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Review: Oxycodone 5/apap 500 and Depakote

This review analyzes the effectiveness and drug interactions between Oxycodone 5/apap 500 and Depakote. It is created by eHealthMe based on reports of 503 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Oxycodone 5/apap 500 and Depakote >>>

What are the drugs

Oxycodone 5/apap 500 (latest outcomes from 276 users) has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain.

Depakote (latest outcomes from 30,913 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

On Aug, 25, 2014: 503 people who take Oxycodone 5/apap 500, Depakote are studied

Oxycodone 5/apap 500, Depakote outcomes

Drug combinations in study:
- Oxycodone 5/apap 500 (acetaminophen; oxycodone hydrochloride)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Oxycodone 5/apap 500 is effective62.50%
(5 of 8 people)
(1 of 5 people)
(2 of 2 people)
(1 of 4 people)
Depakote is effective50.00%
(3 of 6 people)
(0 of 3 people)
(1 of 2 people)
(1 of 4 people)
(1 of 2 people)
(2 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RhabdomyolysisMental Status ChangesType 2 Diabetes MellitusType 2 Diabetes MellitusVomitingItchingWeight IncreasedPain
Scrotal SwellingSuicidal IdeationObesityHyperglycaemic Hyperosmolar Nonketotic SyndromeBiliary DyskinesiaNumbness In Hands Or FeetNausea
AnaemiaWeight IncreasedBlood Triglycerides IncreasedNeurogenic BladderNauseaAnxiety
AggressionContusionBlood Cholesterol IncreasedCerebrovascular AccidentCholecystitis ChronicHeadache
Anal InjuryUrinary Tract InfectionAgitated DepressionAbdominal Pain UpperDepression
Renal ImpairmentIncreased AppetiteAnxiety AggravatedPyrexiaType 2 Diabetes Mellitus
PyrexiaGastric UlcerDepressionArthralgia
FatigueHepatic SteatosisSuicidal IdeationDiabetes Mellitus
Stomach DiscomfortEpistaxisBlood Glucose IncreasedDyspnoea
Haematocrit DecreasedInternational Normalised Ratio IncreasedMood SwingsChest Pain

Drug effectiveness by gender :

Oxycodone 5/apap 500 is effective63.64%
(7 of 11 people)
(2 of 8 people)
Depakote is effective40.00%
(4 of 10 people)
(4 of 9 people)

Most common drug interactions by gender * :

PainDiabetes Mellitus
NauseaType 2 Diabetes Mellitus
HeadacheChest Pain
Pain In ExtremityAnxiety
Type 2 Diabetes MellitusConvulsion

Drug effectiveness by age :

Oxycodone 5/apap 500 is effectiven/an/a100.00%
(1 of 1 people)
(3 of 6 people)
(2 of 7 people)
(2 of 3 people)
(1 of 4 people)
(0 of 3 people)
Depakote is effectiven/an/a0.00%
(0 of 1 people)
(2 of 7 people)
(5 of 6 people)
(1 of 3 people)
(0 of 4 people)
(0 of 3 people)

Most common drug interactions by age * :

Heart Rate Decreasedn/aObesityVomitingNauseaType 2 Diabetes MellitusPainFall
NasopharyngitisHyperglycaemiaType 2 Diabetes MellitusPainNeuropathy PeripheralAnxietyDyspnoea
HeadacheDepressionCholecystitis ChronicDrug DependenceArthralgiaConfusional StateHeadache
Brain DamageType 1 Diabetes MellitusOverdoseDepressionHeadacheBack PainChest Pain
AmnesiaDiabetic KetoacidosisAbdominal Pain UpperAnxietyDiabetes MellitusNauseaAnxiety
Balance DisorderGlycosuriaCholelithiasisBipolar I DisorderDepressionFatigueAsthenia
AbasiaWeight IncreasedPancreatitisAsthmaPain In ExtremityDiarrhoeaConfusional State
NauseaNauseaArthralgiaInsomniaDepressionMyocardial Infarction
Biliary ColicDiabetic NeuropathyBronchitisPainChest DiscomfortNausea
Abdominal DistensionAbdominal PainDysuriaAbdominal PainArthralgiaLoss Of Consciousness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Oxycodone 5/apap 500 and Depakote?

Get connected! Join a mobile support group:
- group for people who take Oxycodone 5/apap 500 and Depakote
- group for people who take Depakote
- group for people who take Oxycodone 5/apap 500

Comments from related studies:

  • From this study (1 year ago):

  • I was in a car accident in 2000. My lower back was trashed, and had to be reconstructed basically. I have fusions and titanium, all of this as causd many other health problems to arise over the last 10 years. But, I live a pretty normal life, most people don't even know there is anything wrong with me. : )

    Ultracet and Ultram, any drug from that family can be very dangerous, I had a serious reaction with Ultracet. I had 3 seizures before we figured out what was happening to me.

    Solu-Medrol was used in the hospital through my IV, for a complicated migraine problem. I do not know if I had some kind of allergic reaction to it, or if that drug just does that to people, but, I was ripping the IV out of my arm! I couldn't stand it! It felt like fire ants were under every inch of my skin crawling and biting me all the way down and back up my arms and legs! It took hours to stop, and it did not help the migraine either.


    Allergic... on Mar, 6, 2013:

    allergic reaction to vancomycin and sulfamethoxazole....
    I was given vancomycin through an iv 2 days ago. Today I decided to take some sulfamethoxazole and the allergic reaction is unbearable. It's been 4 hrs and the burning aching hasn't stopped. How did u manage to stop the allergic reaction. I'm wondering if I should wait it out or go into er.


  • From this study (2 years ago):

  • I was wondering if all of these together could have an adverse effect on my liver?


  • From this study (2 years ago):

  • does this medicines make me have a uti?


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Complete drug side effects:

On eHealthMe, Oxycodone 5/apap 500 (acetaminophen; oxycodone hydrochloride) is often used to treat pain. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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