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Review: Promethazine and Methadone

This review analyzes the effectiveness and drug interactions between Promethazine and Methadone. It is created by eHealthMe based on reports of 390 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Promethazine and Methadone >>>

What are the drugs

Promethazine (latest outcomes from 1,212 users) has active ingredients of promethazine hydrochloride. It is often used in nausea.

Methadone hydrochloride (latest outcomes from 2,819 users) has active ingredients of methadone hydrochloride. It is often used in pain.

On Sep, 22, 2014: 390 people who take Promethazine, Methadone Hydrochloride are studied

Promethazine, Methadone Hydrochloride outcomes

Drug combinations in study:
- Promethazine (promethazine hydrochloride)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Promethazine is effective33.33%
(1 of 3 people)
(2 of 4 people)
(1 of 3 people)
(5 of 6 people)
(1 of 1 people)
(1 of 1 people)
Methadone Hydrochloride is effective50.00%
(3 of 6 people)
(3 of 4 people)
(1 of 2 people)
(1 of 2 people)
(1 of 1 people)
(0 of 3 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Acute Respiratory Distress SyndromeCoeliac Artery Compression SyndromeHepatic NecrosisHeadachesMetastatic NeoplasmHeadachesn/aAnxiety
Drug AbuserConstipationAcute Respiratory Distress SyndromeLymphoedemaPain
ConstipationHepatic NecrosisDrug DependenceLoose ToothNausea
Drug DependencePneumoniaPneumoniaMultiple MyelomaBone Disorder
PneumoniaAcute Respiratory Distress SyndromeCoeliac Artery Compression SyndromeNauseaDepression
Coeliac Artery Compression SyndromeDrug DependenceConstipationOsteoarthritisPyrexia
Cerebral HaemorrhageDrug Withdrawal SyndromeWithdrawal SyndromeOedemaBack Pain
Hepatic NecrosisWithdrawal SyndromePulmonary OedemaObesityAnaemia
ThrombocytopeniaAnaemiaHaemorrhagic AnaemiaKyphosisDental Caries
Intentional OverdoseAnaemia PostoperativeAnaemiaInflammationVomiting

Drug effectiveness by gender :

Promethazine is effective73.33%
(11 of 15 people)
(0 of 3 people)
Methadone Hydrochloride is effective50.00%
(8 of 16 people)
(2 of 3 people)

Most common drug interactions by gender * :

Back PainBone Disorder
Bone DisorderAnxiety
Urinary Tract InfectionErythema
Weight DecreasedPain In Jaw

Drug effectiveness by age :

Promethazine is effectiven/an/a100.00%
(1 of 1 people)
(1 of 6 people)
(6 of 13 people)
(2 of 6 people)
(0 of 1 people)
(1 of 1 people)
Methadone Hydrochloride is effectiven/an/a0.00%
(0 of 1 people)
(2 of 7 people)
(4 of 13 people)
(3 of 6 people)
(0 of 1 people)
(1 of 1 people)

Most common drug interactions by age * :

n/aVasculitis NosPneumonitisNephrogenic Systemic FibrosisHepatic NecrosisDepressionNauseaPain
Skin Lesion NosRenal DisorderDrug AbuserCoeliac Artery Compression SyndromeWeight DecreasedPainBone Disorder
PhotophobiaPancytopeniaNephrolithiasisAcute Respiratory Distress SyndromeAnxietyDepressionAnxiety
Rash NosPerirectal AbscessCholecystitis AcuteDrug Withdrawal SyndromeDyspnoeaAnxietyDental Caries
NauseaObsessive-compulsive DisorderVomitingPneumoniaPyrexiaInjuryOsteomyelitis
Hypertension NosMulti-organ DisorderLeft Ventricular HypertrophyDrug DependencePainAbdominal PainPain In Jaw
Vomiting NosIntestinal HaemorrhageMassNeuropathy PeripheralBack PainFallOsteoarthritis
CellulitisIrritable Bowel SyndromeMobility DecreasedAbdominal PainNauseaArthralgiaAnhedonia
FormicationPneumoniaIntervertebral Disc ProtrusionConstipationImpaired HealingBone DisorderTooth Extraction
Visual Acuity ReducedNephrolithiasisMigraineType 2 Diabetes MellitusChest PainPain In JawAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Promethazine and Methadone?

Comments from related studies:

  • From this study (3 years ago):

  • Havent taken the promethazine just want to know if I should mix it with my other drugs.


Can you answer these questions (what is this?):

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More reviews for: Methadone Hydrochloride, Promethazine

Complete drug side effects:

On eHealthMe, Promethazine (promethazine hydrochloride) is often used to treat nausea. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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