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Review: taking Ritalin and Vicodin together

Summary: drug interactions are reported among people who take Ritalin and Vicodin together.

This review analyzes the effectiveness and drug interactions between Ritalin and Vicodin. It is created by eHealthMe based on reports of 667 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 1, 2015: 667 people who take Ritalin, Vicodin are studied

Ritalin, Vicodin outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Vicodin (acetaminophen; hydrocodone bitartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective36.36%
(4 of 11 people)
(8 of 13 people)
(2 of 10 people)
(4 of 11 people)
(7 of 9 people)
(12 of 13 people)
(2 of 6 people)
(1 of 3 people)
Vicodin is effective36.00%
(9 of 25 people)
(3 of 9 people)
(2 of 4 people)
(3 of 6 people)
(10 of 16 people)
(3 of 6 people)
(2 of 6 people)

Drug effectiveness by gender :

Ritalin is effective57.14%
(32 of 56 people)
(7 of 19 people)
Vicodin is effective44.44%
(24 of 54 people)
(8 of 18 people)

Drug effectiveness by age :

Ritalin is effectiven/an/a0.00%
(0 of 1 people)
(10 of 23 people)
(12 of 42 people)
(9 of 49 people)
(7 of 28 people)
(1 of 11 people)
Vicodin is effectiven/an/a0.00%
(0 of 1 people)
(4 of 19 people)
(13 of 39 people)
(7 of 43 people)
(7 of 27 people)
(1 of 11 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Red FaceCholecystitis ChronicPain In ExtremityRed FaceHigh Blood PressureAnxietyFatiguePain
FatigueTremorDeep Vein ThrombosisBack PainFatigueParanoiaDiarrhoeaDyspnoea
HypotensionNervous System DisorderMental DisorderDeep Vein ThrombosisAbdominal Pain UpperFatigueSuicidal IdeationBack Pain
EmbolismHypotensionChronic Fatigue SyndromePain In ExtremityBiliary Tract DisorderMultiple Drug OverdoseDepression AggravatedFatigue
Malignant MelanomaOrthopnoeaDelusions, MixedMental DisorderPainBipolar DisorderHypersomniaNausea
Back PainRenal ImpairmentHypertensionDry MouthAnhedoniaHallucinationMenstrual DisorderOsteonecrosis Of Jaw
Decreased AppetiteHyponatraemiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessMenorrhagiaGallbladder InjurySuicide AttemptMemory ImpairmentHeadache
Appetite IncreasedPancreatitis AcuteGynaecomastiaSwelling Of The Ankles - Feet - LegsMuscle CrampsIrritable Bowel SyndromeFall
Decreased ActivityPneumoniaAnterograde AmnesiaCoughNumbness And TinglingEczema ExacerbatedConstipation
Bone PainDyspnoeaDysmenorrhoeaNasal UlcerButtock PainThinking SlowedDepression

Most common drug interactions by gender * :

PainBack Pain
Back PainWeight Decreased
Deep Vein ThrombosisChest Pain
Osteonecrosis Of JawAnaemia
NauseaBone Disorder

Most common drug interactions by age * :

n/aAbscess SterileCompleted SuicidePainPainDepressionPainFatigue
Injection Site AbscessPainDeep Vein ThrombosisAnxietyPainFallDyspnoea
VomitingDizzinessConstipationBack PainBack PainGastrointestinal Haemorrhage
Pain In ExtremityInsomniaLung NeoplasmConstipationFatigueBack Pain
AnxietyDyspnoeaNauseaHyperhidrosisNauseaChronic Obstructive Pulmonary Disease
IntussusceptionThrombocytopeniaDecreased InterestPyrexiaBone PainHeadache
NauseaHallucination, AuditoryCellulitisHypertensionDyspnoeaChest Pain
Postoperative AdhesionKeratitisChest PainDyspnoeaTooth InfectionWeight Decreased
Small Intestinal ObstructionInterstitial Lung DiseaseOsteonecrosis Of JawWeight DecreasedDizzinessSwelling

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Ritalin and Vicodin?




You are not alone! Join a related support group:
- support group for people who take Ritalin
- support group for people who take Vicodin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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