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Review: Sertraline and L-methylfolate

This review analyzes the effectiveness and drug interactions between Sertraline and L-methylfolate. It is created by eHealthMe based on reports of 3,091 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Sertraline hydrochloride (what 11,784 Sertraline Hydrochloride users reported?) has active ingredients of sertraline hydrochloride. It is used in depression.

L-methylfolate (what 76 L-methylfolate users reported?) has active ingredients of folic acid. It is used in depression.

On Sep, 12, 2014: 3,091 people who take Sertraline Hydrochloride, L-methylfolate are studied

Sertraline Hydrochloride, L-methylfolate outcomes

Drug combinations in study:
- Sertraline Hydrochloride (sertraline hydrochloride)
- L-methylfolate (folic acid)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sertraline Hydrochloride is effective0.00%
(0 of 1 people)
(3 of 5 people)
(1 of 4 people)
(0 of 9 people)
(7 of 14 people)
(5 of 9 people)
(4 of 5 people)
L-methylfolate is effective0.00%
(0 of 1 people)
(0 of 5 people)
(2 of 4 people)
(3 of 10 people)
(3 of 7 people)
(2 of 3 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnaemiaLoss Of ConsciousnessAtrial Septal DefectIncreased Tendency To BruisePainGingival BleedingConvulsionPain
HyperglycaemiaVentricular Septal DefectHeart Disease CongenitalMuscle FatigueFibromyalgiaImpaired HealingCerebrovascular AccidentNausea
Renal FailureVentricular TachycardiaConstipationDrug Exposure During PregnancyMuscle CrampsFatigueIrritabilityAnxiety
SepsisElectrocardiogram Qt ProlongedDiarrhoeaVomitingRetained Placenta Or MembranesFaeces DiscolouredChronic Myeloid Leukaemia TransformationFatigue
Heart Disease CongenitalPallorRhinorrhoeaWeight DecreasedPregnancy Induced HypertensionAnaemiaMood AlteredAnaemia
Neonatal Respiratory Distress SyndromeSyncopeCoughLeukopeniaPolyhydramniosMyalgiaOesophageal DisorderAsthenia
Growth RetardationPatent Ductus ArteriosusSkin DiscolourationPost Procedural PainShort-term Memory LossThrombocytopeniaNauseaFall
Heart Rate DecreasedDrug Exposure During PregnancyInsomniaPost Procedural HaemorrhageDeliveryMuscle FatigueFatiguePyrexia
ExomphalosCardiac ArrestMotor Developmental DelayHeadacheUmbilical Cord AbnormalityDeep Vein ThrombosisChange In Sustained AttentionDyspnoea
Foetal Exposure During PregnancySepsisPapuleMood SwingsUterine InfectionAnxietyChronic Myeloid LeukaemiaArthralgia

Drug effectiveness by gender :

Sertraline Hydrochloride is effective46.88%
(15 of 32 people)
(5 of 15 people)
L-methylfolate is effective36.36%
(8 of 22 people)
(3 of 11 people)

Most common drug interactions by gender * :

PyrexiaBack Pain
FallChest Pain

Drug effectiveness by age :

Sertraline Hydrochloride is effectiven/an/an/a0.00%
(0 of 1 people)
(2 of 10 people)
(8 of 20 people)
(8 of 35 people)
(2 of 7 people)
L-methylfolate is effectiven/an/an/an/a0.00%
(0 of 4 people)
(4 of 13 people)
(6 of 29 people)
(1 of 7 people)

Most common drug interactions by age * :

Atrial Septal DefectFoetal Exposure During PregnancyFatigueMaternal Exposure During PregnancyConvulsionPainPainNausea
Maternal Drugs Affecting FoetusDrug Exposure During PregnancySedationWeight DecreasedDrug Exposure During PregnancyAstheniaAnxietyPneumonia
Drug Exposure During PregnancyLow Birth Weight BabyAppetite IncreasedPsychotic DisorderAstheniaFatigueNauseaAsthenia
Live BirthPremature BabyVomitingPregnancyAnxietyHeadacheAnaemiaDyspnoea
Premature BabyCerebral PalsyWeight IncreasedFatigueGastrooesophageal Reflux DiseaseChest PainArthralgiaFall
Ventricular Septal DefectMaternal Condition Affecting FoetusPsychotic Disorder NosPostpartum DepressionFatigueDepressionOedema PeripheralFatigue
Cyanosis NeonatalUpper Respiratory Tract InfectionCondition AggravatedInjection Site ErythemaWeight DecreasedDehydrationCellulitisAnaemia
Gross Motor DelayStrabismusColitis UlcerativeWithdrawal SyndromePainAnxietyVomitingDehydration
Agitation NeonatalDrug Exposure Before PregnancyWeight DecreasedUrinary Tract InfectionDysphagiaPyrexiaPyrexiaPain
Infantile Apnoeic AttackParesisPainHyperemesis GravidarumCholestasis Of PregnancyDyspnoeaOsteonecrosis Of JawDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Sertraline and L-methylfolate?

Get connected! Join a mobile support group:
- group for people who take Sertraline and L-methylfolate
- group for people who take L-methylfolate
- group for people who take Sertraline Hydrochloride

Comments from related studies:

  • From this study (8 months ago):

  • most important is Vitamin D3 (cholecalciferol), which your search engine does not recognize. This is a very common over the counter treatment for depression in the U.S. and is often prescribed medically.


  • From this study (9 months ago):

  • I suffer from a variety of conditions, degenerative spondylosis, manic depression, psoriatic arthritis, arthritis, IBS, Fibromyalgia, leukocytes in urine, psychotic episodes, folic acid deficiency anaemia, osteomalacia.


  • From this study (1 year ago):

  • over the last 5 to 6 yrs I've been on these drugs and other anti-depressants. also was in the hospital for close to 3 months 6 plus yrs ago. In the last 3 yrs my dental issues have gone from minor to severe. To where I now have rapid tooth decay. The V.A. which i am a veteran, doesn't cover dental, but would cover dental if it was a result of other treatment. i.e, Clonazepam, creon, folic acid, about 2 yrs with them prescribing seroquel and trying different anti-depressants, like zoloft and zyprexa for short (1 to 3 months) periods of time. And was wondering if any of these drugs could be the cause of me having to now have my teeth pulled and getting dentures?


    Robert on Apr, 12, 2013:

    Zoloft is the most likely culprit, combined with clonazepam, together their similar oral side-effects combine in some cases causing oral and general dental problems. Zoloft's rather common side effect can be dry mouth.

    Clonazepam has properties making it a potent anti-convulsive drug, which are known to cause dental problems in some. It has been the cause of minor gum-soreness and bleeding, and with zoloft theres an interaction, because without saiva present in the mouth as a barrier, dental problems such as receding gum line, bleeding gums and enamel wear, all work to accelerate normal tooth decay, ultimately.

    These two meds have similarities that affect you and your mouth more than the average person. Nothing to worry about , there are dozens upon dozens of different benzos like clonazepam out there, ones with less potent anti seizure properties, and most docs don't even know much about them, yet they still make many of these rarely prescribed meds because of people just like you who could benefit from them.


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More reviews for: L-methylfolate, Sertraline Hydrochloride

Complete drug side effects:

On eHealthMe, Sertraline Hydrochloride (sertraline hydrochloride) is often used to treat depression. L-methylfolate (folic acid) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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