Review: Synthroid and Metformin
This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 11,961 people who take the same drugs from FDA and social media, and is updated regularly.
What are the drugs
Synthroid (latest outcomes from 93,627 users) has active ingredients of levothyroxine sodium. It is used in hypothyroidism.
Metformin (latest outcomes from 100,725 users) has active ingredients of metformin hydrochloride. It is used in diabetes.
On Jul, 28, 2014: 11,961 people who take Synthroid, Metformin are studied
Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Synthroid is effective||10.00%|
(1 of 10 people)
(11 of 41 people)
(13 of 30 people)
(17 of 48 people)
(55 of 91 people)
(65 of 92 people)
(115 of 164 people)
(2 of 2 people)
|Metformin is effective||22.73%|
(5 of 22 people)
(17 of 72 people)
(16 of 40 people)
(22 of 74 people)
(45 of 103 people)
(46 of 82 people)
(23 of 63 people)
(1 of 4 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Nausea||Fatigue||Hypoplastic Left Heart Syndrome||Nausea||Anxiety||Anxiety||Fatigue||Nausea|
|Intentional Overdose||Nausea||Gestational Diabetes||Pain||Pain||Fatigue||Hyperkalaemia||Blood Glucose Increased|
|Diarrhoea||Dyspnoea||Maternal Exposure During Pregnancy||Chest Pain||Cholecystitis Chronic||Lactic Acidosis||Metabolic Acidosis||Fatigue|
|Cardiac Arrest||Dizziness||Ovarian Cyst||Anxiety||Nausea||Dizziness||Renal Failure Acute||Weight Decreased|
|Blood Glucose Increased||Diarrhoea||Infectious Peritonitis||Dyspnoea||Abdominal Pain Upper||Renal Failure Acute||High Blood Sugar||Diarrhoea|
|Hypotension||Vomiting||Weight Increased||Somnolence||Cholelithiasis||Pulmonary Embolism||Dizziness||Pain|
|Pain||Abdominal Pain||Fatigue||Cholecystitis Chronic||Weight Decreased||Sudden Death||Electrocardiogram Pr Prolongation||Dyspnoea|
|Suicide Attempt||Pain||Anxiety||Blood Glucose Increased||Fatigue||Deep Vein Thrombosis||Nausea||Vomiting|
|Pancreatitis Acute||Emotional Distress||Myalgia||Palpitations||Dyspnoea||Gallbladder Disorder||Pain||Headache|
|Pulmonary Embolism||Renal Failure||Alopecia||Feeling Cold||Injury||Chest Pain||Hair Loss||Dizziness|
Drug effectiveness by gender :
|Synthroid is effective||56.85%|
(224 of 394 people)
(53 of 82 people)
|Metformin is effective||37.04%|
(140 of 378 people)
(35 of 81 people)
Most common drug interactions by gender * :
|Nausea||Blood Glucose Increased|
|Blood Glucose Increased||Myocardial Infarction|
|Pain||Renal Failure Acute|
|Weight Decreased||Weight Decreased|
|Dyspnoea||Cardiac Failure Congestive|
Drug effectiveness by age :
|Synthroid is effective||n/a||n/a||0.00%|
(0 of 10 people)
(14 of 55 people)
(38 of 110 people)
(45 of 160 people)
(84 of 235 people)
(96 of 242 people)
|Metformin is effective||n/a||n/a||0.00%|
(0 of 6 people)
(5 of 52 people)
(29 of 101 people)
(37 of 160 people)
(53 of 237 people)
(51 of 242 people)
Most common drug interactions by age * :
|Transposition Of The Great Vessels||n/a||Nausea||Cholecystitis Chronic||Pain||Nausea||Nausea||Nausea|
|Type 2 Diabetes Mellitus||Vomiting||Anxiety||Nausea||Diabetes Mellitus||Blood Glucose Increased||Fatigue|
|Blood Cholesterol Increased||Cholelithiasis||Cholelithiasis||Anxiety||Type 2 Diabetes Mellitus||Weight Decreased||Blood Glucose Increased|
|Ventricular Septal Defect||Cholecystitis Chronic||Pain||Type 2 Diabetes Mellitus||Weight Decreased||Diarrhoea||Diarrhoea|
|Acquired Tracheo-oesophageal Fistula||Headache||Abdominal Pain Upper||Chest Pain||Blood Glucose Increased||Headache||Pain|
|Cardiac Murmur||Abdominal Pain Upper||Abdominal Pain||Headache||Diarrhoea||Dyspnoea||Asthenia|
|Oesophageal Atresia||Gallbladder Cholesterolosis||Nausea||Diabetes Mellitus||Pain||Asthenia||Vomiting|
|Congenital Musculoskeletal Anomaly||Arthralgia||Injury||Pulmonary Embolism||Vomiting||Dizziness||Weight Decreased|
|Premature Baby||Tachycardia||Deep Vein Thrombosis||Deep Vein Thrombosis||Headache||Vomiting||Dyspnoea|
|Maternal Drugs Affecting Foetus||Mydriasis||Gallbladder Disorder||Weight Increased||Dyspnoea||Myocardial Infarction||Dizziness|
* Some reports may have incomplete information.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
You can also:
- Subscribe the study: get notified of updates
- Post a comment: or see what other people said about the study
Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Synthroid and Metformin
- group for people who take Metformin
- group for people who take Synthroid
Comments from related studies:
From this study (3 weeks ago):
From this study (2 months ago):
I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.
IHateRA on Jul, 22, 2014:
My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.
I only took the Celebrex (1 pill) yesterday in a.m., took the Levothyroxine and HCTZ and took 1/2 of Flexeril (a 5 mg tab - 2.5 mg after cut in half) at bedtime. No Ultracet taken yesterday. Was awakened in middle of night wetting myself. Underwear and PJs had a very strong smell of ammonia, which is not usual for me. Concerned about the odor.
Em on Jun, 23, 2014:
HCTZ is a diuretic and should be taken in the morning.
You need to drink more water or you will continue to have
The odor of ammonia in your urine. The urine is concentrating in your bladder during the day and then when the HCTZ kicks in, you're urine is concentrated. You probably wet the bed because you were in very deep sleep and/or dreaming. This with the diuretic is a bad combination. To be safe ask your physician or pharmacist about the best time to take the HCTZ and tell your doctor about the odor of ammonia in your urine. I am not a primary care provider but have been a nurse for 27 years and have an MS degree so my advice and information are probably accurate but are not to be considered MEDICAL ADVICE. This information is only provided to assist you in discussing your medication and symptom, with a primary care provider (MD,DO, PA, FNP, NP. CNS...) and your pharmacist.
Can you answer these questions (what is this?):
- Laryngitis from depression?
I had a heart attack 3yrs ago, finding it hard to handle. Waiting for a complete knee replacement, also long history of back problems. Chronic pain. Diabetic on insulin.
- Can sulfamethoxazole-tmp ds, raise or lower blood sugar.
Symptoms the last 10 days are chills, sweating, light fever (98.9 to 100) sometimes. General malaise, tired, poor sleep. Just depressed, because of the recurrent Infection that no antibiotics (supposedly the bacteria Klesiella-pneumoniae is Sensitive to all the antibiotics I have taken so far)has cl ...
- Has anyone been prescribed methotrexate for granuloma annulare?
I have had GA for 2 years now, however it has gotten progressively worse the past 6 months. It has now spread over 80% of my body. I am seeing an Endocrinologist next week as I believe my thyroid may play a big role in this. My Regular Dr. suggested I speak to Endocrinologist about a drug called Met ...
You may be interested at these reviews (what is this?):
- Shortness of breath after taking levothyroxine for 8-10 yrs.
I have been experiencing shortness of breath lately when taking the levothyroxine. If I stop taking it for a couple of days my shortness of breath is pretty much gone.
- I wish i had never taken ambien
Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered A ...
- Olfactory issues due to metformin use
I've found that the metformin does not smell especially bad, but when I first started taking it, I could smell something horrible - to the point where I pulled apart my cupboards and fridge, fully expecting to find some maggot-riddled rotting meat. Eventually I realized I was smelling normal smel ...
Complete drug side effects:
On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat type 2 diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Synthroid is used in:
- Metformin is used in:
Other drugs that are used to treat the same conditions:
- Synthroid alternatives:
- Metformin alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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