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Review: Propranolol and Zanaflex





Summary: drug interactions are reported among people who take Propranolol and Zanaflex together.

This review analyzes the effectiveness and drug interactions between Propranolol and Zanaflex. It is created by eHealthMe based on reports of 260 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Propranolol and Zanaflex >>>

What are the drugs

Propranolol hydrochloride has active ingredients of propranolol hydrochloride. It is often used in stress and anxiety. (latest outcomes from Propranolol hydrochloride 3,322 users)

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 7,305 users)

On Nov, 29, 2014: 260 people who take Propranolol Hydrochloride, Zanaflex are studied

Propranolol Hydrochloride, Zanaflex outcomes

Drug combinations in study:
- Propranolol Hydrochloride (propranolol hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Propranolol Hydrochloride is effective0.00%
(0 of 1 people)
57.14%
(4 of 7 people)
100.00%
(2 of 2 people)
0.00%
(0 of 4 people)
100.00%
(2 of 2 people)
n/an/a0.00%
(0 of 1 people)
Zanaflex is effective50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
57.14%
(4 of 7 people)
n/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HypotensionInjuryDrowsinessRapid Deep Breathing (hyperventilation)Migrainen/aRapid Deep Breathing (hyperventilation)Pain
DysphagiaDepressionFlatulenceDeathHeadacheExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
Spinal OsteoarthritisAnhedoniaFatigueRheumatoid ArthritisHeart Rate DecreasedWeight Gain - UnintentionalNausea
Muscle SpasmsAnxietySeromaDehydrationGlomerular Filtration Rate DecreasedHeadache
Tongue SpasmEmotional DistressShort-term Memory LossExhaustion, Fatigue, Lethargy, Tiredness, WearinessGastric UlcerAnxiety
Muscle TwitchingPathological GamblingShort-term Memory LossDiarrhoeaArthralgia
Loss Of ConsciousnessObsessive-compulsive DisorderConfusionDiverticulitisAgitation
Blood Pressure IncreasedPainWeight Gain - UnintentionalNauseaInsomnia
OverdoseFearFatigueVulvovaginal Burning SensationHypertension
Sinus ArrestIron Deficiency AnaemiaWeight DecreasedVomiting

Drug effectiveness by gender :

FemaleMale
Propranolol Hydrochloride is effective38.46%
(5 of 13 people)
75.00%
(3 of 4 people)
Zanaflex is effective33.33%
(5 of 15 people)
40.00%
(2 of 5 people)

Most common drug interactions by gender * :

FemaleMale
PainHeadache
DepressionNausea
NauseaDepression
AnxietyPain
MigraineHypertension
PyrexiaDrug Dependence
AgitationDrug Withdrawal Syndrome
HeadacheDisturbance In Attention
ArthralgiaArthralgia
InsomniaVomiting

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Propranolol Hydrochloride is effectiven/an/an/a100.00%
(3 of 3 people)
13.33%
(2 of 15 people)
4.88%
(2 of 41 people)
20.00%
(1 of 5 people)
0.00%
(0 of 3 people)
Zanaflex is effectiven/an/an/a75.00%
(3 of 4 people)
0.00%
(0 of 15 people)
7.14%
(3 of 42 people)
16.67%
(1 of 6 people)
0.00%
(0 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aHypotensionFatiguePainDepressionFallHeadache
ArthralgiaAnxietyAgitationPainInsomniaNausea
WeaknessWeight IncreasedHeadacheHeadachePainGlomerular Filtration Rate Decreased
Urinary Tract InfectionDepressionArthralgiaDrug DependenceDepressionBlood Triglycerides Abnormal
Difficulty In WalkingTremorAnxietyArthralgiaDrug IneffectiveHeart Rate Decreased
OverdoseHypertensionVision BlurredNauseaCarpal Tunnel SyndromeDiverticulitis
Drug Administration ErrorHeart Rate IrregularMigraineConstipationDehydrationDiarrhoea
General Physical Health DeteriorationChest PainNauseaFallWeight IncreasedColitis Ulcerative
FatigueMalaiseAccidental OverdoseInsomniaAngina PectorisDehydration
FibromyalgiaDrug DependenceVomitingOsteoporosisMigraine

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Propranolol and Zanaflex?

You are not alone! Join a related mobile support group:
- support group for people who take Propranolol and Zanaflex
- support group for people who take Propranolol Hydrochloride
- support group for people who take Zanaflex

Can you answer these questions (Ask a question):

  • Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
    1)Coughing up Mucus
    2)Shortness of Breath
    3)Tightness in the Chest"

    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos
  • I am on propranolol 10mg 3tad i now have a stomach bug and have been prescribed vancomycin, is it safe to take both together
    I have a very bad stomach bug, can this be caused by use propranolol, and is it safe and will the vancomycin work, while i am taken propranolol
  • Should i go to the emergency room for severe leg pain. i'm taking propranlol (1 answer)
    Extremely soar legs. Soar throat, swollen thyroid, and headache.;
  • Propranolo & pregabalin - do they produce heart troubles? my meds mix has
    Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!
  • Is it safe to take propranolol with korean ginseng?
    Is it safe to take Propranolol with Korean Ginseng?

More questions for: Propranolol Hydrochloride, Zanaflex

You may be interested at these reviews (Write a review):

  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
  • Extreme tooth sensitivity after 5 years on lyrica
    One year ago, after being on Lyrica for 5 years, I developed extreme tooth sensitivity. It came on very quickly to one tooth, then quickly spread to all of my top front 6 teeth and now the rest of my teeth are sensitive too. When I say sensitive, I mean that I can't even bite a banana using my front teeth!!! I ended up having root canals on my top front 4 teeth and then had to have two of them pulled because even after the root canals, they were extremely sensitive to any sort of touch at all!!! I now have implants for those two teeth and yet the sensitivity continues in the rest of my teeth. The dentist, endodontist, periodontist and family physician can find nothing 'physically' wrong. My gums are healthy. I feel that it is somehow nerve related and that there has been some damage done. I can not even form words properly because my tongue hits the back of my front teeth as I talk (which is normal), but even THAT causes me pain. I have to constantly use Tylenol and Advil (although they really don't give me any relief.) I have gone through no less than 20 tubes of Orajel and Ambesol in the past year. It is pretty much the only thing that gives me any sort of relief. It has completely affected my quality of life, (as if the reason I needed the Lyrica in the first place didn't already do that enough!!) I am confident that it is the Lyrica as I can find no other literature on the Propranolol causing any side effects such as this. I am a very fit, active lady. I happen to have P.O.T.S which is why I am on the Beta Blocker and Lyrica in the first place. I sure hope that if I stop taking the Lyrica, the sensitivity will decrease. At this rate, I'm going to lose all of my teeth! Incidentally, two of my otherwise healthy teeth now feel wiggly as well! Up until recently, I had only typical, age related dental issues. My dentist is perplexed as to what is going on with me. This is so frustrating!
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Zopiclone causing sweating and memory loss
    Been on 10mg Zopivane for probably 5 - 10 years. In 2013 migrated to 15mg Zopiclone. Previously experienced hot flashes 3 times a week and in 2013 has increased to 3 to 5 times a night. Usually I have 3 hours sleep, then after midnight the flashed start. In the morning there are sopping wet clothes all around my bed. Doctor has prescribed a beta blocker to alleviate the sweats, but there is no change. Short term memory is poor - could the Z pill be causing this?
  • Chills while on tizanidine
    Extremely sensitive to cold and have chills several times a day

More reviews for: Propranolol Hydrochloride, Zanaflex

Comments from related studies:

  • From this study (3 months ago):

  • History of comets Pancreas divisum, chronic & recurrent acute pancreatitis, gastric bile reflux
    20+ ERCP/panc stents/sphincterotomies
    Numerous hospitalizations
    Cholecystectomy, appendectomy
    Total Pancretectomy with auto islet cell transplant/splenectomy
    Sub colectomy (80% of colon removed)
    Roux en y
    Small bowel obstruction surgery
    Prior GJ tube placement with feedings
    Prior TPN feedings
    Line sepsis from picc line
    Kidney hydronephrosis due to adhesions around ureter
    Picc line migrated into heart with thrombi at the tip-removed ASAP

    Reply

  • From this study (8 months ago):

  • Cerebral palsy- hemiplegic/temporal lobe seizures, migraines, insomnia, depressed, sad, in pain all day. I have no intention of intention of wanting to do anything except stay in bed and sleep and I'm never hungry.

    Reply

  • From this study (2 years ago):

  • Have started getting petechiae and blood blisters on my forearms.

    Reply

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Complete drug side effects:

On eHealthMe, Propranolol Hydrochloride (propranolol hydrochloride) is often used to treat migraine. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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