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Review: Ritalin and Wellbutrin

This review analyzes the effectiveness and drug interactions between Ritalin and Wellbutrin. It is created by eHealthMe based on reports of 1,511 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Ritalin and Wellbutrin >>>

What are the drugs

Ritalin (latest outcomes from 11,157 users) has active ingredients of methylphenidate hydrochloride. It is used in attention deficit hyperactivity disorder.

Wellbutrin (latest outcomes from 54,804 users) has active ingredients of bupropion hydrochloride. It is used in depression.

On Aug, 14, 2014: 1,511 people who take Ritalin, Wellbutrin are studied

Ritalin, Wellbutrin outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective33.33%
(10 of 30 people)
(22 of 56 people)
(11 of 28 people)
(14 of 37 people)
(22 of 47 people)
(17 of 19 people)
(13 of 19 people)
(2 of 3 people)
Wellbutrin is effective12.50%
(2 of 16 people)
(9 of 40 people)
(3 of 26 people)
(13 of 37 people)
(25 of 57 people)
(18 of 34 people)
(15 of 27 people)
(2 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDiabetes MellitusDiabetes MellitusCholelithiasisFatigueFatigueDry MouthDepression
FatigueSuicidal IdeationArthralgiaAnxietyAnxietyHypertoniaWeight Gain - UnintentionalNausea
HeadacheInsomniaType 2 Diabetes MellitusIrritabilityIrritabilityGrand Mal ConvulsionIrritabilityAnxiety
ManiaSomnolenceMemory ImpairmentConvulsionMemory ImpairmentPostictal StateConvulsionFatigue
InsomniaConvulsionSexual DysfunctionDeafnessDepressionSleep DisorderOverdosePain
DepressionType 2 Diabetes MellitusSuicidal IdeationChemotherapyDizzinessDrug ToxicityErectile DysfunctionFall
Suicidal IdeationAbdominal PainNeuropathy PeripheralDepressionConfusional StateBlood Caffeine IncreasedExhaustion, Fatigue, Lethargy, Tiredness, WearinessBack Pain
DizzinessAnxietyNauseaDiverticulumBlood Lactate Dehydrogenase IncreasedPainGingival BleedingVomiting
Immunocomplex Mediated HypersensitivityNeuropathy PeripheralDiverticulumCataractDiarrhoeaDizzinessLethargyChest Pain
Grand Mal ConvulsionHypertensionDisturbance In AttentionEndometrial DisorderDecreased AppetiteVision BlurredAlcohol InteractionDizziness

Drug effectiveness by gender :

Ritalin is effective41.77%
(66 of 158 people)
(41 of 78 people)
Wellbutrin is effective36.36%
(60 of 165 people)
(27 of 77 people)

Most common drug interactions by gender * :

DizzinessConfusional State
InsomniaDisturbance In Attention
AstheniaVision Blurred

Drug effectiveness by age :

Ritalin is effectiven/an/a42.86%
(9 of 21 people)
(16 of 61 people)
(15 of 104 people)
(37 of 132 people)
(24 of 79 people)
(8 of 38 people)
Wellbutrin is effectiven/an/a26.32%
(5 of 19 people)
(10 of 63 people)
(18 of 103 people)
(29 of 138 people)
(18 of 77 people)
(7 of 32 people)

Most common drug interactions by age * :

HyponatraemiaAgitationFatigueCompleted SuicideNauseaDepressionDepressionDepression
HypotensionAggressionGrand Mal ConvulsionHallucination, AuditoryAnxietyAnxietyDizzinessBack Pain
DyspnoeaVomitingWeight IncreasedFatigueDrug IneffectiveFatigueNauseaNausea
Diabetic ComplicationConvulsionInsomniaSuicidal IdeationConvulsionNauseaFatigueVomiting
ConvulsionDisorientationConvulsions NosDrug DependenceFatigueConstipationAnxietyPain
Nervous System DisorderSudden DeathDiabetes MellitusTremorSuicidal IdeationPainPainFall
OrthopnoeaAbnormal Behaviour NosDrug IneffectiveIrritabilityDiabetes MellitusDizzinessAstheniaPain In Extremity
TremorRetchingDecreased AppetiteMood SwingsDepressionBack PainFallConvulsion
Renal ImpairmentMemory ImpairmentRectal HaemorrhageAnxiety NecAbdominal PainPyrexiaArthralgiaDecreased Appetite
PneumoniaUrticaria NosNauseaNightmareDyspnoeaFallPain In ExtremityWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Ritalin and Wellbutrin
- group for people who take Ritalin
- group for people who take Wellbutrin

Comments from related studies:

  • From this study (3 months ago):

  • Have reduced level of Concerta about two weeks ago


  • From this study (5 months ago):

  • Wellbutrin Xl-150mg
    Concerta- 72mg


  • From this study (6 months ago):

  • Clonidine is also for helping calm down from the stimulant meds.


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Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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