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Review: Seroquel and Acetaminophen

This review analyzes the effectiveness and drug interactions between Seroquel and Acetaminophen. It is created by eHealthMe based on 2,121 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 4, 2014: 2,121 people who reported to have interactions when taking Seroquel, Acetaminophen are studied

Trend of Seroquel, Acetaminophen's drug interactions, side effects and effectiveness reports (8549304)

Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Acetaminophen (acetaminophen)

eHealthMe real world results:

Most common interactions experienced by people in the use of Seroquel, Acetaminophen:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)999
Type 2 Diabetes Mellitus812
Hypertension (high blood pressure)593
Dyspnoea (difficult or laboured respiration)563
Completed Suicide (act of taking one's own life)540
Insomnia (sleeplessness)414
Nausea (feeling of having an urge to vomit)414
Headache (pain in head)361

Most common interactions experienced by people in long term use of Seroquel, Acetaminophen:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Type 2 Diabetes Mellitus297
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)297
Blood Cholesterol Increased213
Hyperlipidaemia (presence of excess lipids in the blood)102
Pancreatitis (inflammation of pancreas)102
Suicidal Ideation100
Obesity (a medical condition in which excess body fat)96
Chest Pain94
Diabetes Mellitus Inadequate Control92
Abdominal Pain84

How effective are the drugs:

not at allsomewhatmoderatehighvery high

Top conditions involved for these people * :

  1. Depression
  2. Pain
  3. Anxiety
  4. Bipolar disorder
  5. Schizophrenia

Top co-used drugs for these people * :

  1. Tylenol
  2. Aspirin
  3. Zyprexa
  4. Risperdal
  5. Ativan

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Acetaminophen, Seroquel

You can also:

Complete drug side effects:

On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Acetaminophen (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 year ago):

  • Need to know if seroquel XR can possibly mimic mania in lithium 300 mg, or whether seroquel can cause affective behaviors in bipolar 1


    Sister Gray head on Jan, 9, 2013:

    Seroquel at 25-75mg results are good sleeping
    This same drug at 100-450 mg wide awake manic.
    This same drug at 500-950mg psychosis mixed with
    3 mgs of Risperdol hospitalization.


  • From this study (1 year ago):

  • Hi there,
    I was on all of these medications (some I still take). I had also had a lap band operation 2 years prior. Recently, I had a strange taste sensation (milk tasted mouldy) and some other products didn't taste right, then I started getting severe reflux. This was around the time I was prescribed to double my nortriptyline dose. I then had burning all the way down my oesophegus which did not cease (I had to go to bed sitting up) and severe stomach and abdominal pain. I ended up vomiting blood and going to the hospital. I then had a sub-total emergency gastrectomy because they found out I had a necrotic stomach (the part above the lap band).
    I am still on some of these medications and hope that they didn't cause my stomach to die, but I am not sure what else it could have been. I am scared and can't get in to see my specialist for another 3 weeks, and my GP doesn't have the special;ist knowledge. Some advice on the possible cause of the necrotic stomach would be appreciated, as would some advice on what to do with my meds. Thanks so much.


  • From this study (1 year ago):

  • I am having a migraine with aura, after going for 4 months without one, the seroquel has helped. i am trying to drink less coffee, and am hoping it will go away, this one with aura has lasted for 5 days. I have some stress, but seem to be fighting the pain. The seroquel has relieved the mania I was experiencing months ago. Migraines are making it difficult to focus consistently throughout the day. I noticed the migraine came back when it became cold outside and I did not want to walk my hour since the winds were pretty cold. I am aware that windy conditions and the going out of them will exacerbate both bipolar mania and migraine symptoms. Please help as this one is lasting way too long. I always take Tylenol when symptoms are not really severe, but think I might be rebounding. My thoughts do not race as in mania but are not consistently the way they need to be to keep my mind off of the migraine and whether its going to go away or not. I have felt great and free from migraine aura, since beginning the seroquel approx 4 months ago. Thank you for any suggestions and for having a web-site where I can find input until I go to the MD and Psych on Dec 5. Regards, Diane and I drink lots of water to help the migraines too.


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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