Drug interactions between Seroquel and Acetaminophen
This is a real world study of Seroquel and Acetaminophen drug interactions. The study is created by eHealthMe based on 2,035 reports from FDA.
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What are the drugs
Seroquel has active ingredients of quetiapine fumarate. It is used in bipolar disorder, insomnia, depression, bipolar i disorder, sleep disorder, stress and anxiety.
Acetaminophen has active ingredients of acetaminophen. It is used in pain, headache, fever, arthritis, cold symptoms, the flu.
On May, 14, 2013: 2,035 people who reported to have interactions when taking Seroquel, Acetaminophen are studied

Drug combinations in study:
- Seroquel (quetiapine fumarate)
- Acetaminophen (acetaminophen)
Most common interactions experienced by people in the use of Seroquel, Acetaminophen:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Diabetes Mellitus | 620 |
| 2 | Type 2 Diabetes Mellitus | 455 |
| 3 | Anxiety | 299 |
| 4 | Dyspnoea | 280 |
| 5 | Completed Suicide | 177 |
| 6 | Nausea | 150 |
| 7 | Headache | 143 |
| 8 | Depression | 140 |
| 9 | Insomnia | 136 |
| 10 | Back Pain | 136 |
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Most common interactions experienced by people in long term use of Seroquel, Acetaminophen:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Type 2 Diabetes Mellitus | 276 |
| 2 | Diabetes Mellitus | 270 |
| 3 | Blood Cholesterol Increased | 133 |
| 4 | Pancreatitis | 49 |
| 5 | Chest Pain | 48 |
| 6 | Diabetes Mellitus Inadequate Control | 42 |
| 7 | Suicidal Ideation | 42 |
| 8 | Abdominal Pain | 42 |
| 9 | Hyperlipidaemia | 41 |
| 10 | Neuropathy Peripheral | 40 |
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Top conditions involved for these people * :
- Depression
- Pain
- Anxiety
- Bipolar disorder
- Schizophrenia
Top co-used drugs for these people * :
- Tylenol
- Aspirin
- Zyprexa
- Risperdal
- Ativan
* Approximation only. Some reports may have incomplete information.
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Side effects in real world:
On eHealthMe, Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Acetaminophen (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (5 months ago):
From this study (6 months ago):
From this study (6 months ago):
From this study (1 year ago):
From this study (2 years ago):
Need to know if seroquel XR can possibly mimic mania in lithium 300 mg, or whether seroquel can cause affective behaviors in bipolar 1
Sister Gray head on Jan, 9, 2013:
Seroquel at 25-75mg results are good sleeping
This same drug at 100-450 mg wide awake manic.
This same drug at 500-950mg psychosis mixed with
3 mgs of Risperdol hospitalization.
Hi there,
I was on all of these medications (some I still take). I had also had a lap band operation 2 years prior. Recently, I had a strange taste sensation (milk tasted mouldy) and some other products didn't taste right, then I started getting severe reflux. This was around the time I was prescribed to double my nortriptyline dose. I then had burning all the way down my oesophegus which did not cease (I had to go to bed sitting up) and severe stomach and abdominal pain. I ended up vomiting blood and going to the hospital. I then had a sub-total emergency gastrectomy because they found out I had a necrotic stomach (the part above the lap band).
I am still on some of these medications and hope that they didn't cause my stomach to die, but I am not sure what else it could have been. I am scared and can't get in to see my specialist for another 3 weeks, and my GP doesn't have the special;ist knowledge. Some advice on the possible cause of the necrotic stomach would be appreciated, as would some advice on what to do with my meds. Thanks so much.
I am having a migraine with aura, after going for 4 months without one, the seroquel has helped. i am trying to drink less coffee, and am hoping it will go away, this one with aura has lasted for 5 days. I have some stress, but seem to be fighting the pain. The seroquel has relieved the mania I was experiencing months ago. Migraines are making it difficult to focus consistently throughout the day. I noticed the migraine came back when it became cold outside and I did not want to walk my hour since the winds were pretty cold. I am aware that windy conditions and the going out of them will exacerbate both bipolar mania and migraine symptoms. Please help as this one is lasting way too long. I always take Tylenol when symptoms are not really severe, but think I might be rebounding. My thoughts do not race as in mania but are not consistently the way they need to be to keep my mind off of the migraine and whether its going to go away or not. I have felt great and free from migraine aura, since beginning the seroquel approx 4 months ago. Thank you for any suggestions and for having a web-site where I can find input until I go to the MD and Psych on Dec 5. Regards, Diane and I drink lots of water to help the migraines too.
Comment: Im not in alcohol withdrawl but in withdrawl of short acting benzodiazepines. Was not on the list/I didnt find it.
Other then that, great site, I am curious what it will say about me :$
I have been taking Seroquel for years and all was fine, until I mixed it with Rivotril, Ibuprofein, and Acetaminophen.
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- A study of drug interactions between Seroquel, Acetaminophen, Coumadin, Aspirin, Digoxin, Spironolactone, Lisinopril, Furosemide for a patient with Anxiety, Depression, Pain. The patient has Weight Increased, Hyperlipidaemia, Diabetic Nephropathy, Diabetic Complication, Diabetes Mellitus Inadequate Control, Diabetes Mellitus (Diabetes), Blood Cholesterol Increased (High Blood Cholesterol)
- A study of drug interactions between Risperdal, Seroquel, Bextra, Abilify, Metformin, Humulin R, Acetaminophen, Norvasc, Valium, Tegretol, Cogentin, Artane, Stelazine, Thorazine Spansule for a patient with Schizophrenia, Schizoaffective Disorder. The patient has Vomiting (Nausea and vomiting), Urticaria, Type 2 Diabetes Mellitus (Type 2 diabetes), Tardive Dyskinesia, Skin Nodule, Skin Candida, Rectal Haemorrhage, Psychotic Disorder, Pressure Of Speech, Palpitations (Heart palpitations), Neuropathy Peripheral, Neck Pain, Mouth Ulceration (Mouth ulcers), Mania, Joint Sprain (Sprains), Hyperglycaemia (Hyperglycemia), Haemorrhoids, Diabetic Ketoacidosis, Diabetes Mellitus (Diabetes), Bronchitis, Back Pain, Asthma, Arthralgia (Joint pain), Anxiety (Stress and anxiety), Anal Fissure, Accidental Overdose
- A study of drug interactions between Tylenol-500, Furosemide, Seroquel, Coumadin, Aspirin, Digoxin, Spironolactone, Lisinopril for a patient with Pain, Anxiety, Depression. The patient has Weight Increased, Hyperlipidaemia, Diabetic Nephropathy, Diabetic Complication, Diabetes Mellitus Inadequate Control, Diabetes Mellitus (Diabetes), Blood Cholesterol Increased (High Blood Cholesterol)
- A study of drug interactions between Xenazine, Potassium Chloride, Oxybutynin, Sodium Bicarbonate, Ferrous Sulfate, Tylenol With Codein #3, Albuterol, Anafranil, Seroquel, Ativan, Multi-vitamins for a patient with Huntington's Disease. The patient has Death
- A study of drug interactions between Memantine Hcl, Ferrous Fumarate, Tylenol-500, Advil Liqui-gels, Aspirin, Amlodipine Besylate And Benazepril Hcl, Trazodone Hcl, Sertraline Hydrochloride, Seroquel, Aricept for a patient with Dementia Alzheimer's Type. The patient has Urinary Tract Infection, Tachycardia, Small Intestinal Obstruction, Red Blood Cell Count Decreased, Nausea, Lethargy (Fatigue), Ileus (Intestinal obstruction), Haemoglobin Decreased, Haematocrit Decreased, Blood Urea Increased, Blood Sodium Increased, Blood Potassium Decreased, Blood Phosphorus Decreased, Blood Magnesium Increased, Blood Glucose Increased, Blood Creatinine Increased, Blood Creatine Phosphokinase Mb Increased, Blood Creatine Phosphokinase Increased, Blood Chloride Increased, Blood Calcium Increased, Blood Bilirubin Increased, Aspartate Aminotransferase Increased, Activated Partial Thromboplastin Time Shortened
- A study of drug interactions between Metoclopramide, Sertraline Hydrochloride, Quetiapine, Acetaminophen, Vancomycin, Clonazepam, Imipenem, Fragmin, Omeprazole, Gemfibrozil, Ecalta, Berodual for a patient with Vomiting, Antidepressant Therapy, Delirium, Antipyresis, Abdominal Infection, Insomnia, Thrombosis Prophylaxis, Prophylaxis Against Gastrointestinal Ulcer, Hyperlipidaemia, Candidiasis. The patient has Hepatitis, Hepatic Enzyme Increased
- A study of drug interactions between Seroquel, Xanax, Ambien, Vasotec, Glucophage, Interferon, Lantus, Nexium, Buspar, Humalog Plus, Humulin N, Protonix, Catapres, Norvasc, Lopressor, Oxycontin, Paxil, Glucotrol, Amaryl, Klonopin, Aricept, Acetaminophen, Wellbutrin Xl, Desimipramine, Senokot, Altitrazodone for a patient with Insomnia. The patient has Upper Respiratory Tract Infection, Type 2 Diabetes Mellitus (Type 2 diabetes), Rhinitis, Retinopathy, Psychotic Disorder, Pneumonia, Panic Disorder, Pain, Oesophagitis, Nephropathy, Major Depression, Limb Injury, Iron Deficiency Anaemia, Hyperlipidaemia, Hyperhidrosis, Hepatitis C, Glossitis, Gastrointestinal Haemorrhage, Diabetic Complication, Diabetes Mellitus Inadequate Control, Death, Comminuted Fracture, Chills, Bradyphrenia, Blood Pressure Increased (High blood pressure), Attention Deficit/hyperactivity Disorder (Attention Deficit Hyperactivity Disorder), Anxiety (Stress and anxiety), Amnesia (Memory loss), Acute Psychosis
- A study of drug interactions between Zyprexa, Risperdal, Desyrel, Catapres, Acetaminophen, Seroquel, Abilify, Trazodone Hcl, Navane, Geodon, Haldol, Atenolol, Nexium, Tricor, Lipitor, Depakote, Prolixin, Lopid, Ativan, Zocor, Protonix, Naprosyn, Glucophage, Lasix, Aspirin, Zetia, Clonopin, Colace for a patient with Schizophrenia, Sleep Disorder, Alcohol Withdrawal Syndrome, Discomfort, Pain, Anxiety, Agitation, Depression, Bipolar Disorder. The patient has Type 2 Diabetes Mellitus (Type 2 diabetes), Tooth Abscess, Sleep Apnoea Syndrome, Skin Laceration, Schizophrenia, Paranoid Type, Schizoaffective Disorder, Obesity, Hypoglycaemia (Hypoglycemia), Hypertension (High blood pressure), Hypercholesterolaemia (High Blood Cholesterol), Gastrooesophageal Reflux Disease, Dyslipidaemia, Arthritis, Alcohol Abuse (Alcoholism)
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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