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Review: taking Omeprazole and Metformin together

Summary: drug interactions are reported among people who take Omeprazole and Metformin together.

This review analyzes the effectiveness and drug interactions between Omeprazole and Metformin. It is created by eHealthMe based on reports of 8,863 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Omeprazole and Metformin >>>

On Apr, 15, 2015: 8,863 people who take Omeprazole, Metformin are studied

Omeprazole, Metformin outcomes

Drug combinations in study:
- Omeprazole (omeprazole)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Omeprazole is effective25.00%
(2 of 8 people)
(13 of 24 people)
(10 of 21 people)
(25 of 34 people)
(43 of 67 people)
(46 of 59 people)
(23 of 28 people)
(0 of 1 people)
Metformin is effective30.77%
(4 of 13 people)
(5 of 19 people)
(9 of 23 people)
(17 of 45 people)
(28 of 63 people)
(21 of 45 people)
(16 of 30 people)
(2 of 3 people)

Drug effectiveness by gender :

Omeprazole is effective66.15%
(86 of 130 people)
(76 of 111 people)
Metformin is effective40.62%
(52 of 128 people)
(50 of 113 people)

Drug effectiveness by age :

Omeprazole is effectiven/an/an/a66.67%
(2 of 3 people)
(16 of 39 people)
(32 of 99 people)
(45 of 124 people)
(67 of 156 people)
Metformin is effectiven/an/an/a25.00%
(1 of 4 people)
(4 of 33 people)
(20 of 98 people)
(31 of 129 people)
(46 of 165 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal Failure AcuteNauseaRenal Failure AcuteErectile DysfunctionDiarrhoeaDiarrhoeaHyperkalaemiaNausea
Stevens-johnson SyndromeIdiopathic Thrombocytopenic PurpuraCardiac Failure CongestiveCholelithiasisHypocalcaemiaMetabolic AcidosisRenal Tubular AcidosisDyspnoea
Upper Gastrointestinal HaemorrhageVomitingArteriosclerosis Coronary ArteryNauseaTetanyTetanyGastric HaemorrhageDiarrhoea
CholangitisRenal FailureMyocardial InfarctionDeep Vein ThrombosisRenal Failure AcuteHypomagnesaemiaEncephalopathyPain
Malignant Neoplasm ProgressionHaemoglobin DecreasedBlood Creatinine IncreasedPainAnxietyRenal Failure AcuteHigh Blood SugarVomiting
General Physical Health DeteriorationPruritusPainAbdominal PainMyocardial InfarctionHypocalcaemiaAnaemiaFatigue
AnuriaFatigueDiarrhoeaVomitingLactic AcidosisLactic AcidosisGastrointestinal PerforationBlood Glucose Increased
Cardiac ArrestRespiratory DistressPancreatitis NosDyspnoeaHypomagnesaemiaBack PainLactic AcidosisChest Pain
DiarrhoeaDiabetes MellitusMalignant AscitesWeight GainGastric HaemorrhageDepressionMulti-organ FailureWeight Decreased
Lactic AcidosisUpper Gastrointestinal HaemorrhageFatigueOedema PeripheralEncephalopathyPyrexiaRenal Failure AcuteRenal Failure Acute

Most common drug interactions by gender * :

DiarrhoeaMyocardial Infarction
VomitingRenal Failure Acute
HeadacheBlood Glucose Increased
FatigueChest Pain
Weight DecreasedPain
Blood Glucose IncreasedFatigue
Chest PainAsthenia

Most common drug interactions by age * :

OsteoporosisMuscle SpasmsAbdominal PainCholecystitis ChronicAgitationNauseaNauseaNausea
HyperlipidaemiaLactic AcidosisCholecystitis ChronicCholelithiasisWhite Blood Cell Count IncreasedDiabetes MellitusPainDyspnoea
HypercalcaemiaHeadache NosBiliary DyskinesiaAbdominal DistensionComa Scale AbnormalChest PainDepressionDiarrhoea
HaematocheziaAbdominal Pain NosGallbladder DisorderPainNeutrophil Count IncreasedPainAnxietyAsthenia
PalpitationsWeight IncreasedDiabetes Mellitus Inadequate ControlOverdoseDiarrhoeaBlood Glucose IncreasedRenal Failure Acute
Rash GeneralisedPainDiabetes MellitusDiabetes MellitusMyocardial InfarctionFatigueVomiting
HypoglycaemiaVomitingDiarrhoeaType 2 Diabetes MellitusHeadacheDiarrhoeaDizziness
Foetal Exposure During PregnancyInjuryNauseaNauseaAnxietyDyspnoeaWeight Decreased
Type 2 Diabetes MellitusNauseaAbdominal Pain UpperPainDyspnoeaChest PainPain
Transient Ischaemic AttackGastric DisorderAbdominal PainDiabetic NeuropathyDepressionBack PainBlood Glucose Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Omeprazole and Metformin on

Do you take Omeprazole and Metformin?




You are not alone! Join a related support group:
- support group for people who take Metformin
- support group for people who take Omeprazole

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Omeprazole (omeprazole) is often used to treat gastroesophageal reflux disease. Metformin (metformin hydrochloride) is often used to treat type 2 diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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