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Review: taking Sonata and Phenergan together

Summary: drug interactions are reported among people who take Sonata and Phenergan together.

This review analyzes the effectiveness and drug interactions between Sonata and Phenergan. It is created by eHealthMe based on reports of 86 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Sonata and Phenergan >>>

What are the drugs

Sonata has active ingredients of zaleplon. It is often used in insomnia. (latest outcomes from 2,192 Sonata users)

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from 13,029 Phenergan users)

On Feb, 24, 2015: 86 people who take Sonata, Phenergan are studied

Sonata, Phenergan outcomes

Drug combinations in study:
- Sonata (zaleplon)
- Phenergan (promethazine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sonata is effectiven/an/an/an/an/a0.00%
(0 of 1 people)
Phenergan is effectiven/an/an/an/a100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vomiting Nosn/aVentricular Septal Defectn/aErection ProblemsErection Problemsn/aPain
DisorientationDrug Exposure During PregnancySkin StriaeSkin StriaeAnxiety
ConfusionAtrial Septal DefectDrug Exposure During Pregnancy
Foetal Distress SyndromeVentricular Septal Defect
Respiratory DistressAnaemia
ApnoeaAtrial Septal Defect
Aortic DisorderRespiratory Distress
Post Procedural ComplicationFoetal Distress Syndrome
Fallot's TetralogyApnoea

Drug effectiveness by gender :

Sonata is effective0.00%
(0 of 1 people)
Phenergan is effective100.00%
(1 of 1 people)

Most common drug interactions by gender * :

Drug Exposure During PregnancyDrug Ineffective
Ventricular Septal DefectMigraine
Atrial Septal DefectMyocardial Infarction
AnaemiaAspartate Aminotransferase Increased
ApnoeaDrug Dependence
Respiratory DistressDyspnoea
Foetal Distress SyndromeChest Pain

Drug effectiveness by age :

Sonata is effectiven/an/an/an/an/a0.00%
(0 of 2 people)
Phenergan is effectiven/an/an/an/an/a50.00%
(1 of 2 people)

Most common drug interactions by age * :

n/an/an/an/aDepressionArthralgiaPancreatic Duct StenosisMyocardial Infarction
HypothyroidismChest PainHepatic CirrhosisIntestinal Stenosis
ConvulsionFallBile Duct StenosisAnastomotic Complication
InsomniaFatigueChronic HepatitisPain In Extremity
Loss Of ConsciousnessDrug IneffectiveSphincter Of Oddi DysfunctionAbdominal Pain
IrritabilityDrug Withdrawal SyndromeConvulsionAspartate Aminotransferase Increased
Gastrooesophageal Reflux DiseaseDiabetes MellitusBlood Pressure IncreasedRectal Haemorrhage
Drug AbuserMuscle SpasmsPortal Vein PhlebitisFatigue
DysarthriaPainFlank PainDrug Hypersensitivity
HypoaesthesiaOedema PeripheralHepatic SteatosisOverdose

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Sonata and Phenergan?

You are not alone! Join a related mobile support group:
- support group for people who take Sonata and Phenergan
- support group for people who take Phenergan
- support group for people who take Sonata

Can you answer these questions (Ask a question):

More questions for: Phenergan, Sonata

You may be interested at these reviews (Write a review):

  • Patients having false positives while on remeron
    I have had a few patients complain they are failing drug tests for Amphetamines while on remeron, and have claimed to have not used any type of Amphetamine or any (Mixed Salts). These patients are all or were on probation, parole, or under some stipulation. Iv realized most of these patients are taking another psych med. The list consists of insomnia meds such as Ambien(zolpidem), Sonata(zaleplon),Lunesta(eszopiclone). Also the Anti-Depressants Lexapro (escitalopram)and Prozac (fluoxetine). One of my patients was on Diazepam (Valium). I have switched medicines, particularly the Ambien, Lexapro, and Prozac have reversed the false negative. I prescribe many of my patients remeron. I'm a big believer in its effects on my patients moods and everyday depression. I have heard this happening before, but this was the first time I have ever had this happen to one of my own patients.(These were 5 separate patients in the span of 16 months) Of course none of these patients were criminalized based on lab results, but the issue still lies there. I know this is common for a lot of script meds to give false positives for narcotics. This is just obviously one I am putting out there. Let me know if anyone has experienced something similar.
  • Fibromyalgia & related health issues (3 responses)
    Fibromyalgia dx after pregnancy of only child at 42/other dx followed and seem to be in conjunction. heart issues did not appear until after the use of fibro meds- cymbalta, lyrica, neurontin, and more. had 1 seizure believed to be related to seretonin syndrome/years and years of mistreatment by doctors. unable to recall how many docs and meds through the years. one other very significant issue- after tooth extraction had puncture to left maxillary sinus-after YEARS of neglect by docs, found max. & ethmoid sinus completely opaque on CAT scan. Had surgery. Now, years later, have mucous plug that sporadically comes out upon sneezing. Fairly recent CAT scan shows sinuses again completely opaque. Certain needs further attention, but basically afraid to go through surgery again. Also- may have had heart attack. ER visit said no, but shortly after, had abnormal ekg. Again, neglect from docs. Am now active advocate for fm/chronic pain patients. Disgusted by the whole lack of interest of medical community. Looking for answers through my own research to try to find a way to improve quality of life...
  • Husband died from depakene
    My husband took Depakene and Mysoline (Phenobarital) for 28 years. No hospital or physician checked his ammonia levels during these years. Ammonia levels needed to be checked every 6 months when taking Valproic Acid.

    As the result of no ammonia levels taken, he suffered from moderate severe atrophy of the brain, metabolic system was destroyed, regular system destroyed, 25 diagnoses due to the side effects of Depakene and died one year ago of mitochondrial encephalopathy.

More reviews for: Phenergan, Sonata

Complete drug side effects:

On eHealthMe, Sonata (zaleplon) is often used to treat insomnia. Phenergan (promethazine hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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