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Review: Synthroid and Metformin

This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on 11,549 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 29, 2014: 11,549 people who reported to have interactions when taking Synthroid, Metformin are studied

Trend of Synthroid, Metformin's drug interactions, side effects and effectiveness reports (5890751)

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Synthroid, Metformin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Nausea (feeling of having an urge to vomit)2,779
Diarrhoea2,614
Dyspnoea (difficult or laboured respiration)2,536
Vomiting2,368
Fatigue (feeling of tiredness)2,205
Pain2,089
Blood Glucose Increased1,934
Weight Decreased1,586
Headache (pain in head)1,535
Dizziness1,505

Most common interactions experienced by people in long term use of Synthroid, Metformin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety151
Renal Failure Acute (rapid kidney dysfunction)98
Pain89
Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)78
Nausea (feeling of having an urge to vomit)76
Cholecystitis Chronic (long lasting infection of gallbladder)72
Fatigue (feeling of tiredness)70
Chest Pain58
Abdominal Pain Upper54
Pulmonary Embolism (blockage of the main artery of the lung)50

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Synthroid4.08%8.16%20.41%45.92%21.43%
Metformin2.68%20.54%33.93%31.25%11.61%

Top conditions involved for these people * :

  1. Diabetes mellitus
  2. Hypertension
  3. Type 2 diabetes mellitus
  4. Hypothyroidism
  5. Depression

Top co-used drugs for these people * :

  1. Glucophage
  2. Aspirin
  3. Lipitor
  4. Byetta
  5. Lisinopril

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Related topic: Metformin, Synthroid

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Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 month ago):

  • My mom was admitted to a nursing home 2-weeks ago before that she was held over at the hospital 13 days, meds was changed, Aricept removed and Detrol she had a staff MD. her primary care md passed away 3 years ago. He put her on her meds and tooked good care of her. She has not been without a primary md but he does not practice outside his offices. Mom had a good mental status did removing Aricept/Detrol trigger bad symptoms?

    Reply

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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