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Review: taking Sertraline and Donepezil together

Summary: drug interactions are reported among people who take Sertraline and Donepezil together.

This review analyzes the effectiveness and drug interactions between Sertraline and Donepezil. It is created by eHealthMe based on reports of 1,111 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Sertraline and Donepezil >>>

On Apr, 19, 2015: 1,111 people who take Sertraline Hydrochloride, Donepezil are studied

Sertraline Hydrochloride, Donepezil outcomes

Drug combinations in study:
- Sertraline Hydrochloride (sertraline hydrochloride)
- Donepezil (donepezil hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sertraline Hydrochloride is effectiven/a42.86%
(3 of 7 people)
(1 of 4 people)
(2 of 5 people)
(1 of 4 people)
(1 of 2 people)
(0 of 2 people)
Donepezil is effective0.00%
(0 of 1 people)
(1 of 13 people)
(0 of 3 people)
(1 of 6 people)
(1 of 4 people)

Drug effectiveness by gender :

Sertraline Hydrochloride is effective38.89%
(7 of 18 people)
(1 of 6 people)
Donepezil is effective11.11%
(2 of 18 people)
(0 of 8 people)

Drug effectiveness by age :

Sertraline Hydrochloride is effectiven/an/an/an/an/a33.33%
(1 of 3 people)
(7 of 37 people)
Donepezil is effectiven/an/an/a0.00%
(0 of 8 people)
(0 of 3 people)
(3 of 38 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
General Physical Health DeteriorationGeneral Physical Health DeteriorationFemoral Neck FractureRhabdomyolysisDiarrhoeaDiarrhoeaDepressionFall
RhabdomyolysisDepressed Level Of ConsciousnessAnaemiaDiarrhoeaFallGallbladder CancerMemory ImpairmentConfusional State
Liver DisorderRespiratory DistressAtrioventricular Block CompleteHypoproteinaemiaConfusional StateGallbladder Cancer MetastaticUrinary Incontinence AggravatedNausea
Circulatory CollapseHypersexualitySyncopeSubdural HaematomaHypernatraemiaIleusMood SwingsDehydration
HypernatraemiaImpulse-control DisorderDiarrhoea NosWeight DecreasedDisorientationFaecalomaConfusion AggravatedAgitation
ShockHyperphagiaDepressionHyperthermia MalignantHypothyroidismInternational Normalised Ratio DecreasedAngerDepression
DehydrationHallucination, OlfactoryNightmareRenal ImpairmentSubdural HaematomaPhlebolithMuscle RigidityAsthenia
ParanoiaInjuryVentricular TachycardiaDehydrationHypoproteinaemiaDehydrationAgitationCondition Aggravated
DiarrhoeaEmotional DistressCondition AggravatedPneumoniaMalnutritionPeriventricular LeukomalaciaDyspnoea
HallucinationPathological GamblingMemory ImpairmentBlood Pressure IncreasedRenal ImpairmentLipase IncreasedSyncope

Most common drug interactions by gender * :

Confusional StateNausea
Depressed Level Of ConsciousnessConfusional State
Condition AggravatedFatigue

Most common drug interactions by age * :

n/aSleep Disordern/aConvulsions NosHepatic Enzyme IncreasedDepressed MoodFallConfusional State
ParanoiaAnticonvulsant Drug Level DecreasedEmotional DisorderType 2 Diabetes MellitusNauseaNausea
HallucinationHeadacheDiabetes MellitusBlood Cholesterol IncreasedConfusional StateFall
AnxietyNauseaCushing's SyndromeMigraineMental Status ChangesDehydration
Acute PsychosisVision BlurredWeight IncreasedFatigueConvulsionAgitation
Status EpilepticusBipolar DisorderPancytopeniaDiarrhoea
Drug Withdrawal ConvulsionsHypothyroidismVomitingCondition Aggravated
Weight IncreasedContusionConfusion
Cardiac DisorderFatigueDepressed Level Of Consciousness
Tardive DyskinesiaAstheniaDysphagia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Sertraline and Donepezil?




You are not alone! Join a related support group:
- support group for people who take Donepezil
- support group for people who take Sertraline Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Sertraline Hydrochloride (sertraline hydrochloride) is often used to treat depression. Donepezil (donepezil hydrochloride) is often used to treat dementia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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