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Review: taking Synthroid and Metformin together

Summary: drug interactions are reported among people who take Synthroid and Metformin together.

This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 11,996 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Synthroid and Metformin >>>

What are the drugs

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from 93,791 Synthroid users)

Metformin has active ingredients of metformin hydrochloride. It is often used in type 2 diabetes. (latest outcomes from 100,962 Metformin users)

On Jan, 27, 2015: 11,996 people who take Synthroid, Metformin are studied

Synthroid, Metformin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective18.18%
(2 of 11 people)
26.19%
(11 of 42 people)
43.75%
(14 of 32 people)
34.62%
(18 of 52 people)
60.64%
(57 of 94 people)
71.13%
(69 of 97 people)
70.45%
(124 of 176 people)
100.00%
(2 of 2 people)
Metformin is effective22.73%
(5 of 22 people)
22.97%
(17 of 74 people)
38.64%
(17 of 44 people)
29.63%
(24 of 81 people)
43.40%
(46 of 106 people)
56.04%
(51 of 91 people)
38.81%
(26 of 67 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFatigueHypoplastic Left Heart SyndromeNauseaCholecystitis ChronicAnxietyFatigueNausea
Intentional OverdoseNauseaMaternal Exposure During PregnancyPainAnxietyFatigueHyperkalaemiaBlood Glucose Increased
DiarrhoeaDyspnoeaGestational DiabetesChest PainPainDizzinessMetabolic AcidosisFatigue
Blood Glucose IncreasedDizzinessOvarian CystAnxietyNauseaLactic AcidosisRenal Failure AcuteWeight Decreased
Cardiac ArrestDiarrhoeaInfectious PeritonitisDyspnoeaAbdominal Pain UpperRenal Failure AcuteHigh Blood SugarDiarrhoea
HypotensionVomitingDepressionSomnolenceCholelithiasisPulmonary EmbolismDizzinessPain
PainAbdominal PainAnxietyBlood Glucose IncreasedWeight DecreasedDeep Vein ThrombosisNauseaDyspnoea
Suicide AttemptEmotional DistressWeight IncreasedCholecystitis ChronicFatigueDepressionElectrocardiogram Pr ProlongationVomiting
Pancreatitis AcutePainFatiguePalpitationsDyspnoeaSudden DeathHair LossHeadache
Lip SwellingInsomniaHigh Blood SugarFeeling ColdHypocalcaemiaChest PainAnxietyDizziness

Drug effectiveness by gender :

FemaleMale
Synthroid is effective57.45%
(239 of 416 people)
63.64%
(56 of 88 people)
Metformin is effective37.41%
(150 of 401 people)
42.53%
(37 of 87 people)

Most common drug interactions by gender * :

FemaleMale
NauseaBlood Glucose Increased
Blood Glucose IncreasedMyocardial Infarction
FatigueNausea
PainRenal Failure Acute
Weight DecreasedWeight Decreased
DiarrhoeaAsthenia
VomitingCardiac Failure Congestive
DyspnoeaDiarrhoea
HeadacheFatigue
DizzinessDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/a0.00%
(0 of 10 people)
25.00%
(15 of 60 people)
35.09%
(40 of 114 people)
28.25%
(50 of 177 people)
35.08%
(87 of 248 people)
39.92%
(103 of 258 people)
Metformin is effectiven/an/a0.00%
(0 of 6 people)
8.77%
(5 of 57 people)
28.30%
(30 of 106 people)
23.16%
(41 of 177 people)
22.49%
(56 of 249 people)
21.32%
(55 of 258 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Transposition Of The Great Vesselsn/aNauseaCholecystitis ChronicPainNauseaNauseaNausea
Type 2 Diabetes MellitusVomitingCholelithiasisNauseaDiabetes MellitusBlood Glucose IncreasedFatigue
Blood Cholesterol IncreasedCholelithiasisAnxietyAnxietyType 2 Diabetes MellitusWeight DecreasedBlood Glucose Increased
Ventricular Septal DefectCholecystitis ChronicPainType 2 Diabetes MellitusWeight DecreasedDiarrhoeaDiarrhoea
Acquired Tracheo-oesophageal FistulaHeadacheAbdominal Pain UpperChest PainDiarrhoeaHeadachePain
Cardiac MurmurAbdominal Pain UpperAbdominal PainHeadacheBlood Glucose IncreasedDyspnoeaAsthenia
Oesophageal AtresiaGallbladder CholesterolosisInjuryDiabetes MellitusVomitingAstheniaVomiting
Congenital Musculoskeletal AnomalyArthralgiaNauseaPulmonary EmbolismPainDizzinessWeight Decreased
Premature BabyTachycardiaGallbladder DisorderDeep Vein ThrombosisHeadacheVomitingDyspnoea
Maternal Drugs Affecting FoetusMydriasisDeep Vein ThrombosisWeight IncreasedDyspnoeaMyocardial InfarctionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Metformin?

You are not alone! Join a related mobile support group:
- support group for people who take Synthroid and Metformin
- support group for people who take Metformin
- support group for people who take Synthroid

Can you answer these questions (Ask a question):

More questions for: Metformin, Synthroid

You may be interested at these reviews (Write a review):

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    I been taking Veltrex for a viral infection in my eye for 3 days and today my blood sugar was 448.My normal blood sugar runs around 146.
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    I have been on levothyroxine for more than ten years and have had two episodes, each lasting over several months of unbearable itching. Doctors seem to deny any connection but are also unable identify the cause of the itching. None of the tests pick anything. Antihistamines are not much of a help. I am still in the throes of the second episode and life is plain, simple miserable.
  • Thrush while on prograf
    I am a health provider at an emergency room and had a patient come in because of a food bolus and when i examined his oral/pharynx I noticed he had thrush. Patient stated it has been their for a while. Patient also stated he has been having progressive difficulty in swallowing. Pt is a kidney transplant patient and has been worked up for other causes of his thrush (including HIV, as per patient results neg) and everything came back negative. I can only conclude that maybe the prograf which is a immunosupressent can possible be the cause
  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Hair loss with metformin hydrochloride usage
    I have been taking the drug Metformin Hydrochloride for about 5 months and definitely find that I am losing hair which is a problem I have never experienced. Always had the healthiest hair, no problems. Well, I am finding that I am losing lair significantly and feel that the manufacturer of this drug should post that this is a side effect as so many have been complaining of the same side effect. I also began having problems with my teeth and always prided myself of having great teeth with no problems. I also understand that if there is a deficiency of Vitamin B12 that this together with taking this drug can cause these issues of hair loss and mouth/teeth problems. Again; I feel this should be totally and more readily informed to anyone taking this drug. I don't feel that anyone should have to give up things important to them to maintain a healthy way of living...I am going to see my physician and discuss what other options that may exist as I am not feeling very comfortable with this drug and the side effects I am experiencing.

More reviews for: Metformin, Synthroid

Comments from related studies:

  • From this study (2 weeks ago):

  • I have a history of pituitary brain tumors (one as an infant, surgically removed and treated with chemo, and one at the age of 7 treated through radiation). I had another brain tumor (miningeoma behind the eye nerves) that has led to these latest bouts of headaches and my rethinking of my health. I have always struggled with weight and am on every hormone replacement due to the effect on my pituitary. I am currently on a mostly vegan diet, which I have generally enjoyed but am starting to reevaluate.

    Reply

  • From this study (2 weeks ago):

  • Vegan diet
    Hormone replacement therapy through drugs for almost entire life, since first brain tumor in 1992

    Reply

  • From this study (2 weeks ago):

  • etizolam and levosulpride drug used for ge reflux for 3 months,

    drug induced parkinsonism observed.Lost muscle tone. Doubtful whether parkinsonism observed is idiopathic or drug induced. If drug induced how far it is curable?

    Reply

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Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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