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Review: Nuvigil and Benadryl





Summary: drug interactions are reported among people who take Nuvigil and Benadryl together.

This review analyzes the effectiveness and drug interactions between Nuvigil and Benadryl. It is created by eHealthMe based on reports of 44 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Nuvigil and Benadryl >>>

What are the drugs

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. (latest outcomes from Nuvigil 4,396 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (view latest outcomes from 29,367 users)

On Nov, 29, 2014: 44 people who take Nuvigil, Benadryl are studied

Nuvigil, Benadryl outcomes

Drug combinations in study:
- Nuvigil (armodafinil)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nuvigil is effective50.00%
(1 of 2 people)
n/an/an/a50.00%
(1 of 2 people)
n/an/an/a
Benadryl is effectiven/an/an/an/a66.67%
(2 of 3 people)
n/a0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Skin Exfoliationn/an/an/aFood Intolerancen/aFood IntoleranceOsteopenia
AcneHypersomniaHypersomniaOsteoporosis
Eye IrritationDepression AggravatedDepression AggravatedPain In Extremity
Heat RashSuicidal IdeationSuicidal IdeationPain
BlisterDecreased InterestDecreased InterestOsteonecrosis Of Jaw
ChillsDecreased AppetiteDecreased AppetiteUrinary Tract Infection
Cerebrovascular AccidentNasal UlcerNasal UlcerOsteoarthritis
PsoriasisCoughCoughInsomnia
ScabDry ThroatDry ThroatArthralgia
Lip DisorderDry MouthDry MouthChronic Obstructive Pulmonary Disease

Drug effectiveness by gender :

FemaleMale
Nuvigil is effective100.00%
(1 of 1 people)
33.33%
(1 of 3 people)
Benadryl is effective50.00%
(1 of 2 people)
50.00%
(1 of 2 people)

Most common drug interactions by gender * :

FemaleMale
OsteopeniaCardiomegaly
Pain In ExtremityUrosepsis
OsteoporosisHepatic Steatosis
PainDepression
Foot FractureMetabolic Acidosis
SwellingLight Chain Analysis Increased
InsomniaSpinal Column Stenosis
Urinary Tract InfectionCough
Osteonecrosis Of JawExostosis
OsteoarthritisSciatica

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Nuvigil is effectiven/an/a0.00%
(0 of 1 people)
n/an/a8.70%
(2 of 23 people)
n/a0.00%
(0 of 1 people)
Benadryl is effectiven/an/a0.00%
(0 of 1 people)
n/an/a0.00%
(0 of 22 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aVenoocclusive Diseasen/an/aDehydrationNauseaOsteopeniaOsteoporosis
Cardio-respiratory ArrestDizzinessHypothyroidismPainAcne
Renal Failure AcuteHaemorrhagePulmonary EmbolismOsteoporosisOsteopenia
Blood Calcium IncreasedPlatelet Count DecreasedInsomniaOsteonecrosis Of JawHeadache
AscitesContusionBack PainPain In ExtremityArthralgia
PyrexiaHeadacheDeep Vein ThrombosisHypoaesthesiaSkin Exfoliation
Pulmonary OedemaChronic Obstructive Pulmonary DiseaseCoughOsteoarthritis
Myocardial IschaemiaHiatus HerniaInjuryBlister
Multi-organ FailureIntervertebral Disc DegenerationExostosisHeat Rash
OliguriaType 2 Diabetes MellitusFoot FractureChills

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Nuvigil and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Nuvigil and Benadryl
- support group for people who take Benadryl
- support group for people who take Nuvigil

Can you answer these questions (Ask a question):

  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Does benadryl work for pet dander? (1 answer)
    hi I have been taking Benadryl or pet dander? It seemed to work well even if I only take one tablet. Does anyone also find that taking one tablet does not make you drowsy? How often should I take one tablet of Benadryl which is 25 mg? has anyone found any other allergy medication that work or pet dander? Thank you very much.
  • What causes a headache only when coughing or shaking the head?
    Head hurts only when shaken or I cough. I suspect benadryl or amytriptaline
  • Does zoloft cause ringing in the ears, like tinnitus? i've been on it for a month and noticed the ringing in the ears about a week ago, and it's just constant ringing and it's driving me insane. (1 answer)
    I've been on most of the medications for more than a year and it hasn't been that bad getting used to them. But I've been on Zoloft and ambien for about a month now, and I've been noticing a lot of side effects. The one I just recently noticed and that has been driving me completely insane, is the ringing in the ears. It's been about a week now and I just don't know what to do anymore. If it is the Zoloft then I can finally just stop taking it and make this stop. If anyone has an answer or knows what to do, PLEASE help. I'm at my wits end.
  • I have a-fib after taking benadryl. i've been off it for a few days, but flutters remain. how long does it last?
    I took 6 pills a day for a week, have been off medication for several days, but A-Fib symptoms continue.

More questions for: Benadryl, Nuvigil

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night.

    I finally realized after suffering this over and over for months, that it only happened when I had taken benadryl.

    It seems that the benadryl causes it after taking it within one hour, I don't know why I didn't connect this until yesterday. Sometimes, more rarely, I also had arm and hand pain.

More reviews for: Benadryl, Nuvigil

Complete drug side effects:

On eHealthMe, Nuvigil (armodafinil) is often used to treat narcolepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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