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Review: taking Synthroid and Milk Thistle together

Summary: drug interactions are reported among people who take Synthroid and Milk Thistle together.

This review analyzes the effectiveness and drug interactions between Synthroid and Milk Thistle. It is created by eHealthMe based on reports of 112 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Synthroid and Milk Thistle >>>

On Apr, 26, 2015: 112 people who take Synthroid, Milk Thistle are studied

Synthroid, Milk Thistle outcomes

Drug combinations in study:
- Synthroid (levothyroxine sodium)
- Milk Thistle (milk thistle)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Synthroid is effectiven/an/an/a50.00%
(1 of 2 people)
(0 of 4 people)
(4 of 6 people)
(4 of 5 people)
Milk Thistle is effectiven/an/a0.00%
(0 of 3 people)
(1 of 2 people)
(1 of 1 people)
(1 of 4 people)

Drug effectiveness by gender :

Synthroid is effective53.33%
(8 of 15 people)
(1 of 2 people)
Milk Thistle is effective37.50%
(3 of 8 people)
(0 of 2 people)

Drug effectiveness by age :

Synthroid is effectiven/an/an/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(5 of 13 people)
(4 of 19 people)
Milk Thistle is effectiven/an/an/an/a0.00%
(0 of 1 people)
(1 of 10 people)
(2 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/an/aChest Tightness Or PressureType 2 Diabetes MellitusLiver CirrhosisLoss Of HairHaemolytic AnaemiaPneumonia
Stiff NeckHypertensionHigh Blood PressureLow Platelet CountUrinary Tract InfectionArthralgia
DizzinessHypothyroidismUrethral PainDiarrheaAbdominal PainDyspnoea
Colon Cancer MetastaticPlatelet CountMuscle MassPneumoniaFatigue
Back PainHemochromatosisFibromyalgiaPlatelet CountInsomnia
Joint StiffnessAnxiety Disorder Due To A General Medical ConditionAnxiety Disorder Due To A General Medical ConditionDizzinessPyrexia
Impaired MemoryDiarrheaLiver CirrhosisType 2 Diabetes MellitusChest Pain
Autonomic Nervous System ImbalanceLoss Of HairHigh Blood PressurePruritus
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessLow Platelet CountHemochromatosisMyelodysplastic Syndrome
Urethral PainFibromyalgiaChest Tightness Or PressureMyocardial Infarction

Most common drug interactions by gender * :

PruritusMyelodysplastic Syndrome
Swelling FaceOsteonecrosis
FatigueHepatitis C
DyspnoeaVarices Oesophageal
Decreased AppetiteWheezing

Most common drug interactions by age * :

n/an/an/an/aPalpitationsOesophageal HaemorrhageChest PainInsomnia
Muscle MassArthropathyMusculoskeletal PainArthralgia
OsteonecrosisFull Blood Count DecreasedPneumonia
PneumoniaBack PainPyrexia
Varices OesophagealMuscle AtrophyNasopharyngitis
Mental Status ChangesTremorDyspnoea
Hepatitis CHaemoglobin DecreasedMyelodysplastic Syndrome
Decreased AppetitePainFatigue
Inappropriate Antidiuretic Hormone SecretionProctalgiaCough
NauseaHeadacheSwelling Face

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Synthroid and Milk Thistle?




You are not alone! Join a related support group:
- support group for people who take Milk Thistle
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Milk Thistle (milk thistle) is often used to treat fatty liver. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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