obstructive Pulmonary Disease

Drug effectiveness by gender :

Nuvigil is effective100.00%
(1 of 1 people)
(1 of 3 people)
Benadryl is effective50.00%
(1 of 2 people)
(1 of 2 people)

Most common drug interactions by gender * :

Pain In ExtremityUrosepsis
OsteoporosisHepatic Steatosis
Foot FractureMetabolic Acidosis
SwellingLight Chain Analysis Increased
InsomniaSpinal Column Stenosis
Urinary Tract InfectionCough
Osteonecrosis Of JawExostosis

Drug effectiveness by age :

Nuvigil is effectiven/an/a0.00%
(0 of 1 people)
(2 of 23 people)
(0 of 1 people)
Benadryl is effectiven/an/a0.00%
(0 of 1 people)
(0 of 22 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions by age * :

n/aVenoocclusive Diseasen/an/aDehydrationNauseaOsteopeniaOsteoporosis
Cardio-respiratory ArrestDizzinessHypothyroidismPainAcne
Renal Failure AcuteHaemorrhagePulmonary EmbolismOsteoporosisOsteopenia
Blood Calcium IncreasedPlatelet Count DecreasedInsomniaOsteonecrosis Of JawHeadache
AscitesContusionBack PainPain In ExtremityArthralgia
PyrexiaHeadacheDeep Vein ThrombosisHypoaesthesiaSkin Exfoliation
Pulmonary OedemaChronic Obstructive Pulmonary DiseaseCoughOsteoarthritis
Myocardial IschaemiaHiatus HerniaInjuryBlister
Multi-organ FailureIntervertebral Disc DegenerationExostosisHeat Rash
OliguriaType 2 Diabetes MellitusFoot FractureChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nuvigil and Benadryl?

Get connected! Join a related mobile support group:
- support group for people who take Nuvigil and Benadryl
- support group for people who take Benadryl
- support group for people who take Nuvigil

Can you answer these questions (what is this?):

More questions for: Benadryl, Nuvigil

You may be interested at these reviews (what is this?):

  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.

  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrolla ...

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Benadryl, Nuvigil

Complete drug side effects:

On eHealthMe, Nuvigil (armodafinil) is often used to treat narcolepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug studies:

More related studies for: Benadryl, Nuvigil

Recent related drug comparison:

More related comparisons for: Benadryl, Nuvigil

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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