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Review: Ritalin and Benadryl

This review analyzes the effectiveness and drug interactions between Ritalin and Benadryl. It is created by eHealthMe based on reports of 325 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Ritalin and Benadryl >>>

What are the drugs

Ritalin (latest outcomes from 11,171 users) has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder.

Benadryl (latest outcomes from 29,335 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Sep, 10, 2014: 325 people who take Ritalin, Benadryl are studied

Ritalin, Benadryl outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective50.00%
(2 of 4 people)
(4 of 8 people)
(2 of 2 people)
(4 of 8 people)
(4 of 4 people)
(2 of 3 people)
(1 of 1 people)
Benadryl is effective25.00%
(3 of 12 people)
(2 of 2 people)
(0 of 3 people)
(3 of 3 people)
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionDisease RecurrenceSuicidal IdeationIrritabilityDrug Effect DecreasedAortic Valve StenosisFeeling AbnormalChest Pain
AggressionUrticariaVomitingInsomniaFatigueExhaustion, Fatigue, Lethargy, Tiredness, WearinessDisabilityBack Pain
Foaming At MouthMalignant HypertensionTardive DyskinesiaObsessive-compulsive DisorderDry ThroatDizzinessBipolar DisorderDyspnoea
AgitationVomitingAnhedoniaAnhedoniaCoughHeadacheSuicidal BehaviourFatigue
Tardive DyskinesiaCarpal Tunnel SyndromePsychomotor HyperactivityFluid RetentionDry MouthHypertensionOsteonecrosis Of Jaw
DizzinessGastrointestinal HaemorrhageManiaTardive DyskinesiaDecreased AppetiteLearning DisabilitySuicidal Ideation
ApnoeaActivated Partial Thromboplastin Time ProlongedNervousnessDecreased InterestMood SwingsPain In Extremity
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessRenal Artery StenosisDisorientationNasal UlcerMental DisorderDepression
HeadacheSleep DisorderNumbness And TinglingRespiratory FailureCryingFall
BronchospasmUmbilical HerniaDepressionType 2 Diabetes MellitusDepressed MoodMetastases To Bone

Drug effectiveness by gender :

Ritalin is effective76.92%
(10 of 13 people)
(9 of 17 people)
Benadryl is effective66.67%
(8 of 12 people)
(2 of 13 people)

Most common drug interactions by gender * :

FatigueBipolar Disorder
Chest PainDisability
DyspnoeaFeeling Abnormal
Back PainAgitation
ArthralgiaLearning Disability
Osteonecrosis Of JawMental Disorder
Pain In ExtremitySuicidal Behaviour
Intervertebral Disc DegenerationCrying
Metastases To BoneSuicidal Ideation
FallDepressed Mood

Drug effectiveness by age :

Ritalin is effectiven/a25.00%
(1 of 4 people)
(6 of 10 people)
(3 of 5 people)
(3 of 11 people)
(2 of 23 people)
(1 of 2 people)
(3 of 3 people)
Benadryl is effectiven/a25.00%
(1 of 4 people)
(3 of 9 people)
(0 of 4 people)
(2 of 6 people)
(0 of 23 people)
(1 of 2 people)
(3 of 3 people)

Most common drug interactions by age * :

AggressionUrticariaWeight IncreasedMouth UlcerationMemory ImpairmentAnxietySomnolenceBack Pain
ConvulsionGastrointestinal HaemorrhageSuicidal IdeationDeep Vein ThrombosisAstheniaDepressionSuicidal IdeationFatigue
PneumoniaActivated Partial Thromboplastin Time ProlongedDiabetes MellitusMalaiseFatiguePain In ExtremityDepressionMetastases To Bone
Diabetic ComplicationInfusion Related ReactionAggressionLactic AcidosisGait DisturbanceGastrooesophageal Reflux DiseaseGun Shot WoundArthritis
Cholecystitis ChronicMastoiditisDystoniaGastrooesophageal Reflux DiseaseHypoaesthesiaPainFeeling AbnormalWeight Decreased
DyspnoeaConvulsionDrug IneffectiveDiabetes MellitusDyspnoeaBladder DisorderChest PainArthralgia
BradycardiaAbdominal PainAngerOral HerpesParaesthesiaFallAnxietyOsteonecrosis Of Jaw
HypotensionCarpal Tunnel SyndromeHepatic SteatosisPalpitationsConfusional StatePyrexiaBipolar DisorderChronic Obstructive Pulmonary Disease
Renal ImpairmentDisease RecurrenceAgitationOedema PeripheralVision BlurredSuicidal IdeationVision BlurredOsteoporosis
TremorAgitationIrritabilityLacrimation IncreasedConvulsionNauseaInsomniaOsteosclerosis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Ritalin and Benadryl?

Get connected! Join a mobile support group:
- group for people who take Ritalin and Benadryl
- group for people who take Benadryl
- group for people who take Ritalin

Comments from related studies:

  • From this study (12 months ago):

  • I often combine all of these at once. changing doses frequently!


  • From this study (2 years ago):

  • Was feeling ill with headache and stomach upset for several days, then drank about 4 mixed drinks and started vomiting violently and shaking and was losing consciousness, still dizzy and achy and nausea and confusion two days later.


  • From this study (5 years ago):

  • can clonodine and benadryl be taken together


Can you answer these questions (what is this?):

  • Can you split the tablet of limitical 200mg?
    I have taken 150mg or 200mg of lamitical for 25 years. I am now spliting the 200 tablet in half to make 300mg. Started sweating big time.

  • Is it safe to take unisom on top of vyvanse
    I have took 5 ritalin 20mg and 2 30 mg vyvanse since early this morning. It is now 1:00in the morning, I'm very tired. I have 2 toddlers that I have to take carevof. Just wanting to know if it is ok to take some unison now so I can get some sleep

  • Concerta and extreme rage
    My 18yr old son has been on 54mg of Concerta for 5+ years now, he suddenly started complaining to me that he was not feeling that it slowed him down like usual to concentrate ect he said it made him depressed down. He stopped taking it for over 3 weeks, then randomly yesterday he decided to take it ...

More questions for: Benadryl, Ritalin

You may be interested at these reviews (what is this?):

  • Seroquel made me weird, indifferent to everything.
    With constant anxiety. I found myself not wanting to be nice to my family, hearting them and seeing the consecuences later , rather than before. I remember wearing a wig to the nutritionist, "just because".

  • Temporal lobe epilepsy in concerta
    My son is 8 years old and has ADHD with severe hyperactivity and impulsivity. He has been on meds since he was 5. We started with Foculin, switched to Daytrana patch and just recently (with the help of his Psychiatrist) decided to try Concerta. We stopped the Daytrana and began titration onto Conc ...

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Benadryl, Ritalin

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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