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Review: Synthroid and Metformin

This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 11,980 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Synthroid and Metformin >>>

What are the drugs

Synthroid (what 93,669 Synthroid users reported?) has active ingredients of levothyroxine sodium. It is used in hypothyroidism.

Metformin (what 100,800 Metformin users reported?) has active ingredients of metformin hydrochloride. It is used in diabetes.

On Sep, 27, 2014: 11,980 people who take Synthroid, Metformin are studied

Synthroid, Metformin outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effective18.18%
(2 of 11 people)
26.83%
(11 of 41 people)
43.33%
(13 of 30 people)
35.42%
(17 of 48 people)
61.29%
(57 of 93 people)
70.83%
(68 of 96 people)
69.41%
(118 of 170 people)
100.00%
(2 of 2 people)
Metformin is effective22.73%
(5 of 22 people)
23.29%
(17 of 73 people)
39.53%
(17 of 43 people)
29.87%
(23 of 77 people)
43.69%
(45 of 103 people)
56.32%
(49 of 87 people)
36.92%
(24 of 65 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFatigueHypoplastic Left Heart SyndromePainCholecystitis ChronicAnxietyFatigueNausea
Intentional OverdoseNauseaGestational DiabetesNauseaAnxietyFatigueMetabolic AcidosisBlood Glucose Increased
DiarrhoeaDyspnoeaMaternal Exposure During PregnancyChest PainPainDizzinessHyperkalaemiaFatigue
Blood Glucose IncreasedDizzinessInfectious PeritonitisAnxietyNauseaLactic AcidosisRenal Failure AcuteWeight Decreased
Cardiac ArrestDiarrhoeaOvarian CystDyspnoeaAbdominal Pain UpperRenal Failure AcuteDizzinessDiarrhoea
HypotensionVomitingFatigueSomnolenceCholelithiasisPulmonary EmbolismHigh Blood SugarPain
Suicide AttemptAbdominal PainWeight IncreasedCholecystitis ChronicWeight DecreasedSudden DeathNauseaDyspnoea
Pancreatitis AcutePainAnxietyBlood Glucose IncreasedFatigueDeep Vein ThrombosisElectrocardiogram Pr ProlongationVomiting
Lip SwellingEmotional DistressDepressionFatigueDyspnoeaDepressionPainHeadache
Pulmonary EmbolismRenal FailurePainFeeling ColdHypocalcaemiaThyroid Function Test AbnormalAnxietyDizziness

Drug effectiveness by gender :

FemaleMale
Synthroid is effective57.25%
(233 of 407 people)
64.63%
(53 of 82 people)
Metformin is effective37.24%
(146 of 392 people)
43.21%
(35 of 81 people)

Most common drug interactions by gender * :

FemaleMale
NauseaBlood Glucose Increased
Blood Glucose IncreasedMyocardial Infarction
FatigueNausea
PainRenal Failure Acute
Weight DecreasedWeight Decreased
DiarrhoeaAsthenia
VomitingDiarrhoea
DyspnoeaCardiac Failure Congestive
HeadacheFatigue
DizzinessDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Synthroid is effectiven/an/a0.00%
(0 of 10 people)
25.45%
(14 of 55 people)
35.09%
(40 of 114 people)
28.48%
(47 of 165 people)
35.98%
(86 of 239 people)
38.98%
(99 of 254 people)
Metformin is effectiven/an/a0.00%
(0 of 6 people)
9.62%
(5 of 52 people)
28.30%
(30 of 106 people)
23.03%
(38 of 165 people)
22.41%
(54 of 241 people)
21.26%
(54 of 254 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Transposition Of The Great Vesselsn/aNauseaCholecystitis ChronicPainNauseaNauseaNausea
Type 2 Diabetes MellitusVomitingAnxietyNauseaDiabetes MellitusBlood Glucose IncreasedFatigue
Blood Cholesterol IncreasedCholelithiasisCholelithiasisAnxietyType 2 Diabetes MellitusWeight DecreasedBlood Glucose Increased
Ventricular Septal DefectCholecystitis ChronicPainType 2 Diabetes MellitusWeight DecreasedDiarrhoeaDiarrhoea
Acquired Tracheo-oesophageal FistulaHeadacheAbdominal Pain UpperChest PainBlood Glucose IncreasedHeadachePain
Cardiac MurmurAbdominal Pain UpperAbdominal PainHeadacheDiarrhoeaDyspnoeaAsthenia
Oesophageal AtresiaGallbladder CholesterolosisNauseaDiabetes MellitusPainAstheniaVomiting
Congenital Musculoskeletal AnomalyArthralgiaInjuryPulmonary EmbolismVomitingDizzinessWeight Decreased
Premature BabyTachycardiaDeep Vein ThrombosisDeep Vein ThrombosisDyspnoeaVomitingDyspnoea
Maternal Drugs Affecting FoetusMydriasisGallbladder DisorderWeight IncreasedHeadacheMyocardial InfarctionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Metformin?

Get connected! Join a mobile support group:
- group for people who take Synthroid and Metformin
- group for people who take Metformin
- group for people who take Synthroid

Comments from related studies:

  • From this study (1 month ago):

  • Painful shoulder accompanied by rash

    Reply

  • From this study (2 months ago):

  • I've been diagnosed with sero-negative rheumatoid arthritis. I have only tested minimally positive on the anti-CCP test and had a slightly high SED rate. My most recent tests showed some slight elevation in some RA marker tests, but nothing really significant. My rheumatologist is now doubting whether I have RA or some other pain syndrome going on.

    Reply

    IHateRA on Jul, 22, 2014:

    My first RA Dr. put me on Plaquenil, it seemed to work for six months, then stopped - I thought the dose would be adjusted but it wasn't, so I went to another RA Doc - C-RP wasn't too high, sero neg. Was put on methotrexate - I ended up with a mouth sore the NEXT day, then bumps started appearing on my face, like zits, but NOT zits. I didn't touch them, but they ulcerated, left me full of scars on face, legs, etc - I have been OFF methotrexate for 5 years AND still have the same problem along with a daily fever (100+) and severe sweating - I knew the bumps were a sign of being allergic to Methotrexate, I quit it right away, called Dr. to get in - they told me 3 months (I was an established patient). In terms of fever and sweating, the ONLY thing I have in common with some of these posts and drug lists is METHOTREXATE - I wouldn't allow a pet to take it. I seem to have more in common with a friend who as MS - but my reg. doc doesn't listen to that. I can't take bio. drugs (live in "fungal" region), so I take pain medicine - as little as possible, I guess the Methotrexate is STILL messing with my body. I have a very good acupuncturist - when I told him that my Doc. wasn't "sure" about RA, he poked me (lightly) with his finger in two places and ask which hurt more. He confirmed the RA as it travels on certain meridians in Chinese medicine. Had I picked a different spot for hurting more, then we would have to figure out what I really had. My joints are deteriorating but now I'm afraid of the drugs for RA, so I just put up with and manage the pain (which is extreme) with pain meds, cold therapy (I love my cryo-cuff), and acupuncture. I wish that the side effects of RA drugs weren't as bad as they are! Leaving Cymbalta, Lyrica, Plaquenil and Methotrexate (all at different times) OUT of my body made me realize that they did affect me - I was "foggy" and sluggish mentally but didn't really notice it until I quit them.

    Reply

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Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat type 2 diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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