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Review: taking Prednisone and Vicodin together

Summary: drug interactions are reported among people who take Prednisone and Vicodin together.

This review analyzes the effectiveness and drug interactions between Prednisone and Vicodin. It is created by eHealthMe based on reports of 8,158 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. (latest outcomes from 150,120 Prednisone users)

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from 35,334 Vicodin users)

On Feb, 28, 2015: 8,158 people who take Prednisone, Vicodin are studied

Prednisone, Vicodin outcomes

Drug combinations in study:
- Prednisone (prednisone)
- Vicodin (acetaminophen; hydrocodone bitartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Prednisone is effective26.83%
(11 of 41 people)
(8 of 27 people)
(0 of 5 people)
(5 of 12 people)
(4 of 16 people)
(10 of 15 people)
(5 of 8 people)
Vicodin is effective34.38%
(11 of 32 people)
(7 of 20 people)
(7 of 15 people)
(8 of 18 people)
(6 of 24 people)
(2 of 11 people)
(3 of 8 people)
(0 of 1 people)

Drug effectiveness by gender :

Prednisone is effective38.46%
(35 of 91 people)
(8 of 33 people)
Vicodin is effective33.33%
(31 of 93 people)
(13 of 36 people)

Drug effectiveness by age :

Prednisone is effectiven/an/a33.33%
(1 of 3 people)
(3 of 12 people)
(5 of 31 people)
(8 of 49 people)
(12 of 96 people)
(14 of 44 people)
Vicodin is effectiven/an/a25.00%
(1 of 4 people)
(6 of 15 people)
(7 of 30 people)
(9 of 50 people)
(11 of 97 people)
(10 of 44 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainHeadachePainOsteonecrosisCellulitisAnxietyAbdominal TendernessPain
DyspnoeaPneumoniaSkin TightnessDizzinessAnxietyCellulitisInjection Site AbscessAnxiety
AnaemiaPainNephrogenic Systemic FibrosisCerebrovascular AccidentDepressionDepressionConstipationNausea
HeadacheDyspnoeaParaesthesiaAnxietyDeep Vein ThrombosisPostoperative Wound ComplicationNauseaDyspnoea
InjuryFebrile NeutropeniaDeformityHypotensionBack PainEndocarditis BacterialPneumonitisArthralgia
AnxietyConstipationActivities Of Daily Living ImpairedOsteomyelitisOsteomyelitisRenal Failure AcuteHypoxiaFatigue
NauseaNauseaInjuryEye DisorderDizzinessSepsisGait DisturbanceBack Pain
Pain In ExtremityPain In ExtremityBack PainGait DisturbanceLoss Of ConsciousnessImpaired HealingLung InfiltrationAsthenia
PneumoniaEye PainHypoaesthesiaMyocardial IschaemiaEndocarditis BacterialEmotional DistressFaeces DiscolouredOedema Peripheral
FatigueVisual DisturbanceArthralgiaAtrial FibrillationNeck PainImmunosuppressionAbdominal DiscomfortAnaemia

Most common drug interactions by gender * :

Oedema PeripheralBack Pain
Back PainPneumonia

Most common drug interactions by age * :

Congenital Cystic Kidney DiseaseInflammatory Bowel DiseaseCholecystitis ChronicPainArthralgiaPainPainPain
Premature BabyCrohn's DiseaseNauseaDeep Vein ThrombosisNauseaAnxietyAnxietyAnxiety
Meningitis NeonatalPostoperative IleusVomitingAnxietyPainHeadacheNauseaDyspnoea
ThrombocytopeniaWeight DecreasedAbdominal Pain UpperDyspnoeaAnxietyFatigueOedema PeripheralPneumonia
Respiratory DistressGastrointestinal Stoma ComplicationPainNauseaPyrexiaDepressionArthralgiaAsthenia
Maternal Drugs Affecting FoetusHyponatraemiaAnxietyPulmonary EmbolismBack PainNauseaFatigueNausea
Neonatal Respiratory Distress SyndromeInfusion Related ReactionCholelithiasisFatigueDyspnoeaBack PainAnaemiaFall
Foetal Growth RetardationHeart Rate AbnormalGallbladder DisorderInjuryChest PainArthralgiaBack PainBack Pain
PancreatitisDrug HypersensitivityAbdominal PainHeadacheAbdominal PainAstheniaDiarrhoeaFatigue
GastritisRespiratory ArrestPulmonary EmbolismVomitingDepressionDyspnoeaBone DisorderAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Prednisone and Vicodin?

You are not alone! Join a related mobile support group:
- support group for people who take Prednisone and Vicodin
- support group for people who take Prednisone
- support group for people who take Vicodin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Prednisone, Vicodin

You may be interested at these reviews (Write a review):

  • Prednisone relieves anosmia
    Having had anosmia for 15 years now the only thing that ever relieves it, albeit temporarily, is prednisone. I have done 2 surgeries to remove polyps (and won't do it again, waste of time and money - the polyps returned within a year), every herb and other "guaranteed cure" (bogus) on the Internet and the only thing that gives me my smell back is prednisone. Have also done allergy injections, nebulizers, neti-pots, Flonase, etc. None of these things work.
    Being without smell is subtly debilitating. It takes away your drive, your pleasures of life and leads to depression. I wish the medical community would apply as much effort here as they do to the loss of hearing or sight since this is in many ways just as debilitating although in more subtle ways.
  • Sleep paralysis while on medrol and norco
    On my 5th day of my dose pack about an hour after taking medrol and a norco I experienced sleep paralysis for the first time. This is the 3rd dose pack in 2 months and I just switched back to norco from Ultram the same day I started the latest dose pack. I felt unusually sleepy before taking my bedtime dose, but felt awake shortly after taking it. My sleep habits have been fluctuating due to sciatic pain which is why I am prescribed this medication.
  • Adverse reaction to prednisone
    Severe allergic reaction. Given prednisone for angioedema attributed to Lisinopril. Within 24 hours, severe red skin on face, bp +200/+100 spikes, shortness of breath, chest pain snd severe heart palpitations. Went to ER. Given another IV cocktail of sulomedrol, Bdnadryl snd Zantac, told to double my prednisone pills to 20 mg twice a day. On fifth day, znother similar reaction but worse. Went in ambulance to ER. Put on oxygen and atavan. Sent home with six day tapering dose. No appetite. Nausea. After last pill, blood pressure spikes, flushing, chills, fatigue, blood sugar crashes, especially at night. Had to eat every two hours. Severe skin pain and itching, going on still after six weeks of stopping meds. This drug has HORRIBLE side effects. None of the drs czn tell me how long this will last, or evdn if it will go away. Eating organic, taking soothing baths, detoxing, taking adrenal, vitamin and mineral suppldments, drinking water and detoxing teas. Some symptoms are a bit better but skin is driving me crazy. How czn this drug be prescribed when drs really don 't know all it does nor how to counteract the horrible side effects!?!?
  • My finger tendons broke on prednisone
    Twelve years ago I was put on prednisone for sudden hearing loss. The prednisone helped the hearing loss (for as long as I took the drug; hearing loss returned after I stopped the prednisone.) But I kept getting ruptured tendons in my fingers, which I had to splint to use. I couldn't figure out why in heck this was happening. My doctor(s) didn't have a clue. I suspected the ruptures might have to do with prednisone. Now I know they were caused by it. When I stopped the prednisone, the tendon-ruptures stopped, too. This should be Must Tell information for any doctor who prescribes this dangerous drug.
  • Prednisone rx 3,3,2,2,1,1 plan suicidal haunts all day (1 response)
    I came home from the Hospitol with a 3,3,2,2,1,1 Rx.
    I took (3) and spent the rest of the day contenplating Suicide.
    The rest of the Rx went in the Toilet by 7:pm.
    I wonder how many this Killed.

More reviews for: Prednisone, Vicodin

Comments from related studies:

  • From this study (2 weeks ago):

  • coolaero on Feb, 7, 2015:

    there wont be side effect other that DEATH


    peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    mtntexas on May, 11, 2013:

    Just ask John Belushi


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Complete drug side effects:

On eHealthMe, Prednisone (prednisone) is often used to treat rheumatoid arthritis. Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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