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Review: taking Plaquenil and Naproxen together

Summary: drug interactions are reported among people who take Plaquenil and Naproxen together.

This review analyzes the effectiveness and drug interactions between Plaquenil and Naproxen. It is created by eHealthMe based on reports of 757 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 17, 2015: 757 people who take Plaquenil, Naproxen are studied

Plaquenil, Naproxen outcomes

Drug combinations in study:
- Plaquenil (hydroxychloroquine sulfate)
- Naproxen (naproxen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Plaquenil is effective0.00%
(0 of 2 people)
(2 of 6 people)
(0 of 4 people)
(2 of 5 people)
(1 of 8 people)
(0 of 5 people)
(1 of 1 people)
Naproxen is effective0.00%
(0 of 2 people)
(2 of 5 people)
(0 of 3 people)
(1 of 5 people)
(1 of 6 people)
(1 of 5 people)
(2 of 3 people)
(0 of 1 people)

Drug effectiveness by gender :

Plaquenil is effective21.43%
(6 of 28 people)
(0 of 3 people)
Naproxen is effective25.93%
(7 of 27 people)
(0 of 3 people)

Drug effectiveness by age :

Plaquenil is effectiven/an/a0.00%
(0 of 4 people)
(2 of 8 people)
(1 of 8 people)
(2 of 24 people)
(1 of 14 people)
(0 of 10 people)
Naproxen is effectiven/an/a25.00%
(1 of 4 people)
(1 of 8 people)
(2 of 20 people)
(2 of 5 people)
(1 of 12 people)
(0 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
EosinophiliaSmall Cell Lung Cancer Stage UnspecifiedGastrointestinal HaemorrhageAtrial FibrillationRetinal DetachmentCoughItchingPain
HypersensitivityAtrial FibrillationSpondylosisCoronary Artery DiseaseSjogren's SyndromeMalaiseHyperlipidaemiaNausea
Blood Alkaline Phosphatase IncreasedCardiac Failure CongestiveDegenerative Joint DiseaseChest PainChronic Fatigue SyndromeNight SweatsGoiterArthralgia
Aspartate Aminotransferase IncreasedTachycardiaOsteoarthritisDyspnoeaMobility DecreasedRetroperitoneal FibrosisFatigueDyspnoea
Alanine Aminotransferase IncreasedRetroperitoneal FibrosisFibromyalgiaThrombophlebitisDiabetes MellitusPolypThroat TightnessHeadache
RashPolypOtotoxicityDuodenal UlcerLupusBurning Mouth SyndromeShortness Of BreathUrinary Tract Infection
HyperlipidaemiaCoughPalpitationsMood AlteredPainful Response To Normal StimuliHidradenitis SuppurativaProteinuriaFatigue
PalpitationsMalaiseSkin ReactionGastrointestinal Haemorrhage NosBradycardiaFibromyalgiaRheumatoid Arthritis
Muscle PainNight SweatsMuscle PainPyloric UlcerPain - JointsSpondylosisDrug Ineffective
Skin ReactionBurning Mouth SyndromeEmotional DistressFibromyalgiaDegenerative Joint DiseasePain In Extremity

Most common drug interactions by gender * :

PainDrug Ineffective
ArthralgiaRheumatoid Arthritis
Urinary Tract InfectionOedema Peripheral
Pain In ExtremityChest Pain
DyspnoeaAtrial Fibrillation
VomitingJoint Swelling
Rheumatoid ArthritisCoronary Artery Disease

Most common drug interactions by age * :

n/aUpper Respiratory Tract Infection NosDermatitis NosPyrexiaNauseaPain In ExtremityUrinary Tract InfectionPneumonia
Autoimmune HepatitisNauseaDiarrhoea NosHeadacheBack PainRheumatoid ArthritisDyspnoea
PyrexiaVomiting NosProteinuriaPainPainNauseaArthralgia
Infection NosChest PainAtelectasisArthralgiaHeadacheVomitingDysphagia
Chest PainSystemic Lupus ErythematosusDyspnoeaAlopeciaAnxietyArthralgiaPain
Muscle CrampsSweating IncreasedFatigueNeck PainInjection Site Reaction NosFatiguePulmonary Fibrosis
Abdominal Pain NosArthralgiaDrug IneffectiveTemporomandibular Joint SyndromeDyspnoeaOsteomyelitisFall
Drug IneffectiveLung InfiltrationDepressionChest PainDrug IneffectivePain In Extremity
Renal Papillary NecrosisAbdominal Pain NosUrinary Tract InfectionSinus TachycardiaPainParaesthesia
Urinary Tract InfectionAnaemiaConvulsionMental Status ChangesFractureUpper Respiratory Tract Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Plaquenil and Naproxen?




You are not alone! Join a related support group:
- support group for people who take Naproxen
- support group for people who take Plaquenil

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Naproxen (naproxen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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