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Review: taking Ritalin and Zoloft together

Summary: drug interactions are reported among people who take Ritalin and Zoloft together.

This review analyzes the effectiveness and drug interactions between Ritalin and Zoloft. It is created by eHealthMe based on reports of 1,193 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 26, 2015: 1,192 people who take Ritalin, Zoloft are studied

Ritalin, Zoloft outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective25.00%
(3 of 12 people)
(9 of 28 people)
(8 of 16 people)
(11 of 16 people)
(8 of 17 people)
(4 of 10 people)
(9 of 13 people)
(3 of 5 people)
Zoloft is effective20.00%
(1 of 5 people)
(10 of 23 people)
(4 of 19 people)
(7 of 21 people)
(6 of 22 people)
(8 of 16 people)
(3 of 6 people)
(2 of 3 people)

Drug effectiveness by gender :

Ritalin is effective48.10%
(38 of 79 people)
(16 of 35 people)
Zoloft is effective38.55%
(32 of 83 people)
(9 of 31 people)

Drug effectiveness by age :

Ritalin is effectiven/a12.50%
(1 of 8 people)
(9 of 33 people)
(15 of 41 people)
(6 of 34 people)
(15 of 41 people)
(7 of 24 people)
(2 of 4 people)
Zoloft is effectiven/a0.00%
(0 of 7 people)
(7 of 31 people)
(11 of 39 people)
(10 of 30 people)
(8 of 49 people)
(3 of 24 people)
(2 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Serotonin SyndromeAbnormal BehaviourIrritabilityDisturbance In AttentionDepressionSluggishnessTinnitusDepression
Blood Pressure IncreasedDepressionSuicidal IdeationSexual DysfunctionChemotherapyLethargyAphasiaPain
Body Temperature IncreasedInsomniaPersonality ChangeAnxietyCataractYeast Infection - VaginaVertigoFatigue
Liver DisorderHyperhidrosisParanoiaHot FlushDeafnessDiplopiaAnemiaNausea
Alanine Aminotransferase IncreasedDrug IneffectiveAgitationLymphadenopathyDisturbance In AttentionCoughExcessive ThirstAnxiety
TachycardiaMood AlteredMemory ImpairmentMemory ImpairmentEndometrial DisorderHeart RacingBedwettingSuicidal Ideation
TachypnoeaAnxietyHeart PoundingMaculopathyDiverticulumCognitive DeteriorationAltered Visual Depth PerceptionWeight Decreased
MydriasisAttention Deficit/hyperactivity DisorderNauseaFibrocystic Breast DiseaseBreast NecrosisChest Pressure SensationNumbness And TinglingAsthenia
HyperhidrosisEuphoric MoodDepressionEndometrial DisorderBreast MassShortness Of BreathMuscle WeaknessBack Pain
Muscle RigidityImpulsive BehaviourAggressionChemotherapyBack PainHeart PoundingArthralgiaFall

Most common drug interactions by gender * :

Back PainHypertension
Weight DecreasedAggression
Suicidal IdeationNausea

Most common drug interactions by age * :

Pancreatitis AcuteWeight IncreasedWeight IncreasedAnxiety NecInsomniaDepressionPainDepression
DizzinessSuicidal IdeationDepression NecSuicidal IdeationCellulitisAnxietyPain
DyspnoeaAggressionDrug Withdrawal SyndromeIrritabilityPainDepressionVomiting
DysstasiaDrug IneffectiveDrug DependenceNauseaAstheniaFatigueNausea
Eye Movement DisorderFatigueHeadache NosChest PainChest PainArthralgiaAsthenia
Gastric DilatationSuicide AttemptNauseaMemory ImpairmentFallBack PainAnaemia
AggressionAbnormal BehaviourWeight IncreasedVomiting NosWeight DecreasedWeight DecreasedDiarrhoea
HeadacheOverdoseNeck PainAttention Deficit/hyperactivity DisorderNeck PainSomnolenceDehydration
AngerAnxietyAggressionDrug IneffectiveOedema PeripheralNauseaInfection
PapilloedemaAgitationPain In LimbFatigueBack PainAnaemiaCough

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Ritalin
- support group for people who take Zoloft

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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