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Review: taking Ritalin and Wellbutrin together

Summary: drug interactions are reported among people who take Ritalin and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Ritalin and Wellbutrin. It is created by eHealthMe based on reports of 1,521 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 6, 2015: 1,521 people who take Ritalin, Wellbutrin are studied

Ritalin, Wellbutrin outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective32.26%
(10 of 31 people)
(22 of 56 people)
(11 of 30 people)
(14 of 37 people)
(23 of 50 people)
(17 of 20 people)
(13 of 21 people)
(2 of 4 people)
Wellbutrin is effective11.11%
(2 of 18 people)
(9 of 41 people)
(3 of 26 people)
(14 of 38 people)
(25 of 59 people)
(18 of 36 people)
(16 of 28 people)
(3 of 6 people)

Drug effectiveness by gender :

Ritalin is effective39.88%
(67 of 168 people)
(41 of 78 people)
Wellbutrin is effective36.00%
(63 of 175 people)
(27 of 77 people)

Drug effectiveness by age :

Ritalin is effectiven/an/a42.86%
(9 of 21 people)
(16 of 63 people)
(15 of 110 people)
(38 of 137 people)
(24 of 94 people)
(8 of 43 people)
Wellbutrin is effectiven/an/a26.32%
(5 of 19 people)
(10 of 65 people)
(19 of 109 people)
(29 of 143 people)
(19 of 92 people)
(8 of 37 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDiabetes MellitusDiabetes MellitusIrritabilityAnxietyFatigueDry MouthDepression
HeadacheSuicidal IdeationType 2 Diabetes MellitusCholelithiasisIrritabilityGrand Mal ConvulsionWeight Gain - UnintentionalAnxiety
ManiaConvulsionMemory ImpairmentAnxietyMemory ImpairmentPostictal StateErectile DysfunctionFatigue
InsomniaType 2 Diabetes MellitusNeuropathy PeripheralDepressionDepressionSleep DisorderOverdosePain
Suicidal IdeationAbdominal PainSexual DysfunctionDisturbance In AttentionConfusional StateDrug ToxicityConvulsionBack Pain
DizzinessNeuropathy PeripheralSuicidal IdeationDiverticulumBlood Lactate Dehydrogenase IncreasedBlood Caffeine IncreasedHot FlashesVomiting
Immunocomplex Mediated HypersensitivityAnxietyDeafnessFibrocystic Breast DiseaseDiarrhoeaAnhedoniaExhaustion, Fatigue, Lethargy, Tiredness, WearinessChest Pain
Grand Mal ConvulsionHeadacheChemotherapyCataractDecreased AppetiteVision BlurredGingival BleedingDizziness

Most common drug interactions by gender * :

DizzinessConfusional State
InsomniaDisturbance In Attention
AstheniaVision Blurred

Most common drug interactions by age * :

HyponatraemiaAgitationFatigueCompleted SuicideNauseaDepressionDepressionDepression
HypotensionAggressionGrand Mal ConvulsionSuicidal IdeationDrug IneffectiveAnxietyDizzinessNausea
DyspnoeaVomitingWeight IncreasedTremorAnxietyFatigueNauseaBack Pain
Diabetic ComplicationConvulsionInsomniaDrug DependenceConvulsionNauseaFatiguePain
ConvulsionDisorientationConvulsions NosHallucination, AuditorySuicidal IdeationConstipationAnxietyVomiting
Nervous System DisorderSudden DeathDiabetes MellitusFatigueDiabetes MellitusDizzinessPainFall
OrthopnoeaAbnormal Behaviour NosDrug IneffectiveMood SwingsFatiguePyrexiaAstheniaPain In Extremity
TremorRetchingDecreased AppetiteIrritabilityDepressionBack PainFallConvulsion
Renal ImpairmentMemory ImpairmentRectal HaemorrhageNauseaAbdominal PainPainPain In ExtremityWeight Decreased
PneumoniaUrticaria NosNauseaDepression AggravatedDyspnoeaFallArthralgiaDecreased Appetite

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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