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Review: taking Tizanidine and Methotrexate together

Summary: drug interactions are reported among people who take Tizanidine and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Tizanidine and Methotrexate. It is created by eHealthMe based on reports of 307 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Tizanidine and Methotrexate >>>

What are the drugs

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from 1,543 Tizanidine hydrochloride users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,233 Methotrexate users)

On Jan, 7, 2015: 307 people who take Tizanidine Hydrochloride, Methotrexate are studied

Tizanidine Hydrochloride, Methotrexate outcomes

Drug combinations in study:
- Tizanidine Hydrochloride (tizanidine hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tizanidine Hydrochloride is effectiven/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 5 people)
n/a100.00%
(1 of 1 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 3 people)
0.00%
(0 of 1 people)
n/a33.33%
(1 of 3 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RhabdomyolysisJoint EffusionVulvovaginal PainInterstitial Lung DiseaseZygomycosisStomach Painn/aFall
AbasiaUterine CancerHerpes ZosterHypoxiaBlood Culture PositivePyrexia
Blood Creatine Phosphokinase IncreasedCholelithiasisGenital HerpesStomach PainUterine CancerArthralgia
HypersomniaDysuriaUrine Phosphate AbnormalJoint EffusionFatigue
FallImpaired Gastric EmptyingDysuriaPneumonia
AtelectasisLeukocytosisCholelithiasisPain
AnaemiaZygomycosisPainHypertension
HypertensionBlood Culture PositiveVocal Cord ParalysisNausea
CoughHaematomaCervix CarcinomaChest Pain
PneumoniaPneumoniaHeart Rate IncreasedBack Pain

Drug effectiveness by gender :

FemaleMale
Tizanidine Hydrochloride is effective20.00%
(1 of 5 people)
25.00%
(1 of 4 people)
Methotrexate is effective25.00%
(1 of 4 people)
40.00%
(2 of 5 people)

Most common drug interactions by gender * :

FemaleMale
FallPain Nos
PyrexiaPneumonia
FatigueSplenomegaly
ArthralgiaSepsis
PainMyalgia
NauseaParaplegia
HypertensionMultiple Sclerosis
PneumoniaInfluenza Like Illness
Back PainEmphysema
Chest PainRheumatoid Arthritis

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tizanidine Hydrochloride is effectiven/an/an/an/a100.00%
(1 of 1 people)
0.00%
(0 of 5 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
Methotrexate is effectiven/an/an/an/a100.00%
(1 of 1 people)
0.00%
(0 of 6 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aFaeces DiscolouredSubarachnoid HaemorrhageNauseaFallArthralgia
Weight DecreasedFibromyalgiaFatigueAnaemiaFall
HypokalaemiaPainIntervertebral DiscitisCoughAngiopathy
Biliary DyskinesiaSplenomegalyPainRhabdomyolysisPain Nos
CholesterosisSepsisArthralgiaPneumoniaHerpes Zoster
Cholecystitis ChronicHeadacheFallUrinary Tract InfectionHypochloraemia
Pain In ExtremityHypertensionHeadachePyrexiaMuscle Spasms
VomitingChest PainPain In ExtremityHypertensionMyalgia
Abdominal PainArthralgiaPyrexiaAbasiaOedema Peripheral
Abdominal Pain UpperRheumatoid ArthritisMalaiseAtelectasisHypokalaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tizanidine and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Tizanidine and Methotrexate
- support group for people who take Methotrexate
- support group for people who take Tizanidine Hydrochloride

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • After recovered from vertigo i conitnue to have ringing behind my right ear. what can i take to help stop the ringing?
    I also take zinc 50 mg, fish oil 1000mg - omega 3 300 mg, vitamin E 400IU, Ginkgo Biloba 120 mg, choline&inositol.
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?
  • What does unmasking mean; and does it mean that i always had hight cholesterol and triglycerides, or did actemra increase them?
    I have failed many RA meds, and now receive actemera x's 10 months I have never had high cholesterol or triglycerides and did not get my cholesterol checked except for the baseline 2/2014 and 12/2014 I was 198 TChol and now am 245; my tri up 85 points. my MD said that now that my inflammation is normal it shows my true cholestorol. I don't understand.

More questions for: Methotrexate, Tizanidine Hydrochloride

You may be interested at these reviews (Write a review):

  • Roaring in the ears from tramadol (taken with dexamethasone)
    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.
  • Weighted feeling in legs
    I was prescribed tizanidine for lower back pain. I have sciatic nerve issues and fibromyalgia. I also have ptsd and just started remembering skiing accident that I had 19 years ago at age of 15 where I suspect concussion and sinal injury that was left untreated do to to medical neglect (waiting on x-ray results). I thought I was having muscle memories until I seen commercial about varicose vein removal and how weighted or heavy leg feelings where disappeared after surgery. I have very noticeable and thick as a snake varicose veins in my legs. I was looking up side effects I have been having dizziness, numbness in back, nausea, trouble bm while taking pill and hot flashes when messing a dose. I thought why not check deep vein thrombosis (which I suspect I have because of varicose veins). Low and behold there are others with this problem. So now I can add that to list. When I miss a dose my legs feel weighted down. I have only been on tizanidine for 1 month and 2 weeks. Very low dose to start 2mg 3x day. Only other meds are vitamins and metformin (which I am on another break from for 3 days now). I feel side effects of tizanidine are worse than benifits.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.

More reviews for: Methotrexate, Tizanidine Hydrochloride

Comments from related studies:

  • From this study (6 months ago):

  • I recently quit taking all meds due to loss of insurance coverage. I have been having symptoms for a week that seem to only get worse

    Reply

  • From this study (1 year ago):

  • I take methotexate weekly.. After a day of taking them, I have terrible chest pain that radiates to my neck, and down my sides

    Reply

Complete drug side effects:

On eHealthMe, Tizanidine Hydrochloride (tizanidine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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