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Review: taking Sulfasalazine and Methotrexate together

Summary: drug interactions are reported among people who take Sulfasalazine and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Sulfasalazine and Methotrexate. It is created by eHealthMe based on reports of 4,061 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Sulfasalazine and Methotrexate >>>

What are the drugs

Sulfasalazine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. (latest outcomes from 11,750 Sulfasalazine users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

On Feb, 27, 2015: 4,060 people who take Sulfasalazine, Methotrexate are studied

Sulfasalazine, Methotrexate outcomes

Drug combinations in study:
- Sulfasalazine (sulfasalazine)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Sulfasalazine is effective0.00%
(0 of 3 people)
0.00%
(0 of 11 people)
8.33%
(1 of 12 people)
0.00%
(0 of 10 people)
30.77%
(4 of 13 people)
55.56%
(5 of 9 people)
75.00%
(3 of 4 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 14 people)
0.00%
(0 of 7 people)
35.71%
(5 of 14 people)
38.89%
(7 of 18 people)
0.00%
(0 of 3 people)
66.67%
(4 of 6 people)
n/a

Drug effectiveness by gender :

FemaleMale
Sulfasalazine is effective19.51%
(8 of 41 people)
23.81%
(5 of 21 people)
Methotrexate is effective31.71%
(13 of 41 people)
14.29%
(3 of 21 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Sulfasalazine is effectiven/a0.00%
(0 of 1 people)
0.00%
(0 of 4 people)
0.00%
(0 of 9 people)
16.67%
(2 of 12 people)
23.81%
(5 of 21 people)
4.35%
(1 of 23 people)
17.24%
(5 of 29 people)
Methotrexate is effectiven/a100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
22.22%
(2 of 9 people)
25.00%
(3 of 12 people)
20.00%
(4 of 20 people)
4.17%
(1 of 24 people)
13.79%
(4 of 29 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaPyrexiaInterstitial Lung DiseasePneumoniaPyrexiaPyrexiaRenal FailurePyrexia
PneumoniaDecreased AppetitePneumoniaRenal FailureWeight DecreasedPulmonary FibrosisPleural EffusionPneumonia
Colitis IschaemicPneumoniaWeight DecreasedTonsil CancerPneumoniaAcute Interstitial PneumonitisRheumatoid ArthritisArthralgia
Rheumatoid ArthritisFatigueAstheniaPyrexiaInterstitial Lung DiseaseAcute Phase ReactionSpinal DisorderRheumatoid Arthritis
Dermatitis AllergicFallArthralgiaRheumatoid ArthritisAnaemiaPneumoniaAnaemiaDyspnoea
HypersensitivityVomitingPneumocystis Jiroveci PneumoniaPleural EffusionPulmonary FibrosisDiverticulitisAstheniaDrug Ineffective
Condition AggravatedNauseaHypoalbuminaemiaDyspnoeaDyspnoeaRenal FailureAtrial FibrillationNausea
RashDiarrhoeaDisseminated Intravascular CoagulationNasopharyngitisArthralgiaTonsil CancerCardiac Failure ChronicDiarrhoea
Metastases To LungCoughHyponatraemiaBreast CancerAstheniaUrinary Tract InfectionChillsInjection Site Pain
ArthritisDyspnoeaHepatorenal SyndromeMalaiseAcute Interstitial PneumonitisGeneral Physical Health DeteriorationHypothyroidismFatigue

Most common drug interactions by gender * :

FemaleMale
PyrexiaPneumonia
Rheumatoid ArthritisPyrexia
DiarrhoeaArthralgia
NauseaDrug Ineffective
ArthralgiaPulmonary Fibrosis
PneumoniaRheumatoid Arthritis
DyspnoeaDyspnoea
Injection Site PainFatigue
Drug IneffectivePain
CoughWeight Decreased

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPyrexiaPyrexiaPyrexiaArthralgiaDiarrhoeaPyrexiaPneumonia
Juvenile Rheumatoid ArthritisRespiratory FailureHeadachePyrexiaPyrexiaDrug IneffectivePyrexia
Condition AggravatedInfectionArthralgiaVomitingAbdominal PainRheumatoid ArthritisDyspnoea
Pain NosDemyelinationDrug HypersensitivityHypoaesthesiaContusionArthralgiaInterstitial Lung Disease
Joint StiffnessCondition AggravatedPainDiarrhoeaPneumoniaCoughRheumatoid Arthritis
Vanillyl Mandelic Acid Urine IncreasedBlood Pressure DecreasedRheumatoid ArthritisFallThrombocytopeniaPainArthralgia
DysphagiaDyspnoeaImpaired HealingNauseaHaematemesisPneumoniaPulmonary Fibrosis
AstheniaInfusion Related ReactionDermatitisGait DisturbanceFull Blood Count AbnormalFatigueDrug Ineffective
Pulmonary Alveolar HaemorrhageChest PainPruritusDizzinessRheumatoid ArthritisWeight DecreasedNausea
Acute Graft Versus Host Disease In IntestineRenal Failure AcuteEczemaMuscle AtrophyNauseaNauseaSepsis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Sulfasalazine and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Sulfasalazine and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Sulfasalazine

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.
  • Is it safe to take zocalo if you are taking humora and methotrexate
    Is it safe to take all three of these together? I need to know if there is any adverse side effects of taking these drugs at the same time?

More questions for: Methotrexate, Sulfasalazine

You may be interested at these reviews (Write a review):

  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Sulfasalazine and the never ending menstrual cycle
    I started this drug and never had menstrual problems begore. Within 3 months, I started my period and it never stopped even with stopping the drug for 3 mon ths. I ended up going my gyne and he prescribed megace. I had been bleeding for a total of 6 months. Made an appt with my rhuemy and explained this situation. His words were "it hasn't been listed in the literature as a side effect". Keep taking it. I started it again. Same situation and same treatment. Never took it again and changed rheumy.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine

More reviews for: Methotrexate, Sulfasalazine

Comments from related studies:

  • From this study (8 months ago):

  • Our 6 year old was diagnosed 4 years ago, polyarticular JRA. She did about 1 year of sulfasalazine combined with prednisone. Then the next year was prednisone and methotrexate. We came of off prednisone in March and remain on 7.5mg of methotrexate once a week.

    She is extremely hyper. She NEVER sits still and is constantly bouncing around. She can't even sit down/sit still long enough to eat a meal.

    We thought that she would calm down a few months after coming off of prednisone since she was on it for 2 years, but that didn't happen. Now we are curious as to whether the hyperness is a result of the methotrexate or a permanent result of the prednisone. Any guidance is appreciated.

    Thank you

    Reply

  • From this study (13 months ago):

  • morning sweating feeling faint then ok rest of the day

    Reply

  • From this study (13 months ago):

  • want to find out if these drugs would cause semen discolouration (yellow, greenish)

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Sulfasalazine (sulfasalazine) is often used to treat rheumatoid arthritis. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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