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Review: Nuvigil and Benadryl

This review analyzes the effectiveness and drug interactions between Nuvigil and Benadryl. It is created by eHealthMe based on 37 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 4, 2014: 37 people who reported to have interactions when taking Nuvigil, Benadryl are studied

Trend of Nuvigil, Benadryl's drug interactions, side effects and effectiveness reports (5710839)

Drug combinations in study:
- Nuvigil (armodafinil)
- Benadryl (diphenhydramine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Nuvigil, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Osteopenia (a condition where bone mineral density is lower than normal)37
Osteoporosis (bones weak and more likely to break)32
Pain28
Urinary Tract Infection28
Pain In Extremity28
Osteonecrosis Of Jaw (death of bone of jaw)28
Osteoarthritis (a joint disease caused by cartilage loss in a joint)26
Insomnia (sleeplessness)26
Swelling26
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe)24

Most common interactions experienced by people in long term use of Nuvigil, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)2
Hypersomnia (excessive daytime sleepiness (eds))2
Cough2
Dry Mouth2
Nasal Ulcer (ulcer of nose)2
Dry Throat2
Decreased Interest2
Depression Aggravated2
Suicidal Ideation2
Food Intolerance (inability to have food)2

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Nuvigil0.00%100.00%0.00%0.00%0.00%
Benadryl0.00%0.00%100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Breast cancer
  2. Pain
  3. Prophylaxis
  4. Sleep disorder
  5. Breast cancer metastatic

Top co-used drugs for these people * :

  1. Nexium
  2. Ambien
  3. Celebrex
  4. Fioricet
  5. Corgard

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Nuvigil

You can also:

Complete drug side effects:

On eHealthMe, Nuvigil (armodafinil) is often used to treat narcolepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Can you answer these questions (what is this?):

More questions for: Benadryl, Nuvigil

You may be interested at these reviews (what is this?):

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

  • Libido increase with xyrem
    Although it appears by my med list that I am a train wreck, its quite the contrary. Now that my migraine headaches have been controlled by Inderal & Cymbalta and my thyroid is under control, the only thing left to do was to fall asleep at the oddest times, which progressed to not being able to stand ...

More reviews for: Benadryl, Nuvigil

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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