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Review: taking Synthroid and Metformin together

Summary: drug interactions are reported among people who take Synthroid and Metformin together.

This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 12,002 people who take the same drugs from FDA and social media, and is updated regularly.


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On Feb, 26, 2015: 12,002 people who take Synthroid, Metformin are studied

Synthroid, Metformin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective18.18%
(2 of 11 people)
(11 of 42 people)
(14 of 32 people)
(19 of 53 people)
(58 of 95 people)
(69 of 97 people)
(125 of 178 people)
(2 of 2 people)
Metformin is effective22.73%
(5 of 22 people)
(17 of 74 people)
(17 of 44 people)
(25 of 82 people)
(47 of 108 people)
(53 of 93 people)
(27 of 68 people)
(1 of 4 people)

Drug effectiveness by gender :

Synthroid is effective57.42%
(240 of 418 people)
(58 of 90 people)
Metformin is effective37.78%
(153 of 405 people)
(39 of 89 people)

Drug effectiveness by age :

Synthroid is effectiven/an/a0.00%
(0 of 10 people)
(15 of 60 people)
(40 of 114 people)
(50 of 177 people)
(88 of 260 people)
(105 of 260 people)
Metformin is effectiven/an/a0.00%
(0 of 6 people)
(5 of 62 people)
(30 of 106 people)
(42 of 180 people)
(58 of 261 people)
(57 of 260 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFatigueHypoplastic Left Heart SyndromePainPainAnxietyFatigueNausea
Intentional OverdoseNauseaMaternal Exposure During PregnancyNauseaCholecystitis ChronicFatigueMetabolic AcidosisBlood Glucose Increased
DiarrhoeaDizzinessGestational DiabetesChest PainAnxietyLactic AcidosisHyperkalaemiaFatigue
Cardiac ArrestDyspnoeaOvarian CystAnxietyNauseaDizzinessRenal Failure AcuteWeight Decreased
Blood Glucose IncreasedDiarrhoeaInfectious PeritonitisSomnolenceAbdominal Pain UpperRenal Failure AcuteDizzinessDiarrhoea
HypotensionVomitingDepressionDyspnoeaCholelithiasisPulmonary EmbolismHigh Blood SugarPain
Suicide AttemptPainAnxietyBlood Glucose IncreasedWeight DecreasedSudden DeathNauseaDyspnoea
PainAbdominal PainWeight IncreasedCholecystitis ChronicFatigueDepressionElectrocardiogram Pr ProlongationVomiting
Pancreatitis AcuteEmotional DistressFatiguePalpitationsDyspnoeaDeep Vein ThrombosisPainHeadache
Pulmonary EmbolismBlood Creatinine IncreasedHigh Blood SugarFeeling ColdChest PainGallbladder DisorderAnxietyDizziness

Most common drug interactions by gender * :

NauseaBlood Glucose Increased
Blood Glucose IncreasedMyocardial Infarction
PainRenal Failure Acute
Weight DecreasedWeight Decreased
VomitingCardiac Failure Congestive

Most common drug interactions by age * :

Transposition Of The Great Vesselsn/aNauseaCholecystitis ChronicPainNauseaNauseaNausea
Type 2 Diabetes MellitusVomitingCholelithiasisNauseaDiabetes MellitusBlood Glucose IncreasedFatigue
Blood Cholesterol IncreasedCholelithiasisAnxietyAnxietyType 2 Diabetes MellitusWeight DecreasedBlood Glucose Increased
Ventricular Septal DefectCholecystitis ChronicPainType 2 Diabetes MellitusWeight DecreasedDiarrhoeaDiarrhoea
Acquired Tracheo-oesophageal FistulaHeadacheAbdominal Pain UpperChest PainBlood Glucose IncreasedHeadachePain
Cardiac MurmurAbdominal Pain UpperAbdominal PainHeadacheDiarrhoeaDyspnoeaAsthenia
Oesophageal AtresiaGallbladder CholesterolosisNauseaDiabetes MellitusVomitingAstheniaVomiting
Congenital Musculoskeletal AnomalyArthralgiaInjuryPulmonary EmbolismPainDizzinessWeight Decreased
Premature BabyTachycardiaGallbladder DisorderDeep Vein ThrombosisDyspnoeaVomitingDyspnoea
Maternal Drugs Affecting FoetusMydriasisDeep Vein ThrombosisWeight IncreasedHeadacheMyocardial InfarctionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Metformin
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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