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Related topic: L-methylfolate, Sertraline Hydrochloride

Review: Sertraline and L-methylfolate

This review analyzes the effectiveness and drug interactions between Sertraline and L-methylfolate. It is created by eHealthMe based on 3,051 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 7, 2014: 3,051 people who reported to have interactions when taking Sertraline Hydrochloride, L-methylfolate are studied

Trend of Sertraline Hydrochloride, L-methylfolate's drug interactions, side effects and effectiveness reports (4330077)

Drug combinations in study:
- Sertraline Hydrochloride (sertraline hydrochloride)
- L-methylfolate (folic acid)

eHealthMe real world results:

Most common interactions experienced by people in the use of Sertraline Hydrochloride, L-methylfolate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Asthenia (weakness)1,133
Dyspnoea (difficult or laboured respiration)907
Arthralgia (joint pain)903
Fatigue (feeling of tiredness)778
Nausea (feeling of having an urge to vomit)720
Anaemia (lack of blood)712

Most common interactions experienced by people in long term use of Sertraline Hydrochloride, L-methylfolate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Mood Altered (changes in mood)19
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)18
Chronic Myeloid Leukaemia Transformation (cancer of blood forming cells spreads to blood cells)12
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)12
Oesophageal Disorder (disease of oesophagus)12
Fibromyalgia (a long-term condition which causes pain all over the body)12
Fatigue (feeling of tiredness)10
Anaemia (lack of blood)6

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Sertraline Hydrochloride5.56%11.11%33.33%50.00%0.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis
  2. Depression
  3. Pain
  4. Hypertension
  5. Multiple myeloma

Top co-used drugs for these people * :

  1. Zoloft
  2. Methotrexate
  3. Prednisone
  4. Aspirin
  5. Humira

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Complete drug side effects:

On eHealthMe, Sertraline Hydrochloride (sertraline hydrochloride) is often used to treat depression. L-methylfolate (folic acid) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 months ago):

  • most important is Vitamin D3 (cholecalciferol), which your search engine does not recognize. This is a very common over the counter treatment for depression in the U.S. and is often prescribed medically.


  • From this study (4 months ago):

  • I suffer from a variety of conditions, degenerative spondylosis, manic depression, psoriatic arthritis, arthritis, IBS, Fibromyalgia, leukocytes in urine, psychotic episodes, folic acid deficiency anaemia, osteomalacia.


  • From this study (1 year ago):

  • over the last 5 to 6 yrs I've been on these drugs and other anti-depressants. also was in the hospital for close to 3 months 6 plus yrs ago. In the last 3 yrs my dental issues have gone from minor to severe. To where I now have rapid tooth decay. The V.A. which i am a veteran, doesn't cover dental, but would cover dental if it was a result of other treatment. i.e, Clonazepam, creon, folic acid, about 2 yrs with them prescribing seroquel and trying different anti-depressants, like zoloft and zyprexa for short (1 to 3 months) periods of time. And was wondering if any of these drugs could be the cause of me having to now have my teeth pulled and getting dentures?


    Robert on Apr, 12, 2013:

    Zoloft is the most likely culprit, combined with clonazepam, together their similar oral side-effects combine in some cases causing oral and general dental problems. Zoloft's rather common side effect can be dry mouth.

    Clonazepam has properties making it a potent anti-convulsive drug, which are known to cause dental problems in some. It has been the cause of minor gum-soreness and bleeding, and with zoloft theres an interaction, because without saiva present in the mouth as a barrier, dental problems such as receding gum line, bleeding gums and enamel wear, all work to accelerate normal tooth decay, ultimately.

    These two meds have similarities that affect you and your mouth more than the average person. Nothing to worry about , there are dozens upon dozens of different benzos like clonazepam out there, ones with less potent anti seizure properties, and most docs don't even know much about them, yet they still make many of these rarely prescribed meds because of people just like you who could benefit from them.


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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Related studies

- L-methylfolate side effects
- Sertraline Hydrochloride side effects



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