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Review: Sertraline and Donepezil

This review analyzes the effectiveness and drug interactions between Sertraline and Donepezil. It is created by eHealthMe based on reports of 1,110 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Sertraline and Donepezil >>>

What are the drugs

Sertraline hydrochloride (latest outcomes from 11,781 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

Donepezil (latest outcomes from 2,832 users) has active ingredients of donepezil hydrochloride. It is often used in dementia.

On Jul, 18, 2014: 1,110 people who take Sertraline Hydrochloride, Donepezil are studied

Sertraline Hydrochloride, Donepezil outcomes

Drug combinations in study:
- Sertraline Hydrochloride (sertraline hydrochloride)
- Donepezil (donepezil hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sertraline Hydrochloride is effectiven/a42.86%
(3 of 7 people)
(1 of 4 people)
(2 of 5 people)
(1 of 3 people)
(1 of 2 people)
(0 of 2 people)
Donepezil is effective0.00%
(0 of 1 people)
(1 of 13 people)
(0 of 3 people)
(1 of 6 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
General Physical Health DeteriorationGeneral Physical Health DeteriorationFemoral Neck FractureRhabdomyolysisDiarrhoeaDiarrhoeaDepressionFall
RhabdomyolysisDepressed Level Of ConsciousnessAnaemiaDiarrhoeaFallGallbladder CancerMemory ImpairmentConfusional State
Liver DisorderRespiratory DistressAtrioventricular Block CompleteHypoproteinaemiaConfusional StateGallbladder Cancer MetastaticUrinary Incontinence AggravatedNausea
Circulatory CollapseHypersexualitySyncopeSubdural HaematomaHypernatraemiaIleusMood SwingsDehydration
HypernatraemiaImpulse-control DisorderDiarrhoea NosWeight DecreasedDisorientationFaecalomaConfusion AggravatedAgitation
ShockHyperphagiaDepressionHyperthermia MalignantHypothyroidismInternational Normalised Ratio DecreasedAngerDepression
DehydrationHallucination, OlfactoryNightmareRenal ImpairmentMalnutritionPhlebolithMuscle RigidityAsthenia
ParanoiaInjuryVentricular TachycardiaDehydrationHypoproteinaemiaDehydrationAgitationCondition Aggravated
DiarrhoeaEmotional DistressCondition AggravatedPneumoniaSubdural HaematomaPeriventricular LeukomalaciaDyspnoea
HallucinationPathological GamblingMemory ImpairmentBlood Pressure IncreasedRenal ImpairmentLipase IncreasedSyncope

Drug effectiveness by gender :

Sertraline Hydrochloride is effective38.89%
(7 of 18 people)
(1 of 5 people)
Donepezil is effective11.11%
(2 of 18 people)
(0 of 7 people)

Most common drug interactions by gender * :

Confusional StateNausea
Depressed Level Of ConsciousnessConfusional State
Condition AggravatedDiarrhoea

Drug effectiveness by age :

Sertraline Hydrochloride is effectiven/an/an/an/an/a33.33%
(1 of 3 people)
(7 of 36 people)
Donepezil is effectiven/an/an/a0.00%
(0 of 8 people)
(0 of 3 people)
(3 of 37 people)

Most common drug interactions by age * :

n/aSleep Disordern/aConvulsions NosHepatic Enzyme IncreasedDepressed MoodFallConfusional State
ParanoiaAnticonvulsant Drug Level DecreasedEmotional DisorderType 2 Diabetes MellitusNauseaNausea
HallucinationHeadacheDiabetes MellitusBlood Cholesterol IncreasedConfusional StateFall
AnxietyNauseaCushing's SyndromeMigraineMental Status ChangesDehydration
Acute PsychosisVision BlurredWeight IncreasedFatigueConvulsionAgitation
Status EpilepticusBipolar DisorderPancytopeniaDiarrhoea
Drug Withdrawal ConvulsionsHypothyroidismVomitingConfusion
Weight IncreasedContusionDepressed Level Of Consciousness
Cardiac DisorderFatigueCondition Aggravated
Tardive DyskinesiaAstheniaDysphagia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Sertraline and Donepezil
- group for people who take Donepezil
- group for people who take Sertraline Hydrochloride

Comments from related studies:

  • From this study (7 months ago):

  • donepezil HCl
    sertraline HCl


  • From this study (2 years ago):

  • fet sick from pravastatin
    black stools
    took aricept and doctor and guardian put me in memorory loss care facility cause I would not take the medication because make me sick it is poison me
    i have 2d grade achool from poland an can't read or write good
    I feel like they are killing me with drugs


  • From this study (2 years ago):

  • Have feelings similar to hangover.. Sometimes short lived other times all day. Tiredness and malaise.


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Complete drug side effects:

On eHealthMe, Sertraline Hydrochloride (sertraline hydrochloride) is often used to treat depression. Donepezil (donepezil hydrochloride) is often used to treat dementia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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