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Review: Plaquenil and Naproxen

This review analyzes the effectiveness and drug interactions between Plaquenil and Naproxen. It is created by eHealthMe based on reports of 755 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Plaquenil and Naproxen >>>

What are the drugs

Plaquenil (latest outcomes from 15,494 users) has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis.

Naproxen (latest outcomes from 21,898 users) has active ingredients of naproxen. It is often used in pain.

On Oct, 13, 2014: 755 people who take Plaquenil, Naproxen are studied

Plaquenil, Naproxen outcomes

Drug combinations in study:
- Plaquenil (hydroxychloroquine sulfate)
- Naproxen (naproxen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Plaquenil is effective0.00%
(0 of 2 people)
(2 of 6 people)
(0 of 4 people)
(2 of 5 people)
(1 of 7 people)
(0 of 4 people)
(1 of 1 people)
Naproxen is effective0.00%
(0 of 2 people)
(2 of 5 people)
(0 of 3 people)
(1 of 5 people)
(1 of 6 people)
(1 of 4 people)
(2 of 3 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
EosinophiliaSmall Cell Lung Cancer Stage UnspecifiedGastrointestinal HaemorrhageAtrial FibrillationRetinal DetachmentMalaiseItchingNausea
HypersensitivityAtrial FibrillationSpondylosisCoronary Artery DiseaseGoiterCoughHyperlipidaemiaPain
Blood Alkaline Phosphatase IncreasedCardiac Failure CongestiveDegenerative Joint DiseaseChest PainItchingNight SweatsGoiterArthralgia
Aspartate Aminotransferase IncreasedTachycardiaOsteoarthritisDyspnoeaBradycardiaPolypFatigueHeadache
Alanine Aminotransferase IncreasedRetroperitoneal FibrosisFibromyalgiaThrombophlebitisFatigueRetroperitoneal FibrosisThroat TightnessDyspnoea
RashPolypOtotoxicityDuodenal UlcerShortness Of BreathBurning Mouth SyndromeShortness Of BreathFatigue
HyperlipidaemiaCoughPalpitationsMood AlteredThroat TightnessFibromyalgiaProteinuriaUrinary Tract Infection
PalpitationsMalaiseSkin ReactionGastrointestinal Haemorrhage NosWeightSpondylosisDrug Ineffective
Muscle PainNight SweatsMuscle PainPyloric UlcerDegenerative Joint DiseaseRheumatoid Arthritis
Skin ReactionBurning Mouth SyndromeEmotional DistressOsteoarthritisPain In Extremity

Drug effectiveness by gender :

Plaquenil is effective23.08%
(6 of 26 people)
(0 of 3 people)
Naproxen is effective26.92%
(7 of 26 people)
(0 of 3 people)

Most common drug interactions by gender * :

PainDrug Ineffective
ArthralgiaRheumatoid Arthritis
Urinary Tract InfectionOedema Peripheral
Pain In ExtremityChest Pain
VomitingAtrial Fibrillation
DyspnoeaJoint Swelling
Rheumatoid ArthritisCoronary Artery Disease

Drug effectiveness by age :

Plaquenil is effectiven/an/a0.00%
(0 of 4 people)
(2 of 7 people)
(1 of 8 people)
(2 of 5 people)
(1 of 14 people)
(0 of 10 people)
Naproxen is effectiven/an/a25.00%
(1 of 4 people)
(1 of 7 people)
(2 of 20 people)
(2 of 5 people)
(1 of 12 people)
(0 of 10 people)

Most common drug interactions by age * :

n/aUpper Respiratory Tract Infection NosDermatitis NosPyrexiaNauseaPain In ExtremityUrinary Tract InfectionPneumonia
Autoimmune HepatitisNauseaProteinuriaHeadacheBack PainRheumatoid ArthritisDyspnoea
PyrexiaVomiting NosDiarrhoea NosPainHeadacheNauseaArthralgia
Infection NosChest PainAtelectasisArthralgiaPainVomitingDysphagia
Chest PainSystemic Lupus ErythematosusDyspnoeaAlopeciaAnxietyArthralgiaPain
Muscle CrampsSweating IncreasedAnaemiaNeck PainInjection Site Reaction NosFatiguePulmonary Fibrosis
Abdominal Pain NosArthralgiaDrug IneffectiveTemporomandibular Joint SyndromeDyspnoeaOsteomyelitisFall
Drug IneffectiveLung InfiltrationDepressionFallDrug IneffectivePain In Extremity
Renal Papillary NecrosisPleuritic PainUrinary Tract InfectionMental Status ChangesPainParaesthesia
Urinary Tract InfectionFatigueConvulsionMusculoskeletal StiffnessFractureUpper Respiratory Tract Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Plaquenil and Naproxen?

Get connected! Join a related mobile support group:
- support group for people who take Plaquenil and Naproxen
- support group for people who take Naproxen
- support group for people who take Plaquenil

Comments from related studies:

  • From this study (1 year ago):

  • I am having most of the symptoms of Hypothyroid, weight gain, very dry skin & hair, easily stressed, palpitations yet my doctor tells me my bloods are normal. No one seems to know why I am feeling so bad all the time.


  • From this study (2 years ago):

  • eosinophilia bowel problems with pain lethargic


  • From this study (2 years ago):

  • For years my high blood pressure was under control with 80MG of Lisinopril. I stopped smoking 11-01-2011 and started getting headaches. I also stopped taking the RA medications. I ended up in the hospital with BP of 212 over 152. in Dec. 2011. Now May 2012), I monitor my BP. Three weeks after stopping Prednisone again the headaches and High Blood Pressure is back. I go off the prednisone because I cannot lose weight which makes my diabetes worse and also makes my hypertension worse.


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More reviews for: Naproxen, Plaquenil

Complete drug side effects:

On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat systemic lupus erythematosus. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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