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Review: Sulfasalazine and Methotrexate

This review analyzes the effectiveness and drug interactions between Sulfasalazine and Methotrexate. It is created by eHealthMe based on 4,014 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 7, 2014: 4,014 people who reported to have interactions when taking Sulfasalazine, Methotrexate are studied

Trend of Sulfasalazine, Methotrexate's drug interactions, side effects and effectiveness reports (5207567)

Drug combinations in study:
- Sulfasalazine (sulfasalazine)
- Methotrexate (methotrexate sodium)

eHealthMe real world results:

Most common interactions experienced by people in the use of Sulfasalazine, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pyrexia (fever)870
Arthralgia (joint pain)707
Dyspnoea (difficult or laboured respiration)697
Pneumonia634
Diarrhoea598
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints)447
Drug Ineffective372
Nausea (feeling of having an urge to vomit)342
Fatigue (feeling of tiredness)324
Injection Site Pain304

Most common interactions experienced by people in long term use of Sulfasalazine, Methotrexate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pyrexia (fever)150
Pneumonia82
Pulmonary Fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)75
Weight Decreased68
Dyspnoea (difficult or laboured respiration)67
Renal Failure (kidney dysfunction)57
Anaemia (lack of blood)54
Chest Pain39
Interstitial Lung Disease38
Nausea (feeling of having an urge to vomit)38

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Sulfasalazine25.00%31.25%31.25%12.50%0.00%
Methotrexate0.00%31.58%42.11%26.32%0.00%

Top conditions involved for these people * :

  1. Rheumatoid arthritis
  2. Psoriatic arthropathy
  3. Ankylosing spondylitis
  4. Hypertension
  5. Pain

Top co-used drugs for these people * :

  1. Folic acid
  2. Remicade
  3. Humira
  4. Enbrel
  5. Prednisone

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Methotrexate, Sulfasalazine

You can also:

Complete drug side effects:

On eHealthMe, Sulfasalazine (sulfasalazine) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

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  • From this study (4 months ago):

  • I have RA, Fibromyalgia, Raynauds Disease, IBS and lactose intolerant. Was diagnosed at age 38 am now 40. Still battling with joint pain, but after taking methotrexate for 11 months I developed severe folliculitis on my legs and arms. I stopped taking mtx for 3 wks and my issue was starting to get better. Am now on injectable mtx for last 2 wks and legs are looking terrible.

    Reply

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More questions for: Methotrexate, Sulfasalazine

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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