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Review: taking Ritalin and Benadryl together

Summary: drug interactions are reported among people who take Ritalin and Benadryl together.

This review analyzes the effectiveness and drug interactions between Ritalin and Benadryl. It is created by eHealthMe based on reports of 326 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Ritalin and Benadryl >>>

What are the drugs

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in narcolepsy. (latest outcomes from 11,219 Ritalin users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

On Feb, 27, 2015: 326 people who take Ritalin, Benadryl are studied

Ritalin, Benadryl outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective50.00%
(2 of 4 people)
(4 of 8 people)
(2 of 2 people)
(4 of 8 people)
(4 of 4 people)
(2 of 3 people)
(1 of 2 people)
Benadryl is effective25.00%
(3 of 12 people)
(2 of 2 people)
(0 of 3 people)
(3 of 3 people)
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(2 of 2 people)

Drug effectiveness by gender :

Ritalin is effective71.43%
(10 of 14 people)
(9 of 17 people)
Benadryl is effective69.23%
(9 of 13 people)
(2 of 13 people)

Drug effectiveness by age :

Ritalin is effectiven/a25.00%
(1 of 4 people)
(6 of 10 people)
(3 of 5 people)
(3 of 11 people)
(2 of 23 people)
(1 of 15 people)
(3 of 3 people)
Benadryl is effectiven/a25.00%
(1 of 4 people)
(3 of 9 people)
(0 of 4 people)
(2 of 6 people)
(0 of 23 people)
(2 of 15 people)
(3 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionDisease RecurrenceSuicidal IdeationIrritabilityDrug Effect DecreasedAortic Valve StenosisFeeling AbnormalChest Pain
AggressionUrticariaVomitingInsomniaFatigueExhaustion, Fatigue, Lethargy, Tiredness, WearinessDisabilityBack Pain
Foaming At MouthMalignant HypertensionTardive DyskinesiaObsessive-compulsive DisorderDry ThroatDizzinessBipolar DisorderDyspnoea
AgitationVomitingAnhedoniaAnhedoniaCoughHeadacheSuicidal BehaviourPain In Extremity
Tardive DyskinesiaCarpal Tunnel SyndromePsychomotor HyperactivityFluid RetentionDry MouthHypertensionFatigue
DizzinessGastrointestinal HaemorrhageManiaTardive DyskinesiaDecreased AppetiteLearning DisabilityDepression
ApnoeaActivated Partial Thromboplastin Time ProlongedNervousnessDecreased InterestMood SwingsSuicidal Ideation
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessRenal Artery StenosisDisorientationNasal UlcerMental DisorderOsteonecrosis Of Jaw
HeadacheSleep DisorderNumbness And TinglingRespiratory FailureCryingMetastases To Bone
BronchospasmUmbilical HerniaDepressionType 2 Diabetes MellitusDepressed MoodFall

Most common drug interactions by gender * :

FatigueBipolar Disorder
Chest PainDisability
DyspnoeaFeeling Abnormal
Back PainAgitation
ArthralgiaLearning Disability
Pain In ExtremityMental Disorder
Osteonecrosis Of JawSuicidal Behaviour
Metastases To BoneCrying
Vision BlurredSuicidal Ideation
Intervertebral Disc DegenerationDepressed Mood

Most common drug interactions by age * :

ConvulsionUrticariaWeight IncreasedMouth UlcerationMemory ImpairmentAnxietyDepressionBack Pain
AggressionGastrointestinal HaemorrhageDiabetes MellitusDeep Vein ThrombosisAstheniaDepressionSomnolenceFatigue
Nervous System DisorderActivated Partial Thromboplastin Time ProlongedSuicidal IdeationMalaiseFatiguePain In ExtremitySuicidal IdeationMetastases To Bone
HypotensionInfusion Related ReactionAggressionLactic AcidosisGait DisturbanceGastrooesophageal Reflux DiseaseBipolar DisorderArthritis
OrthopnoeaMastoiditisAngerGastrooesophageal Reflux DiseaseHypoaesthesiaPainGun Shot WoundWeight Decreased
PneumoniaConvulsionDystoniaDiabetes MellitusDyspnoeaBladder DisorderChest PainArthralgia
TremorAbdominal PainDrug IneffectiveOral HerpesParaesthesiaFallDrug DependenceOsteonecrosis Of Jaw
Renal ImpairmentCarpal Tunnel SyndromeHepatic SteatosisPalpitationsConfusional StatePyrexiaFeeling AbnormalChronic Obstructive Pulmonary Disease
HyponatraemiaDisease RecurrenceAgitationOedema PeripheralVision BlurredSuicidal IdeationVision BlurredOsteoporosis
Pancreatitis AcuteAgitationIrritabilityLacrimation IncreasedConvulsionNauseaInsomniaOsteosclerosis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Ritalin and Benadryl on

Do you take Ritalin and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Ritalin and Benadryl
- support group for people who take Benadryl
- support group for people who take Ritalin

Can you answer these questions (Ask a question):

  • I injected suboxone and now i feel weird this is not the first time i done it but the first time my arm is numb all over dizziness purple pinkish splotches all over my arm wat is wrong
    I shot an eighth of suboxone today and now my arm is purplish and red blotches there was no pain during or after injection only numbness dizziness and I can't get my nail nd to go to white it stays red this has never happened before.
  • I tested positive for methadone, i have never taken this drug (1 answer)
    I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
  • Could ritalin cause temporary dementia in elderly
    I had a period of dementia that lasted for the better part of a day. I was brought to the hospital because they thought I was having a stroke. I have no memory of the event until I was in the hospital. I had been prescribed Ritalin because I have become unable to concentrate as well as I once could. That started about ten years ago and it was also had a very sudden onset, after a case of the flu.
    A Psychiatrist prescribed a dosage of Methylphenidate to be taken twice a day. I had a really hectic day ahead and thought that if I took both of them at once, it would help me get through the ordeal. I am under a lot of stress and thought it may help me cope. I have since thrown them out because the condition started about an hour after I took them according to family members. I don't remember the dosage, but I think it was a lower dosage because I had just started taking them on an "as needed basis." The doctor knew that I was going to use them for that purpose. I used them twice before (at the correct dosage) when I had to concentrate on paperwork, etc. They caused irregular heartbeat and a little bit of anxiety, but they did help me concentrate. The hospital tests ruled out a stroke or TIA. My thyroid level was off and the doctor at the hospital told me to stop the thyroid medication (Armour Thyroid) until I could see my family doctor and be retested. This all happened about five days ago. I'm back to what I consider normal now. Could that episode have been caused by the Ritalin?
    Thank you.
  • What is the reaction to vivitrol and ritalin?
    25 year old client in early recovery from opioid dependence takes ritalin and seroquel and wants to add vivitrol. What are the risks and side effects?
  • Does benadryl work for pet dander? (1 answer)
    hi I have been taking Benadryl or pet dander? It seemed to work well even if I only take one tablet. Does anyone also find that taking one tablet does not make you drowsy? How often should I take one tablet of Benadryl which is 25 mg? has anyone found any other allergy medication that work or pet dander? Thank you very much.

More questions for: Benadryl, Ritalin

You may be interested at these reviews (Write a review):

  • A life of depression and fatigue (1 response)
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • A really bad day ritalin+orange juice
    I took Ritaline, then Orange juice. I couldn't do my exam at all...
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.

More reviews for: Benadryl, Ritalin

Comments from related studies:

  • From this study (1 year ago):

  • I often combine all of these at once. changing doses frequently!


  • From this study (2 years ago):

  • Was feeling ill with headache and stomach upset for several days, then drank about 4 mixed drinks and started vomiting violently and shaking and was losing consciousness, still dizzy and achy and nausea and confusion two days later.


  • From this study (5 years ago):

  • can clonodine and benadryl be taken together


Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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