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Review: taking Ritalin and Benadryl together

Summary: drug interactions are reported among people who take Ritalin and Benadryl together.

This review analyzes the effectiveness and drug interactions between Ritalin and Benadryl. It is created by eHealthMe based on reports of 326 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 29, 2015: 326 people who take Ritalin, Benadryl are studied

Ritalin, Benadryl outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective50.00%
(2 of 4 people)
(4 of 8 people)
(2 of 2 people)
(4 of 8 people)
(4 of 4 people)
(2 of 3 people)
(1 of 2 people)
Benadryl is effective25.00%
(3 of 12 people)
(2 of 2 people)
(0 of 3 people)
(3 of 3 people)
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(2 of 2 people)

Drug effectiveness by gender :

Ritalin is effective71.43%
(10 of 14 people)
(9 of 17 people)
Benadryl is effective69.23%
(9 of 13 people)
(2 of 13 people)

Drug effectiveness by age :

Ritalin is effectiven/a25.00%
(1 of 4 people)
(6 of 10 people)
(3 of 5 people)
(3 of 11 people)
(2 of 23 people)
(1 of 15 people)
(3 of 3 people)
Benadryl is effectiven/a25.00%
(1 of 4 people)
(3 of 9 people)
(0 of 4 people)
(2 of 6 people)
(0 of 23 people)
(2 of 15 people)
(3 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionDisease RecurrenceSuicidal IdeationIrritabilityDrug Effect DecreasedAortic Valve StenosisFeeling AbnormalChest Pain
AggressionUrticariaVomitingInsomniaFatigueExhaustion, Fatigue, Lethargy, Tiredness, WearinessDisabilityBack Pain
Foaming At MouthMalignant HypertensionTardive DyskinesiaObsessive-compulsive DisorderDry ThroatDizzinessBipolar DisorderDyspnoea
AgitationVomitingAnhedoniaAnhedoniaCoughHeadacheSuicidal BehaviourPain In Extremity
Tardive DyskinesiaCarpal Tunnel SyndromePsychomotor HyperactivityFluid RetentionDry MouthHypertensionFatigue
DizzinessGastrointestinal HaemorrhageManiaTardive DyskinesiaDecreased AppetiteLearning DisabilityDepression
ApnoeaActivated Partial Thromboplastin Time ProlongedNervousnessDecreased InterestMood SwingsSuicidal Ideation
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessRenal Artery StenosisDisorientationNasal UlcerMental DisorderOsteonecrosis Of Jaw
HeadacheSleep DisorderNumbness And TinglingRespiratory FailureCryingMetastases To Bone
BronchospasmUmbilical HerniaDepressionType 2 Diabetes MellitusDepressed MoodFall

Most common drug interactions by gender * :

FatigueBipolar Disorder
Chest PainDisability
DyspnoeaFeeling Abnormal
Back PainAgitation
ArthralgiaLearning Disability
Pain In ExtremityMental Disorder
Osteonecrosis Of JawSuicidal Behaviour
Metastases To BoneCrying
Vision BlurredSuicidal Ideation
Intervertebral Disc DegenerationDepressed Mood

Most common drug interactions by age * :

ConvulsionUrticariaWeight IncreasedMouth UlcerationMemory ImpairmentAnxietyDepressionBack Pain
AggressionGastrointestinal HaemorrhageDiabetes MellitusDeep Vein ThrombosisAstheniaDepressionSomnolenceFatigue
Nervous System DisorderActivated Partial Thromboplastin Time ProlongedSuicidal IdeationMalaiseFatiguePain In ExtremitySuicidal IdeationMetastases To Bone
HypotensionInfusion Related ReactionAggressionLactic AcidosisGait DisturbanceGastrooesophageal Reflux DiseaseBipolar DisorderArthritis
OrthopnoeaMastoiditisAngerGastrooesophageal Reflux DiseaseHypoaesthesiaPainGun Shot WoundWeight Decreased
PneumoniaConvulsionDystoniaDiabetes MellitusDyspnoeaBladder DisorderChest PainArthralgia
TremorAbdominal PainDrug IneffectiveOral HerpesParaesthesiaFallDrug DependenceOsteonecrosis Of Jaw
Renal ImpairmentCarpal Tunnel SyndromeHepatic SteatosisPalpitationsConfusional StatePyrexiaFeeling AbnormalChronic Obstructive Pulmonary Disease
HyponatraemiaDisease RecurrenceAgitationOedema PeripheralVision BlurredSuicidal IdeationVision BlurredOsteoporosis
Pancreatitis AcuteAgitationIrritabilityLacrimation IncreasedConvulsionNauseaInsomniaOsteosclerosis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Benadryl
- support group for people who take Ritalin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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