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Review: Remeron and Benadryl

This review analyzes the effectiveness and drug interactions between Remeron and Benadryl. It is created by eHealthMe based on reports of 457 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Remeron and Benadryl >>>

What are the drugs

Remeron (latest outcomes from 12,833 users) has active ingredients of mirtazapine. It is often used in depression.

Benadryl (latest outcomes from 29,335 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Aug, 25, 2014: 457 people who take Remeron, Benadryl are studied

Remeron, Benadryl outcomes

Drug combinations in study:
- Remeron (mirtazapine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Remeron is effective0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(1 of 1 people)
(0 of 1 people)
(0 of 1 people)
Benadryl is effective0.00%
(0 of 3 people)
(0 of 1 people)
(0 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HypotensionDeathMalignant Neoplasm ProgressionHeart Rate AbnormalObstruction GastricPanic Attacksn/aPain
Oedema PeripheralHypotensionColon Cancer MetastaticSleep DisorderFlank PainPitting OedemaAnxiety
HaematomaVentricular ExtrasystolesCalculus UrethralSleep DisorderDepression
Gastrointestinal HaemorrhageSinus TachycardiaPainConstipationDiarrhoea
HyperglycaemiaMyocardial InfarctionPancreatitisDepressionDyspnoea
HyperhidrosisElectrocardiogram AbnormalUrethral StenosisInitial InsomniaBone Disorder
HypoxiaColitis IschaemicType 2 Diabetes MellitusBreathlessnessBack Pain
HypocalcaemiaAcute Myocardial InfarctionPancreatitis AcuteAbdomen - SwollenOsteoarthritis
EndocarditisWeight IncreasedFatigue
DyspnoeaOsteonecrosis Of Jaw

Drug effectiveness by gender :

Remeron is effective33.33%
(2 of 6 people)
(0 of 1 people)
Benadryl is effective0.00%
(0 of 5 people)
(0 of 1 people)

Most common drug interactions by gender * :

Bone DisorderDyspnoea
Back PainConfusional State
OsteoarthritisDecreased Appetite
VomitingWeight Decreased

Drug effectiveness by age :

Remeron is effectiven/an/an/a0.00%
(0 of 2 people)
(2 of 9 people)
(0 of 1 people)
(0 of 1 people)
Benadryl is effectiven/a0.00%
(0 of 1 people)
(0 of 1 people)
(0 of 9 people)
(0 of 1 people)

Most common drug interactions by age * :

Weight Increasedn/aNauseaAnxietyDyspnoeaDepressionAnxietyPeriodontal Disease
Suicide AttemptDepressionGeneral Physical Health DeteriorationAnxietyPainPainOsteoarthritis
Suicidal IdeationHallucinationInjurySuicidal IdeationAnxietyEmotional DistressBone Disorder
NephrolithiasisAbdominal PainPainDepressionBack PainAnhedoniaOsteopenia
Obstruction GastricVomitingEmotional DistressDehydrationFallCoughHyponatraemia
Urethral StenosisSuicidal IdeationPulmonary EmbolismPainDiabetes MellitusInjuryDiarrhoea
Type 2 Diabetes MellitusConfusional StatePancreatitisVomitingNauseaDiscomfortCandidiasis
PancreatitisHypokalaemiaHepatitis FulminantArthralgiaDyspnoeaOsteonecrosis Of JawWeight Decreased
Self-injurious IdeationCaecitisBlood Iron IncreasedBack PainDiarrhoeaBack PainSwollen Tongue
PyrexiaBack PainWeight DecreasedWeight IncreasedPain In ExtremityDiarrhoeaPruritus

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Remeron and Benadryl?

Get connected! Join a mobile support group:
- group for people who take Remeron and Benadryl
- group for people who take Benadryl
- group for people who take Remeron

Comments from related studies:

  • From this study (8 months ago):

  • I took 2 bendryl at about 5 am this morning n two at about 5 today in the after noon my only thing is I take remeron n clodine for sleep will I be ok


  • From this study (4 years ago):

  • I would like to know if it is safe to take them together.


Can you answer these questions (what is this?):

More questions for: Benadryl, Remeron

You may be interested at these reviews (what is this?):

  • Patients having false positives while on remeron
    I have had a few patients complain they are failing drug tests for Amphetamines while on remeron, and have claimed to have not used any type of Amphetamine or any (Mixed Salts). These patients are all or were on probation, parole, or under some stipulation. Iv realized most of these patients are tak ...

  • 91 year old when awaken in morning confused
    91 year old with emphysema. Uses Nebulizer 3x daily, oxygen, zocor, levothyroid wakes up in morning increasingly confused. Clears during day.

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Benadryl, Remeron

Complete drug side effects:

On eHealthMe, Remeron (mirtazapine) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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