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Review: Promethazine and Cyclobenzaprine

This review analyzes the effectiveness and drug interactions between Promethazine and Cyclobenzaprine. It is created by eHealthMe based on reports of 859 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Promethazine and Cyclobenzaprine >>>

What are the drugs

Promethazine (latest outcomes from 1,209 users) has active ingredients of promethazine hydrochloride. It is often used in nausea.

Cyclobenzaprine hydrochloride (latest outcomes from 2,348 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

On Jul, 19, 2014: 859 people who take Promethazine, Cyclobenzaprine Hydrochloride are studied

Promethazine, Cyclobenzaprine Hydrochloride outcomes

Drug combinations in study:
- Promethazine (promethazine hydrochloride)
- Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Promethazine is effective11.11%
(1 of 9 people)
(3 of 6 people)
(1 of 1 people)
(2 of 4 people)
(5 of 7 people)
(3 of 3 people)
(2 of 3 people)
(1 of 1 people)
Cyclobenzaprine Hydrochloride is effective25.00%
(2 of 8 people)
(1 of 4 people)
(0 of 2 people)
(1 of 6 people)
(0 of 5 people)
(3 of 6 people)
(3 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainPainMuscle OedemaShort-term Memory LossBack PainErection ProblemsHeart Rate IncreasedPain
NauseaPulmonary EmbolismArterial Thrombosis LimbFlatulenceNauseaSkin StriaeAnxiety AggravatedBack Pain
Cholecystitis ChronicDisease ProgressionEjection Fraction DecreasedDrowsinessPyrexiaInsomniaAnxiety
Pulmonary EmbolismDeathDyspnoeaSinus TachycardiaAbdominal Pain UpperNausea
Suicide AttemptDrowsinessHaemoglobin DecreasedLong-term Memory LossAbdominal Pain LowerHeadache
Abdominal Pain UpperBurning Mouth SyndromeAbdominal Wall HaematomaBreast TendernessPainChest Pain
Gallbladder CholesterolosisSuicide AttemptBack PainFatigueVomitingVomiting
Food IntoleranceIntentional OverdoseBursitisBiliary ColicPain In Extremity
DeathDepressionTibia FracturePancreatitis ChronicFall
DepressionSwollen TongueAtrioventricular Block CompleteDrowsinessOsteonecrosis Of Jaw

Drug effectiveness by gender :

Promethazine is effective51.72%
(15 of 29 people)
(3 of 5 people)
Cyclobenzaprine Hydrochloride is effective24.14%
(7 of 29 people)
(3 of 5 people)

Most common drug interactions by gender * :

Back PainAnxiety
Chest PainOsteoporosis
Pain In ExtremityOsteoarthritis
Osteonecrosis Of JawDepression

Drug effectiveness by age :

Promethazine is effectiven/an/a100.00%
(1 of 1 people)
(2 of 5 people)
(4 of 14 people)
(5 of 11 people)
(5 of 25 people)
(1 of 2 people)
Cyclobenzaprine Hydrochloride is effectiven/an/a100.00%
(1 of 1 people)
(1 of 4 people)
(2 of 14 people)
(4 of 12 people)
(2 of 25 people)
(0 of 2 people)

Most common drug interactions by age * :

n/an/aCholecystitisNauseaNauseaPainPainBack Pain
Abdominal Pain UpperHeadacheType 2 Diabetes MellitusDepressionAnxietyOsteomyelitis
CholelithiasisAbdominal Pain UpperAnxietyPain In ExtremityBack PainAnxiety
NauseaCholecystitis ChronicVomitingNauseaDiarrhoeaOsteoarthritis
DyspepsiaBack PainConstipationAbdominal PainOsteoarthritisOsteonecrosis Of Jaw
Decreased AppetitePulmonary EmbolismWeight IncreasedChest PainHeadacheWeight Decreased
Gastrooesophageal Reflux DiseaseCholecystitisBack PainOedema PeripheralHypoaesthesiaPain
PancreatitisBronchitisInsomniaBack PainDehydrationAnaemia
Abdominal PainVomitingDyspnoeaAnxietyDepressionDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Promethazine and Cyclobenzaprine
- group for people who take Cyclobenzaprine Hydrochloride
- group for people who take Promethazine

Comments from related studies:

  • From this study (10 months ago):

  • Please help me, I don't know if it is my age or if it is all of this medication and suppliments I am taking but here over the last few month my health has been deterating.


  • From this study (1 year ago):

  • I was in a car accident in 2000. My lower back was trashed, and had to be reconstructed basically. I have fusions and titanium, all of this as causd many other health problems to arise over the last 10 years. But, I live a pretty normal life, most people don't even know there is anything wrong with me. : )

    Ultracet and Ultram, any drug from that family can be very dangerous, I had a serious reaction with Ultracet. I had 3 seizures before we figured out what was happening to me.

    Solu-Medrol was used in the hospital through my IV, for a complicated migraine problem. I do not know if I had some kind of allergic reaction to it, or if that drug just does that to people, but, I was ripping the IV out of my arm! I couldn't stand it! It felt like fire ants were under every inch of my skin crawling and biting me all the way down and back up my arms and legs! It took hours to stop, and it did not help the migraine either.


    Allergic... on Mar, 6, 2013:

    allergic reaction to vancomycin and sulfamethoxazole....
    I was given vancomycin through an iv 2 days ago. Today I decided to take some sulfamethoxazole and the allergic reaction is unbearable. It's been 4 hrs and the burning aching hasn't stopped. How did u manage to stop the allergic reaction. I'm wondering if I should wait it out or go into er.


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More reviews for: Cyclobenzaprine Hydrochloride, Promethazine

Complete drug side effects:

On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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