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Review: NyQuil and Benadryl

This review analyzes the effectiveness and drug interactions between NyQuil and Benadryl. It is created by eHealthMe based on reports of 112 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take NyQuil and Benadryl >>>

What are the drugs

Nyquil (what 1,128 Nyquil users reported?) has active ingredients of acetaminophen; dextromethorphan; doxylamine; pseudoephedrine. It is used in cough.

Benadryl (what 29,335 Benadryl users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in allergies.

On Sep, 10, 2014: 112 people who take NyQuil, Benadryl are studied

NyQuil, Benadryl outcomes

Drug combinations in study:
- NyQuil (acetaminophen; dextromethorphan; doxylamine; pseudoephedrine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NyQuil is effective0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/an/an/an/an/an/a
Benadryl is effective0.00%
(0 of 2 people)
n/a100.00%
(1 of 1 people)
n/an/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pulmonary EmbolismComplicated MigraineComplicated Migrainen/an/an/an/aEmotional Distress
AbasiaPain Nos
PneumoniaCerebrovascular Accident Nos
HypoxiaBlood Pressure Increased
DyspnoeaAnxiety Nec
Condition AggravatedMental Impairment Nos
ErythemaInjury
UrticariaCardiac Failure Congestive
PruritusDyspnoea
Pain In ExtremityGastrooesophageal Reflux Disease

Drug effectiveness by gender :

FemaleMale
NyQuil is effective0.00%
(0 of 3 people)
n/a
Benadryl is effective33.33%
(1 of 3 people)
n/a

Most common drug interactions by gender * :

FemaleMale
Emotional DistressAnxiety Nec
Pain NosPain Nos
Cerebrovascular Accident NosEmotional Distress
Blood Pressure IncreasedBlood Pressure Increased
Anxiety NecCerebrovascular Accident Nos
Mental Impairment NosCardiac Failure Congestive
Suicide AttemptDyspnoea
AnxietyMental Impairment Nos
General Physical Health DeteriorationHeart Disease Congenital
PainHypospadias

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
NyQuil is effectiven/an/an/a0.00%
(0 of 2 people)
n/a0.00%
(0 of 1 people)
n/an/a
Benadryl is effectiven/an/an/a50.00%
(1 of 2 people)
n/a0.00%
(0 of 1 people)
n/an/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aNauseaNon-accidental OverdosePulmonary EmbolismMiddle InsomniaUterine HaemorrhageCardiac Failure
AnxietySuicide AttemptAnxietyBack DisorderVenous Thrombosis Deep LimbSerotonin Syndrome
ParanoiaHepatic FailureEmotional DistressArthritisDyspnoea NosAcute Pulmonary Oedema
AggressionComa NecGeneral Physical Health DeteriorationHypertensionRespiratory Disorder NosTorsade De Pointes
Suicidal IdeationLoss Of Consciousness NecPruritusSomnolenceUrticaria NosRigors
StressCardiac DisorderPainUpper Respiratory Tract InfectionRed EyeVentricular Tachycardia
TearfulnessCerebrovascular AccidentInjuryInsomniaEye PainCardiac Failure Congestive
Abnormal BehaviourComplicated MigraineDeep Vein ThrombosisActivities Of Daily Living ImpairedHeadache NosFatigue
Suicide AttemptPain In ExtremityAdverse Drug ReactionDyspnoeaAtrial Fibrillation
General Physical Health DeteriorationUrticariaBlood Creatinine IncreasedAcute Respiratory FailureOedema Lower Limb

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take NyQuil and Benadryl?

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Complete drug side effects:

On eHealthMe, Nyquil (acetaminophen; dextromethorphan; doxylamine; pseudoephedrine) is often used to treat cough. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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