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Review: Promethazine and Cyclobenzaprine





Summary: drug interactions are reported among people who take Promethazine and Cyclobenzaprine together.

This review analyzes the effectiveness and drug interactions between Promethazine and Cyclobenzaprine. It is created by eHealthMe based on reports of 859 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Promethazine and Cyclobenzaprine >>>

What are the drugs

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (view latest outcomes from 1,213 users)

Cyclobenzaprine hydrochloride has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Cyclobenzaprine hydrochloride 2,373 users)

On Nov, 26, 2014: 859 people who take Promethazine, Cyclobenzaprine Hydrochloride are studied

Promethazine, Cyclobenzaprine Hydrochloride outcomes

Drug combinations in study:
- Promethazine (promethazine hydrochloride)
- Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Promethazine is effective11.11%
(1 of 9 people)
50.00%
(3 of 6 people)
100.00%
(1 of 1 people)
50.00%
(2 of 4 people)
71.43%
(5 of 7 people)
100.00%
(3 of 3 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
Cyclobenzaprine Hydrochloride is effective25.00%
(2 of 8 people)
25.00%
(1 of 4 people)
0.00%
(0 of 2 people)
16.67%
(1 of 6 people)
0.00%
(0 of 5 people)
50.00%
(3 of 6 people)
100.00%
(3 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainPainMuscle OedemaShort-term Memory LossBack PainErection ProblemsHeart Rate IncreasedPain
NauseaPulmonary EmbolismArterial Thrombosis LimbFlatulenceNauseaSkin StriaeAnxiety AggravatedBack Pain
Cholecystitis ChronicDisease ProgressionEjection Fraction DecreasedDrowsinessPyrexiaInsomniaAnxiety
Pulmonary EmbolismDeathDyspnoeaSinus TachycardiaAbdominal Pain UpperNausea
Suicide AttemptDrowsinessHaemoglobin DecreasedLong-term Memory LossAbdominal Pain LowerHeadache
Abdominal Pain UpperBurning Mouth SyndromeAbdominal Wall HaematomaBreast TendernessPainChest Pain
Gallbladder CholesterolosisSuicide AttemptBack PainFatigueVomitingVomiting
Food IntoleranceIntentional OverdoseBursitisBiliary ColicPain In Extremity
DeathDepressionTibia FracturePancreatitis ChronicFall
DepressionSwollen TongueAtrioventricular Block CompleteDrowsinessOsteonecrosis Of Jaw

Drug effectiveness by gender :

FemaleMale
Promethazine is effective51.72%
(15 of 29 people)
60.00%
(3 of 5 people)
Cyclobenzaprine Hydrochloride is effective24.14%
(7 of 29 people)
60.00%
(3 of 5 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
Back PainAnxiety
AnxietyNausea
NauseaConstipation
HeadacheAsthenia
Chest PainOsteoporosis
Pain In ExtremityOsteoarthritis
FallVomiting
VomitingHypotension
Osteonecrosis Of JawDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Promethazine is effectiven/an/a100.00%
(1 of 1 people)
40.00%
(2 of 5 people)
28.57%
(4 of 14 people)
45.45%
(5 of 11 people)
20.00%
(5 of 25 people)
50.00%
(1 of 2 people)
Cyclobenzaprine Hydrochloride is effectiven/an/a100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
14.29%
(2 of 14 people)
33.33%
(4 of 12 people)
8.00%
(2 of 25 people)
0.00%
(0 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aCholecystitisNauseaNauseaPainPainBack Pain
Abdominal Pain UpperHeadacheType 2 Diabetes MellitusDepressionAnxietyOsteomyelitis
CholelithiasisAbdominal Pain UpperAnxietyPain In ExtremityBack PainAnxiety
NauseaCholecystitis ChronicVomitingNauseaDiarrhoeaOsteoarthritis
DyspepsiaBack PainConstipationAbdominal PainOsteoarthritisOsteonecrosis Of Jaw
DiarrhoeaInsomniaPainArthralgiaSinusitisFall
Decreased AppetitePulmonary EmbolismWeight IncreasedChest PainHeadacheWeight Decreased
Gastrooesophageal Reflux DiseaseCholecystitisBack PainOedema PeripheralHypoaesthesiaPain
PancreatitisBronchitisInsomniaBack PainDehydrationAnaemia
Abdominal PainVomitingDyspnoeaAnxietyDepressionDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Promethazine and Cyclobenzaprine?

You are not alone! Join a related mobile support group:
- support group for people who take Promethazine and Cyclobenzaprine
- support group for people who take Cyclobenzaprine Hydrochloride
- support group for people who take Promethazine

Can you answer these questions (Ask a question):

  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Can an im phenergan injection cause neuropathy, where the injection was given?
    I was given a phenergan injection in PACU. Once I was discharged and home, I felt numbness in my leg where the injection was given. I called my MD and was told the numbness was from the position my leg was in during surgery. It has now been 5 months and my upper thigh has neuropathy. Can Phenergan do this?
  • Why would i get copd since i never smoked?
    I have several autoimmune disorders, I was shocked to get the COPD diagnosis since I have never smoked but I had second hand smoke first 23 years of my life.
    My doctor said my Autoimmune Hepatitis and Primary Biliary Cholingitis set me up for COPD.
  • Can phenergan caulse lung problems like pulmary fribrosis (1 answer)
    took these drugs 2 days then 6 months lateri have pulmonary fibrosis is there any connection?
  • My dr. prescribed me phergan. how common is weight gain on this drug?
    A Dr. prescribed me Phenergan and Potassium CL ER today. I read online that Phenergan can cause weight gain. Have any of you been on Phenergan, and if so have you experiences any weight gain or other symptoms I should be made aware of? Thank you in advance.

More questions for: Cyclobenzaprine Hydrochloride, Promethazine

You may be interested at these reviews (Write a review):

  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Fibromyalgia & related health issues (3 responses)
    Fibromyalgia dx after pregnancy of only child at 42/other dx followed and seem to be in conjunction. heart issues did not appear until after the use of fibro meds- cymbalta, lyrica, neurontin, and more. had 1 seizure believed to be related to seretonin syndrome/years and years of mistreatment by doctors. unable to recall how many docs and meds through the years. one other very significant issue- after tooth extraction had puncture to left maxillary sinus-after YEARS of neglect by docs, found max. & ethmoid sinus completely opaque on CAT scan. Had surgery. Now, years later, have mucous plug that sporadically comes out upon sneezing. Fairly recent CAT scan shows sinuses again completely opaque. Certain needs further attention, but basically afraid to go through surgery again. Also- may have had heart attack. ER visit said no, but shortly after, had abnormal ekg. Again, neglect from docs. Am now active advocate for fm/chronic pain patients. Disgusted by the whole lack of interest of medical community. Looking for answers through my own research to try to find a way to improve quality of life...
  • Husband died from depakene
    My husband took Depakene and Mysoline (Phenobarital) for 28 years. No hospital or physician checked his ammonia levels during these years. Ammonia levels needed to be checked every 6 months when taking Valproic Acid.



    As the result of no ammonia levels taken, he suffered from moderate severe atrophy of the brain, metabolic system was destroyed, regular system destroyed, 25 diagnoses due to the side effects of Depakene and died one year ago of mitochondrial encephalopathy.
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    Within 15 minutes of taking Savella, the heat starts in my face and the sweating begins unrelentlessly. And the palpitations begin right away and later will be strong enough to wake me from sleep. Its horrible! I cant go anywhere! I cant tolerate any additional heat anywhere! And if I go out, I must bring a towel with me... it overwhelms me! I hate this!!

More reviews for: Cyclobenzaprine Hydrochloride, Promethazine

Comments from related studies:

  • From this study (12 months ago):

  • My wife died (Suicide??)

    Reply

  • From this study (1 year ago):

  • Please help me, I don't know if it is my age or if it is all of this medication and suppliments I am taking but here over the last few month my health has been deterating.

    Reply

  • From this study (2 years ago):

  • I was in a car accident in 2000. My lower back was trashed, and had to be reconstructed basically. I have fusions and titanium, all of this as causd many other health problems to arise over the last 10 years. But, I live a pretty normal life, most people don't even know there is anything wrong with me. : )

    Ultracet and Ultram, any drug from that family can be very dangerous, I had a serious reaction with Ultracet. I had 3 seizures before we figured out what was happening to me.

    Solu-Medrol was used in the hospital through my IV, for a complicated migraine problem. I do not know if I had some kind of allergic reaction to it, or if that drug just does that to people, but, I was ripping the IV out of my arm! I couldn't stand it! It felt like fire ants were under every inch of my skin crawling and biting me all the way down and back up my arms and legs! It took hours to stop, and it did not help the migraine either.

    Reply

    Allergic... on Mar, 6, 2013:

    allergic reaction to vancomycin and sulfamethoxazole....
    I was given vancomycin through an iv 2 days ago. Today I decided to take some sulfamethoxazole and the allergic reaction is unbearable. It's been 4 hrs and the burning aching hasn't stopped. How did u manage to stop the allergic reaction. I'm wondering if I should wait it out or go into er.

    Reply

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Complete drug side effects:

On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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