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Review: taking Doxycycline and Prograf together

Summary: drug interactions are reported among people who take Doxycycline and Prograf together.

This review analyzes the effectiveness and drug interactions between Doxycycline and Prograf. It is created by eHealthMe based on reports of 103 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. (latest outcomes from 13,701 Doxycycline users)

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. (latest outcomes from 20,082 Prograf users)

On Mar, 2, 2015: 103 people who take Doxycycline, Prograf are studied

Doxycycline, Prograf outcomes

Drug combinations in study:
- Doxycycline (doxycycline hyclate)
- Prograf (tacrolimus)

Drug effectiveness over time :


Drug effectiveness by gender :


Drug effectiveness by age :


Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Stenotrophomonas InfectionStenotrophomonas InfectionIntervertebral Disc ProtrusionPostoperative IleusCardiac Arrestn/an/aAnaemia
Engraft FailurePulmonary HaemorrhageOsteopeniaRenal Failure AcuteMemory ImpairmentHypoaesthesia
Pulmonary HaemorrhageEngraft FailureOvarian CystDevice Related InfectionConfusional StateIntervertebral Disc Protrusion
Muscular WeaknessBiopsy Breast AbnormalOsteoarthritis
ExostosisBreast Cancer FemaleAbscess
Blood Creatinine IncreasedAnaemiaDyspnoea
Post Procedural HaemorrhageEyelid OedemaOpen Wound
AbscessHaemorrhoidsGingival Disorder
Skin UlcerOsteoarthritisFlank Pain
DiarrhoeaNeck PainPain In Jaw

Most common drug interactions by gender * :

Intervertebral Disc ProtrusionHypoaesthesia
Biopsy Breast AbnormalGingival Disorder
Breast Cancer FemaleFlank Pain
OsteopeniaAortic Aneurysm
Ovarian CystImpaired Healing
PainTooth Disorder
AlopeciaPain In Jaw
Weight IncreasedAnaemia
OsteoarthritisOpen Wound

Most common drug interactions by age * :

n/an/an/aHodgkin's DiseaseIntervertebral Disc ProtrusionHypoaesthesiaAspergillosisOsteonecrosis Of Jaw
HypoaesthesiaOvarian CystStress Urinary IncontinenceComplications Of Transplanted KidneyOsteomyelitis
Joint DislocationOsteopeniaAdenomyosisSkin CancerAnaemia
LymphadenopathyAnaemiaSerositisStenotrophomonas InfectionOpen Wound
Foreign Body In EyeBiopsy Breast AbnormalMemory ImpairmentEngraft FailurePain In Jaw
DyspnoeaBreast Cancer FemaleConfusional StatePulmonary HaemorrhageImpaired Healing
AmnesiaOsteoarthritisDizzinessPemphigoidBack Pain
Chest PainErythema Of EyelidCardiac ArrestSepsisTooth Disorder
Corneal AbrasionNeck PainInjuryKidney Transplant RejectionAortic Aneurysm
Neuropathy PeripheralHaemorrhoidsRhinitis AllergicDiabetes MellitusFlank Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Doxycycline and Prograf?

You are not alone! Join a related mobile support group:
- support group for people who take Doxycycline and Prograf
- support group for people who take Doxycycline
- support group for people who take Prograf

Can you answer these questions (Ask a question):

More questions for: Doxycycline, Prograf

You may be interested at these reviews (Write a review):

  • Severe leg/foot/ankle swelling from doxycycline
    Was given five-day course of doxycycline for sinusitis and laryngitis. By end of third day had ankle edema (never had before), then MASSIVE leg/foot/ankle edema by fourth day Discontinued on fifth day after research revealed side effect of doxycycline. Took almost a week for swelling to go comletely away. Also felt completely exhausted and seemed to make the coughing and laryngitis much worse also.
  • Thrush while on prograf
    I am a health provider at an emergency room and had a patient come in because of a food bolus and when i examined his oral/pharynx I noticed he had thrush. Patient stated it has been their for a while. Patient also stated he has been having progressive difficulty in swallowing. Pt is a kidney transplant patient and has been worked up for other causes of his thrush (including HIV, as per patient results neg) and everything came back negative. I can only conclude that maybe the prograf which is a immunosupressent can possible be the cause
  • My experience with lyme
    My final semester at college-

    Woke up to extreme inflammation in what was determined to be a portion of my trapezius on the left side length of my next. It was accompanied by severely swollen lymph nodes throughout my entire body. I went about my day with what to me was seemingly a bad neck cramp and oncoming cold. In the afternoon I decided to participate in Track practice and what occurred after I am unsure about in terms of its relation to me performing physically or an autoimmune response against my peripheral nervous system. The next morning I woke up the left side of my trapezius was completely dysfunctional from its attachment to my cranium all the way down to the mid point of my back. It was accompanied by inflammation and sore pain at the point where the next connects to the shoulder girdle. Over the course of the next 8 months I went undiagnosed with Lyme, having seen neurologists and orthopedics in an attempt to find a solution. Reflecting on the first three months, I experienced significant effects on my emotional stability and cognitive capability. I would have severe mood swings--rage, depression, excitement-- and I would have difficulty with memory and train of thought- all of which can be confirmed by multitude of classmates. By the 8 month mark I had began to feel mild joint pain, particularly in areas I had formerly injured in athletic activity (ankles, lower back). At this point, my accessory nerve had not regenerated in terms of the portion affecting my trapezius, didn't regain any lost muscle function. I saw my physician, who discovered the Lyme infection. I took doxycycline over the next 3 months and saw significant improvement in my trapezius, which was accompanied by a decrease in lymph node size, as proven by comparison of MRIs. My fatigue dissipated and my moods/cognition returned to normal. I've regained about 70% of the function I formerly had with my trapezius (as compared to 0% prior to treatment). I wanted to write this because I have yet to see a similar case, understand the ambiguity of Lyme disease and the array of conditions it causes.
  • Symptons from taking doxycyclin
    I recently went in for a physical, everything was normal except my Creatinine levels. I had severe symptoms from burning hands/knuckles to feeling very tingly like cold needles. Also, burned very easily from sun even with 50 sun screen applied. Should I be worried about the Creatinine levels be abnormally high?
  • Rituxan mental changes (2 responses)
    Within a month my daughter has had altered mental health symptoms such as confusion 'ADD symptoms' decrease in vision, trouble concentrating, frequent headaches and sharp head pain, forgetfulness, blanks out much more and 'feels off'
    it has now been about 5 months since last rituxan

More reviews for: Doxycycline, Prograf

Complete drug side effects:

On eHealthMe, Doxycycline (doxycycline hyclate) is often used to treat acne. Prograf (tacrolimus) is often used to treat liver transplant. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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