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Review: taking Nuvigil and Benadryl together

Summary: drug interactions are reported among people who take Nuvigil and Benadryl together. This review analyzes the effectiveness and drug interactions between Nuvigil and Benadryl. It is created by eHealthMe based on reports of 44 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. (latest outcomes from 4,420 Nuvigil users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

On May, 2, 2015: 44 people who take Nuvigil, Benadryl are studied

Nuvigil, Benadryl outcomes

Drug combinations in study:
- Nuvigil (armodafinil)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nuvigil is effective50.00%
(1 of 2 people)
(1 of 2 people)
Benadryl is effectiven/an/an/an/a66.67%
(2 of 3 people)
(0 of 1 people)

Drug effectiveness by gender :

Nuvigil is effective100.00%
(1 of 1 people)
(1 of 3 people)
Benadryl is effective50.00%
(1 of 2 people)
(1 of 2 people)

Drug effectiveness by age :

Nuvigil is effectiven/an/a0.00%
(0 of 1 people)
(2 of 23 people)
(0 of 1 people)
Benadryl is effectiven/an/a0.00%
(0 of 1 people)
(0 of 22 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Skin Exfoliationn/an/an/aFood Intolerancen/aFood IntoleranceOsteopenia
Eye IrritationDepression AggravatedDepression AggravatedPain In Extremity
Heat RashSuicidal IdeationSuicidal IdeationPain
BlisterDecreased InterestDecreased InterestOsteonecrosis Of Jaw
ChillsDecreased AppetiteDecreased AppetiteUrinary Tract Infection
Cerebrovascular AccidentNasal UlcerNasal UlcerOsteoarthritis
ScabDry ThroatDry ThroatArthralgia
Lip DisorderDry MouthDry MouthChronic Obstructive Pulmonary Disease

Most common drug interactions by gender * :

Pain In ExtremityUrosepsis
OsteoporosisHepatic Steatosis
Foot FractureMetabolic Acidosis
SwellingLight Chain Analysis Increased
InsomniaSpinal Column Stenosis
Urinary Tract InfectionCough
Osteonecrosis Of JawExostosis

Most common drug interactions by age * :

n/aVenoocclusive Diseasen/an/aDehydrationNauseaOsteopeniaOsteoporosis
Cardio-respiratory ArrestDizzinessHypothyroidismPainAcne
Renal Failure AcuteHaemorrhagePulmonary EmbolismOsteoporosisOsteopenia
Blood Calcium IncreasedPlatelet Count DecreasedInsomniaOsteonecrosis Of JawHeadache
AscitesContusionBack PainPain In ExtremityArthralgia
PyrexiaHeadacheDeep Vein ThrombosisHypoaesthesiaSkin Exfoliation
Pulmonary OedemaChronic Obstructive Pulmonary DiseaseCoughOsteoarthritis
Myocardial IschaemiaHiatus HerniaInjuryBlister
Multi-organ FailureIntervertebral Disc DegenerationExostosisHeat Rash
OliguriaType 2 Diabetes MellitusFoot FractureChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nuvigil and Benadryl?


You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Nuvigil

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

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More reviews for: Benadryl, Nuvigil

Complete drug side effects:

On eHealthMe, Nuvigil (armodafinil) is often used to treat narcolepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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