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Review: taking Pepcid and Zantac together

Summary: drug interactions are reported among people who take Pepcid and Zantac together.

This review analyzes the effectiveness and drug interactions between Pepcid and Zantac. It is created by eHealthMe based on reports of 1,308 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Pepcid and Zantac >>>

What are the drugs

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. (latest outcomes from 22,834 Pepcid users)

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. (latest outcomes from 35,538 Zantac users)

On Mar, 3, 2015: 1,307 people who take Pepcid, Zantac are studied

Pepcid, Zantac outcomes

Drug combinations in study:
- Pepcid (famotidine)
- Zantac (ranitidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pepcid is effectiven/an/an/an/a0.00%
(0 of 1 people)
Zantac is effective0.00%
(0 of 1 people)
(0 of 1 people)

Drug effectiveness by gender :

Pepcid is effective0.00%
(0 of 1 people)
Zantac is effective0.00%
(0 of 1 people)
(0 of 1 people)

Drug effectiveness by age :

Pepcid is effectiven/an/an/an/a0.00%
(0 of 1 people)
Zantac is effectiven/an/an/an/a0.00%
(0 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DehydrationAnaemiaHepatic FailureLeukopeniaDepressionOesophagitisAbdominal AbscessPain
SepsisCerebral HaemorrhageMetastases To LiverAnxietyPyrexiaHilar LymphadenopathyAneurysm RupturedNausea
HypotensionEnterocolitisOral SurgeryGallbladder DisorderChillsFatigueBronchial HaemorrhageAnxiety
HyperbilirubinaemiaHepatic Function AbnormalHaemoglobin DecreasedCholecystitis ChronicVitamin D DeficiencyPleurisySepsisFatigue
Mucosal InflammationRenal Failure AcuteHaematocrit DecreasedAbdominal PainCalcium DeficiencyPneumonitisSplenic HaemorrhageVomiting
Cystitis HaemorrhagicBlood Lactic Acid IncreasedPainAnhedoniaDyspepsiaUrinary IncontinenceDyspnoea
Cytomegalovirus InfectionLymphadenopathyGingivitisHeart Rate IrregularOsteoporosisTremorAnaemia
Renal FailureMedullary Thyroid CancerGamma-glutamyltransferase IncreasedLymphoceleDysphagiaPneumothoraxDepression
Drug IneffectiveHaemoglobin DecreasedOsteomyelitisRelapsing-remitting Multiple SclerosisPoor Quality SleepDysphagiaPyrexia
Bk Virus InfectionThyroidectomyAspartate Aminotransferase IncreasedNeutropeniaGastric DisorderDysarthriaGastrooesophageal Reflux Disease

Most common drug interactions by gender * :

Weight DecreasedFatigue
Back PainInjury
Oedema PeripheralDyspnoea

Most common drug interactions by age * :

PyrexiaDeathPainCholecystitis ChronicConvulsionArthralgiaDepressionPain
Multi-organ FailureOesophagitisHaemolytic AnaemiaVomitingPainNauseaPainNausea
NeutropeniaOverdoseElectrocardiogram Qt ProlongedPainOsteopeniaType 2 Diabetes MellitusArthralgiaAnxiety
Lung DisorderVomiting ProjectileAlanine Aminotransferase IncreasedNauseaAstheniaChest PainOsteonecrosis Of JawBone Disorder
IrritabilityStreptococcal Infection NosAspartate Aminotransferase IncreasedAnxietyInsomniaFatigueAnxietyPyrexia
Incision Site InfectionIrritabilityBlood Bilirubin IncreasedDiarrhoeaDepressionPainNauseaWeight Decreased
PainKidney Infection NosAbdominal PainJaundiceWeight DecreasedVomitingBack PainAnaemia
LethargyRenal Failure NosPyrexiaInjuryDysphagiaDyspnoeaFatigueRenal Failure Acute
PneumoniaApnoeaVomitingHeadacheDrug DependenceDepressionDyspnoeaPneumonia
TachycardiaCholecystitis ChronicLymphadenopathyNauseaHeadacheInjuryDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Pepcid and Zantac?

You are not alone! Join a related mobile support group:
- support group for people who take Pepcid and Zantac
- support group for people who take Pepcid
- support group for people who take Zantac

Can you answer these questions (Ask a question):

More questions for: Pepcid, Zantac

You may be interested at these reviews (Write a review):

  • Ranitidine is bad juju
    Used 3-5 times per week for about 1 1/2 years. Noticed:
    shortness of breath
    contstricted throat
    chest pain/pressure
    heart palpatations
    dryness - more so than usual

    I quit taking it and felt much better within 2-3 days.
  • Lansoprazole and vitamin c drug interactions (1 response)
    Whenever I use a gastric ulcer or gastric acid treatment drug and eat any food that contains vitamine C, like lemon, orange, etc. I get a strong skin allergy with swollen insecbyte type itching redness, that lasts about two days for each one.
  • Polyuria associated with zantac
    I was prescribed Zantac 150mg before breakfast and before dinner. After two days, I felt tired and had polyuria (by weight change 650 mL). I had kidney pain so drank water with a tiny bit of salt. Felt very nauseous, but more water helped. Continued to sip water til kidney pain eased. Have discontinued Zantac. Kidneys stopped hurting after about 4 hours. Seem to be ok, now.
  • I got pneumonia while taking topamax, obvious correlation
    I do not take all the medicines above all the time but I am using an implanted pump giving me less than 2mg of dilaudid per day, 75 mg effexor daily and usually buspar. Dr prescribed topamax within 4 days I was hospitalized with Pneumonia, stayed a week came home a week had a clear chest x ray and the next week I got it again and was hospitalized 9 days that time. I knew I had been on the med but could not remember the side effect that made me come off previously until i started it again 2 days ago and woke today with Pneumonia again. Last time my pulmonologist said that the med in combination with the antidepressant which is all I take right now relaxes me too much and it paralyzes my choking reflex causing aspiration of saliva and ultimately waking up sick as the bacteria laced fluid goes crazy in the moist conditions of the lungs.

More reviews for: Pepcid, Zantac

Complete drug side effects:

On eHealthMe, Pepcid (famotidine) is often used to treat gastroesophageal reflux disease. Zantac (ranitidine hydrochloride) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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