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Review: taking Suboxone and Depakote together

Summary: drug interactions are reported among people who take Suboxone and Depakote together.

This review analyzes the effectiveness and drug interactions between Suboxone and Depakote. It is created by eHealthMe based on reports of 51 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Suboxone and Depakote >>>

On Apr, 11, 2015: 51 people who take Suboxone, Depakote are studied

Suboxone, Depakote outcomes

Drug combinations in study:
- Suboxone (buprenorphine hydrochloride; naloxone hydrochloride)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Suboxone is effectiven/a100.00%
(4 of 4 people)
(1 of 1 people)
(2 of 2 people)
(1 of 1 people)
(1 of 1 people)
Depakote is effective0.00%
(0 of 1 people)
(0 of 3 people)
(2 of 3 people)
(0 of 1 people)
(0 of 1 people)

Drug effectiveness by gender :

Suboxone is effective100.00%
(6 of 6 people)
(3 of 3 people)
Depakote is effective40.00%
(2 of 5 people)
(0 of 4 people)

Drug effectiveness by age :

Suboxone is effectiven/an/an/a60.00%
(3 of 5 people)
(3 of 3 people)
(2 of 2 people)
(1 of 1 people)
Depakote is effectiven/an/an/a16.67%
(1 of 6 people)
(0 of 3 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionVomitingDysgeusiaPulmonary OedemaFrequent Headachesn/an/aDrug Withdrawal Syndrome
Oedema PeripheralOedema PeripheralHeadacheNervousnessVomitingPneumonia
LethargyHallucinationDrug Withdrawal SyndromePneumoniaFecal IncontinenceConvulsion
StressDeathDecreased AppetiteTension HeadacheDepression
HallucinationNightmaresCondition AggravatedSubstance AbuseHallucination
PneumoniaCryingOxygen Saturation DecreasedSuicidal Ideation
Tension HeadacheInsomniaSwelling FaceHeadache
Swelling FaceTachyphreniaErectile DisturbanceNausea
Oxygen Saturation DecreasedNegative ThoughtsPericardial Effusion
AnxietySuicidal IdeationInsomnia

Most common drug interactions by gender * :

PneumoniaDrug Withdrawal Syndrome
Pulmonary MassBipolar Disorder
HaemoptysisDrug Dependence
HallucinationSuicidal Ideation
Antiphospholipid SyndromeAnxiety
DepressionDisturbance In Attention
Oedema PeripheralEuphoric Mood
DisorientationBlood Glucose Decreased
Withdrawal SyndromeNausea

Most common drug interactions by age * :

n/an/aDeathDepressionSuicidal IdeationPneumoniaHypoacusisn/a
Drug DependenceNauseaHallucinationFall
Suicidal IdeationCryingPericardial EffusionLoss Of Consciousness
Drug Withdrawal SyndromeDrug Withdrawal SyndromePulmonary MassScab
Condition AggravatedAggressionHaemoptysisExcoriation
SomnolenceDysgeusiaAntiphospholipid SyndromeDrug Withdrawal Syndrome
VomitingBipolar DisorderDisorientationConvulsion
Frequent HeadachesCondition AggravatedOedema PeripheralBlood Glucose Decreased
SedationDepressionHeadacheDrug Dependence
Mental DisorderDepressionOedema Peripheral

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Depakote
- support group for people who take Suboxone

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) is often used to treat opiate withdrawal. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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