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Review: taking Tizanidine and Gabapentin together

Summary: drug interactions are reported among people who take Tizanidine and Gabapentin together.

This review analyzes the effectiveness and drug interactions between Tizanidine and Gabapentin. It is created by eHealthMe based on reports of 2,387 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 4, 2015: 2,387 people who take Tizanidine Hydrochloride, Gabapentin are studied

Tizanidine Hydrochloride, Gabapentin outcomes

Drug combinations in study:
- Tizanidine Hydrochloride (tizanidine hydrochloride)
- Gabapentin (gabapentin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tizanidine Hydrochloride is effective25.00%
(3 of 12 people)
(4 of 22 people)
(3 of 19 people)
(8 of 21 people)
(9 of 18 people)
(3 of 9 people)
(3 of 4 people)
Gabapentin is effective18.18%
(2 of 11 people)
(6 of 25 people)
(1 of 11 people)
(2 of 16 people)
(11 of 27 people)
(2 of 9 people)
(3 of 5 people)

Drug effectiveness by gender :

Tizanidine Hydrochloride is effective32.14%
(27 of 84 people)
(6 of 20 people)
Gabapentin is effective27.38%
(23 of 84 people)
(4 of 20 people)

Drug effectiveness by age :

Tizanidine Hydrochloride is effectiven/an/an/a19.05%
(4 of 21 people)
(5 of 45 people)
(10 of 47 people)
(14 of 48 people)
(0 of 20 people)
Gabapentin is effectiven/an/an/a13.64%
(3 of 22 people)
(4 of 44 people)
(6 of 46 people)
(12 of 48 people)
(2 of 19 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Confusional StateMental DisorderAnxietyDehydrationPainDepressionBladder ProlapsePain
DizzinessPainDyspnoeaCholecystitis ChronicSuicide AttemptFatigueMuscle AtrophyAnxiety
SomnolenceAtelectasisEmotional DistressBreast CancerAnxietySuicide AttemptOedemaDepression
FallDepressionDuodenal UlcerHeadacheRoad Traffic AccidentLoss Of ConsciousnessParaesthesiaFall
NauseaAnxietyDrug Withdrawal SyndromeGeneral Physical Health DeteriorationInsomniaAnxietyAnorexiaDyspnoea
Loss Of ConsciousnessPulmonary EmbolismCushingoidPulmonary EmbolismDepressionHip FractureAdverse ReactionHeadache
Vision BlurredConfusionDehydrationPulmonary InfarctionPulmonary EmbolismIncontinenceBlood Pressure IncreasedNausea
Dry MouthPleural EffusionInsomniaLoss Of Sensation, Numbness And Tingling, Paresthesias, Sensory Loss, Tingling And NumbnessSuicidal IdeationMemory ImpairmentSyncopeFatigue
Myocardial InfarctionHeadacheTremorDeep Vein ThrombosisOverdoseMultiple Sclerosis RelapseActivities Of Daily Living ImpairedAsthenia
FatigueDysarthriaVision BlurredAnxietyConfusional StateHallucinationTremorDrug Ineffective

Most common drug interactions by gender * :

AnxietyBack Pain
DepressionMuscle Spasms
DyspnoeaDrug Dependence
AstheniaPain In Extremity
DizzinessConfusional State

Most common drug interactions by age * :

Epilepsyn/aSerotonin SyndromeAnxietyAnxietyPainPainPain
Drug Effect DecreasedConstipationCompleted SuicideArthralgiaDepressionDepressionFall
General Physical Health DeteriorationIleusDepressionNauseaAnxietyFallDyspnoea
Haemoglobin DecreasedDystoniaMuscle SpasmsPainHeadacheFatigueAnxiety
DiarrhoeaBlepharospasmConfusional StateHeadacheChest PainDyspnoeaHypotension
DehydrationPyrexiaMetabolic AcidosisDyspnoeaMuscle SpasmsAnxietyUrinary Tract Infection
Aspartate Aminotransferase IncreasedAccommodation DisorderHeadacheDrug Withdrawal SyndromeFallBack PainAsthenia
Blood Alkaline Phosphatase IncreasedUrinary Tract InfectionAstheniaNauseaHypertensionMyocardial Infarction
Blood Lactate Dehydrogenase IncreasedDrug IneffectiveDepressionDrug IneffectiveHeadacheConfusional State
BradycardiaNauseaFatigueAstheniaMemory ImpairmentOsteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Gabapentin
- support group for people who take Tizanidine Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tizanidine Hydrochloride (tizanidine hydrochloride) is often used to treat muscle spasms. Gabapentin (gabapentin) is often used to treat neuralgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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