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Review: taking Pseudoephedrine and Hydroxyzine together

Summary: drug interactions are reported among people who take Pseudoephedrine and Hydroxyzine together.

This review analyzes the effectiveness and drug interactions between Pseudoephedrine and Hydroxyzine. It is created by eHealthMe based on reports of 54 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Pseudoephedrine and Hydroxyzine >>>

On Mar, 29, 2015: 54 people who take Pseudoephedrine Hydrochloride, Hydroxyzine are studied

Pseudoephedrine Hydrochloride, Hydroxyzine outcomes

Drug combinations in study:
- Pseudoephedrine Hydrochloride (pseudoephedrine hydrochloride)
- Hydroxyzine (hydroxyzine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pseudoephedrine Hydrochloride is effective0.00%
(0 of 2 people)
(1 of 1 people)
(1 of 2 people)
Hydroxyzine is effective33.33%
(1 of 3 people)
(1 of 3 people)

Drug effectiveness by gender :

Pseudoephedrine Hydrochloride is effective50.00%
(2 of 4 people)
(0 of 1 people)
Hydroxyzine is effective50.00%
(2 of 4 people)
(0 of 2 people)

Drug effectiveness by age :

Pseudoephedrine Hydrochloride is effectiven/a0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 3 people)
(1 of 4 people)
Hydroxyzine is effectiven/a100.00%
(1 of 1 people)
(1 of 2 people)
(0 of 3 people)
(0 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Pressure FluctuationLoss Of Control Of LegsLoss Of Control Of Legsn/an/an/an/aPruritus
Cerebral InfarctionTremorTremorCondition Aggravated
Rash ErythematousSerotonin SyndromeSerotonin SyndromeAnxiety
ConvulsionSweating - ExcessiveSweating - ExcessivePain
Sickle Cell AnaemiaHeadache
Herpes Zoster OphthalmicFatigue

Most common drug interactions by gender * :

NauseaCondition Aggravated
PainDiabetes Mellitus
FatigueTonsillar Hypertrophy
AgitationPharyngolaryngeal Pain
InsomniaBlood Cholesterol Increased
Back PainDyslipidaemia

Most common drug interactions by age * :

n/an/aBenign Intracranial HypertensionMigraine NosHeadachePruritusCerebral InfarctionAbnormal Dreams
Menstruation IrregularRash GeneralisedNauseaRash ErythematousFrustration
Impaired HealingHypotensionDermatitis NosPruritusAgitation
HaemoperitoneumOptic Nerve DisorderSinusitis NosHerpes Zoster OphthalmicAnger
NauseaHyperhidrosisBlood Cholesterol IncreasedConvulsionMood Altered
PhotophobiaVisual ImpairmentAnorexiaEncephalopathyDyspnoea
MenorrhagiaFatigueGait Abnormal NosSickle Cell AnaemiaAlanine Aminotransferase Increased
Paraesthesia NecAnxietyAnxietyPainBlood Potassium Decreased
Vaginal HaemorrhageCoughSleep Apnoea SyndromeHeadacheAspartate Aminotransferase Increased
Ectopic PregnancyNasopharyngitisStress Urinary IncontinenceToxic Epidermal NecrolysisBlood Bilirubin Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Hydroxyzine
- support group for people who take Pseudoephedrine Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Pseudoephedrine Hydrochloride (pseudoephedrine hydrochloride) is often used to treat nasal congestion. Hydroxyzine (hydroxyzine hydrochloride) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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