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Review: Sulfasalazine and Methotrexate

This review analyzes the effectiveness and drug interactions between Sulfasalazine and Methotrexate. It is created by eHealthMe based on reports of 4,055 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Sulfasalazine and Methotrexate >>>

What are the drugs

Sulfasalazine (latest outcomes from 11,722 users) has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis.

Methotrexate (latest outcomes from 131,079 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

On Jul, 15, 2014: 4,054 people who take Sulfasalazine, Methotrexate are studied

Sulfasalazine, Methotrexate outcomes

Drug combinations in study:
- Sulfasalazine (sulfasalazine)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sulfasalazine is effective0.00%
(0 of 3 people)
0.00%
(0 of 11 people)
10.00%
(1 of 10 people)
0.00%
(0 of 10 people)
27.27%
(3 of 11 people)
55.56%
(5 of 9 people)
66.67%
(2 of 3 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 14 people)
0.00%
(0 of 7 people)
33.33%
(4 of 12 people)
37.50%
(6 of 16 people)
0.00%
(0 of 3 people)
60.00%
(3 of 5 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaInterstitial Lung DiseasePneumoniaPyrexiaPyrexiaRenal FailurePyrexia
PneumoniaDecreased AppetitePneumoniaRenal FailureWeight DecreasedPulmonary FibrosisPleural EffusionPneumonia
Colitis IschaemicPneumoniaWeight DecreasedTonsil CancerPneumoniaAcute Interstitial PneumonitisRheumatoid ArthritisArthralgia
Rheumatoid ArthritisFatigueArthralgiaPyrexiaInterstitial Lung DiseaseAcute Phase ReactionSpinal DisorderRheumatoid Arthritis
Dermatitis AllergicFallAstheniaRheumatoid ArthritisPulmonary FibrosisPneumoniaAnaemiaDyspnoea
HypersensitivityVomitingPneumocystis Jiroveci PneumoniaPleural EffusionAnaemiaDiverticulitisCardiac Failure ChronicDrug Ineffective
Condition AggravatedNauseaHypoalbuminaemiaDyspnoeaDyspnoeaRenal FailureAstheniaNausea
RashDiarrhoeaDisseminated Intravascular CoagulationNasopharyngitisArthralgiaTonsil CancerAtrial FibrillationDiarrhoea
Metastases To LungCoughHepatorenal SyndromeBreast CancerAstheniaUrinary Tract InfectionDyspnoeaInjection Site Pain
ArthritisDyspnoeaHyponatraemiaMalaiseAcute Phase ReactionGeneral Physical Health DeteriorationHypertensive EmergencyFatigue

Drug effectiveness by gender :

FemaleMale
Sulfasalazine is effective15.79%
(6 of 38 people)
26.32%
(5 of 19 people)
Methotrexate is effective26.32%
(10 of 38 people)
15.79%
(3 of 19 people)

Most common drug interactions by gender * :

FemaleMale
PyrexiaPneumonia
Rheumatoid ArthritisPyrexia
DiarrhoeaArthralgia
NauseaDrug Ineffective
PneumoniaRheumatoid Arthritis
ArthralgiaPulmonary Fibrosis
DyspnoeaDyspnoea
Injection Site PainFatigue
Drug IneffectivePain
CoughWeight Decreased

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Sulfasalazine is effectiven/a0.00%
(0 of 1 people)
0.00%
(0 of 4 people)
0.00%
(0 of 9 people)
10.00%
(1 of 10 people)
23.81%
(5 of 21 people)
4.55%
(1 of 22 people)
14.81%
(4 of 27 people)
Methotrexate is effectiven/a100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
22.22%
(2 of 9 people)
10.00%
(1 of 10 people)
20.00%
(4 of 20 people)
4.35%
(1 of 23 people)
11.11%
(3 of 27 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPyrexiaPyrexiaPyrexiaArthralgiaDiarrhoeaPyrexiaPneumonia
Juvenile Rheumatoid ArthritisRespiratory FailureHeadachePyrexiaPyrexiaDrug IneffectivePyrexia
Condition AggravatedInfectionArthralgiaVomitingAbdominal PainRheumatoid ArthritisInterstitial Lung Disease
Pain NosDemyelinationDrug HypersensitivityHypoaesthesiaContusionArthralgiaDyspnoea
Joint StiffnessCondition AggravatedPainDiarrhoeaPneumoniaCoughRheumatoid Arthritis
Vanillyl Mandelic Acid Urine IncreasedBlood Pressure DecreasedRheumatoid ArthritisDizzinessThrombocytopeniaPainArthralgia
DysphagiaDyspnoeaImpaired HealingNauseaHaematemesisFatiguePulmonary Fibrosis
AstheniaInfusion Related ReactionDermatitisFallFull Blood Count AbnormalPneumoniaDrug Ineffective
Pulmonary Alveolar HaemorrhageChest PainPruritusGait DisturbanceRheumatoid ArthritisNauseaNausea
Acute Graft Versus Host Disease In IntestineRenal Failure AcuteEczemaMuscular WeaknessNauseaWeight DecreasedSepsis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Sulfasalazine and Methotrexate
- group for people who take Methotrexate
- group for people who take Sulfasalazine

Comments from related studies:

  • From this study (1 week ago):

  • Our 6 year old was diagnosed 4 years ago, polyarticular JRA. She did about 1 year of sulfasalazine combined with prednisone. Then the next year was prednisone and methotrexate. We came of off prednisone in March and remain on 7.5mg of methotrexate once a week.

    She is extremely hyper. She NEVER sits still and is constantly bouncing around. She can't even sit down/sit still long enough to eat a meal.

    We thought that she would calm down a few months after coming off of prednisone since she was on it for 2 years, but that didn't happen. Now we are curious as to whether the hyperness is a result of the methotrexate or a permanent result of the prednisone. Any guidance is appreciated.

    Thank you

    Reply

  • From this study (5 months ago):

  • morning sweating feeling faint then ok rest of the day

    Reply

  • From this study (5 months ago):

  • want to find out if these drugs would cause semen discolouration (yellow, greenish)

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Sulfasalazine (sulfasalazine) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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