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Review: Suboxone and Depakote





Summary: drug interactions are reported among people who take Suboxone and Depakote together.

This review analyzes the effectiveness and drug interactions between Suboxone and Depakote. It is created by eHealthMe based on reports of 51 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Suboxone and Depakote >>>

What are the drugs

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. (latest outcomes from Suboxone 8,267 users)

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 30,928 users)

On Dec, 4, 2014: 51 people who take Suboxone, Depakote are studied

Suboxone, Depakote outcomes

Drug combinations in study:
- Suboxone (buprenorphine hydrochloride; naloxone hydrochloride)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Suboxone is effectiven/a100.00%
(4 of 4 people)
100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
n/an/a
Depakote is effective0.00%
(0 of 1 people)
0.00%
(0 of 3 people)
n/an/a66.67%
(2 of 3 people)
0.00%
(0 of 1 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionVomitingDysgeusiaPulmonary OedemaFrequent Headachesn/an/aDrug Withdrawal Syndrome
Oedema PeripheralOedema PeripheralHeadacheNervousnessVomitingPneumonia
LethargyHallucinationDrug Withdrawal SyndromePneumoniaFecal IncontinenceConvulsion
StressDeathDecreased AppetiteTension HeadacheDepression
HallucinationNightmaresCondition AggravatedSubstance AbuseHallucination
PneumoniaCryingOxygen Saturation DecreasedSuicidal Ideation
Tension HeadacheInsomniaSwelling FaceHeadache
Swelling FaceTachyphreniaErectile DisturbanceNausea
Oxygen Saturation DecreasedNegative ThoughtsPericardial Effusion
AnxietySuicidal IdeationInsomnia

Drug effectiveness by gender :

FemaleMale
Suboxone is effective100.00%
(6 of 6 people)
100.00%
(3 of 3 people)
Depakote is effective40.00%
(2 of 5 people)
0.00%
(0 of 4 people)

Most common drug interactions by gender * :

FemaleMale
PneumoniaDrug Withdrawal Syndrome
HeadacheConvulsion
Pulmonary MassBipolar Disorder
HaemoptysisDrug Dependence
HallucinationSuicidal Ideation
Antiphospholipid SyndromeAnxiety
DepressionDisturbance In Attention
Oedema PeripheralEuphoric Mood
DisorientationBlood Glucose Decreased
Withdrawal SyndromeNausea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Suboxone is effectiven/an/an/a60.00%
(3 of 5 people)
100.00%
(3 of 3 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
n/a
Depakote is effectiven/an/an/a16.67%
(1 of 6 people)
0.00%
(0 of 3 people)
50.00%
(1 of 2 people)
n/an/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aDeathDepressionSuicidal IdeationPneumoniaHypoacusisn/a
Drug DependenceNauseaHallucinationFall
Suicidal IdeationCryingPericardial EffusionLoss Of Consciousness
Drug Withdrawal SyndromeDrug Withdrawal SyndromePulmonary MassScab
Condition AggravatedAggressionHaemoptysisExcoriation
SomnolenceDysgeusiaAntiphospholipid SyndromeDrug Withdrawal Syndrome
VomitingBipolar DisorderDisorientationConvulsion
Frequent HeadachesCondition AggravatedOedema PeripheralBlood Glucose Decreased
SedationDepressionHeadacheDrug Dependence
Mental DisorderDepressionOedema Peripheral

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Suboxone and Depakote?

You are not alone! Join a related mobile support group:
- support group for people who take Suboxone and Depakote
- support group for people who take Depakote
- support group for people who take Suboxone

Can you answer these questions (Ask a question):

More questions for: Depakote, Suboxone

You may be interested at these reviews (Write a review):

  • Suboxone treatment may have caused my trichotillomania
    It's a long story of how I became addicted to opiates after 15+ years of chronic pain, but I decided to give up pain killers and try suboxone/subutex treatment. Shortly thereafter, I began pulling hair. First from my head, then when the bald spots became too obvious I started pulling from all over. It seemed to be triggered by stress or anxiety but not always. I did not make an association until recently, when I finally stopped the suboxone. It was two weeks of miserable withdrawal, much worse than from pain killers themselves, but I am finally out of the haze I'd be in all of that time, and I have no urge to pull hair whatsoever. I don't know how often the association of suboxone use and trichotillomania has been examined, but I wanted to share my experience in case anyone else is in a similar situation. Also, if you are considering starting suboxone treatment, don't. Withdrawal from opiates will lead to a few pretty rough days, but that's nothing compared to what you'll go through during suboxone withdrawal.
  • Pacemaker experience
    I had a pacemaker installed about 5 weeks ago. I went to the doctors because I was feeling fatigue, shortness of breath, I felt as if someone was holding my heart in their hand and I had some confusion and dizziness.

    To get to the point, after my first visit with my PCP I decided to go directly to emergency via 911 since my PCP was basically ignoring, or better put, had no sense of urgency regarding how I was feeling even though she knew my heart rate had dropped and was steady at 44 bpm, my normal rate 62 bpm.

    The night I was in observation at the hospital I dropped to 20 bpm, next day I had a pacemaker installed, had I not taken the initiative to call the hospital I don't know if I would have continued dropping until I was dead, I don't know enough about the science behind this to draw that conclusion but common sense tells me yes.

    I have explained this in another post but I cannot find it, not sure what I am doing wrong, so I am writing another post because I have more to add after a couple of weeks since my last post.

    The issue I have is I am still tired after more than a month after the installation of the pacemaker. I had the bpm (beats per minute) on my pacemaker increased from 60, the factory settings, to somewhere in the mid 60's.......so I thought. I went to the hospital twice to have my pacemaker "tweaked" but when I met with the cardiologist for my "one week" follow up, which took almost three weeks to see him due to his heavy schedule, he told me there were never any changes made to my pacemaker, I was still at 60 bpm. How could this be since I was told twice it had been increased? I had the wand on my chest and the nurse made the changes which were made due to my complaining about being exhausted still, the reason I went to the PCP in the first place five weeks ago.
    Was she playing mind games, thinking the power of suggestion would make me feel better? If so I am disgusted to think she would feel I was faking my feelings of exhaustion, what she did had absolutely no effect on how poorly I was feeling.

    To get to the point, I finally had my first meeting with the surgeon, he raised my bpm to 75 from 60, was going to go to 80 but changed his mind. The moment he made the change to 75 bpm from my original 60 he asked if I was feeling better, feeling better after 60 seconds of changing the bpm, how is that possible? I told him no, kind of too soon to tell. His reply was "it looks like we have done everything we can on our end, your heart was not significantly damaged, your pacemaker is working as it should, therefore there must be something else making you feel so poorly so I suggest you see an internal medicine specialist." My brain had a big WHAT sign flashing, I couldn't believe what he was saying, basically beat it and move on, I don't have the time to deal with you anymore. Lets see, the appointment lasted 25 minutes and he does not have the time to work with me anymore, sorry but that irritates the hell out of me.

    He was washing his hands of me, nothing else he could do so spend time and money finding out what the problem is with an internest, it is not my heart according to the cardiologist. The appointment ended and I left wondering how I was going to find out what is causing my issues.

    To my great fortune a nurse with 20 years experience teaching doctors and nurses how to use the pacemaker computer asked me to come into her office after my appointment with the cardiologist, she asked me this prior to seeing the doctor. Thank God she did as the doctor did not do a thorough job adjusting the pacemaker, she adjusted what the doctor had, tweaked the pacemaker a bit, had me walk for 10 minutes and come back to the office and did a bit more tweaking, I slowly started feeling a touch better. She asked me to come back in two weeks and she would see if the pacemaker needed to be tweaked a bit more. I was walking on air, still not close to my "normal", thrilled I was not just a number being tossed in the heap of unfixed people. I am feeling 70% better than how I felt prior to the doctor and her tweaking the pacemaker. Had she not been there that day and had the opportunity to do this I would be on a never ending search for what is making me feel so exhausted and!
    dizzy.

    There is a moral to this which I will let you draw your own conclusion. In my mind it is trust God will intervene, he certainly did when the nurse asked me to see her after the appointment with the surgeon. The reason I feel this way is because she was there and is only there on Fridays, the day I had my appointment. I never would have gone back again after my meeting with the doctor and I would have been spending needless hours and money looking through the wrong box for what ales me. Now it is obvious it was my pacemaker settings, my heart rate was set too low and the pacemaker was not fine tuned properly with the proper slope and other settings.

    Don't let these doctors do what mine tried doing with me, be aggressive and insist on more adjustments if you have issues similar to mine.

    AS I sit here I am still tired, I could easily take a nap but I am better than I was yesterday, significantly.

    Best of luck to all. Your comments will be very much appreciated.
  • Yawning after taking sub
    Within a few minutes after I take my Suboxone film I seem to get intense yawning event along with runny nose & watery eyes lasting 5-15 mins. Sometimes I can make it subside by drinking a lot of water if I am in a place I can get it. I have been on Sub for approx 5 yrs. & have only noticed this side effect during the past 1 yr or so. It doesn't seem to matter if I take 1/2 or a whole film, (4mg or 8mg.)
    While this isn't life shattering it can be quite annoying if I am out in public, at work, etc. The yawning gets so intense at times I feel like my jaw will unhinge & can't control it at all.
    It seems paradoxical to me. Previously taking Sub would stop any typical opiate withdrawal symptoms such a yawing & runny nose & eyes. Now it actually causes this effect. I don't get any other feelings of going into withdrawal. Just those I mentioned. Could it be a reaction to the naloxone?
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Insomnia from suboxone (1 response)
    Does Suboxone cause insomnia? Hell yes, I haven't slept properly for years and I wish I had never gone on it. My night is my day and daybreak is when i'm heading off to sleep,I try to wake up about 11 am but that is still half the day gone. I am so so over it, all I can do is reduce my dose

    and that's what I am doing. :(

More reviews for: Depakote, Suboxone

Comments from related studies:

  • From this study (6 months ago):

  • I am waking you 4-5 times a week between 3-4 am crying and yelling.I have the same dream every night, detail for detail.it's always the same, I get a call to come to the hospital something to do with my husband. I go there and they don't say anything to me just walk me into a room and he is laying on a bed covered head to toe in a white sheet and his head is wrapped in several sheets. They never ask me to identify him or say a word to me but i know its him.wieirdest most scariest thing in my life. I literally wake up immediately and Ii'm crying, screaming no and calling for him, all sweaty. He gets me up and holi spent ds me and makes sure I see he is ok but th emotional and physical are taking its toll. I feel like something horrible is going t
    To happened to him
    Is this happening from a side affects from my meds or how should i handle this I'm to scared at nights sometimes bc I'm worried about having another of t

    Reply

    op_diom on Jul, 6, 2014:

    I had this happen to me all the time. I changed to taking my dosage of suboxone to once in the late morning lunch time period and once before I got to sleep. Taking it spread out during the day and near bedtime keeps your receptors sufficiently blocked all day and night so you don't start experiencing terrors at night due to withdrawal. Helped me tremendously and I can honestly say those night terrors I experienced during withdrawal and weaning periods were some of the most horrific experiences I have ever gone through in my entire life. One you start to wean off, cut down slivers each week or two -- take your time

    Reply

  • From this study (1 year ago):

  • Nocturnal fecal incontinence

    Reply

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Complete drug side effects:

On eHealthMe, Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) is often used to treat opiate withdrawal. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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