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Review: taking Risperdal and Trazodone together

Summary: drug interactions are reported among people who take Risperdal and Trazodone together.

This review analyzes the effectiveness and drug interactions between Risperdal and Trazodone. It is created by eHealthMe based on reports of 2,577 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Risperdal has active ingredients of risperidone. It is often used in bipolar disorder. (latest outcomes from 42,220 Risperdal users)

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from 6,651 Trazodone hydrochloride users)

On Feb, 14, 2015: 2,577 people who take Risperdal, Trazodone Hydrochloride are studied

Risperdal, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Risperdal (risperidone)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Risperdal is effective25.00%
(2 of 8 people)
(1 of 12 people)
(0 of 4 people)
(1 of 7 people)
(3 of 7 people)
(2 of 5 people)
(2 of 3 people)
(0 of 1 people)
Trazodone Hydrochloride is effective0.00%
(0 of 2 people)
(4 of 10 people)
(0 of 7 people)
(4 of 8 people)
(2 of 5 people)
(4 of 6 people)
(2 of 4 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Type 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes Mellitus
InsomniaDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusNeuropathy PeripheralType 2 Diabetes MellitusType 2 Diabetes Mellitus
Renal FailureNauseaNeuropathy PeripheralPancreatitisObesityWeight IncreasedDiabetic NeuropathyWeight Increased
Diabetes MellitusNeuropathy PeripheralBlood Cholesterol IncreasedWeight IncreasedBlood Cholesterol IncreasedDiabetes MellitusGastric UlcerBlood Cholesterol Increased
HallucinationHyperglycaemiaBack PainBlood Cholesterol IncreasedWeight IncreasedBlood Triglycerides IncreasedNeuropathy PeripheralDepression
SomnolenceHyperlipidaemiaHyperglycaemiaHyperlipidaemiaNeuropathy PeripheralDiabetes Mellitus Inadequate ControlHyperlipidaemiaPancreatitis
HypertensionPancreatitisDiabetic NeuropathyPainDiabetes Mellitus Inadequate ControlHyperlipidaemiaHyperglycaemiaDiabetes Mellitus Inadequate Control
Musculoskeletal PainVomitingBlood Triglycerides IncreasedTardive DyskinesiaHyperlipidaemiaObesityExhaustion, Fatigue, Lethargy, Tiredness, WearinessSuicidal Ideation
PancreatitisDiabetic NeuropathyHyperlipidaemiaObesityThrombosisBlood Cholesterol IncreasedAdverse Drug ReactionNeuropathy Peripheral
Pancreatitis AcuteType 1 Diabetes MellitusSpinal Column StenosisBlood Triglycerides IncreasedBlood Triglycerides IncreasedDiabetic KetoacidosisBlood Cholesterol IncreasedHyperglycaemia

Drug effectiveness by gender :

Risperdal is effective26.67%
(8 of 30 people)
(3 of 17 people)
Trazodone Hydrochloride is effective37.93%
(11 of 29 people)
(6 of 15 people)

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
Blood Cholesterol IncreasedBlood Cholesterol Increased
PancreatitisDiabetes Mellitus Inadequate Control
Diabetes Mellitus Inadequate ControlSuicidal Ideation
NauseaDiabetic Neuropathy
ObesityNeuropathy Peripheral
Neuropathy PeripheralFatigue

Drug effectiveness by age :

Risperdal is effectiven/a0.00%
(0 of 2 people)
(1 of 8 people)
(1 of 14 people)
(3 of 10 people)
(3 of 7 people)
(1 of 14 people)
(2 of 20 people)
Trazodone Hydrochloride is effectiven/a0.00%
(0 of 2 people)
(3 of 8 people)
(5 of 14 people)
(4 of 9 people)
(2 of 6 people)
(2 of 11 people)
(1 of 19 people)

Most common drug interactions by age * :

Type 2 Diabetes MellitusAggressionElectrocardiogram Qt ProlongedDiabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusMyocardial Infarction
Diabetes MellitusWeight IncreasedDeliriumType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusFall
Blood Cholesterol IncreasedAgitationTachycardiaSuicidal IdeationBlood Cholesterol IncreasedBlood Cholesterol IncreasedWeight IncreasedNeuroleptic Malignant Syndrome
HypertensionStaringHypotensionVision BlurredObesityNeuropathy PeripheralDiabetic NeuropathyRenal Failure
AggressionSuicidal BehaviourAggressionWeight IncreasedDiabetes Mellitus Inadequate ControlWeight IncreasedDiabetes Mellitus Inadequate ControlSerotonin Syndrome
Neuroleptic Malignant SyndromeScreamingWeight IncreasedDizzinessDepressionDiabetes Mellitus Inadequate ControlDepressionFlushing
HyperlipidaemiaIntentional Self-injuryOverdoseMajor DepressionWeight IncreasedDiabetic NeuropathyHyperglycaemiaAsthenia
ConvulsionBipolar DisorderConvulsionBack PainNauseaPancreatitisBlood Cholesterol IncreasedHypotension
Weight IncreasedBiteAgitationPancreatitisPancreatitisObesityInsomniaPyrexia
Drug Administration ErrorConvulsionSuicidal IdeationAbdominal Pain UpperChest PainBack PainChest PainDeath

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Risperdal and Trazodone?

You are not alone! Join a related mobile support group:
- support group for people who take Risperdal and Trazodone
- support group for people who take Risperdal
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Risperdal, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • Pain meds that cause insomnia
    I currently take 7.5 mg of Vicoprofen for pain for my Anklyosing Spondylitis. I have tried Vicodin and Norco previously, but nothing worked as well as the Vicoprofen. I have never had to up my dosage and I am still getting the same level of relief as I was when I first started it over a year and a half ago. I swear by the Vicoprofen and would recommend it to anyone who has any type of related pain, but, there is one downfall. Every time I take my pain meds I get a huge burst of energy. My pain is usually worst at night, so I have no choice but to take it before bed. More times than not it causes me to suffer extreme insomnia, which is no fun. Up until recently I just suffered through it. I went and saw my primary today and told her about the issues and she suggested I try Trazodone to help ease my mind so I can fall asleep easier and faster. I'm really hoping it works because I don't want to have to switch pain meds because they work so well, but I can't go much longer only getting 2-3 hours of sleep during the week.
    I will wrote another review in a week or so regarding my experience taking the Trazodone with the Vicoprofen.
  • Does paxil use cause lymphoma or other types of cancer
    I have been taking Paxil daily since 1997. For 14 years, I have had severe itching, a constant low grade fever with chills and night sweats. The itching is constant and so extreme that I scratch until the top layer of skin is gone, leaving a large area of scabs. The lymphoma tumors just appeared 6 weeks ago. I was also recently diagnosed with myeloma. I feel that Paxil may be to blame. I do not have a family history of cancer. I have been taking Trazodone at bedtime for 14 years also, which might also be a cause.
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    I trusted a dr who mr that trazodone as safe.inow am impotent . Ease do not prescribe t o men .
  • Long-term use of risperidone and antidepressants
    I have been using Risperdal and antidepressants for 14 years for bipolar disorder. Last month I was diagnosed with adrenal insufficiency and progesterone deficiency. My cholesterol suddenly became high, I was tired all the time and more symptoms relating to my eventual diagnosis of adrenal insufficiency and progesterone deficiency. I must also say that at the same time of starting treatment I stopped using birth control pills. I feel there needs to be caution taken in all of these drugs. They seem to have a severe effect on hormone balance in the body.
  • Hit and miss sleep with dextroamphetamine
    Started drug 2 months ago and have seen an improvement in my focus. Ziprosidone for my depression causes me to get dead tired by 7 pm. Once I started taking Dextroamphetamine I started having insomnia 2 times a week. I think I would rather sleep early than stay up all night and then try and stay awake at work. So many drugs and even more side effects. Also Trazadone is no help for getting me to sleep. The only good side affect I have seen is I am down 26 pounds.

More reviews for: Risperdal, Trazodone Hydrochloride

Comments from related studies:

  • From this study (4 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Risperdal (risperidone) is often used to treat bipolar disorder. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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