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Review: taking Synthroid and Metformin together

Summary: drug interactions are reported among people who take Synthroid and Metformin together. This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 12,010 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>

 

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What are the drugs

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from 93,877 Synthroid users)

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from 101,050 Metformin users)

On Apr, 28, 2015: 12,010 people who take Synthroid, Metformin are studied

Synthroid, Metformin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective18.18%
(2 of 11 people)
26.19%
(11 of 42 people)
43.75%
(14 of 32 people)
35.85%
(19 of 53 people)
61.05%
(58 of 95 people)
70.00%
(70 of 100 people)
70.88%
(129 of 182 people)
100.00%
(2 of 2 people)
Metformin is effective22.73%
(5 of 22 people)
22.97%
(17 of 74 people)
37.78%
(17 of 45 people)
30.49%
(25 of 82 people)
42.73%
(47 of 110 people)
56.38%
(53 of 94 people)
40.00%
(28 of 70 people)
25.00%
(1 of 4 people)

Drug effectiveness by gender :

FemaleMale
Synthroid is effective57.65%
(245 of 425 people)
64.44%
(58 of 90 people)
Metformin is effective37.47%
(154 of 411 people)
43.82%
(39 of 89 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/a0.00%
(0 of 10 people)
25.00%
(15 of 60 people)
35.09%
(40 of 114 people)
28.25%
(50 of 177 people)
34.10%
(89 of 261 people)
40.37%
(109 of 270 people)
Metformin is effectiven/an/a0.00%
(0 of 6 people)
8.06%
(5 of 62 people)
28.30%
(30 of 106 people)
23.33%
(42 of 180 people)
22.14%
(58 of 262 people)
21.56%
(58 of 269 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFatigueHypoplastic Left Heart SyndromePainCholecystitis ChronicFatigueFatigueNausea
Intentional OverdoseNauseaMaternal Exposure During PregnancyNauseaPainAnxietyMetabolic AcidosisBlood Glucose Increased
DiarrhoeaDizzinessGestational DiabetesChest PainAnxietyLactic AcidosisHyperkalaemiaFatigue
Cardiac ArrestDyspnoeaInfectious PeritonitisAnxietyNauseaDizzinessRenal Failure AcuteWeight Decreased
Blood Glucose IncreasedDiarrhoeaOvarian CystSomnolenceAbdominal Pain UpperRenal Failure AcuteDizzinessDiarrhoea
HypotensionVomitingWeight IncreasedDyspnoeaCholelithiasisPulmonary EmbolismHigh Blood SugarPain
Suicide AttemptPainFatigueBlood Glucose IncreasedWeight DecreasedDepressionNauseaDyspnoea
PainAbdominal PainDepressionCholecystitis ChronicDyspnoeaDeep Vein ThrombosisElectrocardiogram Pr ProlongationVomiting
Pancreatitis AcuteEmotional DistressAnxietyPalpitationsFatigueSudden DeathPainHeadache
Pulmonary EmbolismBlood Creatinine IncreasedMyalgiaFeeling ColdHypocalcaemiaVentricular ExtrasystolesAnxietyDizziness

Most common drug interactions by gender * :

FemaleMale
NauseaBlood Glucose Increased
Blood Glucose IncreasedMyocardial Infarction
FatigueNausea
PainRenal Failure Acute
Weight DecreasedWeight Decreased
DiarrhoeaAsthenia
VomitingCardiac Failure Congestive
DyspnoeaDiarrhoea
HeadacheFatigue
DizzinessDyspnoea

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Transposition Of The Great Vesselsn/aNauseaCholecystitis ChronicPainNauseaNauseaNausea
Type 2 Diabetes MellitusVomitingCholelithiasisNauseaDiabetes MellitusBlood Glucose IncreasedFatigue
Blood Cholesterol IncreasedCholelithiasisAnxietyAnxietyType 2 Diabetes MellitusWeight DecreasedBlood Glucose Increased
Ventricular Septal DefectCholecystitis ChronicPainType 2 Diabetes MellitusWeight DecreasedDiarrhoeaDiarrhoea
Acquired Tracheo-oesophageal FistulaHeadacheAbdominal Pain UpperChest PainBlood Glucose IncreasedHeadachePain
Cardiac MurmurAbdominal Pain UpperAbdominal PainHeadacheDiarrhoeaDyspnoeaAsthenia
Oesophageal AtresiaGallbladder CholesterolosisNauseaDiabetes MellitusVomitingAstheniaVomiting
Congenital Musculoskeletal AnomalyArthralgiaInjuryPulmonary EmbolismPainDizzinessWeight Decreased
Premature BabyTachycardiaGallbladder DisorderDeep Vein ThrombosisDyspnoeaVomitingDyspnoea
Maternal Drugs Affecting FoetusMydriasisDeep Vein ThrombosisWeight IncreasedHeadacheMyocardial InfarctionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Synthroid and Metformin on

Do you take Synthroid and Metformin?

 

You are not alone! Join a related support group:
- support group for people who take Metformin
- support group for people who take Synthroid

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Metformin, Synthroid

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Comments from related studies:

  • From this study (2 weeks ago):

  • I have epilepsy and chronic migraine syndrome, I always have a headache one side of my head. I have seizures everyday. Since last April, I have had one sort of a rash or another. I have not felt well for this entire time too. I have already come of Phenytoin, Atorvastatin, Lamictal and Topiramate. As I have been thinking it was one of my drugs. But it only makes things calmer for a couple of weeks and then the symptoms return to how they were before. I am waiting to see a rheumatologist currently, so still unaware of what is causing my problems.
    I have had a CRP test and that was 9 at the time of the test. Now my smptoms are growing again, I don't know if that makes it likely it might be higher. I have spent this past year in a situation that makes you feel like you are being attached by your own body. It's very frightening when you feel as though you are going through this and people can't always see the rash but it is definitely attacking the skin.

    Reply

  • From this study (2 months ago):

  • Back, shoulders, neck, scalp, small blind bumps and swollen skin tags, soreness and intermittent heat and sweating on neck

    Reply

  • From this study (2 months ago):

  • Flank pain
    Hit that will not go away
    Lower pelvic pain
    Urge to urinate

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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