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Review: Ritalin and Zoloft

This review analyzes the effectiveness and drug interactions between Ritalin and Zoloft. It is created by eHealthMe based on reports of 1,190 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Ritalin and Zoloft >>>

What are the drugs

Ritalin (latest outcomes from 11,152 users) has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder.

Zoloft (latest outcomes from 78,096 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

On Jul, 14, 2014: 1,189 people who take Ritalin, Zoloft are studied

Ritalin, Zoloft outcomes

Drug combinations in study:
- Ritalin (methylphenidate hydrochloride)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ritalin is effective25.00%
(3 of 12 people)
29.63%
(8 of 27 people)
50.00%
(8 of 16 people)
68.75%
(11 of 16 people)
46.67%
(7 of 15 people)
40.00%
(4 of 10 people)
69.23%
(9 of 13 people)
60.00%
(3 of 5 people)
Zoloft is effective20.00%
(1 of 5 people)
45.45%
(10 of 22 people)
21.05%
(4 of 19 people)
30.00%
(6 of 20 people)
28.57%
(6 of 21 people)
50.00%
(8 of 16 people)
50.00%
(3 of 6 people)
66.67%
(2 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Serotonin SyndromeAbnormal BehaviourIrritabilityDisturbance In AttentionDepressionSluggishnessTinnitusDepression
Blood Pressure IncreasedInsomniaSuicidal IdeationSexual DysfunctionChemotherapyLethargyAphasiaPain
Body Temperature IncreasedHyperhidrosisPersonality ChangeAnxietyCataractYeast Infection - VaginaVertigoFatigue
Liver DisorderDrug IneffectiveParanoiaHot FlushDeafnessDiplopiaAnemiaNausea
Alanine Aminotransferase IncreasedDepressionAgitationLymphadenopathyDisturbance In AttentionCoughExcessive ThirstAnxiety
TachycardiaMood AlteredMemory ImpairmentMemory ImpairmentFibrocystic Breast DiseaseHeart RacingBedwettingSuicidal Ideation
TachypnoeaAnxietyHeart PoundingMaculopathyDiverticulumCognitive DeteriorationAltered Visual Depth PerceptionWeight Decreased
MydriasisEuphoric MoodNauseaFibrocystic Breast DiseaseBreast NecrosisChest Pressure SensationNumbness And TinglingAsthenia
HyperhidrosisAttention Deficit/hyperactivity DisorderDepressionEndometrial DisorderBreast DysplasiaShortness Of BreathMuscle WeaknessBack Pain
Muscle RigidityImpulsive BehaviourAggressionChemotherapyBack PainHeart PoundingArthralgiaFall

Drug effectiveness by gender :

FemaleMale
Ritalin is effective48.05%
(37 of 77 people)
44.12%
(15 of 34 people)
Zoloft is effective38.27%
(31 of 81 people)
30.00%
(9 of 30 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
DepressionCellulitis
NauseaAnxiety
FatiguePain
Back PainAggression
Weight DecreasedHypertension
AstheniaAnaemia
FallFatigue
Suicidal IdeationNeck Pain
ArthralgiaOsteonecrosis Of Jaw

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Ritalin is effectiven/a12.50%
(1 of 8 people)
25.81%
(8 of 31 people)
35.00%
(14 of 40 people)
17.65%
(6 of 34 people)
36.59%
(15 of 41 people)
29.17%
(7 of 24 people)
100.00%
(2 of 2 people)
Zoloft is effectiven/a0.00%
(0 of 7 people)
24.14%
(7 of 29 people)
28.95%
(11 of 38 people)
33.33%
(10 of 30 people)
16.33%
(8 of 49 people)
12.50%
(3 of 24 people)
50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pancreatitis AcuteWeight IncreasedWeight IncreasedDepression NecInsomniaDepressionPainDepression
DizzinessSuicidal IdeationAnxiety NecSuicidal IdeationCellulitisAnxietyPain
DyspnoeaAggressionDrug Withdrawal SyndromeIrritabilityPainDepressionVomiting
DysstasiaFatigueHeadache NosNauseaAstheniaFatigueNausea
Eye Movement DisorderDrug IneffectiveDrug DependenceChest PainChest PainArthralgiaDiarrhoea
Gastric DilatationOverdoseNauseaMemory ImpairmentFallBack PainAnaemia
AggressionSuicide AttemptNeck PainVomiting NosWeight DecreasedWeight DecreasedAsthenia
HeadacheAnxietyPain In LimbAttention Deficit/hyperactivity DisorderNeck PainSomnolenceDehydration
AngerAgitationWeight IncreasedDrug IneffectiveOedema PeripheralNauseaBack Pain
PapilloedemaAbnormal BehaviourSuicidal IdeationFatigueBack PainAnaemiaInfection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Ritalin and Zoloft
- group for people who take Ritalin
- group for people who take Zoloft

Comments from related studies:

  • From this study (7 months ago):

  • Also diagnosed with myasthenia gravis. Not treated with meds

    Reply

  • From this study (1 year ago):

  • Kevin Peters Ph.d on Mar, 4, 2013:

    Sammy, I'm a white 45 male; just wanted to agree on that Klonopin remark. When I was 21 I had my second kidney transplant which was a BAD issue all together, at any rate the hospital did not include my medications taken at home after my surgery. I went thru the worst hallucinations and jerking and seizures you could ever possibly imagine. This went on for almost 3 1/2 weeks before we decided to have me taken OUT of the hospital and relocated before they ended up taking my life. Then the whole staff of paychology including the chief of psychiatry cane in my room to see what they could do, Finallu. During one of my few moments of clarity the C.O.F after blaming me if talking "drugs" prior to my transplant listened to my word of telling him the meds I was on before being admitted. After asking when was the last time I had received my Klonopin and me not knowing, he then reviewed the charts, and didn't see me receiving this med once. He stormed out of the room of about 9 docs and came back in with two Klonopin; for the first time in almost 4 weeks and after three surgeries the first 72 hours I was hospitalized, I was sleeping like a baby, for about 49 hours with NO MORE hallucinations, or seizures or jerking! I finally got out of there without a kidney since that kidney was supposed to go to another man named the same as I in a different city! I do take Xanax and probably always will. The half life on Klonopin is much different hence one if its dangers, Nevwr Ever stop this drug cold! I've been on dialysis 25 1/2 years now and suffered from intense skin cancers, but have fought and done all I can do to live a normal as possible life, working full time except when I'm in yet another surgery, over 32 general anesthetic procedures since 1987. I was the youngest boy-man to ever be on the USA soccer team ready to play in the Korea 1988 Olympics. What a change in life.....
    All the Best,
    K. Peters

    Reply

    chris on Jun, 4, 2011:

    i have been taking clonzepam and trazedone and my speech is a very hoarse voice, I am wondering if if my speech problem is from these drugs's side effects.

    Reply

    TwoDimes on Apr, 15, 2012:

    Upon occasion, I, too, have become hoarse and from the use of Klonopin. I was VERY hoarse when I tried to cold turkey off of 4mgs of Klonopin. I am now down to 1.5mgs per day and, still, (as I said, upon occasion, I become hoarse. I am sure that the use of Klonopin is the causative factor. - TwoDimes -

    Reply

    SammySushi on Jul, 10, 2012:

    Omigosh, never cold turkey clonopin, esp that high of a dose. My dad had a major seizure and hallucinations doing so.

    Reply

    Christophe on Nov, 13, 2012:

    Hello,
    I suffer from Hypothyroidism, High Cholesterol & Cancer survivor because of Zyprexa use and previously being prescribed Carbamezapine causing Thyroid damage. My best advice to you if you don't want Hypothyroidism is have regular blood tests, Thyroid damage can be undetected for up to 5 years with no symptoms found on regular blood tests prematurally. Make sure you buy iodised salt to use on food when eating this will help reduce your risk of getting Hypothyroidism. two signs of Hypothyriodism which the Carbamezapine & Zyprexa medication boxes labels wont tell you is if your face becomes puffed up, red or sun sensitive while taking these medications this is a sign of Hypothyroidism. It wont be found on your blood test but later on it could appear out of the blue. The other sign to look for is baldness or hair loss on your head, this is another symptom. I hope these comments will help you. You have to weight up the benefits and negatives taking medications if you decide to take these medicines or not. It depends on how you cope with the drug side effects.
    from Christophe

    Reply

    AUDREY on Dec, 16, 2012:

    STARTED TAKING DILTIAZEM 60 MG AND I AM VERY CONSTIPATED. 70 YEARS OLD, HEART SURGERY A FAST HEART RATE....

    Reply

    Sonya on Feb, 24, 2013:

    You definately need to take a stool softener...straining during defication can cause major problems in people with cardiac problems.

    Reply

  • From this study (1 year ago):

  • I was prescribed Concerta first to alleviate the fatigue associated with a sleep disorder. The duraction of time I was on this medication was about twelve weeks with the first 6 weeks on a lower dose. Because I developed a tolerance to the Concerta, I was then prescribed the SR Ritalin which I took for about three to four weeks before stopping it totally. With the Concerta, I started to experience joint and muscle aches. Then with the SR Ritalin the pains became more noticeable the longer I took it consequitively. I also noticed muscle weakness numerous times when doing activities. Since I stopped these medications, I have not felt the same type of pain and have not noticed muscle weakness. Should I avoid using the non-SR Ritalin too even if at a low dose used three times a week to help with waking up in the morning?

    Reply

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    I had a brain hemorrhage in my occipital lobe. It left me with with a partial seizure disorder. The seizures would interrupt my ability to see. I was trying different anti-seizure medication and they all made me more tired and more depressed. My neurologist decided to try topamax. On topamax I ...

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    Causes psychosis, bipolar anxiety and seizures. Violence happens on all psychiatric drugs. Curing psychosis and deafness took the complete abandonment of psychiatry.

More reviews for: Ritalin, Zoloft

Complete drug side effects:

On eHealthMe, Ritalin (methylphenidate hydrochloride) is often used to treat attention deficit hyperactivity disorder. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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