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Review: Synthroid and Metformin

This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 11,961 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Synthroid and Metformin >>>

What are the drugs

Synthroid (latest outcomes from 93,598 users) has active ingredients of levothyroxine sodium. It is often used in hypothyroidism.

Metformin (latest outcomes from 100,693 users) has active ingredients of metformin hydrochloride. It is often used in type 2 diabetes.

On Jul, 28, 2014: 11,961 people who take Synthroid, Metformin are studied

Synthroid, Metformin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective10.00%
(1 of 10 people)
26.83%
(11 of 41 people)
43.33%
(13 of 30 people)
35.42%
(17 of 48 people)
60.44%
(55 of 91 people)
70.65%
(65 of 92 people)
70.12%
(115 of 164 people)
100.00%
(2 of 2 people)
Metformin is effective22.73%
(5 of 22 people)
23.61%
(17 of 72 people)
40.00%
(16 of 40 people)
29.73%
(22 of 74 people)
43.69%
(45 of 103 people)
56.10%
(46 of 82 people)
36.51%
(23 of 63 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFatigueHypoplastic Left Heart SyndromeNauseaAnxietyAnxietyFatigueNausea
Intentional OverdoseNauseaGestational DiabetesPainPainFatigueHyperkalaemiaBlood Glucose Increased
DiarrhoeaDyspnoeaMaternal Exposure During PregnancyChest PainCholecystitis ChronicLactic AcidosisMetabolic AcidosisFatigue
Cardiac ArrestDizzinessOvarian CystAnxietyNauseaDizzinessRenal Failure AcuteWeight Decreased
Blood Glucose IncreasedDiarrhoeaInfectious PeritonitisDyspnoeaAbdominal Pain UpperRenal Failure AcuteHigh Blood SugarDiarrhoea
HypotensionVomitingWeight IncreasedSomnolenceCholelithiasisPulmonary EmbolismDizzinessPain
PainAbdominal PainFatigueCholecystitis ChronicWeight DecreasedSudden DeathElectrocardiogram Pr ProlongationDyspnoea
Suicide AttemptPainAnxietyBlood Glucose IncreasedFatigueDeep Vein ThrombosisNauseaVomiting
Pancreatitis AcuteEmotional DistressMyalgiaPalpitationsDyspnoeaGallbladder DisorderPainHeadache
Pulmonary EmbolismRenal FailureAlopeciaFeeling ColdInjuryChest PainHair LossDizziness

Drug effectiveness by gender :

FemaleMale
Synthroid is effective56.85%
(224 of 394 people)
64.63%
(53 of 82 people)
Metformin is effective37.04%
(140 of 378 people)
43.21%
(35 of 81 people)

Most common drug interactions by gender * :

FemaleMale
NauseaBlood Glucose Increased
Blood Glucose IncreasedMyocardial Infarction
FatigueNausea
PainRenal Failure Acute
Weight DecreasedWeight Decreased
DiarrhoeaAsthenia
VomitingDiarrhoea
DyspnoeaCardiac Failure Congestive
HeadacheFatigue
DizzinessDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/a0.00%
(0 of 10 people)
25.45%
(14 of 55 people)
34.55%
(38 of 110 people)
28.12%
(45 of 160 people)
35.74%
(84 of 235 people)
39.67%
(96 of 242 people)
Metformin is effectiven/an/a0.00%
(0 of 6 people)
9.62%
(5 of 52 people)
28.71%
(29 of 101 people)
23.12%
(37 of 160 people)
22.36%
(53 of 237 people)
21.07%
(51 of 242 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Transposition Of The Great Vesselsn/aNauseaCholecystitis ChronicPainNauseaNauseaNausea
Type 2 Diabetes MellitusVomitingAnxietyNauseaDiabetes MellitusBlood Glucose IncreasedFatigue
Blood Cholesterol IncreasedCholelithiasisCholelithiasisAnxietyType 2 Diabetes MellitusWeight DecreasedBlood Glucose Increased
Ventricular Septal DefectCholecystitis ChronicPainType 2 Diabetes MellitusWeight DecreasedDiarrhoeaDiarrhoea
Acquired Tracheo-oesophageal FistulaHeadacheAbdominal Pain UpperChest PainBlood Glucose IncreasedHeadachePain
Cardiac MurmurAbdominal Pain UpperAbdominal PainHeadacheDiarrhoeaDyspnoeaAsthenia
Oesophageal AtresiaGallbladder CholesterolosisNauseaDiabetes MellitusPainAstheniaVomiting
Congenital Musculoskeletal AnomalyArthralgiaInjuryPulmonary EmbolismVomitingDizzinessWeight Decreased
Premature BabyTachycardiaDeep Vein ThrombosisDeep Vein ThrombosisHeadacheVomitingDyspnoea
Maternal Drugs Affecting FoetusMydriasisGallbladder DisorderWeight IncreasedDyspnoeaMyocardial InfarctionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Synthroid and Metformin
- group for people who take Metformin
- group for people who take Synthroid

Comments from related studies:

  • From this study (3 weeks ago):

  • I only took the Celebrex (1 pill) yesterday in a.m., took the Levothyroxine and HCTZ and took 1/2 of Flexeril (a 5 mg tab - 2.5 mg after cut in half) at bedtime. No Ultracet taken yesterday. Was awakened in middle of night wetting myself. Underwear and PJs had a very strong smell of ammonia, which is not usual for me. Concerned about the odor.

    Reply

    Em on Jun, 23, 2014:

    HCTZ is a diuretic and should be taken in the morning.
    You need to drink more water or you will continue to have
    The odor of ammonia in your urine. The urine is concentrating in your bladder during the day and then when the HCTZ kicks in, you're urine is concentrated. You probably wet the bed because you were in very deep sleep and/or dreaming. This with the diuretic is a bad combination. To be safe ask your physician or pharmacist about the best time to take the HCTZ and tell your doctor about the odor of ammonia in your urine. I am not a primary care provider but have been a nurse for 27 years and have an MS degree so my advice and information are probably accurate but are not to be considered MEDICAL ADVICE. This information is only provided to assist you in discussing your medication and symptom, with a primary care provider (MD,DO, PA, FNP, NP. CNS...) and your pharmacist.

    Reply

  • From this study (4 weeks ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • Can people with hypothyroidism take garcinia cambogia?
    I have hypothyroidism, ITP, and MCTD. With me having all of these issues and taking all these different medications, I was wondering if it would be safe for me to take a diet pill named garcinia cambogia.

  • Could any of the following drugs cause bullous pemphigoid
    I have not developed blisters, just hives. I have been tested for most common allergies and appear not to have allergies. I have seen some descriptions on line and with drugs that seem t indicate a relation between these drugs and Bullous pemphigoid, but I have not been able to find more than a lin ...

  • Could acromegaly cause temporal arteritis?i
    I was diagnosed with acromegaly '08. I have had transphenoidal tumor removal and radiation. New onset of severe pain temples, nausea, neck pain I don't want to call my doctor and sound like a hypochondriac Does anyone have experience with having acromegaly and ending up with temporal arteritis

More questions for: Metformin, Synthroid

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  • Olfactory issues due to metformin use
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  • Bone infections involving my teeth crohns and prednisone over the past 12 years
    Dentist [2] tell me the abscesses are in the bones and I've had several root canals, bridges, bone surgeries that last 3 years, teeth became so mobile after the bone economy I had them pulled and now a partial one month ago. Bone loss etc. I don't have the ridges in my mouth that most Crohn patients ...

  • How an integrative wellness approach cured me of insomnia, ibs, and more
    For 10+ years, I suffered with insomnia and a host of other problems including intestinal distress, headaches, psoriasis, anxiety, cognitive issues, hypothyroid, chronic itching, restless leg, etc. Traditional medicine, aka taking drugs, was not working to heal me. Since childhood, I’ve had IBS, h ...

More reviews for: Metformin, Synthroid

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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